BE903232A - Composes antibiotiques et leur procede de preparation - Google Patents

Composes antibiotiques et leur procede de preparation

Info

Publication number
BE903232A
BE903232A BE0/215580A BE215580A BE903232A BE 903232 A BE903232 A BE 903232A BE 0/215580 A BE0/215580 A BE 0/215580A BE 215580 A BE215580 A BE 215580A BE 903232 A BE903232 A BE 903232A
Authority
BE
Belgium
Prior art keywords
preparation
antibiotic compounds
compounds
streptomyces
agriculture
Prior art date
Application number
BE0/215580A
Other languages
English (en)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB848423278A external-priority patent/GB8423278D0/en
Priority claimed from GB848432519A external-priority patent/GB8432519D0/en
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BE903232A publication Critical patent/BE903232A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/01—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing oxygen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Les composés répondant à la formule (I) peuvent possèder un groupe 5-OH ou-OMe et, en position 25, un radical isopropylène à substitution méthylique, étylique ou isopropylique. Ces composés conviennent en agriculture ou en médecine comme substances antiparasitaires et se préparent par la culture de souches de Streptomyces, plus particulièrement de Streptomyces thermoarchaensis NCIB 12015.
BE0/215580A 1984-09-14 1985-09-13 Composes antibiotiques et leur procede de preparation BE903232A (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB848423278A GB8423278D0 (en) 1984-09-14 1984-09-14 Antibiotic compounds
GB848432519A GB8432519D0 (en) 1984-12-21 1984-12-21 Antibiotic compounds

Publications (1)

Publication Number Publication Date
BE903232A true BE903232A (fr) 1986-03-13

Family

ID=26288220

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/215580A BE903232A (fr) 1984-09-14 1985-09-13 Composes antibiotiques et leur procede de preparation

Country Status (33)

Country Link
US (2) US4898821A (fr)
JP (2) JPH07116199B2 (fr)
KR (1) KR940004098B1 (fr)
AT (1) AT396250B (fr)
AU (1) AU596565B2 (fr)
BE (1) BE903232A (fr)
BG (1) BG44205A3 (fr)
BR (1) BR8504457A (fr)
CA (1) CA1313155C (fr)
CH (1) CH666690A5 (fr)
CS (1) CS268803B2 (fr)
DE (1) DE3532794A1 (fr)
DK (1) DK162099C (fr)
ES (2) ES8704545A1 (fr)
FI (1) FI87366C (fr)
FR (1) FR2570390B1 (fr)
GB (1) GB2166436B (fr)
GR (1) GR852232B (fr)
HU (1) HU197046B (fr)
IE (1) IE59394B1 (fr)
IL (1) IL76385A (fr)
IT (1) IT1182857B (fr)
LU (1) LU86074A1 (fr)
NL (1) NL8502511A (fr)
NZ (1) NZ213463A (fr)
PH (2) PH21995A (fr)
PL (1) PL152148B1 (fr)
PT (1) PT81125B (fr)
RO (1) RO92478A (fr)
SE (2) SE502748C2 (fr)
SU (1) SU1738090A3 (fr)
UA (1) UA19162A (fr)
ZW (1) ZW15585A1 (fr)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LV5536A3 (lv) * 1984-09-14 1994-03-10 American Cyanamid Co Panemiens antibiotikas s-541 iegusanai streptomicetu celmi-antibiotikas s-541 producenti
US4696922A (en) * 1984-11-26 1987-09-29 Ciba-Geigy Corporation 5-azolylacetoxymilbemycins as ecto- and endoparasites
AT399441B (de) * 1985-04-30 1995-05-26 American Cyanamid Co Schädlingsbekämpfungsmittel und verfahren zur bekämpfung von schädlingen
IL78621A (en) * 1985-04-30 1991-06-30 American Cyanamid Co Mylbemycin analogs,their preparation and pesticidal compositions containing them
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina
IE67373B1 (en) * 1985-09-13 1996-03-20 American Cyanamid Co Macrolide antibiotics and their preparation
GB8606116D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Process
GB8606105D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Chemical compounds
CA1325395C (fr) * 1986-03-12 1993-12-21 Michael V.J. Ramsay Compose de type macrolide
NZ219575A (en) * 1986-03-12 1990-04-26 Glaxo Group Ltd Phosphate, substituted alkoxy, or amino-carbonyloxy derivatives of milbemycin, and pesticidal compositions
GB8606120D0 (en) * 1986-03-12 1986-04-16 Glaxo Group Ltd Process
AT398312B (de) * 1986-03-12 1994-11-25 American Cyanamid Co Verfahren zur herstellung einer neuen makroliden verbindung
GB8613790D0 (en) * 1986-06-06 1986-07-09 Glaxo Group Ltd Chemical compounds
CA1296329C (fr) * 1986-06-06 1992-02-25 Derek R. Sutherland Composes de type macrolide
US5840704A (en) * 1986-07-16 1998-11-24 Pfizer Inc. Antiparasitic agents and process for their preparation
EP0253378A3 (fr) * 1986-07-18 1988-03-23 Ciba-Geigy Ag Dérivés des antibiotiques S541 substitués en position 13-bêta par un alkyle, pour combattre les parasites des animaux domestiques et des plantes
DE3750495T2 (de) * 1986-07-24 1995-02-23 Beecham Group Plc Milbemycin-Derivate mit parasitenabtötender Aktivität, ein Verfahren zu ihrer Herstellung und die sie enthaltenden Zusammensetzungen.
EP0259779B1 (fr) * 1986-09-12 1994-08-10 American Cyanamid Company Dérivés des composés LL-F28249 comportant en position 23 un groupement oxo(céto) ou imine
ATE82017T1 (de) * 1986-09-12 1992-11-15 American Cyanamid Co 23-deoxy-derivate von ll-f28249-verbindungen.
US5019589A (en) * 1986-09-12 1991-05-28 American Cyanamid Company Δ23 -LL-F28249 compounds
US5149832A (en) * 1986-09-12 1992-09-22 American Cyanamid Company Mono and diacyl derivatives of ll-f28249 compounds
US4916154A (en) * 1986-09-12 1990-04-10 American Cyanamid Company 23-Imino derivatives of LL-F28249 compounds
US4886828A (en) * 1986-09-12 1989-12-12 American Cyanamid Company Δ22 -derivatives of LL-F28249 compounds
US5234831A (en) * 1987-01-23 1993-08-10 Pfizer Inc Cultures for production of B avermectins
US5525506A (en) * 1987-01-23 1996-06-11 Pfizer Inc. Process for production of avermectins and cultures therefor
US5238848A (en) * 1987-01-23 1993-08-24 Pfizer Inc Cultures for production of avermectins
US5183749A (en) * 1987-02-04 1993-02-02 Sankyo Company, Ltd. Microbial process for the preparation of milbemycin derivatives
US4897416A (en) * 1987-02-18 1990-01-30 Ciba-Geigy Corporation Insecticides and parasiticides
US4956479A (en) * 1987-03-06 1990-09-11 American Cyanamid Company 23-deoxy-27-chloro derivatives of LL-F28249 compounds
US4886829A (en) * 1987-03-06 1989-12-12 American Cyanamid Company 23-Oxo (keto) and 23-imino derivatives of mono- and diepoxy LL-F28249 compounds
US4855317A (en) * 1987-03-06 1989-08-08 Ciba-Geigy Corporation Insecticides and parasiticides
US4851428A (en) * 1987-03-06 1989-07-25 American Cyanamid Company Mono- and diepoxide derivatives of Δ22-LL-F28249 compounds
US4876272A (en) * 1987-03-06 1989-10-24 American Cyanamid Company Mono- and diepoxide derivatives of LL-F28249 compounds
US4886830A (en) * 1987-03-06 1989-12-12 American Cyanamid Company Mono- and diepoxide derivatives of 23-deoxyl-LL-F28249 compounds
US4806527A (en) * 1987-03-16 1989-02-21 Merck & Co., Inc. Avermectin derivatives
US4871719A (en) * 1987-03-24 1989-10-03 Ciba-Geigy Corporation Composition for controlling parasites in productive livestock
EP0285561A3 (fr) * 1987-03-27 1989-10-25 Ciba-Geigy Ag Dérivés de la milbémycine à activité antiparasitaire et insecticide
GB8721377D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical compounds
GB8721375D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical process
GB8721378D0 (en) * 1987-09-11 1987-10-21 Glaxo Group Ltd Chemical process
GB8721647D0 (en) * 1987-09-15 1987-10-21 Pfizer Ltd Antiparasitic agents
US5240850A (en) * 1987-10-23 1993-08-31 Pfizer Inc. Cultures for production of avermectin aglycones
ATE87926T1 (de) * 1987-11-09 1993-04-15 Pfizer Ethylierte avermectine.
GB8726730D0 (en) 1987-11-14 1987-12-16 Pfizer Ltd Antiparasitic agents
GB8803836D0 (en) * 1988-02-18 1988-03-16 Glaxo Group Ltd Compositions
GB8804440D0 (en) * 1988-02-25 1988-03-23 Pfizer Ltd Antiparasitic agents
GB8805978D0 (en) * 1988-03-14 1988-04-13 Glaxo Group Ltd Process
GB8813760D0 (en) * 1988-06-10 1988-07-13 American Cyanamid Co Chemical process
NZ232422A (en) * 1989-02-16 1992-11-25 Merck & Co Inc 13-ketal milbemycin derivatives and parasiticides
US5322692A (en) * 1989-02-28 1994-06-21 American Cyanamid Company Sustained release bolus effective for the prolonged prevention, treatment or control of nematode, acarid and endo- and ectoparasitic infestations of ruminants
EP0393890B1 (fr) * 1989-04-11 1992-08-12 Pfizer Limited Compositions injectables à base de 25-cyclohexyle avermectine B1
US6001822A (en) * 1989-04-11 1999-12-14 Pfizer Inc. Antiparasitic formulations
ES2087099T3 (es) 1989-08-11 1996-07-16 American Cyanamid Co Agentes arilpirrolicos insecticidas, acaricidas y nematicidas y procedimientos.
NZ234802A (en) * 1989-08-14 1992-11-25 Merck & Co Inc Long acting injectable formulations comprising an avermectin compound and triacetin. treatment for internal and external parasites of animals
US5055454A (en) * 1989-10-30 1991-10-08 Merck & Co., Inc. 13-epi-avermectin derivatives useful as antiparasitic agents
US5830875A (en) * 1989-10-30 1998-11-03 Merck & Co., Inc. 24-and 25-substituted avermectin and milbemycin derivatives
US5208222A (en) * 1991-03-28 1993-05-04 Merck & Co., Inc. 4"-and 4'-alkylthio avermectin derivatives
US5262400A (en) * 1991-06-20 1993-11-16 Merck & Co., Inc. 4α-substituted avermectin derivatives
MD24B1 (ro) * 1991-07-09 1994-05-31 Parfumerii Si Cosmetice Vioric Compozitie de substante odorante
GB9205007D0 (en) * 1992-03-07 1992-04-22 Pfizer Ltd Antiparasitic agents
US5229415A (en) * 1992-03-24 1993-07-20 Merck & Co., Inc. Alkylthio alkyl avermectins are active antiparasitic agents
US6103504A (en) * 1992-03-25 2000-08-15 Pfizer Inc. Process for production of avermectins and cultures therefor
US6486195B1 (en) * 1993-08-19 2002-11-26 Merck & Co., Inc. Thermodynamically stable crystal form of 4″-deoxy-4″-epi-methylamino avermectin B1a/B1b benzoic acid salt and processes for its preparation
JP2855181B2 (ja) 1993-12-10 1999-02-10 敏雄 鈴木 松類の枯損防止用組成物及び防止方法
AU9785698A (en) 1997-10-02 1999-04-27 Microcide Pharmaceuticals, Inc. Fungal efflux pump inhibitors
ES2258062T3 (es) 2000-10-10 2006-08-16 Wyeth Composicion antihelmintica.
GB0205253D0 (en) * 2002-03-06 2002-04-17 Univ Gent Immediate release pharmaceutical granule compositions and a continuous process for making them
WO2006091038A1 (fr) * 2005-02-25 2006-08-31 Medigenes Co., Ltd. Composition pharmaceutique pour le traitement de la dystrophie corneenne d'avellino comporte du plasma sanguin et ou du serum
CN100394983C (zh) * 2006-01-09 2008-06-18 浙江海正药业股份有限公司 含有大豆油的多拉菌素注射液

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4914624A (fr) * 1972-06-08 1974-02-08
SE434277B (sv) * 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4171314A (en) * 1977-12-19 1979-10-16 Merck & Co., Inc. 13-Halo and 13-deoxy C-076 compounds
IL56149A (en) * 1977-12-19 1989-09-28 Merck & Co Inc 13-halo and 13-deoxy derivatives of c-076 compounds,their preparation and method for the treatment of parasitic infections in animals therewith
US4173571A (en) * 1977-12-19 1979-11-06 Merck & Co., Inc. 13-Halo and 13-deoxy derivatives of C-076 compounds
US4200581A (en) * 1978-08-04 1980-04-29 Merck & Co., Inc. Alkyl derivatives of C-076 compounds
NZ201681A (en) * 1981-09-03 1985-11-08 Merck & Co Inc Avermectin derivatives and parasiticidal compositions
DE3519834C2 (de) * 1984-06-05 1993-12-16 American Cyanamid Co Neue antibiotische Wirkstoffe, Verfahren zu ihrer Gewinnung und ihre Anwendung zur Bekämpfung von Infektionen bei Tieren und Pflanzen
IL78621A (en) * 1985-04-30 1991-06-30 American Cyanamid Co Mylbemycin analogs,their preparation and pesticidal compositions containing them
ES8800986A1 (es) * 1985-07-27 1987-12-01 Pfizer Un procedimiento para la produccion de un nuevo derivado de avermectina

Also Published As

Publication number Publication date
PL152148B1 (en) 1990-11-30
KR860002576A (ko) 1986-04-26
RO92478A (fr) 1987-09-30
NZ213463A (en) 1993-04-28
FR2570390B1 (fr) 1987-11-27
CS654685A2 (en) 1989-08-14
IT8548551A0 (it) 1985-09-13
FI87366B (fi) 1992-09-15
US4935531A (en) 1990-06-19
AU4742685A (en) 1986-03-20
BR8504457A (pt) 1986-07-15
JPS61118387A (ja) 1986-06-05
PT81125A (en) 1985-10-01
IL76385A (en) 1990-09-17
GB2166436B (en) 1989-05-24
JPH07213278A (ja) 1995-08-15
SE8504254L (sv) 1986-03-15
SE8504254D0 (sv) 1985-09-13
KR940004098B1 (ko) 1994-05-13
PL255360A1 (en) 1988-02-18
CH666690A5 (de) 1988-08-15
NL8502511A (nl) 1986-04-01
AT396250B (de) 1993-07-26
HUT39779A (en) 1986-10-29
GR852232B (fr) 1986-01-14
DK162099C (da) 1992-02-24
SU1738090A3 (ru) 1992-05-30
IE852263L (en) 1986-03-14
DE3532794A1 (de) 1986-04-17
ES557237A0 (es) 1988-08-01
SE8802985L (sv) 1988-08-25
SE502748C2 (sv) 1995-12-18
PH24247A (en) 1990-05-04
GB8522699D0 (en) 1985-10-16
GB2166436A (en) 1986-05-08
JPH07116199B2 (ja) 1995-12-13
DK418085D0 (da) 1985-09-13
ZW15585A1 (en) 1986-04-23
PT81125B (pt) 1987-10-20
ES8704545A1 (es) 1987-04-01
FI853520L (fi) 1986-03-15
FI853520A0 (fi) 1985-09-13
SE469173B (sv) 1993-05-24
ATA268485A (de) 1992-11-15
AU596565B2 (en) 1990-05-10
ES8802555A1 (es) 1988-08-01
US4898821A (en) 1990-02-06
BG44205A3 (en) 1988-10-14
JP2566385B2 (ja) 1996-12-25
FI87366C (fi) 1992-12-28
IE59394B1 (en) 1994-02-23
CS268803B2 (en) 1990-04-11
IL76385A0 (en) 1986-01-31
DK418085A (da) 1986-03-15
PH21995A (en) 1988-05-02
UA19162A (uk) 1997-12-25
FR2570390A1 (fr) 1986-03-21
SE8802985D0 (sv) 1988-08-25
CA1313155C (fr) 1993-01-26
IT1182857B (it) 1987-10-05
DK162099B (da) 1991-09-16
LU86074A1 (fr) 1986-04-03
HU197046B (en) 1989-02-28
ES546962A0 (es) 1987-04-01

Similar Documents

Publication Publication Date Title
BE903232A (fr) Composes antibiotiques et leur procede de preparation
EP0271581A4 (fr) Nouveaux composes dc-88a et dc-89a1, et procede pour leur preparation.
EP0170006A2 (fr) Agents et leurs méthodes de production, méthodes et compositions contenant ces agents pour lutter contre les infections dûes aux helminthes, aux arthropodes, aux ectoparasites et aux acariens
IL75337A (en) Polyenoic acids omega-substituted by a 4,5-dimethoxy-2-methyl-quinone or a 4,5-dimethoxy-2-methyl-phenyl group,process for the preparation thereof and pharmaceutical compositions containing the same
KR880004097A (ko) 글리코펩티드 항생물질
MA20878A1 (fr) Derives d'indolizine, leur procede de preparation ainsi que les compositions en contenant
EP0215654A3 (en) Macrolide antibiotics and their preparation
US4464466A (en) Process of producing lincomycin nucleotides
US5317030A (en) Method and compositions for helmintic, arthropod ectoparasitic and acaridal infections with novel agents
US4383109A (en) Lincomycin nucleotides
US3207750A (en) Derivatives of decoyinine
BE904864A (fr) Derives de la quinoleine, leur procede de preparation et compositions pharmaceutiques les contenant.
AU7827787A (en) Novel 23-imino derivatives of 23-keto compounds
US3856938A (en) Antibiotic em{14 49
FR2421181A1 (fr) Derives de substitution de spirooxazolidinone steroidienne, leur procede de preparation et compositions pharmaceutiques les contenant
EP1132383A4 (fr) Nouveaux derives d'aloefurane, leur procede de preparation, les preparations pharmaceutiques les contenant et leur utilisation comme medicament
BE902774A (fr) Diacyloxy-1,8 acyl-10 anthrones procede de preparation et utilisation en medecine humaine ou veterinaire et en cosmetique.
PT85673A (en) Process for preparing novel mono and dyacil derivatives of ll-f28249 compounds
US5198464A (en) Method and compositions for helmintic, arthropod ectoparasitic and acaridal infections with novel agents
IL69093A (en) Method for preparing 20-deoxo-23-de(mycinosyloxy)tylosin antibiotics,the novel 20-deoxo-23-de(mycinoslyloxy)tylosin derivatives,their use as intermediates and pharmaceutical compositions containing them
CA1046965A (fr) Naphthyridinomycines produite par un streptomyces
US3592926A (en) Antifungals bk217beta and bk217upsilon and process for producing same
US5089478A (en) Method for the control of pneumocystis carinii
CA1163938A (fr) Traitement d'une maladie due a des protozoaires, grace a des 3-(5'-ribonucleotides) de lincomycine
DE3569538D1 (en) Novel antibiotics, process for their preparation and pharmaceutical compositions containing them

Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: AMERICAN CYANAMID CY

Effective date: 19970930