BE904867A - Procede de preparation de sels d'heparine: - Google Patents

Procede de preparation de sels d'heparine:

Info

Publication number: BE904867A
Authority: BE; Belgium
Prior art keywords: heparinate; preparation; heparin; cation; phases
Prior art date: 1985-06-04

Application number

BE0/216737A

Other languages

English (en)

French (fr)

Original Assignee

Richter Gedeon Vegyeszet

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-06-04

Filing date

1986-06-03

Publication date

1986-10-01

1986-06-03 Application filed by Richter Gedeon Vegyeszet filed Critical Richter Gedeon Vegyeszet

1986-10-01 Publication of BE904867A publication Critical patent/BE904867A/fr

Links

HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical class OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 title abstract 4
238000000034 method Methods 0.000 title abstract 3
238000002360 preparation method Methods 0.000 title abstract 2
229920000669 heparin Polymers 0.000 abstract 4
239000007864 aqueous solution Substances 0.000 abstract 2
-1 heparinate cation Chemical class 0.000 abstract 2
238000000746 purification Methods 0.000 abstract 2
150000003839 salts Chemical class 0.000 abstract 2
238000000926 separation method Methods 0.000 abstract 2
239000000243 solution Substances 0.000 abstract 2
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
229910052791 calcium Inorganic materials 0.000 abstract 1
239000011575 calcium Substances 0.000 abstract 1
238000004090 dissolution Methods 0.000 abstract 1
239000003960 organic solvent Substances 0.000 abstract 1
238000001556 precipitation Methods 0.000 abstract 1
239000002904 solvent Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0075—Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
General Health & Medical Sciences (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Materials Engineering (AREA)
Biochemistry (AREA)
Engineering & Computer Science (AREA)
Polymers & Plastics (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BE0/216737A 1985-06-04 1986-06-03 Procede de preparation de sels d'heparine: BE904867A (fr)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
HU852197A HU193769B (en)	1985-06-04	1985-06-04	Sodium-exchanging process for producing pharmaceutically acceptable heparinates applicable even for injections

Publications (1)

Publication Number	Publication Date
BE904867A true BE904867A (fr)	1986-10-01

Family

ID=10958239

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BE0/216737A BE904867A (fr)	1985-06-04	1986-06-03	Procede de preparation de sels d'heparine:

Country Status (6)

Country	Link
AT (1)	AT397250B (de)
BE (1)	BE904867A (de)
FR (1)	FR2582657B1 (de)
GB (1)	GB2176200B (de)
HU (1)	HU193769B (de)
IT (1)	IT1190124B (de)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
SE8702254D0 (sv) *	1987-05-29	1987-05-29	Kabivitrum Ab	Novel heparin derivatives
HU208029B (en) *	1988-06-03	1993-07-28	Italfarmaco Spa	Process for producing glycose-amino-glycane salts and pharmaceutical compositions containing them
CN117088997B (zh) *	2023-07-17	2025-05-30	盐城凯利药业有限公司	一种肝素钠的制备工艺

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE1013641B (de) *	1956-03-20	1957-08-14	Nordmark Werke Gmbh	Verfahren zur Reinigung von Heparin
GB904112A (en) *	1958-12-19	1962-08-22	Roussel Uclaf	Improvements in or relating to heparine and derivatives thereof
US2989438A (en) *	1958-12-29	1961-06-20	Roussel Uclaf	Process of purifying heparin, and product produced therefrom
US3058884A (en) *	1959-09-14	1962-10-16	Abbott Lab	Process for purifying heparin
US3160563A (en) *	1960-05-13	1964-12-08	Ormonoterapia Richter Spa	Purification of heaprin
US3342683A (en) *	1964-02-25	1967-09-19	Taiyo Gyogyo Kabushiki Kaisha	Heparin from whale tissue and method of preparing same
US3451996A (en) *	1968-02-12	1969-06-24	Thompson Farms Co	Method for the preparation of heparin
US3817831A (en) *	1973-01-10	1974-06-18	Wilson Pharm & Chem Corp	Process for production of alkali metal salt of heparin
GB2027728B (en) *	1978-08-08	1983-03-30	Choay Sa	Physiologically acceptable heparin
IT1141263B (it) *	1980-02-29	1986-10-01	Italfarmaco Spa	Metodo per la preparazione di eparinato di calcio

1985
- 1985-06-04 HU HU852197A patent/HU193769B/hu unknown
1986
- 1986-05-28 AT AT0144386A patent/AT397250B/de not_active IP Right Cessation
- 1986-06-02 FR FR868607875A patent/FR2582657B1/fr not_active Expired - Lifetime
- 1986-06-03 BE BE0/216737A patent/BE904867A/fr not_active IP Right Cessation
- 1986-06-04 IT IT20676/86A patent/IT1190124B/it active
- 1986-06-04 GB GB8613593A patent/GB2176200B/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
IT8620676A0 (it)	1986-06-04
GB2176200B (en)	1990-01-24
IT1190124B (it)	1988-02-10
GB8613593D0 (en)	1986-07-09
FR2582657B1 (fr)	1991-12-13
GB2176200A (en)	1986-12-17
HU193769B (en)	1987-11-30
AT397250B (de)	1994-02-25
FR2582657A1 (fr)	1986-12-05
IT8620676A1 (it)	1987-12-04
ATA144386A (de)	1993-07-15

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Legal Events

Date

Code

Title

Description

1996-12-31

RE

Patent lapsed

Owner name: RICHTER GEDEON VEGYESZETI GYAR R.T.

Effective date: 19960630