BE905200A - Procede de preparation d'une forme granulaire a liberation retardee d'un principe actif et forme granulaire obtenue. - Google Patents

Procede de preparation d'une forme granulaire a liberation retardee d'un principe actif et forme granulaire obtenue.

Info

Publication number
BE905200A
BE905200A BE0/216995A BE216995A BE905200A BE 905200 A BE905200 A BE 905200A BE 0/216995 A BE0/216995 A BE 0/216995A BE 216995 A BE216995 A BE 216995A BE 905200 A BE905200 A BE 905200A
Authority
BE
Belgium
Prior art keywords
granular form
preparation
delayed
active ingredient
dispersible
Prior art date
Application number
BE0/216995A
Other languages
English (en)
Original Assignee
Zyma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zyma Sa filed Critical Zyma Sa
Publication of BE905200A publication Critical patent/BE905200A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procédé de préparation d'une forme granulaire à libération retardée d'une substance pharmaceutiquement active, ou de leurs mélanges, où l'on enrobe une substance pharmaceutiquement active granulée ou cristalline, ou leurs mélanges, avec un mélange de matières enrobantes constitué essentiellement d'un mélange homogène d'un (méthyl+éthyl) ester de l'acide poly(H + méth)-acrylique qui est insoluble mais dispersable dans l'eau et d'une éthyl-cellulose qui est insoluble mais dispersable dans l'eau dans un rapport pondéral de 20:1 à 1:5, caractérisé en ce qu'on chauffe les granules enrobés pendant au moins 5 minutes à des températures élevées allant de 50 degrés à 12 degrés C ainsi que la forme granulaire obtenue.
BE0/216995A 1985-07-31 1986-07-30 Procede de preparation d'une forme granulaire a liberation retardee d'un principe actif et forme granulaire obtenue. BE905200A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB858519310A GB8519310D0 (en) 1985-07-31 1985-07-31 Granular active substances

Publications (1)

Publication Number Publication Date
BE905200A true BE905200A (fr) 1987-01-30

Family

ID=10583125

Family Applications (1)

Application Number Title Priority Date Filing Date
BE0/216995A BE905200A (fr) 1985-07-31 1986-07-30 Procede de preparation d'une forme granulaire a liberation retardee d'un principe actif et forme granulaire obtenue.

Country Status (23)

Country Link
US (1) US4728513A (fr)
JP (1) JPS6229514A (fr)
AT (1) AT392901B (fr)
AU (1) AU596804B2 (fr)
BE (1) BE905200A (fr)
CH (1) CH670566A5 (fr)
DE (1) DE3625458A1 (fr)
DK (1) DK361786A (fr)
ES (1) ES2000577A6 (fr)
FI (1) FI863074L (fr)
FR (1) FR2585570B1 (fr)
GB (2) GB8519310D0 (fr)
GR (1) GR862017B (fr)
HU (1) HU196304B (fr)
IL (1) IL79537A (fr)
IT (1) IT1195985B (fr)
LU (1) LU86523A1 (fr)
NL (1) NL8601961A (fr)
NZ (1) NZ217028A (fr)
PH (1) PH23531A (fr)
PT (1) PT83093B (fr)
SE (1) SE8603247L (fr)
ZA (1) ZA865691B (fr)

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Also Published As

Publication number Publication date
AU596804B2 (en) 1990-05-17
US4728513A (en) 1988-03-01
GR862017B (en) 1986-12-23
GB2178313A (en) 1987-02-11
ZA865691B (en) 1987-03-25
LU86523A1 (fr) 1987-02-04
SE8603247L (sv) 1987-02-01
GB8618153D0 (en) 1986-09-03
FR2585570A1 (fr) 1987-02-06
IL79537A0 (en) 1986-10-31
AU6068586A (en) 1987-02-05
HU196304B (en) 1988-11-28
IL79537A (en) 1991-01-31
HUT41630A (en) 1987-05-28
IT8648323A0 (it) 1986-07-29
FI863074A0 (fi) 1986-07-28
SE8603247D0 (sv) 1986-07-29
GB8519310D0 (en) 1985-09-04
FR2585570B1 (fr) 1990-03-23
ATA205686A (de) 1990-12-15
FI863074A7 (fi) 1987-02-01
IT1195985B (it) 1988-11-03
NZ217028A (en) 1989-08-29
AT392901B (de) 1991-07-10
DK361786A (da) 1987-02-01
PH23531A (en) 1989-08-25
NL8601961A (nl) 1987-02-16
GB2178313B (en) 1989-08-23
PT83093B (pt) 1989-01-30
FI863074L (fi) 1987-02-01
DK361786D0 (da) 1986-07-30
ES2000577A6 (es) 1988-03-01
JPS6229514A (ja) 1987-02-07
PT83093A (en) 1986-08-01
DE3625458A1 (de) 1987-02-12
CH670566A5 (fr) 1989-06-30

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Legal Events

Date Code Title Description
RE Patent lapsed

Owner name: ZYMA S.A.

Effective date: 19910731