BG100939A - Алфа-1-антихимотрипсинови аналози имащи еластазна инхибираща активност - Google Patents

Алфа-1-антихимотрипсинови аналози имащи еластазна инхибираща активност

Info

Publication number
BG100939A
BG100939A BG100939A BG10093996A BG100939A BG 100939 A BG100939 A BG 100939A BG 100939 A BG100939 A BG 100939A BG 10093996 A BG10093996 A BG 10093996A BG 100939 A BG100939 A BG 100939A
Authority
BG
Bulgaria
Prior art keywords
alpha
analogues
antimimotripsin
elastic
analysis
Prior art date
Application number
BG100939A
Other languages
English (en)
Inventor
Barry Cooperman
Harvey Rubin
Norman Schechter
Zhi Wang
Original Assignee
The Trustees Of The University Of Pennsylvania
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Trustees Of The University Of Pennsylvania filed Critical The Trustees Of The University Of Pennsylvania
Publication of BG100939A publication Critical patent/BG100939A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

Аналозите на човешки -1-антихимотрипсин, където аминокиселината при 358-ма позиция е избрана от групата, включваща метионин, изолевцин, валин, аланин, аспарагинова киселина, треонин и глутаминова киселина, са ефективни инхибитори на човешка неутрофилна еластаза. Изобретението се отнася и до секвенции на нуклеинови киселини, кодиращи аналозите, доекспресионни вектори, до трансформираниклетки гостопрпиемници и до метод за получаване на аналозите.
BG100939A 1994-03-31 1996-10-28 Алфа-1-антихимотрипсинови аналози имащи еластазна инхибираща активност BG100939A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/221,078 US5674708A (en) 1989-06-23 1994-03-31 α-1-antichymotrypsin analogues having elastase inhibitory activity
PCT/US1994/004735 WO1995027055A1 (en) 1994-03-31 1994-04-29 α-1-ANTICHYMOTRYPSIN ANALOGUES HAVING ELASTASE INHIBITORY ACTIVITY

Publications (1)

Publication Number Publication Date
BG100939A true BG100939A (bg) 1997-10-31

Family

ID=22826247

Family Applications (1)

Application Number Title Priority Date Filing Date
BG100939A BG100939A (bg) 1994-03-31 1996-10-28 Алфа-1-антихимотрипсинови аналози имащи еластазна инхибираща активност

Country Status (17)

Country Link
US (1) US5674708A (bg)
EP (1) EP0754228A4 (bg)
JP (1) JPH09512423A (bg)
CN (1) CN1145637A (bg)
AU (1) AU696995B2 (bg)
BG (1) BG100939A (bg)
CA (1) CA2186908A1 (bg)
CZ (1) CZ281796A3 (bg)
FI (1) FI963891A7 (bg)
HU (1) HUT74901A (bg)
LV (1) LV11747B (bg)
NO (1) NO964022D0 (bg)
NZ (1) NZ269619A (bg)
PL (1) PL316433A1 (bg)
SI (1) SI9420082A (bg)
SK (1) SK138196A3 (bg)
WO (1) WO1995027055A1 (bg)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827662A (en) * 1989-06-23 1998-10-27 The Trustees Of The University Of Pennsylvania Methods for detecting genetic mutations resulting in protease inhibitor insufficiencies
US5723316A (en) * 1989-06-23 1998-03-03 Trustees Of The University Of Pennsylvania α-1-antichymotrypsin analogues having chymase inhibiting activity
US6458777B1 (en) 1998-03-13 2002-10-01 Mucosal Therapeutics Llc Methods and compositions for treating and preventing mucositis
US6242473B1 (en) * 1999-01-08 2001-06-05 Maxim Pharmaceuticals, Inc. Treatment and prevention of reactive oxygen metabolite-mediated cellular damage
CA2423423A1 (en) * 2000-09-29 2003-03-21 Ono Pharmaceutical Co., Ltd. Medecines of ulcerative colitis
DK1392354T3 (da) 2001-04-30 2005-07-04 Switch Biotech Ag Anvendelse af alpha-1-antichymotrypsin til fremstillingen af en sammensætning til behandling, forebyggelse eller diagnose af dårligt helende diabetiske sår
DE10121255A1 (de) 2001-04-30 2002-11-07 Switch Biotech Ag Verwendung von alpha 1-Antichymotrypsin Polypeptiden oder diese kodierende Nukleinsäuren, oder einer ein ACT Polypeptid oder diese kodierende Nukleinsäure exprimierende Zelle, zur Behandlung und/oder Prävention von diabetes-assoziierten und/oder arteriellen schlecht heilenden Wunden und zur Identifizierung von pharmakologisch aktiven Substanzen
EP1415664A1 (en) * 2002-10-30 2004-05-06 Switch Biotech Aktiengesellschaft Use of alpha 1-antichymotrypsin in combination with alpha-1-antitrypsin for treating/preventing diabetes associated or poorly healing arterial wounds
US20070104699A1 (en) * 2005-09-29 2007-05-10 University Of Alberta Compositions for and methods of granzyme B inhibition
US10531655B2 (en) 2011-12-02 2020-01-14 The Regents Of The University Of California Reperfusion protection solution and uses thereof
WO2021020509A1 (ja) * 2019-07-31 2021-02-04 株式会社ステムリム 間葉系幹細胞の増殖促進または減少抑制のための組成物
US12342819B2 (en) * 2019-08-23 2025-07-01 The Hong Kong University Of Science And Technology Elasnin, a bacteriostatic agent that has potent antibiofilm activities against both mono- and multi-species biofilm
CN114650819A (zh) 2019-09-17 2022-06-21 美莱奥生物制药第四有限公司 用于治疗移植物排斥、闭塞性细支气管炎综合征和移植物抗宿主病的阿维来司他
WO2021209740A1 (en) 2020-04-16 2021-10-21 Mereo Biopharma 4 Limited Methods involving neutrophil elastase inhibitor alvelestat for treating coronavirus infection
EP4419102A1 (en) 2021-10-20 2024-08-28 Mereo Biopharma 4 Limited Neutrophil elastase inhibitors for use in the treatment of fibrosis

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4732973A (en) * 1984-06-14 1988-03-22 Chiron Corporation Active site modified protease α-1-antitrypsin inhibitors
US4916117A (en) * 1986-12-24 1990-04-10 John Lezdey Treatment of inflammation using alpha 1-antichymotrypsin
US5008242A (en) * 1986-12-24 1991-04-16 John Lezdey Treatment of inflammation using 1-antichymotrypsin
US5266465A (en) * 1989-06-23 1993-11-30 The Trustees Of The University Of Pennsylvania α-1-antichymotrypsin, analogues and methods of production
US5252725A (en) * 1989-06-23 1993-10-12 The Trustees Of The University Of Pennsylvania α-1-antichymotrypsin, analogues and methods of production
US5723316A (en) * 1989-06-23 1998-03-03 Trustees Of The University Of Pennsylvania α-1-antichymotrypsin analogues having chymase inhibiting activity
US5079336A (en) * 1989-06-23 1992-01-07 The Trustees Of The University Of Pennsylvania α-1-antichymotrypsin, analogues and methods of production

Also Published As

Publication number Publication date
NZ269619A (en) 1998-01-26
HU9602674D0 (en) 1996-11-28
FI963891A0 (fi) 1996-09-27
SK138196A3 (en) 1997-07-09
WO1995027055A1 (en) 1995-10-12
LV11747A (lv) 1997-04-20
AU696995B2 (en) 1998-09-24
PL316433A1 (en) 1997-01-06
SI9420082A (en) 1997-06-30
AU7393694A (en) 1995-10-23
FI963891L (fi) 1996-09-27
US5674708A (en) 1997-10-07
LV11747B (en) 1997-10-20
CN1145637A (zh) 1997-03-19
CZ281796A3 (en) 1997-05-14
CA2186908A1 (en) 1995-10-12
HUT74901A (en) 1997-02-28
JPH09512423A (ja) 1997-12-16
NO964022L (no) 1996-09-24
EP0754228A1 (en) 1997-01-22
NO964022D0 (no) 1996-09-24
EP0754228A4 (en) 1997-12-10
FI963891A7 (fi) 1996-09-27

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