BG102041A - Oxidized heterocycles containing sulphonamide aspartylprotease inhibitors - Google Patents

Oxidized heterocycles containing sulphonamide aspartylprotease inhibitors

Info

Publication number: BG102041A
Authority: BG; Bulgaria
Prior art keywords: aspartylprotease; inhibitors; oxidized; hiv; heterocycles containing
Prior art date: 1995-04-19

Application number

BG102041A

Other languages

Bulgarian (bg)

English (en)

Inventor

Roger Tung

Govinda BHISETTI

Original Assignee

Vertex Pharmaceuticals Incorporated

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-04-19

Filing date

1997-11-13

Publication date

1998-09-30

1997-11-13 Application filed by Vertex Pharmaceuticals Incorporated filed Critical Vertex Pharmaceuticals Incorporated

1998-09-30 Publication of BG102041A publication Critical patent/BG102041A/xx

Links

239000003696 aspartic proteinase inhibitor Substances 0.000 title abstract 2
125000000623 heterocyclic group Chemical group 0.000 title 1
FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 title 1
229940124530 sulfonamide Drugs 0.000 title 1
241000713772 Human immunodeficiency virus 1 Species 0.000 abstract 2
108010017640 Aspartic Acid Proteases Proteins 0.000 abstract 1
102000004580 Aspartic Acid Proteases Human genes 0.000 abstract 1
241000725303 Human immunodeficiency virus Species 0.000 abstract 1
108010016183 Human immunodeficiency virus 1 p16 protease Proteins 0.000 abstract 1
108010016191 Human immunodeficiency virus 2 p16 protease Proteins 0.000 abstract 1
241000700605 Viruses Species 0.000 abstract 1
230000000840 anti-viral effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000005764 inhibitory process Effects 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
150000003456 sulfonamides Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/32—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D317/34—Oxygen atoms
- C07D317/36—Alkylene carbonates; Substituted alkylene carbonates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings

Landscapes

Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Virology (AREA)
Veterinary Medicine (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Molecular Biology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
Furan Compounds (AREA)
Pyrane Compounds (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)
Enzymes And Modification Thereof (AREA)

BG102041A 1995-04-19 1997-11-13 Oxidized heterocycles containing sulphonamide aspartylprotease inhibitors BG102041A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/424,810 US5691372A (en)	1995-04-19	1995-04-19	Oxygenated-Heterocycle containing sulfonamide inhibitors of aspartyl protease
PCT/US1996/005473 WO1996033187A1 (en)	1995-04-19	1996-04-18	Oxygenated-heterocycle containing sulfonamide inhibitors of aspartyl protease

Publications (1)

Publication Number	Publication Date
BG102041A true BG102041A (en)	1998-09-30

Family

ID=23683966

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG102041A BG102041A (en)	1995-04-19	1997-11-13	Oxidized heterocycles containing sulphonamide aspartylprotease inhibitors

Country Status (34)

Country	Link
US (2)	US5691372A (cs)
EP (3)	EP1136479B1 (cs)
JP (1)	JP4240532B2 (cs)
KR (1)	KR100485237B1 (cs)
CN (1)	CN1110491C (cs)
AP (2)	AP9600827A0 (cs)
AR (1)	AR004663A1 (cs)
AT (3)	ATE479674T1 (cs)
AU (1)	AU712913B2 (cs)
BG (1)	BG102041A (cs)
BR (1)	BR9608033A (cs)
CA (1)	CA2217745C (cs)
CO (1)	CO4700433A1 (cs)
CZ (1)	CZ329497A3 (cs)
DE (3)	DE69618779T2 (cs)
DK (1)	DK0833826T3 (cs)
EA (1)	EA000906B1 (cs)
EE (1)	EE9700254A (cs)
ES (3)	ES2256117T3 (cs)
GE (1)	GEP20001915B (cs)
HU (1)	HUP9801948A3 (cs)
IL (1)	IL117962A0 (cs)
IS (1)	IS4575A (cs)
MY (1)	MY115797A (cs)
NO (1)	NO974744L (cs)
NZ (1)	NZ307342A (cs)
PE (1)	PE43697A1 (cs)
PL (1)	PL322904A1 (cs)
PT (1)	PT833826E (cs)
SK (1)	SK143097A3 (cs)
TR (1)	TR199701194T1 (cs)
TW (1)	TW404945B (cs)
WO (1)	WO1996033187A1 (cs)
ZA (1)	ZA962891B (cs)

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AR031520A1 (es) *	1999-06-11	2003-09-24	Vertex Pharma	Un compuesto inhibidor de aspartilo proteasa, una composicion que lo comprende y un metodo para tratar un paciente con dicha composicion
PL204924B1 (pl) *	1999-10-06	2010-02-26	Tibotec Pharm Ltd	Heksahydrofuro [2,3-b] furanylo-3-N-{3(1,3-benzodioksolilo-5-sulfonylo) (izobutylo) amino] -1-benzylo-2-hydroksypropylo} karbaminian oraz jego zastosowanie
BR0109602A (pt)	2000-03-30	2004-06-29	Bristol Myers Squibb Co	Glóbulos de liberação controlada contendo estavudina
OA12464A (en) *	2001-04-09	2006-05-24	Tibotec Pharm Ltd	Broadspectrum 2-(substituted-amino)-benzoxazole sulfonamide HIV protease inhibitors.
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1995
- 1995-04-19 US US08/424,810 patent/US5691372A/en not_active Expired - Lifetime
1996
- 1996-04-11 TW TW085104278A patent/TW404945B/zh not_active IP Right Cessation
- 1996-04-11 ZA ZA962891A patent/ZA962891B/xx unknown
- 1996-04-17 AR ARP960102210A patent/AR004663A1/es unknown
- 1996-04-17 AP APAP/P/1996/000827A patent/AP9600827A0/en unknown
- 1996-04-18 CN CN96193903A patent/CN1110491C/zh not_active Expired - Fee Related
- 1996-04-18 AU AU56655/96A patent/AU712913B2/en not_active Expired
- 1996-04-18 SK SK1430-97A patent/SK143097A3/sk unknown
- 1996-04-18 TR TR97/01194T patent/TR199701194T1/xx unknown
- 1996-04-18 ES ES01113575T patent/ES2256117T3/es not_active Expired - Lifetime
- 1996-04-18 IL IL11796296A patent/IL117962A0/xx unknown
- 1996-04-18 EP EP01113575A patent/EP1136479B1/en not_active Expired - Lifetime
- 1996-04-18 ES ES96913811T patent/ES2171670T3/es not_active Expired - Lifetime
- 1996-04-18 PE PE1996000266A patent/PE43697A1/es not_active Application Discontinuation
- 1996-04-18 CZ CZ973294A patent/CZ329497A3/cs unknown
- 1996-04-18 PT PT96913811T patent/PT833826E/pt unknown
- 1996-04-18 CA CA2217745A patent/CA2217745C/en not_active Expired - Lifetime
- 1996-04-18 EE EE9700254A patent/EE9700254A/xx unknown
- 1996-04-18 AT AT05028389T patent/ATE479674T1/de not_active IP Right Cessation
- 1996-04-18 BR BR9608033A patent/BR9608033A/pt not_active Application Discontinuation
- 1996-04-18 WO PCT/US1996/005473 patent/WO1996033187A1/en not_active Ceased
- 1996-04-18 JP JP53195396A patent/JP4240532B2/ja not_active Expired - Lifetime
- 1996-04-18 AP APAP/P/1997/001104A patent/AP862A/en active
- 1996-04-18 HU HU9801948A patent/HUP9801948A3/hu unknown
- 1996-04-18 EP EP05028389A patent/EP1637528B1/en not_active Expired - Lifetime
- 1996-04-18 DE DE69618779T patent/DE69618779T2/de not_active Expired - Lifetime
- 1996-04-18 PL PL96322904A patent/PL322904A1/xx unknown
- 1996-04-18 EA EA199700330A patent/EA000906B1/ru not_active IP Right Cessation
- 1996-04-18 ES ES05028389T patent/ES2351970T3/es not_active Expired - Lifetime
- 1996-04-18 DE DE69638252T patent/DE69638252D1/de not_active Expired - Lifetime
- 1996-04-18 MY MYPI96001465A patent/MY115797A/en unknown
- 1996-04-18 DE DE69635679T patent/DE69635679T2/de not_active Expired - Lifetime
- 1996-04-18 AT AT01113575T patent/ATE314360T1/de active
- 1996-04-18 AT AT96913811T patent/ATE212344T1/de active
- 1996-04-18 EP EP96913811A patent/EP0833826B1/en not_active Expired - Lifetime
- 1996-04-18 GE GEAP19963972A patent/GEP20001915B/en unknown
- 1996-04-18 KR KR1019970707346A patent/KR100485237B1/ko not_active Expired - Lifetime
- 1996-04-18 DK DK96913811T patent/DK0833826T3/da active
- 1996-04-19 CO CO96019067A patent/CO4700433A1/es unknown
1997
- 1997-10-02 IS IS4575A patent/IS4575A/is unknown
- 1997-10-08 NZ NZ307342A patent/NZ307342A/en unknown
- 1997-10-14 NO NO974744A patent/NO974744L/no not_active Application Discontinuation
- 1997-11-13 BG BG102041A patent/BG102041A/xx unknown
- 1997-11-24 US US08/977,365 patent/US5990155A/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
CO4700433A1 (es)	1998-12-29
ATE212344T1 (de)	2002-02-15
AU5665596A (en)	1996-11-07
CZ329497A3 (cs)	1998-03-18
DE69635679T2 (de)	2006-08-31
AU712913B2 (en)	1999-11-18
NO974744D0 (no)	1997-10-14
EA199700330A1 (ru)	1998-04-30
DK0833826T3 (da)	2002-05-06
MY115797A (en)	2003-09-30
ES2256117T3 (es)	2006-07-16
ZA962891B (en)	1996-10-15
IS4575A (is)	1997-10-02
ATE479674T1 (de)	2010-09-15
JP4240532B2 (ja)	2009-03-18
AP862A (en)	2000-08-04
DE69618779T2 (de)	2002-08-29
ATE314360T1 (de)	2006-01-15
PE43697A1 (es)	1997-10-11
IL117962A0 (en)	1996-08-04
US5691372A (en)	1997-11-25
SK143097A3 (en)	1998-03-04
JPH11504628A (ja)	1999-04-27
ES2351970T3 (es)	2011-02-14
AP9600827A0 (en)	1997-10-17
EP1136479B1 (en)	2005-12-28
CN1184474A (zh)	1998-06-10
DE69635679D1 (de)	2006-02-02
KR100485237B1 (ko)	2005-09-30
HUP9801948A2 (hu)	1999-09-28
WO1996033187A1 (en)	1996-10-24
HUP9801948A3 (en)	2002-04-29
EE9700254A (et)	1998-04-15
GEP20001915B (en)	2000-01-05
EP0833826B1 (en)	2002-01-23
DE69618779D1 (de)	2002-03-14
NZ307342A (en)	1999-04-29
EP1136479A1 (en)	2001-09-26
EA000906B1 (ru)	2000-06-26
ES2171670T3 (es)	2002-09-16
HK1092791A1 (en)	2007-02-16
AP9701104A0 (en)	1997-10-31
EP1637528B1 (en)	2010-09-01
US5990155A (en)	1999-11-23
TW404945B (en)	2000-09-11
DE69638252D1 (de)	2010-10-14
BR9608033A (pt)	1999-01-12
TR199701194T1 (xx)	1998-03-21
EP0833826A1 (en)	1998-04-08
CA2217745C (en)	2011-07-05
EP1637528A1 (en)	2006-03-22
PT833826E (pt)	2002-06-28
HK1009811A1 (en)	1999-06-11
AR004663A1 (es)	1999-03-10
NO974744L (no)	1997-10-14
PL322904A1 (en)	1998-03-02
CN1110491C (zh)	2003-06-04
CA2217745A1 (en)	1996-10-24
KR19990007823A (ko)	1999-01-25

Publication	Publication Date	Title
BG102041A (en)	1998-09-30	Oxidized heterocycles containing sulphonamide aspartylprotease inhibitors
BG102048A (en)	1998-08-31	Tetrahydrofuran-containing sulphonamides as aspartylprotease inhibitors
CA2143208A1 (en)	1994-03-17	Sulfonamide inhibitors of hiv-aspartyl protease
GR3024181T3 (en)	1997-10-31	N-(alkanoylamino-2-hydroxypropyl)-sulfonamides useful as retroviral protease inhibitors.
GR3029378T3 (en)	1999-05-28	Hydroxyethylamino sulphonamides useful as retroviral protease inhibitors
CA2210889A1 (en)	1996-07-25	Bis-sulfonamide hydroxyethylamino retroviral protease inhibitors
KR950702960A (ko)	1995-08-23	레트로바이러스 프로테아제 저해제로서 유용한 히드록시에틸아미노 술폰아미드(hydroxyethylamino sulfonamides useful as retroviral protease inhibitors)
CA2140928A1 (en)	1994-02-26	Sulfonylalkanoylamino hydroxyethylamino sulfonamides useful as retroviral protease inhibitors
AU5736494A (en)	1994-07-19	Cyclic sulfone containing retroviral protease inhibitors
CA2096409A1 (en)	1992-05-20	Retroviral protease inhibitors
MY119031A (en)	2005-03-31	Pyran-2-ones and 5,6-dihydropyran-2-ones useful for treating hiv and other retroviruses
GR3020451T3 (en)	1996-10-31	Retroviral protease inhibitors
CA2215066A1 (en)	1996-09-19	Sulfonylalkanoylamino hydroxyethylamino sulfonamide retroviral protease inhibitors
HU9301446D0 (en)	1993-11-29	Inhibitors or fetrovirus protease
SI1159278T1 (sl)	2006-06-30	Inhibitorji aspartil proteaze
FI935779A7 (fi)	1994-06-23	HIV-proteaasin inhibiittoreita, jotka ovat hyödyllisiä AIDSin hoitoa varten
AU4765396A (en)	1996-08-07	Method of preparing retroviral protease inhibitor intermediates
GR3023044T3 (en)	1997-07-30	Succinoylamino hydroxyethylamino sulfamic acid derivatives useful as retroviral protease inhibitors.
MX9708055A (es)	1998-01-31	Inhibidores de aspartil proteasa consistentes en sulfonamida que contiene heterociclo oxigenado.
MX9708057A (es)	1998-01-31	Sulfonamidas que contienen thf inhibidoras de la aspartilproteasa.
SU661039A1 (ru)	1979-05-05	Сталь