BG102781A - Isolated dimer fibroblastactivation protein alpha and its application - Google Patents
Isolated dimer fibroblastactivation protein alpha and its applicationInfo
- Publication number
- BG102781A BG102781A BG102781A BG10278198A BG102781A BG 102781 A BG102781 A BG 102781A BG 102781 A BG102781 A BG 102781A BG 10278198 A BG10278198 A BG 10278198A BG 102781 A BG102781 A BG 102781A
- Authority
- BG
- Bulgaria
- Prior art keywords
- application
- fibroblastactivation
- protein alpha
- isolated dimer
- dimer
- Prior art date
Links
- 102100023832 Prolyl endopeptidase FAP Human genes 0.000 title 1
- 239000000539 dimer Substances 0.000 title 1
- 108010072257 fibroblast activation protein alpha Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/70517—CD8
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/06—Preparation of peptides or proteins produced by the hydrolysis of a peptide bond, e.g. hydrolysate products
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/026—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a baculovirus
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Oncology (AREA)
- Pathology (AREA)
- Plant Pathology (AREA)
- Epidemiology (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/619,280 US5767242A (en) | 1994-04-20 | 1996-03-18 | Isolated dimeric fibroblast activation protein alpha, and uses thereof |
| PCT/US1997/004215 WO1997034927A1 (en) | 1996-03-18 | 1997-03-12 | Isolated dimeric fibroblast activation protein alpha, and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG102781A true BG102781A (en) | 1999-09-30 |
Family
ID=24481231
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG102781A BG102781A (en) | 1996-03-18 | 1998-09-18 | Isolated dimer fibroblastactivation protein alpha and its application |
Country Status (23)
| Country | Link |
|---|---|
| US (2) | US5767242A (de) |
| EP (1) | EP0960127B1 (de) |
| JP (1) | JP4102441B2 (de) |
| KR (1) | KR20000064655A (de) |
| CN (1) | CN1214052A (de) |
| AT (1) | ATE449106T1 (de) |
| AU (1) | AU729369B2 (de) |
| BG (1) | BG102781A (de) |
| BR (1) | BR9708100A (de) |
| CA (1) | CA2242342C (de) |
| CZ (1) | CZ299698A3 (de) |
| DE (1) | DE69739665D1 (de) |
| DK (1) | DK0960127T3 (de) |
| EE (1) | EE03693B1 (de) |
| ES (1) | ES2334183T3 (de) |
| HU (1) | HUP0104468A3 (de) |
| IL (1) | IL125124A0 (de) |
| NO (1) | NO984298D0 (de) |
| NZ (2) | NZ331758A (de) |
| PL (1) | PL328947A1 (de) |
| SK (1) | SK126798A3 (de) |
| TR (1) | TR199801845T2 (de) |
| WO (1) | WO1997034927A1 (de) |
Families Citing this family (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6455677B1 (en) | 1998-04-30 | 2002-09-24 | Boehringer Ingelheim International Gmbh | FAPα-specific antibody with improved producibility |
| US6979697B1 (en) * | 1998-08-21 | 2005-12-27 | Point Therapeutics, Inc. | Regulation of substrate activity |
| US6890904B1 (en) | 1999-05-25 | 2005-05-10 | Point Therapeutics, Inc. | Anti-tumor agents |
| CA2373643A1 (en) * | 1999-05-25 | 2000-11-30 | Point Therapeutics, Inc. | Anti-tumor comprising boroproline compounds |
| EP1806138A1 (de) * | 1999-05-25 | 2007-07-11 | Point Therapeutics, Inc. | Anti-tumor präparate enthaltend boroprolin verbindungen |
| US20030092890A1 (en) * | 1999-07-28 | 2003-05-15 | Genentech, Inc. | Secreted and transmembrane polypeptides and nucleic acids encoding the same |
| CA2441228A1 (en) * | 2001-03-23 | 2002-10-03 | Aphton Corporation | Combination treatment of pancreatic cancer |
| US20090191232A1 (en) * | 2001-05-04 | 2009-07-30 | Gevas Philip C | Combination therapy for the treatment of tumors |
| KR20040049830A (ko) * | 2001-07-09 | 2004-06-12 | 애프톤 코포레이션 | 간, 폐 및 식도의 암 및 전암 상태의 치료 및 예방 |
| EP2204181A3 (de) | 2002-04-30 | 2010-09-22 | Trustees Of Tufts College | Protease-Hemmer |
| EP1578362A4 (de) * | 2002-07-09 | 2008-11-05 | Point Therapeutics Inc | Kombinationstherapie mit einer boroprolin-verbindung |
| US20080057491A1 (en) * | 2003-02-07 | 2008-03-06 | Mckee Patrick A | Substrates and inhibitors of antiplasmin cleaving enzyme and methods of use |
| US7309774B2 (en) | 2003-02-07 | 2007-12-18 | The Board Of Regents Of The University Of Oklahoma | Antiplasmin cleaving enzyme |
| CN1781023A (zh) * | 2003-03-28 | 2006-05-31 | 埃弗顿有限公司 | 胃泌素激素免疫测定 |
| WO2005071073A1 (en) * | 2004-01-09 | 2005-08-04 | Point Therapeutics, Inc. | Fap compositions and the use thereof for immunomodulation |
| AU2005228897B2 (en) * | 2004-03-29 | 2009-12-10 | Cancer Advances, Inc. | Monoclonal antibodies to gastrin hormone |
| US20090010919A1 (en) * | 2004-07-29 | 2009-01-08 | Bayer Healthcare Ag | Diagnostics and Therapeutics for Diseases Associated With Fibroblast Activation Protein (Fap) |
| JP2008513536A (ja) | 2004-09-22 | 2008-05-01 | レセプター バイオロジックス インコーポレイテッド | プロガストリンに対するモノクローナル抗体 |
| US20090238862A1 (en) * | 2004-10-27 | 2009-09-24 | Wen-Tien Chen | Methods and Compositions for Seprase Inactivation |
| WO2006058286A2 (en) | 2004-11-24 | 2006-06-01 | Techlab, Inc. | Device and method for detection of analytes |
| US8067248B2 (en) | 2005-12-14 | 2011-11-29 | Luwig Institute for Cancer Research | Method for diagnosing rheumatoid arthritis via assaying myofibroblast-like synoviocytes for fibroblast activation protein |
| US8933201B2 (en) | 2006-06-07 | 2015-01-13 | The Board Of Regents Of The University Of Oklahoma | Substrates and inhibitors of antiplasmin cleaving enzyme and fibroblast activation protein and methods of use |
| DK2035581T3 (da) * | 2006-06-21 | 2012-10-08 | Scripps Research Inst | Dna-sammensætning mod tumorstromaantigen fap og fremgangsmåder til anvendelse deraf |
| CA2753884A1 (en) | 2009-02-27 | 2010-09-02 | Trustees Of Tufts College | Soft protease inhibitors, and pro-soft forms thereof |
| WO2014102312A2 (en) * | 2012-12-28 | 2014-07-03 | Life Sciences Research Partners Vzw | Minimally toxic prodrugs |
| CN103267852B (zh) * | 2013-05-15 | 2015-03-25 | 中国医学科学院北京协和医院 | 成纤维激活蛋白α在制备胰腺癌预后试剂盒中的用途 |
| IL291922B1 (en) | 2014-06-13 | 2026-01-01 | Tufts College | FAP-activated medical materials and related uses |
| CN105859866B (zh) * | 2016-05-27 | 2019-08-13 | 郑州大学 | Fap来源的抗肿瘤ctl表位肽p265及其应用 |
| US20200237936A1 (en) | 2016-12-14 | 2020-07-30 | Purdue Research Foundation | Fibroblast activation protein (fap)-targeted imaging and therapy |
| US12150978B2 (en) | 2017-06-15 | 2024-11-26 | Cancer Advances Inc. | Compositions and methods for preventing tumors and cancer |
| JP7469225B2 (ja) | 2017-06-15 | 2024-04-16 | キャンサー アドヴァンシーズ インク． | 腫瘍及び癌に対する体液性及び細胞性免疫を誘発するための組成物及び方法 |
| GB201710973D0 (en) | 2017-07-07 | 2017-08-23 | Avacta Life Sciences Ltd | Scaffold proteins |
| WO2022136586A1 (en) | 2020-12-22 | 2022-06-30 | Cobiores Nv | Compounds comprising a tetrapeptidic moiety |
| WO2022167664A1 (en) | 2021-02-07 | 2022-08-11 | Cobiores Nv | Compounds comprising a tetrapeptidic moiety |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1320734C (en) * | 1986-02-04 | 1993-07-27 | Suntory Limited | Pyrrolidineamide derivative of acylamino acid and pharmaceutical composition containing the same |
| US5587299A (en) * | 1994-04-20 | 1996-12-24 | Memorial Sloan-Kettering Cancer Center | Isolated nucleic acid molecule coding for fibroblast activation protein alpha and uses thereof |
-
1996
- 1996-03-18 US US08/619,280 patent/US5767242A/en not_active Expired - Lifetime
-
1997
- 1997-03-12 ES ES97916024T patent/ES2334183T3/es not_active Expired - Lifetime
- 1997-03-12 CZ CZ982996A patent/CZ299698A3/cs unknown
- 1997-03-12 PL PL97328947A patent/PL328947A1/xx unknown
- 1997-03-12 CA CA2242342A patent/CA2242342C/en not_active Expired - Fee Related
- 1997-03-12 HU HU0104468A patent/HUP0104468A3/hu unknown
- 1997-03-12 WO PCT/US1997/004215 patent/WO1997034927A1/en not_active Ceased
- 1997-03-12 DK DK97916024.9T patent/DK0960127T3/da active
- 1997-03-12 SK SK1267-98A patent/SK126798A3/sk unknown
- 1997-03-12 AU AU23302/97A patent/AU729369B2/en not_active Ceased
- 1997-03-12 CN CN97193176A patent/CN1214052A/zh active Pending
- 1997-03-12 IL IL12512497A patent/IL125124A0/xx unknown
- 1997-03-12 JP JP53359297A patent/JP4102441B2/ja not_active Expired - Fee Related
- 1997-03-12 BR BR9708100-0A patent/BR9708100A/pt not_active Application Discontinuation
- 1997-03-12 NZ NZ331758A patent/NZ331758A/xx unknown
- 1997-03-12 EP EP97916024A patent/EP0960127B1/de not_active Expired - Lifetime
- 1997-03-12 DE DE69739665T patent/DE69739665D1/de not_active Expired - Lifetime
- 1997-03-12 EE EE9800306A patent/EE03693B1/xx not_active IP Right Cessation
- 1997-03-12 TR TR1998/01845T patent/TR199801845T2/xx unknown
- 1997-03-12 KR KR1019980707369A patent/KR20000064655A/ko not_active Ceased
- 1997-03-12 AT AT97916024T patent/ATE449106T1/de active
- 1997-10-01 US US08/940,391 patent/US5965373A/en not_active Expired - Lifetime
-
1998
- 1998-09-17 NO NO984298A patent/NO984298D0/no not_active Application Discontinuation
- 1998-09-18 BG BG102781A patent/BG102781A/xx unknown
-
1999
- 1999-05-03 NZ NZ335543A patent/NZ335543A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR9708100A (pt) | 2000-01-04 |
| EE9800306A (et) | 1999-02-15 |
| HUP0104468A3 (en) | 2004-10-28 |
| CZ299698A3 (cs) | 1999-01-13 |
| NO984298L (no) | 1998-09-17 |
| EE03693B1 (et) | 2002-04-15 |
| CN1214052A (zh) | 1999-04-14 |
| EP0960127A1 (de) | 1999-12-01 |
| CA2242342C (en) | 2013-05-14 |
| TR199801845T2 (xx) | 1998-12-21 |
| CA2242342A1 (en) | 1997-09-25 |
| ES2334183T3 (es) | 2010-03-05 |
| JP2000507100A (ja) | 2000-06-13 |
| IL125124A0 (en) | 1999-01-26 |
| NZ335543A (en) | 2001-03-30 |
| PL328947A1 (en) | 1999-03-01 |
| ATE449106T1 (de) | 2009-12-15 |
| AU2330297A (en) | 1997-10-10 |
| US5965373A (en) | 1999-10-12 |
| DE69739665D1 (de) | 2009-12-31 |
| NZ331758A (en) | 2000-01-28 |
| SK126798A3 (en) | 1999-05-07 |
| EP0960127B1 (de) | 2009-11-18 |
| NO984298D0 (no) | 1998-09-17 |
| DK0960127T3 (da) | 2010-03-29 |
| EP0960127A4 (de) | 2004-09-08 |
| JP4102441B2 (ja) | 2008-06-18 |
| US5767242A (en) | 1998-06-16 |
| KR20000064655A (ko) | 2000-11-06 |
| AU729369B2 (en) | 2001-02-01 |
| WO1997034927A1 (en) | 1997-09-25 |
| HUP0104468A2 (hu) | 2002-04-29 |
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