BG103686A - Тиазолови бензенсулфонамиди като бета3 агонисти за лечението на диабет и затлъстяване - Google Patents

Тиазолови бензенсулфонамиди като бета3 агонисти за лечението на диабет и затлъстяване Download PDF

Info

Publication number: BG103686A
Authority: BG; Bulgaria
Prior art keywords: ethyl; phenyl; hydroxy; benzenesulfonamide; amino
Prior art date: 1997-01-28

Application number

BG103686A

Other languages

Bulgarian (bg)

English (en)

Inventor

Robert MATHVINK

Emma Parmee

Samuel Tolman

Ann Weber

Original Assignee

Merck & Co. Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-01-28

Filing date

1999-08-24

Publication date

2000-06-30

1997-03-12 Priority claimed from GBGB9705041.3A external-priority patent/GB9705041D0/en

1999-08-24 Application filed by Merck & Co. Inc. filed Critical Merck & Co. Inc.

2000-06-30 Publication of BG103686A publication Critical patent/BG103686A/bg

Links

208000008589 Obesity Diseases 0.000 title claims abstract description 7
235000020824 obesity Nutrition 0.000 title claims abstract description 7
206010012601 diabetes mellitus Diseases 0.000 title claims description 9
239000000556 agonist Substances 0.000 title description 16
MYEFHJZLNOFLNK-UHFFFAOYSA-N benzenesulfonamide;1,3-thiazole Chemical class C1=CSC=N1.NS(=O)(=O)C1=CC=CC=C1 MYEFHJZLNOFLNK-UHFFFAOYSA-N 0.000 title description 2
150000001875 compounds Chemical class 0.000 claims abstract description 119
239000000203 mixture Substances 0.000 claims abstract description 39
238000000034 method Methods 0.000 claims abstract description 24
KHBQMWCZKVMBLN-UHFFFAOYSA-N Benzenesulfonamide Chemical class NS(=O)(=O)C1=CC=CC=C1 KHBQMWCZKVMBLN-UHFFFAOYSA-N 0.000 claims abstract description 19
HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims abstract description 8
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125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 189
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 119
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 92
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Diabetes (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Obesity (AREA)
Psychiatry (AREA)
Hematology (AREA)
Pain & Pain Management (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BG103686A 1997-01-28 1999-08-24 Тиазолови бензенсулфонамиди като бета3 агонисти за лечението на диабет и затлъстяване BG103686A (bg)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US3676097P	1997-01-28	1997-01-28
GBGB9705041.3A GB9705041D0 (en)	1997-03-12	1997-03-12	Thiazole benzenesulfonamides as selective B3 agonists for the treatment of diabetes and obesity
PCT/US1998/001317 WO1998032753A1 (en)	1997-01-28	1998-01-23	THIAZOLE BENZENESULFONAMIDES AS β3 AGONISTS FOR THE TREATMENT OF DIABETES AND OBESITY

Publications (1)

Publication Number	Publication Date
BG103686A true BG103686A (bg)	2000-06-30

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ID=26311166

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BG103686A BG103686A (bg)	1997-01-28	1999-08-24	Тиазолови бензенсулфонамиди като бета3 агонисти за лечението на диабет и затлъстяване

Country Status (22)

Country	Link
EP (1)	EP0968209A1 (id)
JP (1)	JP2001509166A (id)
KR (1)	KR20000070568A (id)
CN (1)	CN1251099A (id)
AR (1)	AR011092A1 (id)
AU (1)	AU728812B2 (id)
BG (1)	BG103686A (id)
BR (1)	BR9807096A (id)
CA (1)	CA2278739A1 (id)
EA (1)	EA199900692A1 (id)
EE (1)	EE9900328A (id)
HR (1)	HRP980044A2 (id)
HU (1)	HUP0002053A3 (id)
ID (1)	ID22273A (id)
IL (1)	IL131130A0 (id)
IS (1)	IS5131A (id)
NO (1)	NO993646L (id)
PE (1)	PE52299A1 (id)
PL (1)	PL334833A1 (id)
SK (1)	SK100099A3 (id)
TR (1)	TR199902442T2 (id)
WO (1)	WO1998032753A1 (id)

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DE19824175A1 (de) *	1998-05-29	1999-12-02	Novartis Ag	Amino-azol-Verbindungen
EP1743655B1 (en)	2000-01-21	2014-06-25	Novartis AG	Combinations comprising dipeptidylpeptidase-iv inhibitors and antidiabetic agents
US20030018061A1 (en) *	2000-01-28	2003-01-23	Kohei Ogawa	Novel remedies with the use of beta 3 agonist
TR200401359T4 (tr)	2000-03-31	2004-08-23	Pfizer Products Inc.	İkame edilmiş piridinlerin hazırlanmasına yönelik işlem
EP1303509B1 (en)	2000-07-13	2012-11-28	Eli Lilly And Company	Beta3 adrenergic agonists
US6537994B2 (en)	2000-07-17	2003-03-25	Wyeth	Heterocyclic β3 adrenergic receptor agonists
US6410734B1 (en)	2000-07-17	2002-06-25	Wyeth	2-substituted thiazolidinones as beta-3 adrenergic receptor agonists
US6465501B2 (en)	2000-07-17	2002-10-15	Wyeth	Azolidines as β3 adrenergic receptor agonists
US6525202B2 (en)	2000-07-17	2003-02-25	Wyeth	Cyclic amine phenyl beta-3 adrenergic receptor agonists
US6498170B2 (en)	2000-07-17	2002-12-24	Wyeth	Cyclamine sulfonamides as β-3 adrenergic receptor agonists
US6369232B1 (en) *	2000-08-15	2002-04-09	Hoffmann-La Roche Inc.	Tetrazolyl-phenyl acetamide glucokinase activators
WO2002038544A2 (en)	2000-11-10	2002-05-16	Eli Lilly And Company	3-substituted oxindole beta 3 agonists
CA2431171A1 (en) *	2000-12-08	2002-06-13	Takeda Chemical Industries, Ltd.	Substituted thiazole derivatives bearing 3-pyridyl groups, process for preparing the same and use thereof
AR035605A1 (es)	2000-12-11	2004-06-16	Bayer Corp	Derivados de aminometil cromano di-sustituidos, un metodo para su preparacion, composiciones farmaceuticas y el uso de dichos derivados para la manufactura de medicamentos utiles como agonistas beta-3-adreno-receptores
AR035858A1 (es)	2001-04-23	2004-07-21	Bayer Corp	Derivados de cromano 2,6-sustituidos,composiciones farmaceuticas,uso de dichos derivados para la manufactura de medicamentos utiles como agonistas adrenorreceptores beta-3
CA2450562A1 (en) *	2001-06-22	2003-01-03	Merck & Co., Inc.	Tyrosine kinase inhibitors
AU2002318206A1 (en)	2001-08-14	2003-03-03	Jolie Anne Bastian	3-substituted oxindole beta-3 agonists
US7208505B2 (en)	2001-08-14	2007-04-24	Eli Lilly And Company	β3 adrenergic agonists
JP2005507932A (ja) *	2001-10-12	2005-03-24	バイエル・フアーマシユーチカルズ・コーポレーシヨン	肥満の処置のためのフェニル置換５−員窒素含有複素環
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1998
- 1998-01-23 ID IDW990755A patent/ID22273A/id unknown
- 1998-01-23 HU HU0002053A patent/HUP0002053A3/hu unknown
- 1998-01-23 SK SK1000-99A patent/SK100099A3/sk unknown
- 1998-01-23 IL IL13113098A patent/IL131130A0/xx unknown
- 1998-01-23 TR TR1999/02442T patent/TR199902442T2/xx unknown
- 1998-01-23 PL PL98334833A patent/PL334833A1/xx unknown
- 1998-01-23 CA CA002278739A patent/CA2278739A1/en not_active Abandoned
- 1998-01-23 EP EP98903677A patent/EP0968209A1/en not_active Withdrawn
- 1998-01-23 CN CN98803585A patent/CN1251099A/zh active Pending
- 1998-01-23 KR KR1019997006814A patent/KR20000070568A/ko not_active Withdrawn
- 1998-01-23 JP JP53214898A patent/JP2001509166A/ja active Pending
- 1998-01-23 BR BR9807096-7A patent/BR9807096A/pt not_active IP Right Cessation
- 1998-01-23 WO PCT/US1998/001317 patent/WO1998032753A1/en not_active Ceased
- 1998-01-23 EE EEP199900328A patent/EE9900328A/xx unknown
- 1998-01-23 AU AU60384/98A patent/AU728812B2/en not_active Ceased
- 1998-01-23 EA EA199900692A patent/EA199900692A1/ru unknown
- 1998-01-27 AR ARP980100357A patent/AR011092A1/es unknown
- 1998-01-28 PE PE1998000064A patent/PE52299A1/es not_active Application Discontinuation
- 1998-01-28 HR HR9705041.3A patent/HRP980044A2/hr not_active Application Discontinuation
1999
- 1999-07-23 IS IS5131A patent/IS5131A/is unknown
- 1999-07-27 NO NO993646A patent/NO993646L/no not_active Application Discontinuation
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Also Published As

Publication number	Publication date
AU6038498A (en)	1998-08-18
JP2001509166A (ja)	2001-07-10
NO993646D0 (no)	1999-07-27
PL334833A1 (en)	2000-03-27
CA2278739A1 (en)	1998-07-30
HUP0002053A3 (en)	2001-09-28
IS5131A (is)	1999-07-23
CN1251099A (zh)	2000-04-19
HRP980044A2 (en)	1998-10-31
ID22273A (id)	1999-09-23
AU728812B2 (en)	2001-01-18
PE52299A1 (es)	1999-05-26
EA199900692A1 (ru)	2000-02-28
BR9807096A (pt)	2000-04-18
NO993646L (no)	1999-09-27
IL131130A0 (en)	2001-01-28
AR011092A1 (es)	2000-08-02
KR20000070568A (ko)	2000-11-25
SK100099A3 (en)	2000-05-16
EP0968209A1 (en)	2000-01-05
WO1998032753A1 (en)	1998-07-30
TR199902442T2 (xx)	2000-07-21
HUP0002053A2 (hu)	2001-08-28
EE9900328A (et)	2000-02-15

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