BG103722A - Penylxanthine esters and amides - Google Patents

Penylxanthine esters and amides

Info

Publication number: BG103722A
Authority: BG; Bulgaria
Prior art keywords: amides; esters; integer; methyl; value
Prior art date: 1997-02-14

Application number

BG103722A

Other languages

Bulgarian (bg)

English (en)

Inventor

Susan DALUGE

Douglas LIVINGSTONE

Gerald Wolberg

Original Assignee

Glaxo Group Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-02-14

Filing date

1999-09-09

Publication date

2000-06-30

1999-09-09 Application filed by Glaxo Group Limited filed Critical Glaxo Group Limited

2000-06-30 Publication of BG103722A publication Critical patent/BG103722A/xx

Links

150000001408 amides Chemical class 0.000 title abstract 2
150000002148 esters Chemical class 0.000 title abstract 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
229910052739 hydrogen Inorganic materials 0.000 abstract 2
239000001257 hydrogen Substances 0.000 abstract 2
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
ACCCXSZCOGNLFL-UHFFFAOYSA-N 8-phenyl-3,7-dihydropurine-2,6-dione Chemical class N1C=2C(=O)NC(=O)NC=2N=C1C1=CC=CC=C1 ACCCXSZCOGNLFL-UHFFFAOYSA-N 0.000 abstract 1
239000000853 adhesive Substances 0.000 abstract 1
230000001070 adhesive effect Effects 0.000 abstract 1
230000001413 cellular effect Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
230000003511 endothelial effect Effects 0.000 abstract 1
208000026278 immune system disease Diseases 0.000 abstract 1
230000004968 inflammatory condition Effects 0.000 abstract 1
239000012453 solvate Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Immunology (AREA)
Rheumatology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Ophthalmology & Optometry (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Transplantation (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Vascular Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

BG103722A 1997-02-14 1999-09-09 Penylxanthine esters and amides BG103722A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB9703044.9A GB9703044D0 (en)	1997-02-14	1997-02-14	Phenyl xanthine esters and amides
PCT/EP1998/000784 WO1998035966A1 (en)	1997-02-14	1998-02-12	Substituted (1,3-bis(cyclohexylmethyl)-1,2,3,6-tetrahydro-2,6-dioxo-9h-purin-8-yl)phenyl derivatives, their preparation and their use in the treatment of inflammatory conditions and immune disorders

Publications (1)

Publication Number	Publication Date
BG103722A true BG103722A (en)	2000-06-30

Family

ID=10807635

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG103722A BG103722A (en)	1997-02-14	1999-09-09	Penylxanthine esters and amides

Country Status (37)

Country	Link
US (3)	US6355646B1 (pl)
EP (1)	EP0970081B1 (pl)
JP (1)	JP2001511792A (pl)
KR (1)	KR100522639B1 (pl)
CN (1)	CN1140527C (pl)
AP (1)	AP1000A (pl)
AR (1)	AR011441A1 (pl)
AT (1)	ATE304542T1 (pl)
AU (1)	AU754456B2 (pl)
BG (1)	BG103722A (pl)
BR (1)	BR9807682B1 (pl)
CA (1)	CA2280730C (pl)
CO (1)	CO4940444A1 (pl)
CZ (1)	CZ298764B6 (pl)
DE (1)	DE69831559T2 (pl)
DK (1)	DK0970081T3 (pl)
EA (1)	EA199900648A1 (pl)
EE (1)	EE9900348A (pl)
ES (1)	ES2249822T3 (pl)
GB (1)	GB9703044D0 (pl)
HR (1)	HRP980077A2 (pl)
HU (1)	HU225962B1 (pl)
ID (1)	ID22770A (pl)
IL (1)	IL131179A (pl)
IS (1)	IS5144A (pl)
MY (1)	MY118545A (pl)
NO (1)	NO325685B1 (pl)
NZ (1)	NZ336923A (pl)
PE (1)	PE58899A1 (pl)
PL (1)	PL188018B1 (pl)
SK (1)	SK110399A3 (pl)
TR (1)	TR199901942T2 (pl)
TW (1)	TW520371B (pl)
UA (1)	UA57767C2 (pl)
WO (1)	WO1998035966A1 (pl)
YU (1)	YU38399A (pl)
ZA (1)	ZA981175B (pl)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9703044D0 (en) *	1997-02-14	1997-04-02	Glaxo Group Ltd	Phenyl xanthine esters and amides
GB9817623D0 (en) *	1998-08-13	1998-10-07	Glaxo Group Ltd	Pharmaceutical compounds
US6545002B1 (en) *	1999-06-01	2003-04-08	University Of Virginia Patent Foundation	Substituted 8-phenylxanthines useful as antagonists of A2B adenosine receptors
FR2804958B1 (fr) *	2000-02-15	2005-07-08	Hoechst Marion Roussel Inc	Derives de xanthine, leur procede de preparation et les intermediaires de ce procede, leur application comme medicament et les compositions pharmaceutiques les renfermant
JP2004523559A (ja) *	2001-02-28	2004-08-05	スミスクラインビーチャムコーポレーション	過敏性腸症候群および機能性胃腸症の治療方法
US7125993B2 (en) *	2001-11-09	2006-10-24	Cv Therapeutics, Inc.	A2B adenosine receptor antagonists
US20080318983A1 (en) *	2001-11-09	2008-12-25	Rao Kalla	A2b adenosine receptor antagonists
US20040072848A1 (en) *	2002-02-26	2004-04-15	Huber Brian E	Methods of treating irritable bowel syndrome and functional dyspepsia
AU2012227249B2 (en) *	2003-12-16	2014-10-02	Nektar Therapeutics	Chemically modified small molecules
HRP20140361T1 (hr) *	2003-12-16	2014-05-23	Nektar Therapeutics	Monodisperzne smjese pegiliranog naloksola
US20060182692A1 (en)	2003-12-16	2006-08-17	Fishburn C S	Chemically modified small molecules
WO2005102976A1 (en) *	2004-04-21	2005-11-03	Smithkline Beecham Corporation	Process for preparing nonaethylene glycol monomethyl ether
SI1789053T1 (sl) *	2004-09-01	2012-09-28	Gilead Sciences Inc	Postopek celjenja rane z uporabo antagonistov A2B adenozinskih receptorjev
US20070059740A1 (en) *	2005-08-26	2007-03-15	Linden Joel M	Method of targeting a2b adenosine receptor antagonist therapy
US8193200B2 (en) *	2007-01-04	2012-06-05	University Of Virginia Patent Foundation	Antagonists of A2B adenosine receptors for treatment of inflammatory bowel disease

Family Cites Families (18)

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Publication number	Priority date	Publication date	Assignee	Title
GB8510758D0 (en)	1985-04-27	1985-06-05	Wellcome Found	Compounds
US4968672A (en)	1987-01-02	1990-11-06	The United States Of America As Represented By The Department Of Health And Human Services	Adenosine receptor prodrugs
US5015647A (en)	1987-04-24	1991-05-14	Burroughs Wellcome Co.	Method for treating viral infections
GB8826595D0 (en)	1988-11-14	1988-12-21	Beecham Wuelfing Gmbh & Co Kg	Active compounds
GB8906792D0 (en)	1989-03-23	1989-05-10	Beecham Wuelfing Gmbh & Co Kg	Treatment and compounds
NZ240644A (en)	1990-11-21	1994-08-26	Smithkline Beecham Corp	Use of xanthine derivatives to inhibit the production of tumour necrosis factor (tnf)
GB9210839D0 (en) *	1992-05-21	1992-07-08	Smithkline Beecham Plc	Novel compounds
TW252044B (pl) *	1992-08-10	1995-07-21	Boehringer Ingelheim Kg
JP2613355B2 (ja)	1992-09-28	1997-05-28	協和醗酵工業株式会社	パーキンソン氏病治療剤
GB9415529D0 (en) *	1994-08-01	1994-09-21	Wellcome Found	Phenyl xanthine derivatives
DE19535504A1 (de)	1995-09-25	1997-03-27	Bayer Ag	Substituierte Xanthine
ATE226583T1 (de) *	1996-06-07	2002-11-15	Hoechst Ag	Verwendung von theophyllinderivaten zur behandlung und propylaxe von schockzuständen, neue xanthinverbindungen und verfahren zu deren herstellung
GB9703044D0 (en) *	1997-02-14	1997-04-02	Glaxo Group Ltd	Phenyl xanthine esters and amides
US6117878A (en)	1998-02-24	2000-09-12	University Of Virginia	8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors
WO1999043673A1 (en)	1998-02-26	1999-09-02	Zenyaku Kogyo Kabushiki Kaisha	1-azaindolizine derivatives
GB9817623D0 (en) *	1998-08-13	1998-10-07	Glaxo Group Ltd	Pharmaceutical compounds
US6649629B2 (en)	1999-12-23	2003-11-18	Nitromed, Inc.	Nitrosated and nitrosylated cyclooxygenase-2 inhibitors, compositions and methods of use
US6751206B1 (en) *	2000-06-29	2004-06-15	Qualcomm Incorporated	Method and apparatus for beam switching in a wireless communication system

1997
- 1997-02-14 GB GBGB9703044.9A patent/GB9703044D0/en active Pending
1998
- 1998-02-11 MY MYPI98000546A patent/MY118545A/en unknown
- 1998-02-11 PE PE1998000099A patent/PE58899A1/es not_active Application Discontinuation
- 1998-02-11 CO CO98007044A patent/CO4940444A1/es unknown
- 1998-02-12 CN CNB988039419A patent/CN1140527C/zh not_active Expired - Fee Related
- 1998-02-12 TR TR1999/01942T patent/TR199901942T2/xx unknown
- 1998-02-12 DK DK98908090T patent/DK0970081T3/da active
- 1998-02-12 JP JP53534098A patent/JP2001511792A/ja not_active Ceased
- 1998-02-12 WO PCT/EP1998/000784 patent/WO1998035966A1/en not_active Ceased
- 1998-02-12 SK SK1103-99A patent/SK110399A3/sk unknown
- 1998-02-12 IL IL13117998A patent/IL131179A/en not_active IP Right Cessation
- 1998-02-12 DE DE69831559T patent/DE69831559T2/de not_active Expired - Lifetime
- 1998-02-12 KR KR10-1999-7007276A patent/KR100522639B1/ko not_active Expired - Fee Related
- 1998-02-12 ID IDW990879A patent/ID22770A/id unknown
- 1998-02-12 YU YU38399A patent/YU38399A/sh unknown
- 1998-02-12 CA CA002280730A patent/CA2280730C/en not_active Expired - Fee Related
- 1998-02-12 AT AT98908090T patent/ATE304542T1/de active
- 1998-02-12 ZA ZA9801175A patent/ZA981175B/xx unknown
- 1998-02-12 AU AU66221/98A patent/AU754456B2/en not_active Ceased
- 1998-02-12 ES ES98908090T patent/ES2249822T3/es not_active Expired - Lifetime
- 1998-02-12 HU HU0000894A patent/HU225962B1/hu not_active IP Right Cessation
- 1998-02-12 US US09/367,313 patent/US6355646B1/en not_active Expired - Lifetime
- 1998-02-12 PL PL98335135A patent/PL188018B1/pl unknown
- 1998-02-12 EA EA199900648A patent/EA199900648A1/ru unknown
- 1998-02-12 AP APAP/P/1999/001622A patent/AP1000A/en active
- 1998-02-12 EP EP98908090A patent/EP0970081B1/en not_active Expired - Lifetime
- 1998-02-12 BR BRPI9807682-5A patent/BR9807682B1/pt not_active IP Right Cessation
- 1998-02-12 CZ CZ0288799A patent/CZ298764B6/cs not_active IP Right Cessation
- 1998-02-12 EE EEP199900348A patent/EE9900348A/xx unknown
- 1998-02-12 NZ NZ336923A patent/NZ336923A/en unknown
- 1998-02-13 AR ARP980100664A patent/AR011441A1/es active IP Right Grant
- 1998-02-13 HR HR9703044.9A patent/HRP980077A2/hr not_active Application Discontinuation
- 1998-02-24 TW TW087102632A patent/TW520371B/zh not_active IP Right Cessation
- 1998-12-02 UA UA99084601A patent/UA57767C2/uk unknown
1999
- 1999-07-30 IS IS5144A patent/IS5144A/is unknown
- 1999-08-13 NO NO19993915A patent/NO325685B1/no not_active IP Right Cessation
- 1999-09-09 BG BG103722A patent/BG103722A/xx unknown
2001
- 2001-06-01 US US09/872,546 patent/US6437124B1/en not_active Expired - Fee Related
2002
- 2002-06-17 US US10/174,414 patent/US7002012B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
AU6622198A (en)	1998-09-08
PE58899A1 (es)	1999-06-17
CA2280730C (en)	2006-10-10
TW520371B (en)	2003-02-11
CA2280730A1 (en)	1998-08-20
NO993915D0 (no)	1999-08-13
CN1252071A (zh)	2000-05-03
EP0970081A1 (en)	2000-01-12
CZ288799A3 (cs)	2000-04-12
KR20000071010A (ko)	2000-11-25
AP9901622A0 (en)	1999-09-30
ATE304542T1 (de)	2005-09-15
AR011441A1 (es)	2000-08-16
YU38399A (sh)	2002-06-19
ES2249822T3 (es)	2006-04-01
PL188018B1 (pl)	2004-11-30
ZA981175B (en)	1999-08-12
HUP0000894A2 (hu)	2001-05-28
HK1022907A1 (en)	2000-08-25
IL131179A0 (en)	2001-01-28
HRP980077A2 (en)	1998-12-31
CZ298764B6 (cs)	2008-01-23
EA199900648A1 (ru)	2000-04-24
NZ336923A (en)	2001-02-23
SK110399A3 (en)	2000-06-12
US20030181471A1 (en)	2003-09-25
AP1000A (en)	2001-08-11
IL131179A (en)	2004-05-12
NO993915L (no)	1999-10-13
WO1998035966A1 (en)	1998-08-20
EE9900348A (et)	2000-02-15
ID22770A (id)	1999-12-09
MY118545A (en)	2004-12-31
KR100522639B1 (ko)	2005-10-19
DE69831559D1 (de)	2005-10-20
TR199901942T2 (xx)	1999-12-21
BR9807682A (pt)	2000-02-15
DE69831559T2 (de)	2006-06-14
US6437124B1 (en)	2002-08-20
CN1140527C (zh)	2004-03-03
IS5144A (is)	1999-07-30
UA57767C2 (uk)	2003-07-15
US7002012B2 (en)	2006-02-21
GB9703044D0 (en)	1997-04-02
US6355646B1 (en)	2002-03-12
PL335135A1 (en)	2000-04-10
HU225962B1 (en)	2008-01-28
JP2001511792A (ja)	2001-08-14
CO4940444A1 (es)	2000-07-24
DK0970081T3 (da)	2006-02-06
EP0970081B1 (en)	2005-09-14
HUP0000894A3 (en)	2002-04-29
BR9807682B1 (pt)	2009-01-13
NO325685B1 (no)	2008-07-07
AU754456B2 (en)	2002-11-14

Publication	Publication Date	Title
PT695758E (pt)	2002-09-30	Amidas e esteres de pentapeptidos inibidores de cancro humano
MX9805181A (es)	1998-10-31	Derivados de lactona a partir de derivados de 17.beta- carboxi, carbotio y amida androstano.
AU2284099A (en)	1999-10-18	Poly-aminoacid derivatives and their use in compositions for treating keratinousfibres
ES2173185T3 (es)	2002-10-16	Empleo de derivados de tetrahidropteridina como inhibidores de la no-sintasa.
ATE248175T1 (de)	2003-09-15	Epothilonderivate und ihre verwendung als antitumormittel
MX235505B (pl)	2006-04-05
UY24244A1 (es)	2001-10-25	Derivados bicíclicos y policíclicos de isotiazolona
AR001440A1 (es)	1997-10-22	Nuevos taxoides, su preparación y composiciones farmacéuticas que los contienen.
RU94029662A (ru)	1996-07-10	Фосфонооксиметиловые эфиры производных таксана, фармацевтическая композиция, способы лечения
NO179142C (no)	1996-08-14	3-benzyliden-1-karbamoyl-2-pyrrolidon-analoger
PT839154E (pt)	2004-05-31	Peptidos e composicoes biologicamente activos sua utilizacao
TR199800602A2 (xx)	1999-10-21	Dithiolan t�revleri, haz�rlanmalar� ve terap�tik etkileri.
LV12618A (en)	2001-02-20	Use of sulphamate derivatives as steroid sulphatase inhibitors
IL123701A0 (en)	1998-10-30	Heterocyclic fungicides
TR199901765T2 (xx)	1999-10-21	S�lfomid-metalloproteaz inhibit�rleri
BG104885A (en)	2001-05-31	Novel heterocyclically substituted amides with cysteine protease-inhibiting effect
YU38399A (sh)	2002-06-19	Supstituisani derivati 1,3-bis(cikloheksilmetil)-1,2,3,6-tetrahidro-2,6-diokso-9h-purin-8-il)fenila,njihovo dobijanje i upotreba za proizvodnju medikamenata za lečenje inflamatornih stanja i imuno poremećaja
BG102701A (en)	1999-04-30	2-hetaroylcyclohexan-1,3-dions
AU2209500A (en)	2000-07-12	Inhibitors of alpha4beta1 mediated cell adhesion
TR199802384T2 (xx)	1999-03-22	N�rodejeneratif hastal�klar�n tedavisinde yararl� farmas�tik bile�imlerin haz�rlanmas� i�in P-Aminofenol t�revlerinin kullan�m�.
AP2000001761A0 (en)	2000-03-31	Pyrrolopyrrolone derivatives as inhibitors of neutrophil elastase.
TR199902350T2 (xx)	2000-04-21	Yeni piridin t�revleri ve onlardan olu�an farmakotik bile�imler.
MY128261A (en)	2007-01-31	New substituted azetidinones as anti-inflammatory and antidegenerative agents
TR199701013T1 (xx)	1998-02-21	Nitrik oksit synthas'�n�n inhibit�rleri olarak mercapto ve seleno t�revleri.
DE69418744D1 (de)	1999-07-08	Verwendung von Pregnanderivaten zur Behandlung von Tumoren