BG104175A - Метод за получаване на секретагоги на растежен хормон - Google Patents

Метод за получаване на секретагоги на растежен хормон Download PDF

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Publication number
BG104175A
BG104175A BG104175A BG10417500A BG104175A BG 104175 A BG104175 A BG 104175A BG 104175 A BG104175 A BG 104175A BG 10417500 A BG10417500 A BG 10417500A BG 104175 A BG104175 A BG 104175A
Authority
BG
Bulgaria
Prior art keywords
formula
compound
oxo
acid
methyl
Prior art date
Application number
BG104175A
Other languages
Bulgarian (bg)
English (en)
Inventor
Frank BUSCH
Charles Chiu
Clifford MELTZ
Ronald POST
Peter Rose
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of BG104175A publication Critical patent/BG104175A/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
BG104175A 1999-02-26 2000-02-22 Метод за получаване на секретагоги на растежен хормон BG104175A (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12274599P 1999-02-26 1999-02-26

Publications (1)

Publication Number Publication Date
BG104175A true BG104175A (bg) 2000-12-29

Family

ID=22404505

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104175A BG104175A (bg) 1999-02-26 2000-02-22 Метод за получаване на секретагоги на растежен хормон

Country Status (43)

Country Link
US (2) US6541634B2 (da)
EP (2) EP1031575B1 (da)
JP (3) JP3437813B2 (da)
KR (2) KR100372063B1 (da)
CN (3) CN1515570A (da)
AP (1) AP1221A (da)
AR (2) AR029617A1 (da)
AT (1) ATE277944T1 (da)
AU (1) AU764122B2 (da)
BG (1) BG104175A (da)
BR (2) BRPI0000967B8 (da)
CA (1) CA2299495C (da)
CO (1) CO5160252A1 (da)
DE (1) DE60014212T2 (da)
DK (1) DK1031575T3 (da)
DZ (1) DZ3018A1 (da)
EA (1) EA003218B1 (da)
EE (1) EE200000193A (da)
ES (1) ES2226712T3 (da)
GT (1) GT200000018A (da)
HN (1) HN2000000021A (da)
HR (1) HRP20000103A2 (da)
HU (1) HUP0000907A3 (da)
ID (1) ID24861A (da)
IL (2) IL157103A (da)
IN (1) IN192352B (da)
IS (1) IS5380A (da)
MA (1) MA25072A1 (da)
NO (1) NO20000965L (da)
NZ (1) NZ503062A (da)
OA (1) OA11325A (da)
PA (1) PA8491201A1 (da)
PE (1) PE20001550A1 (da)
PL (1) PL338628A1 (da)
PT (1) PT1031575E (da)
SG (1) SG90096A1 (da)
SI (1) SI1031575T1 (da)
SK (1) SK284982B6 (da)
TN (1) TNSN00035A1 (da)
TR (1) TR200000536A2 (da)
TW (2) TWI286142B (da)
UA (1) UA70306C2 (da)
ZA (1) ZA200000888B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1132388A3 (en) * 2000-03-09 2004-03-03 Pfizer Products Inc. Hexahydropyrazolo[4,3-c]pyridine metabolites
AU2001264977B2 (en) 2000-05-30 2005-04-14 Merck & Co., Inc. Melanocortin receptor agonists
AU2003237595A1 (en) * 2003-05-26 2004-12-13 Biocon Limited Process for the preparation of s(+)-2-ethoxy-4-(n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl)benzoic acid derivatives
WO2005027913A1 (en) * 2003-09-19 2005-03-31 Pfizer Products Inc. Pharmaceutical compositions and methods comprising combinations of 2-alkylidene-19-nor-vitamin d derivatives and a growth hormone secretagogue
US9117477B2 (en) 2013-05-08 2015-08-25 HGST Netherlands B.V. Perpendicular magnetic recording media having novel seed layer
BR112015029586B1 (pt) * 2013-05-28 2022-05-03 Raqualia Pharma Inc Formas polimorfas
CN109320515A (zh) * 2018-11-22 2019-02-12 常州大学 一种Capromorelin手性中间体的不对称合成方法
CN120265641A (zh) * 2023-04-21 2025-07-04 长春金赛药业有限责任公司 GHSR 1a激动剂、药物组合物及其制备方法和应用
CN119285632A (zh) * 2024-10-09 2025-01-10 威海中腾医药科技有限公司 一种基于酵母醇脱氢酶催化氧化的卡普瑞林中间体的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8610980D0 (en) 1986-05-06 1986-06-11 Ici America Inc Heterocyclic fused tricyclic compounds
GB8901423D0 (en) 1989-01-23 1989-03-15 Fujisawa Pharmaceutical Co Pyrazolopyridine compound and processes for preparation thereof
US5578593A (en) 1992-12-11 1996-11-26 Merck & Co., Inc. Spiro piperidines and homologs promote release of growth hormone
CN1174504A (zh) 1993-11-09 1998-02-25 麦克公司 促进生长激素释放的哌啶、吡咯烷和六氢－1h－吖庚因
US5609150A (en) 1995-04-18 1997-03-11 Maged; Jeffrey M. Method for dilating respiratory passages
TW432073B (en) 1995-12-28 2001-05-01 Pfizer Pyrazolopyridine compounds
AU2334097A (en) 1996-03-21 1997-10-10 Merck & Co., Inc. 4-spiroindoline piperidines promote release of growth hormone
WO1997036873A1 (en) 1996-04-03 1997-10-09 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
UA53716C2 (uk) 1997-06-25 2003-02-17 Пфайзер Продактс Інк. Тартратна сіль заміщеного дипептиду, спосіб її одержання, проміжні сполуки та спосіб їх одержання, фармацевтична композиція (варіанти), спосіб підвищення рівнів ендогенного гормону росту та спосіб лікування або профілактики захворювань (варіанти)
JP3514774B2 (ja) 1997-06-25 2004-03-31 ファイザー・インク 成長ホルモン分泌促進薬としてのジペプチド誘導体
UA64751C2 (uk) 1997-06-25 2004-03-15 Пфайзер Продактс Інк. Спосіб лікування інсулінової толерантності речовинами, які посилюють секрецію гормону росту (варіанти) та фармацевтична композиція (варіанти)

Also Published As

Publication number Publication date
HN2000000021A (es) 2001-02-02
JP3437813B2 (ja) 2003-08-18
KR20010006698A (ko) 2001-01-26
IL157103A0 (en) 2004-02-08
AR053722A2 (es) 2007-05-16
TR200000536A2 (tr) 2000-09-21
EP1031575A1 (en) 2000-08-30
EE200000193A (et) 2000-10-16
EP1031575B1 (en) 2004-09-29
AP1221A (en) 2003-11-03
PT1031575E (pt) 2004-11-30
OA11325A (en) 2003-10-27
SI1031575T1 (en) 2005-02-28
JP2003261565A (ja) 2003-09-19
IL134599A0 (en) 2001-04-30
EA200000172A3 (ru) 2000-10-30
JP2003327585A (ja) 2003-11-19
HU0000907D0 (en) 2000-04-28
US20020002283A1 (en) 2002-01-03
PE20001550A1 (es) 2001-01-11
ZA200000888B (en) 2001-08-23
AU1947100A (en) 2000-08-31
EA200000172A2 (ru) 2000-08-28
ES2226712T3 (es) 2005-04-01
ID24861A (id) 2000-08-31
GT200000018A (es) 2001-08-16
PL338628A1 (en) 2000-08-28
US6673929B2 (en) 2004-01-06
US6541634B2 (en) 2003-04-01
ATE277944T1 (de) 2004-10-15
HUP0000907A3 (en) 2001-05-28
DE60014212T2 (de) 2005-12-15
CN1837205A (zh) 2006-09-27
CO5160252A1 (es) 2002-05-30
SK284982B6 (sk) 2006-03-02
TW200718702A (en) 2007-05-16
BRPI0000967B1 (pt) 2012-06-12
SK2302000A3 (en) 2000-11-07
BRPI0017522B1 (pt) 2013-09-24
DZ3018A1 (fr) 2004-03-20
HRP20000103A2 (en) 2001-04-30
KR100372063B1 (ko) 2003-02-14
US20030158414A1 (en) 2003-08-21
NO20000965D0 (no) 2000-02-25
AR029617A1 (es) 2003-07-10
PA8491201A1 (es) 2001-04-30
TWI286142B (en) 2007-09-01
NZ503062A (en) 2001-07-27
BRPI0000967B8 (pt) 2021-12-07
AU764122B2 (en) 2003-08-07
CN1270960A (zh) 2000-10-25
EA003218B1 (ru) 2003-02-27
CA2299495C (en) 2010-06-15
CA2299495A1 (en) 2000-08-26
JP2000247974A (ja) 2000-09-12
BRPI0017522A2 (da) 2009-12-22
KR100361783B1 (ko) 2002-11-22
SG90096A1 (en) 2002-07-23
TNSN00035A1 (fr) 2005-11-10
IS5380A (is) 2000-08-27
JP4051314B2 (ja) 2008-02-20
DE60014212D1 (de) 2004-11-04
MA25072A1 (fr) 2000-10-01
HUP0000907A2 (en) 2001-03-28
IL157103A (en) 2007-07-24
IL134599A (en) 2006-12-10
AP2000001754A0 (en) 2000-03-31
IN192352B (da) 2004-04-10
DK1031575T3 (da) 2005-01-03
CN1137891C (zh) 2004-02-11
NO20000965L (no) 2000-08-28
CN1515570A (zh) 2004-07-28
EP1449842A1 (en) 2004-08-25
KR20020065455A (ko) 2002-08-13
UA70306C2 (en) 2004-10-15
BRPI0017522B8 (pt) 2021-05-25
BRPI0000967A (pt) 2001-09-11
HK1030219A1 (en) 2001-04-27

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