MA25072A1 - PROCEDES PERFECTIONNéS POUR LA PREPARATION SECRETAGOGUES D'HORMONES DE CROISSANCE - Google Patents

PROCEDES PERFECTIONNéS POUR LA PREPARATION SECRETAGOGUES D'HORMONES DE CROISSANCE

Info

Publication number
MA25072A1
MA25072A1 MA25911A MA25911A MA25072A1 MA 25072 A1 MA25072 A1 MA 25072A1 MA 25911 A MA25911 A MA 25911A MA 25911 A MA25911 A MA 25911A MA 25072 A1 MA25072 A1 MA 25072A1
Authority
MA
Morocco
Prior art keywords
preparation
secretagogue
improved processes
growth hormones
compounds
Prior art date
Application number
MA25911A
Other languages
English (en)
Inventor
Frank Robert Busch
Charles Kwok-Fung Chiu
Clifford Nathaniel Meltz
Ronald James Post
Peter Robert Rose
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of MA25072A1 publication Critical patent/MA25072A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

L'INVENTION CONCERNE DES PROCÉDÉS PERFECTIONNÉS POUR PRÉPARER DES COMPOSÉS DE FORMULE II. ET DES COMPOSÉS DE FORMULE III. DANS LESQUELS R1, R2, R3 ET PRT REPRÉSENTENT DIVERS RADICAUX. APPLICATION : UTILISATION DE CES COMPOSÉS POUR LA PRÉPARATION DE COMPOSÉS SÉCRÉTAGOGUES D'HORMONES DE CROISSANCE.
MA25911A 1999-02-26 2000-02-23 PROCEDES PERFECTIONNéS POUR LA PREPARATION SECRETAGOGUES D'HORMONES DE CROISSANCE MA25072A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12274599P 1999-02-26 1999-02-26

Publications (1)

Publication Number Publication Date
MA25072A1 true MA25072A1 (fr) 2000-10-01

Family

ID=22404505

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25911A MA25072A1 (fr) 1999-02-26 2000-02-23 PROCEDES PERFECTIONNéS POUR LA PREPARATION SECRETAGOGUES D'HORMONES DE CROISSANCE

Country Status (43)

Country Link
US (2) US6541634B2 (fr)
EP (2) EP1449842A1 (fr)
JP (3) JP3437813B2 (fr)
KR (2) KR100372063B1 (fr)
CN (3) CN1515570A (fr)
AP (1) AP1221A (fr)
AR (2) AR029617A1 (fr)
AT (1) ATE277944T1 (fr)
AU (1) AU764122B2 (fr)
BG (1) BG104175A (fr)
BR (2) BRPI0017522B8 (fr)
CA (1) CA2299495C (fr)
CO (1) CO5160252A1 (fr)
DE (1) DE60014212T2 (fr)
DK (1) DK1031575T3 (fr)
DZ (1) DZ3018A1 (fr)
EA (1) EA003218B1 (fr)
EE (1) EE200000193A (fr)
ES (1) ES2226712T3 (fr)
GT (1) GT200000018A (fr)
HN (1) HN2000000021A (fr)
HR (1) HRP20000103A2 (fr)
HU (1) HUP0000907A3 (fr)
ID (1) ID24861A (fr)
IL (2) IL134599A (fr)
IN (1) IN192352B (fr)
IS (1) IS5380A (fr)
MA (1) MA25072A1 (fr)
NO (1) NO20000965L (fr)
NZ (1) NZ503062A (fr)
OA (1) OA11325A (fr)
PA (1) PA8491201A1 (fr)
PE (1) PE20001550A1 (fr)
PL (1) PL338628A1 (fr)
PT (1) PT1031575E (fr)
SG (1) SG90096A1 (fr)
SI (1) SI1031575T1 (fr)
SK (1) SK284982B6 (fr)
TN (1) TNSN00035A1 (fr)
TR (1) TR200000536A2 (fr)
TW (2) TW200718702A (fr)
UA (1) UA70306C2 (fr)
ZA (1) ZA200000888B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1132388A3 (fr) * 2000-03-09 2004-03-03 Pfizer Products Inc. Métabolites de hexahydropyrazolo[4,3-c]pyridines
EP1289526A4 (fr) 2000-05-30 2005-03-16 Merck & Co Inc Agonistes du recepteur de la melanocortine
WO2004103983A1 (fr) * 2003-05-26 2004-12-02 Biocon Limited Procede de preparation de derives d'acide benzoique s(+)-2-ethoxy-4-[n-{1-(2-piperidinophelyl)-3-methyl-1- butyl} aminocarbonylmethyl]
WO2005027913A1 (fr) * 2003-09-19 2005-03-31 Pfizer Products Inc. Compositions pharmaceutiques et methodes de traitement consistant en des associations d'un derive de la 2-alkylidene-19-nor-vitamine d et d'un secretagogue de l'hormone de croissance
US9117477B2 (en) 2013-05-08 2015-08-25 HGST Netherlands B.V. Perpendicular magnetic recording media having novel seed layer
TWI629982B (zh) 2013-05-28 2018-07-21 拉夸里亞創藥股份有限公司 多晶型形式
CN109320515A (zh) * 2018-11-22 2019-02-12 常州大学 一种Capromorelin手性中间体的不对称合成方法
WO2024217441A1 (fr) * 2023-04-21 2024-10-24 长春金赛药业有限责任公司 Agoniste de ghsr 1a, composition pharmaceutique et son procédé de préparation et son utilisation
CN119285632B (zh) * 2024-10-09 2026-08-11 威海中腾医药科技有限公司 一种基于酵母醇脱氢酶催化氧化的卡普瑞林中间体的制备方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8610980D0 (en) 1986-05-06 1986-06-11 Ici America Inc Heterocyclic fused tricyclic compounds
GB8901423D0 (en) 1989-01-23 1989-03-15 Fujisawa Pharmaceutical Co Pyrazolopyridine compound and processes for preparation thereof
US5578593A (en) 1992-12-11 1996-11-26 Merck & Co., Inc. Spiro piperidines and homologs promote release of growth hormone
BR9408019A (pt) 1993-11-09 1997-08-26 Merck & Co Inc Composto composição util para aumentar a produção endógena ou a liberaçao de hormonio do crescimento em ser humano ou um animal e para o tratamento da osteoporose processos para aumentar os niveis de hormônio do crescimento em um ser humano ou um animal e a eficácia de alimentação promover o crescimento aumentar a produçao de leite e melhorar a qualidade da carcaça de gado para tratar ou previnir uma condição selecionada para tratar osteoporose e para preparar um composto
US5609150A (en) 1995-04-18 1997-03-11 Maged; Jeffrey M. Method for dilating respiratory passages
TW432073B (en) 1995-12-28 2001-05-01 Pfizer Pyrazolopyridine compounds
AU2334097A (en) 1996-03-21 1997-10-10 Merck & Co., Inc. 4-spiroindoline piperidines promote release of growth hormone
AU2722297A (en) 1996-04-03 1997-10-22 Merck & Co., Inc. Piperidines, pyrrolidines and hexahydro-1h-azepines promote release of growth hormone
US6251902B1 (en) 1997-06-25 2001-06-26 Pfizer Inc. Dipeptide derivatives as growth hormone secretagogues
UA53716C2 (uk) 1997-06-25 2003-02-17 Пфайзер Продактс Інк. Тартратна сіль заміщеного дипептиду, спосіб її одержання, проміжні сполуки та спосіб їх одержання, фармацевтична композиція (варіанти), спосіб підвищення рівнів ендогенного гормону росту та спосіб лікування або профілактики захворювань (варіанти)
UA64751C2 (uk) * 1997-06-25 2004-03-15 Пфайзер Продактс Інк. Спосіб лікування інсулінової толерантності речовинами, які посилюють секрецію гормону росту (варіанти) та фармацевтична композиція (варіанти)

Also Published As

Publication number Publication date
KR20020065455A (ko) 2002-08-13
TR200000536A2 (tr) 2000-09-21
TW200718702A (en) 2007-05-16
DZ3018A1 (fr) 2004-03-20
SK2302000A3 (en) 2000-11-07
EA200000172A2 (ru) 2000-08-28
BRPI0000967B8 (pt) 2021-12-07
AR053722A2 (es) 2007-05-16
BRPI0000967A (pt) 2001-09-11
HUP0000907A2 (en) 2001-03-28
JP2000247974A (ja) 2000-09-12
US20020002283A1 (en) 2002-01-03
DK1031575T3 (da) 2005-01-03
IL134599A (en) 2006-12-10
EE200000193A (et) 2000-10-16
EP1031575B1 (fr) 2004-09-29
IL157103A (en) 2007-07-24
JP2003327585A (ja) 2003-11-19
TWI286142B (en) 2007-09-01
CN1515570A (zh) 2004-07-28
IN192352B (fr) 2004-04-10
AU764122B2 (en) 2003-08-07
ATE277944T1 (de) 2004-10-15
EA200000172A3 (ru) 2000-10-30
PL338628A1 (en) 2000-08-28
GT200000018A (es) 2001-08-16
ID24861A (id) 2000-08-31
KR20010006698A (ko) 2001-01-26
SG90096A1 (en) 2002-07-23
HN2000000021A (es) 2001-02-02
PA8491201A1 (es) 2001-04-30
NO20000965D0 (no) 2000-02-25
CN1137891C (zh) 2004-02-11
JP3437813B2 (ja) 2003-08-18
US6673929B2 (en) 2004-01-06
CN1837205A (zh) 2006-09-27
OA11325A (en) 2003-10-27
JP4051314B2 (ja) 2008-02-20
AR029617A1 (es) 2003-07-10
BRPI0017522B1 (pt) 2013-09-24
JP2003261565A (ja) 2003-09-19
AU1947100A (en) 2000-08-31
UA70306C2 (en) 2004-10-15
BRPI0017522B8 (pt) 2021-05-25
CO5160252A1 (es) 2002-05-30
ES2226712T3 (es) 2005-04-01
IL157103A0 (en) 2004-02-08
US6541634B2 (en) 2003-04-01
EP1031575A1 (fr) 2000-08-30
IL134599A0 (en) 2001-04-30
US20030158414A1 (en) 2003-08-21
EA003218B1 (ru) 2003-02-27
BG104175A (bg) 2000-12-29
DE60014212T2 (de) 2005-12-15
BRPI0000967B1 (pt) 2012-06-12
ZA200000888B (en) 2001-08-23
PT1031575E (pt) 2004-11-30
HU0000907D0 (en) 2000-04-28
KR100372063B1 (ko) 2003-02-14
BRPI0017522A2 (fr) 2009-12-22
HRP20000103A2 (en) 2001-04-30
HUP0000907A3 (en) 2001-05-28
DE60014212D1 (de) 2004-11-04
PE20001550A1 (es) 2001-01-11
KR100361783B1 (ko) 2002-11-22
CN1270960A (zh) 2000-10-25
EP1449842A1 (fr) 2004-08-25
CA2299495C (fr) 2010-06-15
IS5380A (is) 2000-08-27
AP2000001754A0 (en) 2000-03-31
NZ503062A (en) 2001-07-27
SK284982B6 (sk) 2006-03-02
HK1030219A1 (en) 2001-04-27
CA2299495A1 (fr) 2000-08-26
SI1031575T1 (en) 2005-02-28
AP1221A (en) 2003-11-03
TNSN00035A1 (fr) 2005-11-10
NO20000965L (no) 2000-08-28

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