BG104302A - Метод за получаване на заместени 4-фенил-4-цианоциклохексанови киселини - Google Patents

Метод за получаване на заместени 4-фенил-4-цианоциклохексанови киселини

Info

Publication number
BG104302A
BG104302A BG104302A BG10430200A BG104302A BG 104302 A BG104302 A BG 104302A BG 104302 A BG104302 A BG 104302A BG 10430200 A BG10430200 A BG 10430200A BG 104302 A BG104302 A BG 104302A
Authority
BG
Bulgaria
Prior art keywords
phenyl
preparing substituted
cyanocyclohexanoic
acids
group
Prior art date
Application number
BG104302A
Other languages
English (en)
Inventor
Kevin Webb
Wilford Mendelson
Jianhao Chen
Original Assignee
Smithkline Beecham Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corporation filed Critical Smithkline Beecham Corporation
Publication of BG104302A publication Critical patent/BG104302A/bg

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D303/00Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02Compounds containing oxirane rings
    • C07D303/48Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00Carboxylic acid nitriles
    • C07C255/45Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/52Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/12Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BG104302A 1997-10-10 2000-04-05 Метод за получаване на заместени 4-фенил-4-цианоциклохексанови киселини BG104302A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6161397P 1997-10-10 1997-10-10
PCT/US1998/021061 WO1999018793A1 (en) 1997-10-10 1998-10-07 Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Publications (1)

Publication Number Publication Date
BG104302A true BG104302A (bg) 2001-08-31

Family

ID=22036929

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104302A BG104302A (bg) 1997-10-10 2000-04-05 Метод за получаване на заместени 4-фенил-4-цианоциклохексанови киселини

Country Status (30)

Country Link
EP (1) EP1043930A4 (bg)
JP (1) JP2001519363A (bg)
KR (1) KR100560038B1 (bg)
CN (1) CN1192025C (bg)
AP (1) AP1335A (bg)
AR (1) AR015952A1 (bg)
AU (1) AU741832B2 (bg)
BG (1) BG104302A (bg)
BR (1) BR9814064A (bg)
CA (1) CA2305614A1 (bg)
DZ (1) DZ2619A1 (bg)
EA (1) EA003609B1 (bg)
HU (1) HUP0003905A3 (bg)
ID (1) ID25536A (bg)
IL (1) IL135434A (bg)
MA (1) MA24670A1 (bg)
MY (1) MY122105A (bg)
NO (1) NO20001777L (bg)
NZ (1) NZ503759A (bg)
OA (1) OA11347A (bg)
PE (1) PE121599A1 (bg)
PL (1) PL191974B1 (bg)
SA (1) SA99191000A (bg)
SK (1) SK4902000A3 (bg)
TR (1) TR200000945T2 (bg)
TW (1) TW440557B (bg)
UA (1) UA67753C2 (bg)
UY (2) UY25201A1 (bg)
WO (1) WO1999018793A1 (bg)
ZA (1) ZA989228B (bg)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
EP1237851A4 (en) * 1999-12-15 2004-06-23 Smithkline Beecham SALES OF I CIS / I-4-CYANO-4-3- (CYCLOPENTYLOXY) -4-METHOXYPHENYL] CYCLHEXAN-1-CARBONIC ACID
EP1250313B1 (en) * 2000-01-26 2006-11-02 SmithKline Beecham Corporation Monohydrate of cis-lithium-cyano-4- 3-(cyclopentyloxy)-4-methoxyphenyl|cyclohexanecarboxylate
WO2001068600A2 (en) 2000-03-16 2001-09-20 Inflazyme Pharmaceuticals Limited Benzylated pde4 inhibitors
KR20030070150A (ko) 2001-01-31 2003-08-27 화이자 프로덕츠 인크. Pde4 이소자임 억제제로서 유용한 에테르 유도체
OA12542A (en) 2001-01-31 2006-06-05 Pfizer Prod Inc Thiazolyl-, oxazolyl-, pyrrolyl-, and imidazolyl-acid amide derivatives useful as inhibitors of PDE4isozymes.
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
JP2004520386A (ja) 2001-01-31 2004-07-08 ファイザー・プロダクツ・インク Pde4アイソザイムの阻害剤として有用なニコチンアミドビアリール誘導体
CN102491959B (zh) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 一种环氧乙烷衍生物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021478A (en) * 1972-07-13 1977-05-03 The Upjohn Company Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
HU225869B1 (en) * 1992-04-02 2007-11-28 Smithkline Beecham Corp Compounds with antiallergic and antiinflammatory activity and pharmaceutical compns. contg. them
US5524438A (en) * 1994-12-15 1996-06-11 United Technologies Corporation Segmented bulkhead liner for a gas turbine combustor
UY24882A1 (es) * 1997-02-12 2001-08-27 Smithkline Beecham Corp Ácidos 4-fenil-4-ciano-ciclohexanoicos sustituidos
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Also Published As

Publication number Publication date
ID25536A (id) 2000-10-12
UY25524A1 (es) 2000-02-23
AP2000001782A0 (en) 2000-06-30
DZ2619A1 (fr) 2003-03-08
PE121599A1 (es) 2000-02-19
UY25201A1 (es) 2001-08-27
AU741832B2 (en) 2001-12-13
IL135434A0 (en) 2001-05-20
NO20001777D0 (no) 2000-04-06
WO1999018793A1 (en) 1999-04-22
NZ503759A (en) 2002-03-01
CN1192025C (zh) 2005-03-09
EA200000406A1 (ru) 2000-10-30
NO20001777L (no) 2000-05-03
PL339759A1 (en) 2001-01-02
KR20010015709A (ko) 2001-02-26
HUP0003905A3 (en) 2002-01-28
JP2001519363A (ja) 2001-10-23
BR9814064A (pt) 2000-09-26
SK4902000A3 (en) 2000-11-07
AU9687498A (en) 1999-05-03
CA2305614A1 (en) 1999-04-22
AP1335A (en) 2004-11-29
OA11347A (en) 2003-12-17
MY122105A (en) 2006-03-31
EA003609B1 (ru) 2003-06-26
MA24670A1 (fr) 1999-07-01
HUP0003905A2 (en) 2001-03-28
CN1275052A (zh) 2000-11-29
UA67753C2 (uk) 2004-07-15
EP1043930A1 (en) 2000-10-18
EP1043930A4 (en) 2004-09-15
TR200000945T2 (tr) 2000-10-23
KR100560038B1 (ko) 2006-03-13
PL191974B1 (pl) 2006-07-31
AR015952A1 (es) 2001-05-30
IL135434A (en) 2004-12-15
TW440557B (en) 2001-06-16
ZA989228B (en) 1999-04-12
SA99191000A (ar) 2005-12-03

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