MA24670A1 - Methode pour la preparation d'acides 4-phenyl-4-cyano-cyclohexanoiques substitues - Google Patents

Methode pour la preparation d'acides 4-phenyl-4-cyano-cyclohexanoiques substitues

Info

Publication number
MA24670A1
MA24670A1 MA25278A MA25278A MA24670A1 MA 24670 A1 MA24670 A1 MA 24670A1 MA 25278 A MA25278 A MA 25278A MA 25278 A MA25278 A MA 25278A MA 24670 A1 MA24670 A1 MA 24670A1
Authority
MA
Morocco
Prior art keywords
cyano
preparation
phenyl
substituted
cyclohexanoic acids
Prior art date
Application number
MA25278A
Other languages
English (en)
Inventor
Webb Kevin
Mendelson Wilford
Chen Jian-Hoa
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of MA24670A1 publication Critical patent/MA24670A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C255/46—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of non-condensed rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/52—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575—Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'INVENTION CONCERNE UN PROCÉDÉ POUR LA PRÉPARATION DE L'ACIDE 4-CYANO- (3-CYCLOPENTYLOXY) -4-MÉTHOXYPHÉNYL) - CYCLOHEXANOiQUE ET SES ANALOGUES.ELLE CONCERNE ÉGALEMENT DES INTERMÉDIAIRES UTILISÉS à CETTE FIN, AINSI QU'UNE COMPOSITION CONTENANT UN TEL COMPOSÉ. APPLICATION : UTILISATION DE CE COMPOSÉ OU DE CETTE COMPOSITION POUR LE TRAITEMENT DE DIVERSES MALADIES EN INHIBANT LE SITE CATALYTIQUE DE L'ENRYME PDE IV.
MA25278A 1997-10-10 1998-10-02 Methode pour la preparation d'acides 4-phenyl-4-cyano-cyclohexanoiques substitues MA24670A1 (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6161397P 1997-10-10 1997-10-10

Publications (1)

Publication Number Publication Date
MA24670A1 true MA24670A1 (fr) 1999-07-01

Family

ID=22036929

Family Applications (1)

Application Number Title Priority Date Filing Date
MA25278A MA24670A1 (fr) 1997-10-10 1998-10-02 Methode pour la preparation d'acides 4-phenyl-4-cyano-cyclohexanoiques substitues

Country Status (30)

Country Link
EP (1) EP1043930A4 (fr)
JP (1) JP2001519363A (fr)
KR (1) KR100560038B1 (fr)
CN (1) CN1192025C (fr)
AP (1) AP1335A (fr)
AR (1) AR015952A1 (fr)
AU (1) AU741832B2 (fr)
BG (1) BG104302A (fr)
BR (1) BR9814064A (fr)
CA (1) CA2305614A1 (fr)
DZ (1) DZ2619A1 (fr)
EA (1) EA003609B1 (fr)
HU (1) HUP0003905A3 (fr)
ID (1) ID25536A (fr)
IL (1) IL135434A (fr)
MA (1) MA24670A1 (fr)
MY (1) MY122105A (fr)
NO (1) NO20001777L (fr)
NZ (1) NZ503759A (fr)
OA (1) OA11347A (fr)
PE (1) PE121599A1 (fr)
PL (1) PL191974B1 (fr)
SA (1) SA99191000A (fr)
SK (1) SK4902000A3 (fr)
TR (1) TR200000945T2 (fr)
TW (1) TW440557B (fr)
UA (1) UA67753C2 (fr)
UY (2) UY25201A1 (fr)
WO (1) WO1999018793A1 (fr)
ZA (1) ZA989228B (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9920152D0 (en) * 1999-08-25 1999-10-27 Smithkline Beecham Plc Novel process
WO2001043692A2 (fr) * 1999-12-15 2001-06-21 Smithkline Beecham Corporation SELS D'ACIDE CARBOXYLIQUE Cis-4-CYANO-4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]CYCLOHEXANE-1
HK1051030A1 (zh) * 2000-01-26 2003-07-18 Smithkline Beecham Corporation 顺-锂-腈-4-[3-(环戊氧基)-4-甲氧苯基]环己烷羧酸酯的单水合物
US6555572B2 (en) 2000-03-16 2003-04-29 Inflazyme Pharmaceuticals Ltd. Benzylated PDE4 inhibitors
PL364135A1 (en) 2001-01-31 2004-12-13 Pfizer Products Inc. Nicotinamide biaryl derivatives useful as inhibitors of pde4 isozymes
BR0116850A (pt) 2001-01-31 2004-02-25 Pfizer Prod Inc Derivados de amida de ácido tiazolil-, oxazolil-, pirrolil- e imidazolil- úteis como inibidores de isoenzimas de pde4
CN1527830A (zh) 2001-01-31 2004-09-08 �Ʒ� 用作pde4同工酶的抑制剂的醚衍生物
US7250518B2 (en) 2001-01-31 2007-07-31 Pfizer Inc. Nicotinamide acids, amides, and their mimetics active as inhibitors of PDE4 isozymes
CN102491959B (zh) * 2011-12-19 2015-03-25 江苏澄扬作物科技有限公司 一种环氧乙烷衍生物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4021478A (en) * 1972-07-13 1977-05-03 The Upjohn Company Preparation of carboxylic acids from glycidonitriles with ionic lewis acids
CA2133439C (fr) * 1992-04-02 2005-07-26 Siegfried Benjamin Christensen, Iv Composes utiles pour le traitement des maladies d'origine allergique et inflammatoire
US5524438A (en) * 1994-12-15 1996-06-11 United Technologies Corporation Segmented bulkhead liner for a gas turbine combustor
UY24882A1 (es) * 1997-02-12 2001-08-27 Smithkline Beecham Corp Ácidos 4-fenil-4-ciano-ciclohexanoicos sustituidos
US6452022B1 (en) * 1997-10-10 2002-09-17 Smithkline Beecham Corporation Method for preparing substituted 4-phenyl-4-cyanocyclohexanoic acids

Also Published As

Publication number Publication date
IL135434A (en) 2004-12-15
TW440557B (en) 2001-06-16
ID25536A (id) 2000-10-12
UA67753C2 (uk) 2004-07-15
AU741832B2 (en) 2001-12-13
TR200000945T2 (tr) 2000-10-23
NO20001777D0 (no) 2000-04-06
PL339759A1 (en) 2001-01-02
EA200000406A1 (ru) 2000-10-30
EP1043930A4 (fr) 2004-09-15
BG104302A (en) 2001-08-31
BR9814064A (pt) 2000-09-26
EP1043930A1 (fr) 2000-10-18
PL191974B1 (pl) 2006-07-31
AP2000001782A0 (en) 2000-06-30
SA99191000A (ar) 2005-12-03
HUP0003905A2 (en) 2001-03-28
PE121599A1 (es) 2000-02-19
CN1192025C (zh) 2005-03-09
IL135434A0 (en) 2001-05-20
WO1999018793A1 (fr) 1999-04-22
AR015952A1 (es) 2001-05-30
MY122105A (en) 2006-03-31
KR100560038B1 (ko) 2006-03-13
HUP0003905A3 (en) 2002-01-28
AU9687498A (en) 1999-05-03
JP2001519363A (ja) 2001-10-23
ZA989228B (en) 1999-04-12
KR20010015709A (ko) 2001-02-26
NO20001777L (no) 2000-05-03
AP1335A (en) 2004-11-29
UY25201A1 (es) 2001-08-27
UY25524A1 (es) 2000-02-23
NZ503759A (en) 2002-03-01
EA003609B1 (ru) 2003-06-26
CA2305614A1 (fr) 1999-04-22
OA11347A (en) 2003-12-17
CN1275052A (zh) 2000-11-29
DZ2619A1 (fr) 2003-03-08
SK4902000A3 (en) 2000-11-07

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