BG104484A - Сайт - специфично получаване на конюгати от полиетилен- гликол - grf - Google Patents

Сайт - специфично получаване на конюгати от полиетилен- гликол - grf

Info

Publication number
BG104484A
BG104484A BG104484A BG10448400A BG104484A BG 104484 A BG104484 A BG 104484A BG 104484 A BG104484 A BG 104484A BG 10448400 A BG10448400 A BG 10448400A BG 104484 A BG104484 A BG 104484A
Authority
BG
Bulgaria
Prior art keywords
site
peg
specific preparation
congrates
grf
Prior art date
Application number
BG104484A
Other languages
English (en)
Other versions
BG64815B1 (bg
Inventor
Francesco Veronese
Paolo Caliceti
Oddone Schiavon
Original Assignee
Applied Research Systems ARS Holding N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems ARS Holding N.V. filed Critical Applied Research Systems ARS Holding N.V.
Publication of BG104484A publication Critical patent/BG104484A/bg
Publication of BG64815B1 publication Critical patent/BG64815B1/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Birds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

Изобретението се отнася до метод за сайт-специфичен препарат на hGRF-PEG конюгати, съдържащи един или повече РЕG единици (за mol hGR), ковалентно свързани с Лизин12 и/или Лизин21, и/или N алфа, при който метод реакцията на конюгация между hGRF пептида и активиран РЕG се провежда в разтвор и желаният hGRF-PEG конюгат може да бъде пречистен чрез хроматография. Изобретението се отнася също до конюгатите, приготвени по този метод, до тяхното използване при третиране, превантивност и диагностика на недостатъчност на растежен хормон.
BG10448A 1997-12-03 2000-05-29 Сайт - специфично получаване на конюгати от полиетилен- гликол - grf BG64815B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97121264A EP0922446A1 (en) 1997-12-03 1997-12-03 Solution-phase site-specific preparation of GRF-PEG conjugates

Publications (2)

Publication Number Publication Date
BG104484A true BG104484A (bg) 2000-12-29
BG64815B1 BG64815B1 (bg) 2006-05-31

Family

ID=8227732

Family Applications (1)

Application Number Title Priority Date Filing Date
BG10448A BG64815B1 (bg) 1997-12-03 2000-05-29 Сайт - специфично получаване на конюгати от полиетилен- гликол - grf

Country Status (29)

Country Link
US (3) US6528485B1 (bg)
EP (2) EP0922446A1 (bg)
JP (2) JP2001524505A (bg)
KR (1) KR100561768B1 (bg)
CN (1) CN1149967C (bg)
AR (1) AR017780A1 (bg)
AT (1) ATE236607T1 (bg)
AU (1) AU755285B2 (bg)
BG (1) BG64815B1 (bg)
BR (1) BR9815159A (bg)
CA (1) CA2312004C (bg)
DE (1) DE69813291T2 (bg)
DK (1) DK1037587T3 (bg)
EA (1) EA004269B1 (bg)
EE (1) EE200000319A (bg)
ES (1) ES2194376T3 (bg)
HU (1) HUP0100507A3 (bg)
IL (2) IL136551A0 (bg)
NO (1) NO327238B1 (bg)
NZ (1) NZ504570A (bg)
PL (1) PL192082B1 (bg)
PT (1) PT1037587E (bg)
SI (1) SI1037587T1 (bg)
SK (1) SK8242000A3 (bg)
TR (1) TR200001615T2 (bg)
TW (1) TWI254641B (bg)
UA (1) UA73716C2 (bg)
WO (1) WO1999027897A1 (bg)
ZA (1) ZA9811068B (bg)

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CN103547591A (zh) 2011-04-21 2014-01-29 瑟瑞技术公司 生长激素释放因子(grf)类似物及其用途
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WO2013190520A2 (en) 2012-06-22 2013-12-27 The General Hospital Corporation Gh-releasing agents in the treatment of vascular stenosis and associated conditions
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Also Published As

Publication number Publication date
NO20002664D0 (no) 2000-05-24
NZ504570A (en) 2003-10-31
HUP0100507A2 (hu) 2001-08-28
PL192082B1 (pl) 2006-08-31
CN1149967C (zh) 2004-05-19
EP0922446A1 (en) 1999-06-16
NO327238B1 (no) 2009-05-18
HUP0100507A3 (en) 2001-11-28
IL136551A (en) 2008-12-29
AR017780A1 (es) 2001-10-24
EP1037587A1 (en) 2000-09-27
JP5431874B2 (ja) 2014-03-05
IL136551A0 (en) 2001-06-14
KR100561768B1 (ko) 2006-03-16
TR200001615T2 (tr) 2000-12-21
PL341139A1 (en) 2001-03-26
US7317002B2 (en) 2008-01-08
ZA9811068B (en) 1999-06-28
AU1563399A (en) 1999-06-16
US6528485B1 (en) 2003-03-04
EA004269B1 (ru) 2004-02-26
WO1999027897A9 (en) 1999-09-30
AU755285B2 (en) 2002-12-05
DK1037587T3 (da) 2003-07-28
DE69813291D1 (de) 2003-05-15
EP1037587B1 (en) 2003-04-09
HK1034203A1 (en) 2001-10-19
WO1999027897A1 (en) 1999-06-10
BG64815B1 (bg) 2006-05-31
UA73716C2 (en) 2005-09-15
CA2312004C (en) 2009-05-19
DE69813291T2 (de) 2003-11-13
SI1037587T1 (en) 2003-08-31
EA200000601A1 (ru) 2000-12-25
CA2312004A1 (en) 1999-06-10
NO20002664L (no) 2000-07-13
PT1037587E (pt) 2003-08-29
JP2010024245A (ja) 2010-02-04
TWI254641B (en) 2006-05-11
JP2001524505A (ja) 2001-12-04
EE200000319A (et) 2001-08-15
CN1280483A (zh) 2001-01-17
ATE236607T1 (de) 2003-04-15
BR9815159A (pt) 2000-10-10
SK8242000A3 (en) 2001-01-18
US20050159353A1 (en) 2005-07-21
US6869932B2 (en) 2005-03-22
ES2194376T3 (es) 2003-11-16
KR20010032494A (ko) 2001-04-25
US20040029794A1 (en) 2004-02-12

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