BG104801A - Indole-2,3-dione-3-oxime derivatives for therapeutical use - Google Patents

Indole-2,3-dione-3-oxime derivatives for therapeutical use

Info

Publication number: BG104801A
Authority: BG; Bulgaria
Prior art keywords: dione; indole; oxime derivatives; therapeutical use; therapeutical
Prior art date: 1998-03-31

Application number

BG104801A

Other languages

Bulgarian (bg)

English (en)

Inventor

Frank Waetjen

Jorgen Drejer

Original Assignee

Neurosearch A/S

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-03-31

Filing date

2000-09-27

Publication date

2001-04-30

2000-09-27 Application filed by Neurosearch A/S filed Critical Neurosearch A/S

2001-04-30 Publication of BG104801A publication Critical patent/BG104801A/xx

Links

LNMAXZZQNSPQSR-UHFFFAOYSA-N 3-(hydroxyamino)indol-2-one Chemical class C1=CC=CC2=NC(=O)C(NO)=C21 LNMAXZZQNSPQSR-UHFFFAOYSA-N 0.000 title abstract 2
230000001225 therapeutic effect Effects 0.000 title 1
208000037765 diseases and disorders Diseases 0.000 abstract 1
239000003257 excitatory amino acid Substances 0.000 abstract 1
230000002461 excitatory amino acid Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Psychology (AREA)
Addiction (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Indole Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BG104801A 1998-03-31 2000-09-27 Indole-2,3-dione-3-oxime derivatives for therapeutical use BG104801A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DK45298		1998-03-31
DK46298		1998-04-01
PCT/DK1999/000194 WO1999049864A1 (en)	1998-03-31	1999-03-30	Indole-2,3-dione-3-oxime derivatives for therapeutic use

Publications (1)

Publication Number	Publication Date
BG104801A true BG104801A (en)	2001-04-30

Family

ID=26064032

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG104801A BG104801A (en)	1998-03-31	2000-09-27	Indole-2,3-dione-3-oxime derivatives for therapeutical use

Country Status (10)

Country	Link
US (1)	US6239128B1 (de)
EP (1)	EP1066037B1 (de)
JP (1)	JP2002509885A (de)
AT (1)	ATE285772T1 (de)
AU (1)	AU751414B2 (de)
BG (1)	BG104801A (de)
CA (1)	CA2326576A1 (de)
DE (1)	DE69922936T2 (de)
NZ (1)	NZ507259A (de)
WO (1)	WO1999049864A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO2000071102A2 (en) *	1999-05-19	2000-11-30	Neurosearch A/S	Inhibitors of proton-gated cation channels and their use in the treatment of ischaemic disorders
EP1736468A3 (de) *	2000-01-24	2007-01-03	NeuroSearch A/S	Isatinderivate mit neurotropischer Aktivität geeignet zur Behandlung von NGF-bedingten Krankheiten
MXPA04000358A (es)	2001-07-13	2004-05-04	Pharmacia & Up John Company	Hexahidroazepino (4,5-g) indoles e indolinas como ligandos del receptor 5-ht.
CA2493244A1 (en) *	2002-08-22	2004-03-04	Neurosearch A/S	A method of preparing enantiomers of indole-2,3-dione-3-oxime derivatives
KR20080070749A (ko) *	2005-11-23	2008-07-30	페인셉터 파마 코포레이션	개폐 이온 통로를 조절하기 위한 조성물 및 방법
US20080004282A1 (en) *	2006-04-10	2008-01-03	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
WO2007115403A1 (en) *	2006-04-10	2007-10-18	Painceptor Pharma Corporation	Compositions and methods for modulating gated ion channels
EP2066323A2 (de) *	2006-09-12	2009-06-10	NeuroSearch AS	Pharmazeutische zusammensetzungen mit kombinationen aus einer antagonistischen ampa-/kainat-verbindung und einem hemmer eines multdrug-resistenzproteins
CN102653538A (zh) *	2011-03-04	2012-09-05	爱斯医药科技(南京)有限公司	Spd-502的制备方法
CN104725372B (zh) *	2015-01-28	2017-02-22	天津科技大学	四环吲哚生物碱衍生物及其制备和应用
JP7576921B2 (ja)	2020-03-30	2024-11-01	東ソー株式会社	Ｏ－置換ヒドロキシルアミン誘導体の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
NZ267081A (en) *	1993-05-13	1997-11-24	Neurosearch As	Hetero-fused indole and quinoxaline compounds and medicaments thereof
GB9418357D0 (en) *	1994-09-12	1994-11-02	Chiroscience Ltd	Amidation process
NZ293265A (en) *	1994-09-14	1998-01-26	Neurosearch As	5-aryl-isoquinoline-2-one-3-acyloxime derivatives fused with a n-heterocyclic ring
UA54403C2 (uk) *	1996-10-01	2003-03-17	Н'Юросерч А/С	Похідні індол-2,3-діон-3-оксиму, фармацевтична композиція, спосіб лікування розладу чи захворювання ссавців, у тому числі людини та спосіб одержання похідних індол-2,3-діон-3-оксиму

1999
- 1999-03-30 WO PCT/DK1999/000194 patent/WO1999049864A1/en not_active Ceased
- 1999-03-30 NZ NZ507259A patent/NZ507259A/en unknown
- 1999-03-30 JP JP2000540828A patent/JP2002509885A/ja not_active Withdrawn
- 1999-03-30 DE DE69922936T patent/DE69922936T2/de not_active Expired - Lifetime
- 1999-03-30 EP EP99910150A patent/EP1066037B1/de not_active Expired - Lifetime
- 1999-03-30 AU AU29219/99A patent/AU751414B2/en not_active Ceased
- 1999-03-30 AT AT99910150T patent/ATE285772T1/de not_active IP Right Cessation
- 1999-03-30 CA CA002326576A patent/CA2326576A1/en not_active Abandoned
2000
- 2000-09-27 BG BG104801A patent/BG104801A/xx unknown
- 2000-09-29 US US09/675,214 patent/US6239128B1/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
NZ507259A (en)	2003-07-25
AU2921999A (en)	1999-10-18
EP1066037B1 (de)	2004-12-29
EP1066037A1 (de)	2001-01-10
DE69922936D1 (de)	2005-02-03
US6239128B1 (en)	2001-05-29
AU751414B2 (en)	2002-08-15
ATE285772T1 (de)	2005-01-15
CA2326576A1 (en)	1999-10-07
JP2002509885A (ja)	2002-04-02
WO1999049864A1 (en)	1999-10-07
DE69922936T2 (de)	2005-12-08

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IL165696A0 (en)	2006-01-15	Substituted 1,3-diphenykprop-2-en-1-one derivatives and preparation and uses thereof
MY115977A (en)	2003-10-31	Synthetic excitatory amino acids
AU2002343557A1 (en)	2003-06-10	Substituted aryl 1,4-pyrazine derivatives
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MY130489A (en)	2007-06-29	Substituted aryl 1, 4-pyrazine derivatives
EP1042305A4 (de)	2003-05-14	HEMMUNG DER p38 KINASE UNTER VERWENDUNG VON SYMMETRISCHEN UND ASYMMETRISCHEN DIPHENYLHARNSTOFFEN
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ATE366099T1 (de)	2007-07-15	Vorrichtung zur physikalischen therapie der schulter
IL127918A0 (en)	1999-11-30	Novel amino sugar and related sugar derivatives of indolylopyrrolocarbazoles their use as antitumor agents and pharmaceutical formulations
MX9704030A (es)	1998-02-28	1,1-dioxidos de 2-heterocicliloxi y tiometil-1,2,5-tiadiazolidin-3-ona y composiciones y metodo de uso de los mismos.
IE902288L (en)	1990-12-26	Tetrazolylmethylpiperidine carboxylic acid
AU1945795A (en)	1995-10-03	Thieno{ 2,3-b}indoles, their preparation and use
HUP9901630A3 (en)	2001-11-28	Indole-2,3-dione-3-oxime derivatives as antagonists of excitatory amino acids, preparation and use thereof
AU2921999A (en)	1999-10-18	Indole-2,3-dione-3-oxime derivatives for therapeutic use
GR3034575T3 (en)	2001-01-31	Steroid nitrite ester derivatives useful as anti-inflammatory drugs
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TR200001102T2 (tr)	2000-08-21	İkameli tetrahidropirimidinen türevleri, üretimleri ve kullanımları.
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DK1040191T3 (da)	2005-12-19	RANTES-mutanter og terapeutiske anvendelser heraf
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WO2001057042A3 (de)	2001-12-27	4-pyridyl- und 2,4-pyrimidinyl-substituierte pyrrolderivate und ihre anwendung in der pharmazie
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