BG104803A - N-/(заместени петчленни ди- или триаза - диненаситени пръстенни) карбонил / гуанидинови производни за лечение на исхемия - Google Patents

N-/(заместени петчленни ди- или триаза - диненаситени пръстенни) карбонил / гуанидинови производни за лечение на исхемия Download PDF

Info

Publication number
BG104803A
BG104803A BG104803A BG10480300A BG104803A BG 104803 A BG104803 A BG 104803A BG 104803 A BG104803 A BG 104803A BG 10480300 A BG10480300 A BG 10480300A BG 104803 A BG104803 A BG 104803A
Authority
BG
Bulgaria
Prior art keywords
mono
alkyl
compound
pharmaceutically acceptable
optionally
Prior art date
Application number
BG104803A
Other languages
Bulgarian (bg)
English (en)
Inventor
Ernest Hamanaka
- PEREZ Angel GUZMAN
Roger Ruggeri
Ronald WESTER
Christian MULARSKI
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of BG104803A publication Critical patent/BG104803A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/428—Thiazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
    • C07D249/06—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles with aryl radicals directly attached to ring atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Biomedical Technology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)
BG104803A 1998-02-27 2000-09-27 N-/(заместени петчленни ди- или триаза - диненаситени пръстенни) карбонил / гуанидинови производни за лечение на исхемия BG104803A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7636298P 1998-02-27 1998-02-27
PCT/IB1999/000206 WO1999043663A1 (fr) 1998-02-27 1999-02-05 Derives de la n-[(a cycle di ou triaza diinsature substitue) carbonyle] guanidine utilises pour le traitement de l'ischemie

Publications (1)

Publication Number Publication Date
BG104803A true BG104803A (bg) 2001-05-31

Family

ID=22131525

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104803A BG104803A (bg) 1998-02-27 2000-09-27 N-/(заместени петчленни ди- или триаза - диненаситени пръстенни) карбонил / гуанидинови производни за лечение на исхемия

Country Status (39)

Country Link
US (2) US6492401B1 (fr)
EP (2) EP1454902A1 (fr)
JP (2) JP2002504546A (fr)
KR (4) KR20030083004A (fr)
CN (1) CN1289326A (fr)
AP (1) AP9901478A0 (fr)
AR (1) AR015526A1 (fr)
AT (1) ATE286034T1 (fr)
AU (1) AU739403B2 (fr)
BG (1) BG104803A (fr)
BR (1) BR9908332A (fr)
CA (1) CA2321642A1 (fr)
CO (1) CO4980897A1 (fr)
DE (1) DE69922930T2 (fr)
DK (1) DK1056729T3 (fr)
DZ (1) DZ2729A1 (fr)
EA (1) EA003603B1 (fr)
ES (1) ES2237080T3 (fr)
GT (1) GT199900022A (fr)
HR (2) HRP20010666A2 (fr)
HU (1) HUP0204418A3 (fr)
ID (1) ID25505A (fr)
IL (1) IL136588A0 (fr)
IS (1) IS5548A (fr)
NO (1) NO20004192D0 (fr)
NZ (1) NZ504769A (fr)
OA (1) OA11450A (fr)
PA (1) PA8468401A1 (fr)
PE (1) PE20000334A1 (fr)
PL (1) PL342444A1 (fr)
PT (1) PT1056729E (fr)
SI (1) SI1056729T1 (fr)
SK (1) SK12342000A3 (fr)
TN (1) TNSN99028A1 (fr)
TR (1) TR200002480T2 (fr)
TW (1) TWI226329B (fr)
WO (1) WO1999043663A1 (fr)
YU (1) YU46200A (fr)
ZA (1) ZA991578B (fr)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1056729E (pt) * 1998-02-27 2005-04-29 Pfizer Prod Inc Derivados de n-[ciclo di- ou tri-aza di-insaturado de cinco membros substituido) carbonil] guanidina para o tratamento de isquemia
FR2795726A1 (fr) * 1999-06-30 2001-01-05 Aventis Cropscience Sa Nouveaux pyrazoles fongicides
UA72002C2 (en) * 1999-10-29 2005-01-17 Pfizer Prod Inc Inhibitors crystals of sodium-hydrogen exchange of 1 type, a method for the preparation thereof (variants), a pharmaceuticalcomposition based thereon and a method for the reduction of tissue damage
US6441176B1 (en) * 1999-10-29 2002-08-27 Pfizer Inc. Method for preparing sodium-hydrogen exchanger type 1 inhibitor
YU54202A (sh) 2000-01-18 2006-01-16 Agouron Pharmaceuticals Inc. Jedinjenja indazola, farmaceutske smeše i postupci za stimulisanje i inhibiranje ćelijske proliferacije
HN2001000008A (es) 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
US6570013B2 (en) 2000-02-16 2003-05-27 Pfizer Inc Salts of zopolrestat
US6555569B2 (en) * 2000-03-07 2003-04-29 Pfizer Inc. Use of heteroaryl substituted N-(indole-2-carbonyl-) amides for treatment of infection
US6395767B2 (en) 2000-03-10 2002-05-28 Bristol-Myers Squibb Company Cyclopropyl-fused pyrrolidine-based inhibitors of dipeptidyl peptidase IV and method
JP2004501083A (ja) 2000-04-18 2004-01-15 アゴーロン・ファーマシューティカルズ・インコーポレイテッド プロテインキナーゼを阻害するためのピラゾール
EP1276737A1 (fr) * 2000-04-28 2003-01-22 Pfizer Products Inc. Inhibiteurs de l'echangeur sodium-hydrogene de type 1
US6852733B2 (en) 2000-04-28 2005-02-08 Pfizer Inc. Sodium-hydrogen exchanger type 1 inhibitor
IL144507A0 (en) * 2000-07-31 2002-05-23 Pfizer Prod Inc Use of glycogen phosphorylase inhibitors to inhibit tumor growth
EP1337508A1 (fr) 2000-11-28 2003-08-27 Pfizer Products Inc. Preparation d'inhibiteurs de type 1 d'echangeur de sodium-hydrogene
IL147696A0 (en) * 2001-01-25 2002-08-14 Pfizer Prod Inc Combination therapy
US6423705B1 (en) 2001-01-25 2002-07-23 Pfizer Inc. Combination therapy
CN1479737A (zh) * 2001-01-31 2004-03-03 �Ʒ� 钠-质子交换蛋白1型抑制剂的乙醇盐
WO2002098429A1 (fr) * 2001-06-07 2002-12-12 Pfizer Products Inc. Formes salines du zopolrestat, a savoir ethanolamine, diethanolamine ou triethanolamine
WO2003002062A2 (fr) * 2001-06-29 2003-01-09 Tularik Inc. Derives de bis-aryl thiazole
HRP20040385A2 (en) * 2001-11-02 2005-06-30 Aventis Pharmaceuticals Inc. Pharmaceutical composition comprising an adenosine a<sub>1</sub>/a<sub>2</sub> agonist and a sodium hydrogen exchanger inhibitor
EP1456181A1 (fr) 2001-12-19 2004-09-15 Pfizer Products Inc. Methodes de preparation d'inhibiteurs de type 1 d'echangeurs de sodium-hydrogene
BR0307195A (pt) * 2002-01-30 2004-11-03 Pfizer Prod Inc Composições farmacêuticas de mesilato de zoniporide e processos para melhorar a solubilidade do zoniporide
MXPA04008646A (es) * 2002-05-02 2004-12-06 Pfizer Prod Inc Tratamiento para la diabetes y complicaciones diabeticas con inhibidores del nhe-1.
US7057046B2 (en) 2002-05-20 2006-06-06 Bristol-Myers Squibb Company Lactam glycogen phosphorylase inhibitors and method of use
FR2840302B1 (fr) 2002-06-03 2004-07-16 Aventis Pharma Sa Derives d'isoindolones, procede de preparation et intermediaire de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant
FR2842526B1 (fr) * 2002-07-16 2007-07-13 Aventis Pharma Sa Compositions pharmaceutiques contenant un derive de 3-guanidinocarbonyl-1-heteroaryl-indole, procede de preparation a titre de medicaments
FR2842524B1 (fr) * 2002-07-16 2005-04-22 Aventis Pharma Sa Compositions pharmaceutiques contenant un derive de 3-guanidinocarbonyl-1-heteroaryl-pyrrole, leur procede de preparation a titre de medicaments
FR2842525B1 (fr) * 2002-07-16 2005-05-13 Aventis Pharma Sa Derives de 3-guanidinocarbonyl-1-heteroaryl-indole, procede de preparation a titre de medicaments et compositions pharmaceutiques les renfermant
ATE440827T1 (de) 2002-12-04 2009-09-15 Ore Pharmaceuticals Inc Melanocortin-rezeptormodulatoren
CN100436445C (zh) * 2003-02-07 2008-11-26 第一制药株式会社 吡唑衍生物
NZ547752A (en) 2003-11-12 2009-12-24 Phenomix Corp Heterocyclic boronic acid compounds for inhibiting dipeptidyl peptidase-IV
US7576121B2 (en) 2003-11-12 2009-08-18 Phenomix Corporation Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
US7317109B2 (en) 2003-11-12 2008-01-08 Phenomix Corporation Pyrrolidine compounds and methods for selective inhibition of dipeptidyl peptidase-IV
TW200526641A (en) * 2003-12-26 2005-08-16 Daiichi Seiyaku Co Amidopyrazole derivatives
WO2005079803A1 (fr) * 2004-02-13 2005-09-01 Pfizer Products, Inc. Composes pour traitement des maladies cardio-vasculaires
CA2573848A1 (fr) 2004-07-12 2006-02-16 Phenomix Corporation Composes cyano contraints
US7365061B2 (en) 2004-11-15 2008-04-29 Bristol-Myers Squibb Company 2-Amino-3-functionalized tetralin derivatives and related glycogen phosphorylase inhibitors
WO2006055462A1 (fr) 2004-11-15 2006-05-26 Bristol-Myers Squibb Company Derives 2-amino-4- tetraline fonctionnalisee et inhibiteurs de la glycogene phosphorylase associes
WO2006053274A2 (fr) 2004-11-15 2006-05-18 Bristol-Myers Squibb Company Derives de tetraline 2-amino-1-fonctionnalises et inhibiteurs correspondants de glycogene phosphorylase
US7223786B2 (en) 2004-11-15 2007-05-29 Bristol-Myers Squibb Company 2-aminonaphthalene derivatives and related glycogen phosphorylase inhibitors
PT1853296E (pt) * 2005-01-10 2012-09-26 Debiopharm Sa Utilização de um undecapeptídeo cíclico para a preparação de um medicamento para administração em situações de miocardia isquêmica
EP2527337A1 (fr) 2005-04-14 2012-11-28 Bristol-Myers Squibb Company Inhibiteurs de la 11-bêta hydroxystéroïde déshydrogénase de type I
US7825139B2 (en) 2005-05-25 2010-11-02 Forest Laboratories Holdings Limited (BM) Compounds and methods for selective inhibition of dipeptidyl peptidase-IV
US8318941B2 (en) 2006-07-06 2012-11-27 Bristol-Myers Squibb Company Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors
US7727978B2 (en) 2006-08-24 2010-06-01 Bristol-Myers Squibb Company Cyclic 11-beta hydroxysteroid dehydrogenase type I inhibitors
US8546394B2 (en) 2007-04-17 2013-10-01 Bristol-Myers Squibb Company Substituted [1,2,4]triazolo[4,3-A]pyrazine 11-beta-hydroxysteroid dehydrogenase inhibitors
CN101808995A (zh) 2007-07-27 2010-08-18 百时美施贵宝公司 新颖的葡糖激酶激活剂及其使用方法
EP2294066B9 (fr) * 2008-04-28 2015-03-11 Janssen Pharmaceutica, N.V. Benzoimidazoles comme inhibiteurs de la prolyl hydroxylase
US10517839B2 (en) 2008-06-09 2019-12-31 Cornell University Mast cell inhibition in diseases of the retina and vitreous
WO2010058858A1 (fr) * 2008-11-21 2010-05-27 ラクオリア創薬株式会社 Nouveau dérivé de pyrazole-3-carboxamide doté d’une activité antagoniste du récepteur 5-ht2b
WO2010094090A2 (fr) * 2009-02-18 2010-08-26 Katholleke Universiteit Leuven Synucléinopathies
US8592396B2 (en) 2010-04-14 2013-11-26 Bristol-Myers Squibb Company Glucokinase activators and methods of using same
CN102408385B (zh) * 2011-06-20 2014-06-18 雅本化学股份有限公司 一种2-取代-2h-1,2,3-三氮唑衍生物的制备方法
CN102408386B (zh) * 2011-07-27 2014-05-07 雅本化学股份有限公司 2,4-二取代-2h-1,2,3-三氮唑衍生物的制备方法
BR112014006940A2 (pt) 2011-09-23 2017-04-04 Bayer Ip Gmbh uso de derivados de ácido 1-fenilpirazol-3-carboxílico 4-substituído como agentes contra estresse abiótico em plantas
US9273034B2 (en) 2011-10-25 2016-03-01 Janssen Pharmaceutica Nv Meglumine salt formulations of 1-(5,6-dichloro-1H-benzo[D]imidazol-2-yl)-1H-pyrazole-4-carboxylic acid
EP2819675A4 (fr) * 2012-02-27 2015-07-22 Essentialis Inc Sels d'ouvreurs des canaux potassiques atp et leurs utilisations
US10759781B2 (en) 2015-08-06 2020-09-01 Ube Industries, Ltd. Substituted guanidine derivatives
JPWO2017057695A1 (ja) * 2015-09-30 2018-07-19 東レ株式会社 ジフェニルピラゾール誘導体及びその医薬用途
DK3395801T3 (da) 2015-12-16 2021-05-10 Nippon Soda Co Arylazolforbindelse og skadedyrsbekæmpelsesmiddel
WO2018058109A1 (fr) 2016-09-26 2018-03-29 Nusirt Sciences, Inc. Compositions et méthodes pour le traitement de troubles métaboliques
CN108017584B (zh) * 2017-06-20 2021-03-23 南开大学 A3腺苷受体的小分子拮抗剂

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2104931B1 (fr) * 1970-09-08 1975-01-10 Ferlux
CA2121391A1 (fr) * 1993-04-28 1994-10-29 Atsuyuki Kojima Derives d'indoloylguanidine
IL109570A0 (en) * 1993-05-17 1994-08-26 Fujisawa Pharmaceutical Co Guanidine derivatives, pharmaceutical compositions containing the same and processes for the preparation thereof
EP0639573A1 (fr) * 1993-08-03 1995-02-22 Hoechst Aktiengesellschaft Hétérocycles à cinq chaînons benzocondensés, procédé pour leur préparation, leur utilisation comme médicament et comme diagnostique aussi bien que les produits pharmaceutiques le contenant
US5852046A (en) 1993-08-03 1998-12-22 Hoechst Aktiengesellschaft Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them
DE4412334A1 (de) * 1994-04-11 1995-10-19 Hoechst Ag Substituierte N-Heteroaroylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
CA2160600A1 (fr) * 1994-10-18 1996-04-19 Masahumi Kitano Derives de l'indoloylguanidine
NZ314105A (en) 1996-02-02 1997-12-19 Sumitomo Pharma Guanidine derivative substituted with a substituted indole which is peri condensed with a heterocyclic ring
JPH09291076A (ja) * 1996-04-24 1997-11-11 Sumitomo Pharmaceut Co Ltd 置換グアニジン誘導体およびその製法
AR009435A1 (es) * 1996-12-16 2000-04-12 Yamanouchi Pharma Co Ltd Derivado de guanaidina n-[carbonil(heteroaril-substituida de 5 miembros)], un inhibidor del intercambiador de na+/h+ que comprende dicho derivado y usosen la fabricacion de medicamentos.
PT1056729E (pt) * 1998-02-27 2005-04-29 Pfizer Prod Inc Derivados de n-[ciclo di- ou tri-aza di-insaturado de cinco membros substituido) carbonil] guanidina para o tratamento de isquemia

Also Published As

Publication number Publication date
YU46200A (sh) 2003-02-28
EA003603B1 (ru) 2003-06-26
SI1056729T1 (en) 2005-04-30
HRP20010666A2 (en) 2001-10-31
NZ504769A (en) 2005-04-29
AU739403B2 (en) 2001-10-11
CA2321642A1 (fr) 1999-09-02
PE20000334A1 (es) 2000-05-13
JP2002504546A (ja) 2002-02-12
PA8468401A1 (es) 2000-09-29
EP1454902A1 (fr) 2004-09-08
KR20030078886A (ko) 2003-10-08
US6974813B2 (en) 2005-12-13
KR20030083004A (ko) 2003-10-23
US6492401B1 (en) 2002-12-10
KR100449600B1 (ko) 2004-09-21
EP1056729B1 (fr) 2004-12-29
CO4980897A1 (es) 2000-11-27
WO1999043663A1 (fr) 1999-09-02
BR9908332A (pt) 2000-11-07
DE69922930T2 (de) 2005-12-29
ID25505A (id) 2000-10-05
SK12342000A3 (sk) 2001-03-12
GT199900022A (es) 2000-08-15
TR200002480T2 (tr) 2000-12-21
ES2237080T3 (es) 2005-07-16
ZA991578B (en) 2000-08-28
AR015526A1 (es) 2001-05-02
PT1056729E (pt) 2005-04-29
KR100407903B1 (ko) 2003-12-01
IL136588A0 (en) 2001-06-14
DK1056729T3 (da) 2005-04-11
DZ2729A1 (fr) 2005-03-01
EP1056729A1 (fr) 2000-12-06
DE69922930D1 (de) 2005-02-03
AU2070699A (en) 1999-09-15
OA11450A (en) 2003-12-04
EA200000789A1 (ru) 2001-02-26
AP9901478A0 (en) 1999-03-31
HRP20000550A2 (en) 2001-02-28
TWI226329B (en) 2005-01-11
NO20004192L (no) 2000-08-22
KR20010041397A (ko) 2001-05-15
IS5548A (is) 2000-06-27
KR20030009548A (ko) 2003-01-29
JP2005041879A (ja) 2005-02-17
HUP0204418A3 (en) 2003-10-28
HUP0204418A2 (hu) 2003-04-28
US20030149043A1 (en) 2003-08-07
CN1289326A (zh) 2001-03-28
TNSN99028A1 (fr) 2005-11-10
NO20004192D0 (no) 2000-08-22
ATE286034T1 (de) 2005-01-15
PL342444A1 (en) 2001-06-04

Similar Documents

Publication Publication Date Title
BG104803A (bg) N-/(заместени петчленни ди- или триаза - диненаситени пръстенни) карбонил / гуанидинови производни за лечение на исхемия
KR100481605B1 (ko) 허혈증 치료용 화합물
KR100569324B1 (ko) Ｈｉｖ 치료용 피라졸 유도체
US20030055021A1 (en) Compounds for the treatment of ischemia
CZ20032321A3 (en) Fused heterocyclic compounds
US20040198693A1 (en) Compounds for the treatment of ischemia
KR20170012559A (ko) P53-mdm2 단백질-단백질 상호작용 억제제로서 1,1&#39;&#39;,2,5&#39;&#39;-테트라하이드로스피로[인돌-3,2&#39;&#39;-피롤]-2,5&#39;&#39;-디온계를 포함하는 화합물
WO2005090328A1 (fr) Composition hétérocyclique et son utilisation
RU2288223C2 (ru) 1, 2, 4-триазольное производное, способы его получения, фармацевтическая композиция, промежуточное соединение и способ его получения
CN114846004B (zh) 抗疟药
MXPA00008400A (en) N-[(substituted five-membered di- or triaza diunsaturated ring)carbonyl]guanidine derivatives for the treatment of ischemia
CZ20002988A3 (cs) Deriváty N-{(substituovaný pětičlenný di- nebo triaza-di-nenasycený kruh)karbonyl} guanidinu pro léčení ischemie
AU779106B2 (en) Method for preparing sodium-hydrogen exchanger type 1 inhibitor
CA2389020A1 (fr) Cristaux d&#39;inhibiteurs de l&#39;echangeur sodium-hydrogene de type 1
BR112022012224B1 (pt) Formulação farmacêutica, métodos para preparar um composto da fórmula (ia) e para preparar um composto da fórmula (ib), intermediário, e, uso de um derivado ou de uma formulação farmacêutica