BG104899A - Antipicornaviral compounds and compositions, their pharmaceutical use and materials for their synthesis - Google Patents
Antipicornaviral compounds and compositions, their pharmaceutical use and materials for their synthesisInfo
- Publication number
- BG104899A BG104899A BG104899A BG10489900A BG104899A BG 104899 A BG104899 A BG 104899A BG 104899 A BG104899 A BG 104899A BG 10489900 A BG10489900 A BG 10489900A BG 104899 A BG104899 A BG 104899A
- Authority
- BG
- Bulgaria
- Prior art keywords
- synthesis
- compounds
- compositions
- materials
- pharmaceutical use
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- 239000000463 material Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 241001144416 Picornavirales Species 0.000 abstract 1
- 241000709664 Picornaviridae Species 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 230000004071 biological effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000816 peptidomimetic Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/18—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Medicines Containing Plant Substances (AREA)
- Hydrogenated Pyridines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8382898P | 1998-04-30 | 1998-04-30 | |
| US9835898P | 1998-08-28 | 1998-08-28 | |
| PCT/US1999/000260 WO1999057135A1 (en) | 1998-04-30 | 1999-01-05 | Antipicornaviral compounds, their preparation and use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG104899A true BG104899A (en) | 2001-08-31 |
Family
ID=26769788
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG104899A BG104899A (en) | 1998-04-30 | 2000-11-01 | Antipicornaviral compounds and compositions, their pharmaceutical use and materials for their synthesis |
Country Status (33)
| Country | Link |
|---|---|
| US (3) | US6531452B1 (pt) |
| EP (1) | EP1073672B1 (pt) |
| JP (1) | JP2003526600A (pt) |
| KR (1) | KR20010043004A (pt) |
| CN (1) | CN1198838C (pt) |
| AP (1) | AP2000001934A0 (pt) |
| AT (2) | ATE248186T1 (pt) |
| AU (1) | AU768539B2 (pt) |
| BG (1) | BG104899A (pt) |
| BR (1) | BR9910573A (pt) |
| CA (1) | CA2326763A1 (pt) |
| DE (2) | DE69928140D1 (pt) |
| DK (1) | DK1073672T3 (pt) |
| EA (1) | EA003856B1 (pt) |
| EE (1) | EE200000621A (pt) |
| ES (1) | ES2205760T3 (pt) |
| GE (1) | GEP20022824B (pt) |
| HR (1) | HRP20000623A2 (pt) |
| HU (1) | HUP0400624A2 (pt) |
| IL (1) | IL138609A0 (pt) |
| IS (1) | IS5633A (pt) |
| LT (1) | LT4846B (pt) |
| LV (1) | LV12666B (pt) |
| NO (1) | NO20005411L (pt) |
| NZ (1) | NZ507633A (pt) |
| OA (1) | OA11503A (pt) |
| PL (1) | PL351250A1 (pt) |
| PT (1) | PT1073672E (pt) |
| SI (1) | SI20428A (pt) |
| SK (1) | SK284714B6 (pt) |
| TR (1) | TR200003159T2 (pt) |
| WO (1) | WO1999057135A1 (pt) |
| YU (1) | YU66000A (pt) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2326763A1 (en) | 1998-04-30 | 1999-11-11 | Theodore O. Johnson, Jr. | Antipicornaviral compounds and compositions, their pharmaceutical uses, and methods for their synthesis |
| US6355807B1 (en) | 1999-08-24 | 2002-03-12 | Agouron Pharmaceuticals, Inc. | Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates |
| US6774243B2 (en) | 1999-08-24 | 2004-08-10 | Agouron Pharmaceuticals, Inc. | Efficient synthetic routes for the preparation of rhinovirus protease inhibitors and key intermediates |
| PE20010517A1 (es) * | 1999-08-24 | 2001-05-16 | Agouron Pharma | Las rutas sinteticas eficientes para la preparacion de los inhibidores de la proteasa del rinovirus y los intermedios claves |
| PA8507801A1 (es) * | 1999-12-03 | 2002-08-26 | Agouron Pharma | Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis |
| PE20011277A1 (es) | 2000-04-14 | 2002-01-07 | Agouron Pharma | Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis |
| US6632825B2 (en) | 2000-06-14 | 2003-10-14 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis |
| WO2004093860A1 (en) * | 2003-04-21 | 2004-11-04 | Pfizer Inc. | Inhibitors of sars related coronavirus proteinase |
| US20040235952A1 (en) * | 2003-05-05 | 2004-11-25 | Agouron Pharmaceuticals, Inc. | Inhibitors of severe acute respiratory syndrome (SARS) 3C-like proteinase |
| EP1704142A4 (en) * | 2003-12-31 | 2008-08-20 | Taigen Biotechnology Co Ltd | PROTEASE INHIBITORS |
| US7462594B2 (en) | 2003-12-31 | 2008-12-09 | Taigen Biotechnology Co., Ltd. | Peptide-like compounds that inhibit coronaviral 3CL and flaviviridae viral proteases |
| CN100363346C (zh) * | 2004-10-22 | 2008-01-23 | 清华大学 | 冠状病毒主蛋白酶的小分子抑制剂、制备方法及其应用 |
| US7893657B2 (en) * | 2006-12-19 | 2011-02-22 | Anand Kumar Chavakula | Multi-power charger and battery backup system |
| KR100891699B1 (ko) | 2007-04-10 | 2009-04-03 | 광주과학기술원 | 7-아미노-4-((s)-3-(4-플루오로페닐)-2-((r)-3-메틸-2-(5-메틸이소옥사졸-3-카복사미도)부탄아미도)프로판아미도)-7-옥소-2-헵테노에이트 유도체, 이의 제조방법 및 이를 유효성분으로 함유하는 바이러스성 질환의 예방 및 치료용 약학적 조성물 |
| US7741327B2 (en) | 2008-04-16 | 2010-06-22 | Hoffmann-La Roche Inc. | Pyrrolidinone glucokinase activators |
| US8791235B2 (en) | 2008-05-21 | 2014-07-29 | Novagenesis Foundation | Selective caspase inhibitors and uses thereof |
| WO2010133000A1 (en) | 2009-05-21 | 2010-11-25 | New World Laboratories Inc. | Selective caspase inhibitors and uses thereof |
| US8178689B2 (en) | 2010-06-17 | 2012-05-15 | Hoffman-La Roche Inc. | Tricyclic compounds |
| DK2697246T3 (en) * | 2011-04-15 | 2018-05-28 | Genesis Tech Limited | SELECTIVE CYSTEIN PROTEASE INHIBITORS AND USES THEREOF |
| CN102838523A (zh) * | 2011-06-23 | 2012-12-26 | 南开大学 | 抗肠病毒71(ev71)戊内酰胺类化合物及其制备方法和用途 |
| CN103145608B (zh) * | 2011-12-07 | 2015-09-02 | 南开大学 | 抗肠病毒71(ev71)己内酰胺类化合物及其制备方法和用途 |
| RU2518314C2 (ru) | 2012-08-30 | 2014-06-10 | Общество С Ограниченной Ответственностью "Фарминтерпрайсез" | Способ и средство активации irf-3 для лечения и профилактики заболеваний, вызываемых (+) phk-содержащими вирусами |
| CN110105348A (zh) * | 2019-03-08 | 2019-08-09 | 南开大学 | 新型迈克尔受体类肠病毒71型抑制剂的制备及用途 |
| BR112021024310A2 (pt) | 2019-06-05 | 2022-02-15 | Univ Emory | Peptidomiméticos para o tratamento de infecções por coronavírus e picornavírus |
| US20230157998A1 (en) | 2020-03-06 | 2023-05-25 | Pfizer Inc. | Methods of Inhibiting SARS-CoV-2 Replication and Treating Corona Virus Disease 2019 |
| WO2021195661A1 (en) * | 2020-03-23 | 2021-09-30 | Gregg John M H | Anti-viral compounds and methods for administration thereof |
| WO2022156692A1 (zh) * | 2021-01-22 | 2022-07-28 | 中国人民解放军军事科学院军事医学研究院 | 一种环肽类病毒蛋白酶抑制剂,其制备方法,及其在抗病毒药物中的应用 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4652676A (en) | 1985-05-06 | 1987-03-24 | General Foods Corporation | L-aminodicarboxylic acid alkenes |
| AU2251892A (en) | 1991-06-14 | 1993-01-12 | Chiron Corporation | Inhibitors of picornavirus proteases |
| US5374623A (en) | 1992-08-20 | 1994-12-20 | Prototek, Inc. | Cysteine protease inhibitors effective for in vivo use |
| US5514778A (en) | 1993-07-01 | 1996-05-07 | Eli Lilly And Company | Anti-picornaviral agents |
| US5486623A (en) | 1993-12-08 | 1996-01-23 | Prototek, Inc. | Cysteine protease inhibitors containing heterocyclic leaving groups |
| IL112759A0 (en) | 1994-02-25 | 1995-05-26 | Khepri Pharmaceuticals Inc | Novel cysteine protease inhibitors |
| IT1269511B (it) | 1994-05-17 | 1997-04-01 | Univ Degli Studi Milano | Derivati di acidi ammino-solfonici , loro impiego nella sintesi di pseudopeptidi e procedimento per la loro preparazione |
| US5498616A (en) * | 1994-11-04 | 1996-03-12 | Cephalon, Inc. | Cysteine protease and serine protease inhibitors |
| IT1281031B1 (it) | 1995-11-17 | 1998-02-11 | Carlo Chiaves | Struttura prefabbricata per la realizzazione di opere costruite a cielo aperto, particolarmente per cavalcavia autostradali, |
| IL120310A (en) | 1996-03-01 | 2002-02-10 | Akzo Nobel Nv | Serine protease inhibitors and pharmaceuticals containing them |
| ES2242225T3 (es) * | 1996-05-14 | 2005-11-01 | Agouron Pharmaceuticals, Inc. | Inhibidores de proteasas 3c antipicornavirales y procedimientos correspondientes de utilizacion y de preparacion. |
| US5856530A (en) | 1996-05-14 | 1999-01-05 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and methods for their use and preparation |
| WO1997049668A1 (en) | 1996-06-13 | 1997-12-31 | Smithkline Beecham Corporation | Inhibitiors of cysteine protease |
| CA2289541A1 (en) * | 1997-03-28 | 1998-10-08 | Peter S. Dragovich | Antipicornaviral compouds, compositions containing them, and methods for their use |
| US6331554B1 (en) * | 1997-03-28 | 2001-12-18 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds, compositions containing them, and methods for their use |
| US6020371A (en) | 1997-03-28 | 2000-02-01 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds compositions containing them and methods for their use |
| US5962487A (en) | 1997-12-16 | 1999-10-05 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and methods for their use and preparation |
| CA2326763A1 (en) | 1998-04-30 | 1999-11-11 | Theodore O. Johnson, Jr. | Antipicornaviral compounds and compositions, their pharmaceutical uses, and methods for their synthesis |
| US6369226B1 (en) | 1999-06-21 | 2002-04-09 | Agouron Pharmaceuticals, Inc. | Substituted benzamide inhibitors of rhinovirus 3C protease |
| EP1206484B1 (en) | 1999-08-04 | 2004-10-06 | Agouron Pharmaceuticals, Inc. | Antipicornaviral compounds and compositions, their pharmaceutical uses, and materials for their synthesis |
| CN1524960A (zh) | 1999-08-24 | 2004-09-01 | ������ҩ������˾ | 制备异噁唑甲酰胺及其类似物的方法和中间体 |
| PE20010517A1 (es) | 1999-08-24 | 2001-05-16 | Agouron Pharma | Las rutas sinteticas eficientes para la preparacion de los inhibidores de la proteasa del rinovirus y los intermedios claves |
| PA8507801A1 (es) | 1999-12-03 | 2002-08-26 | Agouron Pharma | Compuestos y composiciones antipicornavirales, sus usos farmaceuticos y los materiales para su sintesis |
-
1999
- 1999-01-05 CA CA002326763A patent/CA2326763A1/en not_active Abandoned
- 1999-01-05 EP EP99900780A patent/EP1073672B1/en not_active Expired - Lifetime
- 1999-01-05 SK SK1604-2000A patent/SK284714B6/sk unknown
- 1999-01-05 EE EEP200000621A patent/EE200000621A/xx unknown
- 1999-01-05 DE DE69928140T patent/DE69928140D1/de not_active Expired - Lifetime
- 1999-01-05 PL PL99351250A patent/PL351250A1/xx not_active Application Discontinuation
- 1999-01-05 PT PT99900780T patent/PT1073672E/pt unknown
- 1999-01-05 ES ES99900780T patent/ES2205760T3/es not_active Expired - Lifetime
- 1999-01-05 CN CNB998056278A patent/CN1198838C/zh not_active Expired - Fee Related
- 1999-01-05 AT AT99900780T patent/ATE248186T1/de not_active IP Right Cessation
- 1999-01-05 KR KR1020007011851A patent/KR20010043004A/ko not_active Ceased
- 1999-01-05 BR BR9910573-0A patent/BR9910573A/pt not_active IP Right Cessation
- 1999-01-05 GE GEAP19995606A patent/GEP20022824B/en unknown
- 1999-01-05 AU AU20287/99A patent/AU768539B2/en not_active Ceased
- 1999-01-05 IL IL13860999A patent/IL138609A0/xx unknown
- 1999-01-05 NZ NZ507633A patent/NZ507633A/en unknown
- 1999-01-05 AT AT03009409T patent/ATE308557T1/de not_active IP Right Cessation
- 1999-01-05 HU HU0400624A patent/HUP0400624A2/hu unknown
- 1999-01-05 TR TR2000/03159T patent/TR200003159T2/xx unknown
- 1999-01-05 AP APAP/P/2000/001934A patent/AP2000001934A0/en unknown
- 1999-01-05 SI SI9920041A patent/SI20428A/sl not_active IP Right Cessation
- 1999-01-05 DK DK99900780T patent/DK1073672T3/da active
- 1999-01-05 LT LT2000109A patent/LT4846B/lt not_active IP Right Cessation
- 1999-01-05 DE DE69910762T patent/DE69910762T2/de not_active Expired - Fee Related
- 1999-01-05 HR HR20000623A patent/HRP20000623A2/hr not_active Application Discontinuation
- 1999-01-05 JP JP2000547104A patent/JP2003526600A/ja not_active Withdrawn
- 1999-01-05 WO PCT/US1999/000260 patent/WO1999057135A1/en not_active Ceased
- 1999-01-05 EA EA200001133A patent/EA003856B1/ru not_active IP Right Cessation
- 1999-01-05 YU YU66000A patent/YU66000A/sh unknown
- 1999-04-29 US US09/301,977 patent/US6531452B1/en not_active Expired - Fee Related
-
2000
- 2000-09-22 IS IS5633A patent/IS5633A/is unknown
- 2000-10-20 OA OA1200000288A patent/OA11503A/en unknown
- 2000-10-27 NO NO20005411A patent/NO20005411L/no not_active Application Discontinuation
- 2000-11-01 BG BG104899A patent/BG104899A/xx unknown
- 2000-12-19 LV LV000162A patent/LV12666B/xx unknown
-
2002
- 2002-11-06 US US10/289,982 patent/US6995142B2/en not_active Expired - Fee Related
-
2005
- 2005-08-24 US US11/210,717 patent/US20060046966A1/en not_active Abandoned
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