BG105111A - BENZIMIDAZOLES, THEIR RECEIVING AND USE OF THE MEDICINAL PRODUCTS - Google Patents
BENZIMIDAZOLES, THEIR RECEIVING AND USE OF THE MEDICINAL PRODUCTSInfo
- Publication number
- BG105111A BG105111A BG105111A BG10511101A BG105111A BG 105111 A BG105111 A BG 105111A BG 105111 A BG105111 A BG 105111A BG 10511101 A BG10511101 A BG 10511101A BG 105111 A BG105111 A BG 105111A
- Authority
- BG
- Bulgaria
- Prior art keywords
- compounds
- formula
- benzimidazoles
- receiving
- group
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/14—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
- C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing alicyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Съединенията имат формула, в която значенията на Ra до Rc, A, Ar и В са посочени в описанието. Изобретението се отнася и до техни тавтомери, стереоизомери, смеси, пролекарства и производни, които на мястото на карбоксилна група съдържат група, коятопри физиологичните условия е отрицателно заредена, и до техни соли, по-специално до техни физиологично приемливи соли с неорганични или органични киселини или основи. Съединенията с посочената формула, в която Rc e цианогрупа, са междинни продукти за получаване на останалите съединения със същата формула, а тези, в чиято формула Rc е една от посочените в описанието амидиногрупи, имат ценни фармакологични свойства, по-специално антитромбозна активност.The compounds have the formula in which the meanings of Ra to Rc, A, Ar and B are given in the description. The invention also relates to their tautomers, stereoisomers, mixtures, prodrugs and derivatives which, in place of a carboxyl group, contain a group which, under physiological conditions, is negatively charged and to their salts, in particular their physiologically acceptable salts with inorganic or organic acids or bases. Compounds of the formula in which Rc is a cyano group are intermediates for the preparation of the other compounds of the same formula, and those in which Rc is one of the amidino groups described herein have valuable pharmacological properties, in particular antithrombotic activity.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1998129964 DE19829964A1 (en) | 1998-07-04 | 1998-07-04 | New benzimidazolyl amidine or nitrile compounds, used as thrombin inhibitors, antithrombotic agents or intermediates |
| DE1998157202 DE19857202A1 (en) | 1998-12-11 | 1998-12-11 | New benzimidazolyl amidine or nitrile compounds, useful as thrombin inhibitors or antithrombotic agents, for treating deep leg vein thrombosis |
| DE1999112690 DE19912690A1 (en) | 1999-03-20 | 1999-03-20 | New benzimidazolyl amidine or nitrile compounds, useful as thrombin inhibitors or antithrombotic agents, for treating deep leg vein thrombosis |
| PCT/EP1999/004531 WO2000001704A2 (en) | 1998-07-04 | 1999-07-01 | Benzimidazoles, production thereof and use thereof as medicaments |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG105111A true BG105111A (en) | 2001-12-29 |
Family
ID=27218486
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG105111A BG105111A (en) | 1998-07-04 | 2001-01-03 | BENZIMIDAZOLES, THEIR RECEIVING AND USE OF THE MEDICINAL PRODUCTS |
Country Status (33)
| Country | Link |
|---|---|
| EP (1) | EP1095025B1 (en) |
| JP (1) | JP4224215B2 (en) |
| KR (1) | KR20010083087A (en) |
| CN (1) | CN1152866C (en) |
| AR (1) | AR019222A1 (en) |
| AT (1) | ATE229511T1 (en) |
| AU (1) | AU763094C (en) |
| BG (1) | BG105111A (en) |
| BR (1) | BR9911826A (en) |
| CA (1) | CA2337804C (en) |
| CO (1) | CO5080729A1 (en) |
| DE (1) | DE59903765D1 (en) |
| DK (1) | DK1095025T3 (en) |
| EA (1) | EA003947B1 (en) |
| EE (1) | EE04236B1 (en) |
| ES (1) | ES2188192T3 (en) |
| HR (1) | HRPK20010007B1 (en) |
| HU (1) | HUP0200710A3 (en) |
| ID (1) | ID26774A (en) |
| IL (1) | IL140060A0 (en) |
| MX (1) | MXPA00012819A (en) |
| MY (1) | MY123310A (en) |
| NO (1) | NO20010028D0 (en) |
| NZ (1) | NZ509625A (en) |
| PE (1) | PE20000754A1 (en) |
| PL (1) | PL345852A1 (en) |
| PT (1) | PT1095025E (en) |
| SK (1) | SK283744B6 (en) |
| TR (1) | TR200100148T2 (en) |
| TW (1) | TWI248435B (en) |
| UA (1) | UA70951C2 (en) |
| WO (1) | WO2000001704A2 (en) |
| YU (1) | YU84700A (en) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19907813A1 (en) * | 1999-02-24 | 2000-08-31 | Boehringer Ingelheim Pharma | Substituted bicyclic heterocycles, their preparation and their use as pharmaceuticals |
| AR023510A1 (en) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | A TEAM OF PARTS, PHARMACEUTICAL FORMULATION AND USE OF A THROMBIN INHIBITOR. |
| US6451832B2 (en) | 1999-12-23 | 2002-09-17 | Boehringer Ingelheim Pharma Kg | Benzimidazoles with antithrombotic activity |
| DE19962329A1 (en) * | 1999-12-23 | 2001-06-28 | Boehringer Ingelheim Pharma | New substituted 2-(phenylaminomethyl)-benzimidazoles, used as thrombin inhibitors, serine protease inhibitors, antithrombotic agents and intermediates |
| EP1193248A1 (en) * | 2000-09-30 | 2002-04-03 | Aventis Pharma Deutschland GmbH | Malonamid and malonamic ester derivatives with antithrombotic activity, their preparation and their use |
| US8048917B2 (en) | 2005-04-06 | 2011-11-01 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7232924B2 (en) | 2001-06-11 | 2007-06-19 | Xenoport, Inc. | Methods for synthesis of acyloxyalkyl derivatives of GABA analogs |
| US6818787B2 (en) | 2001-06-11 | 2004-11-16 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7186855B2 (en) | 2001-06-11 | 2007-03-06 | Xenoport, Inc. | Prodrugs of GABA analogs, compositions and uses thereof |
| US7169934B2 (en) * | 2002-06-20 | 2007-01-30 | Boehringer Ingelheim International Gmbh | (R) 2-(4-amidinophenylaminomethyl)-1-methyl-5-[1-(carboxymethylamino)-1 (pyrrolidinocarbonyl)-ethyl]-benzimidazole, the monohydrochloride thereof, preparation thereof and the use as pharmaceutical composition |
| DE10227666A1 (en) * | 2002-06-20 | 2004-01-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | (R) -2- (4-amidinophenylaminomethyl) -1-methyl-5- [1- (carboxymethylamino) -1- (pyrrolidinocarbonyl) ethyl] benzimidazole, its monohydrochloride, process for its preparation and use as a medicament |
| DE10227668A1 (en) * | 2002-06-20 | 2004-01-08 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Medicines for the treatment of systemic inflammatory response syndrome |
| AU2002368133A1 (en) * | 2002-07-29 | 2004-02-16 | Shizuoka Coffein Co., Ltd. | 1,3-azole derivative and medicinal composition containing the derivative for treatment for thombosis |
| CN100513398C (en) | 2002-12-03 | 2009-07-15 | Axys药物公司 | 2- (2-hydroxybiphenyl-3-yl) -1H-benzimidazole-5-carboxamidine derivatives as factor VIIA inhibitors |
| PE20040804A1 (en) | 2002-12-19 | 2004-12-31 | Boehringer Ingelheim Pharma | CARBOXAMID DERIVATIVES AS INHIBITORS OF THE Xa FACTOR |
| DE10359797A1 (en) | 2003-12-19 | 2005-07-21 | Bayer Chemicals Ag | Process for the preparation of N, N'-carbonyldiazoles |
| US7371743B2 (en) | 2004-02-28 | 2008-05-13 | Boehringer Ingelheim International Gmbh | Carboxylic acid amides, the preparation thereof and their use as medicaments |
| TWI350168B (en) | 2004-05-07 | 2011-10-11 | Incyte Corp | Amido compounds and their use as pharmaceuticals |
| DE102004027821A1 (en) * | 2004-06-08 | 2006-01-05 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Benzimidazoles, process for their preparation and their use as medicaments |
| EP1609784A1 (en) * | 2004-06-25 | 2005-12-28 | Boehringer Ingelheim Pharma GmbH & Co.KG | Process for the preparation of 4-(benzimidazolylmethylamino)-benzamidines |
| GB0507577D0 (en) | 2005-04-14 | 2005-05-18 | Novartis Ag | Organic compounds |
| DE102005061623A1 (en) * | 2005-12-21 | 2007-06-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Improved process for the preparation of 4- (benzimidazolylmethylamino) -benzamidines and their salts |
| DE102005061624A1 (en) * | 2005-12-21 | 2007-06-28 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Improved process for the preparation of salts of 4- (benzimidazolylmethylamino) -benzamidines |
| US9062056B2 (en) | 2008-09-09 | 2015-06-23 | Boehringer Ingelheim International Gmbh | Aza-benzimidazolone Chymase inhibitors |
| US20110301192A1 (en) * | 2008-10-01 | 2011-12-08 | The Regents Of The University Of California | Inhibitors of Cyclin Kinase Inhibitor p21 |
| JP5535931B2 (en) * | 2008-10-27 | 2014-07-02 | 武田薬品工業株式会社 | Bicyclic compound |
| IN2013CN01340A (en) | 2010-07-23 | 2015-08-07 | Connexios Life Sciences Pvt Ltd | |
| US10077251B2 (en) | 2012-10-29 | 2018-09-18 | Biophore India Pharmaceuticals Pvt. Ltd. | Process for the synthesis of Dabigatran Etexilate and its intermediates |
| US9533971B2 (en) | 2012-10-29 | 2017-01-03 | Biophore India Pharmaceuticals Pvt. Ltd | Process for the synthesis of dabigatran and its intermediates |
| CN103214422B (en) * | 2013-05-07 | 2015-07-15 | 南通大学 | Preparation methods and anti-cancer effect of novel substituted amido imidazolone derivatives |
| CN110343089A (en) * | 2018-04-02 | 2019-10-18 | 上海美悦生物科技发展有限公司 | Benzimidazole derivative and pharmaceutical use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59139357A (en) * | 1983-01-28 | 1984-08-10 | Torii Yakuhin Kk | Amidine derivative |
| AU675680B2 (en) * | 1992-10-14 | 1997-02-13 | Merck & Co., Inc. | Fibrinogen receptor antagonists |
| US5849759A (en) * | 1995-12-08 | 1998-12-15 | Berlex Laboratories, Inc. | Naphthyl-substituted benzimidazole derivatives as anti-coagulants |
| EP0960102A1 (en) * | 1996-07-08 | 1999-12-01 | Du Pont Pharmaceuticals Company | AMIDINOINDOLES, AMIDINOAZOLES, AND ANALOGS THEREOF AS INHIBITORS OF FACTOR Xa AND OF THROMBIN |
| PE121699A1 (en) * | 1997-02-18 | 1999-12-08 | Boehringer Ingelheim Pharma | BICYCLE HETERO CYCLES DISSTITUTED AS INHIBITORS OF THROMBIN |
-
1999
- 1999-06-29 TW TW088110926A patent/TWI248435B/en active
- 1999-07-01 YU YU84700A patent/YU84700A/en unknown
- 1999-07-01 HR HR20000476A patent/HRPK20010007B1/en not_active IP Right Cessation
- 1999-07-01 HU HU0200710A patent/HUP0200710A3/en unknown
- 1999-07-01 NZ NZ509625A patent/NZ509625A/en unknown
- 1999-07-01 DK DK99932765T patent/DK1095025T3/en active
- 1999-07-01 PT PT99932765T patent/PT1095025E/en unknown
- 1999-07-01 EP EP99932765A patent/EP1095025B1/en not_active Expired - Lifetime
- 1999-07-01 WO PCT/EP1999/004531 patent/WO2000001704A2/en not_active Ceased
- 1999-07-01 UA UA2001020813A patent/UA70951C2/en unknown
- 1999-07-01 EA EA200100042A patent/EA003947B1/en not_active IP Right Cessation
- 1999-07-01 IL IL14006099A patent/IL140060A0/en unknown
- 1999-07-01 CN CNB998082414A patent/CN1152866C/en not_active Expired - Fee Related
- 1999-07-01 SK SK8-2001A patent/SK283744B6/en unknown
- 1999-07-01 ES ES99932765T patent/ES2188192T3/en not_active Expired - Lifetime
- 1999-07-01 ID IDW20010009A patent/ID26774A/en unknown
- 1999-07-01 EE EEP200100009A patent/EE04236B1/en not_active IP Right Cessation
- 1999-07-01 JP JP2000558106A patent/JP4224215B2/en not_active Expired - Fee Related
- 1999-07-01 AU AU49033/99A patent/AU763094C/en not_active Ceased
- 1999-07-01 TR TR2001/00148T patent/TR200100148T2/en unknown
- 1999-07-01 KR KR1020017000069A patent/KR20010083087A/en not_active Abandoned
- 1999-07-01 BR BR9911826-2A patent/BR9911826A/en not_active IP Right Cessation
- 1999-07-01 MX MXPA00012819A patent/MXPA00012819A/en not_active IP Right Cessation
- 1999-07-01 DE DE59903765T patent/DE59903765D1/en not_active Expired - Lifetime
- 1999-07-01 PL PL99345852A patent/PL345852A1/en not_active Application Discontinuation
- 1999-07-01 AT AT99932765T patent/ATE229511T1/en not_active IP Right Cessation
- 1999-07-01 CA CA002337804A patent/CA2337804C/en not_active Expired - Fee Related
- 1999-07-02 CO CO99041718A patent/CO5080729A1/en unknown
- 1999-07-02 PE PE1999000620A patent/PE20000754A1/en not_active Application Discontinuation
- 1999-07-05 AR ARP990103241A patent/AR019222A1/en unknown
- 1999-07-05 MY MYPI99002822A patent/MY123310A/en unknown
-
2001
- 2001-01-03 BG BG105111A patent/BG105111A/en unknown
- 2001-01-03 NO NO20010028A patent/NO20010028D0/en unknown
Also Published As
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