BG105123A - Tetrahydroquinaline derivatives as glycine antagonists - Google Patents

Tetrahydroquinaline derivatives as glycine antagonists

Info

Publication number: BG105123A
Authority: BG; Bulgaria
Prior art keywords: group; alkyl; chain; amino; tetrahydroquinaline
Prior art date: 1998-06-10

Application number

BG105123A

Other languages

Bulgarian (bg)

English (en)

Inventor

Fabio Romano Di

Original Assignee

Glaxo Wellcome Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-10

Filing date

2001-01-08

Publication date

2001-11-30

1998-06-10 Priority claimed from GBGB9812408.4A external-priority patent/GB9812408D0/en

1998-06-10 Priority claimed from GBGB9812410.0A external-priority patent/GB9812410D0/en

2001-01-08 Application filed by Glaxo Wellcome Spa filed Critical Glaxo Wellcome Spa

2001-11-30 Publication of BG105123A publication Critical patent/BG105123A/xx

Links

229940127337 Glycine Antagonists Drugs 0.000 title abstract 2
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical group N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
229910052799 carbon Inorganic materials 0.000 abstract 2
125000004432 carbon atom Chemical group C* 0.000 abstract 2
125000005843 halogen group Chemical group 0.000 abstract 2
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
125000006163 5-membered heteroaryl group Chemical group 0.000 abstract 1
125000006164 6-membered heteroaryl group Chemical group 0.000 abstract 1
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
239000005864 Sulphur Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004663 dialkyl amino group Chemical group 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
125000005842 heteroatom Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
-1 hydroxy, amino Chemical group 0.000 abstract 1
125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 1
229910052757 nitrogen Chemical group 0.000 abstract 1
125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
231100000252 nontoxic Toxicity 0.000 abstract 1
230000003000 nontoxic effect Effects 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

BG105123A 1998-06-10 2001-01-08 Tetrahydroquinaline derivatives as glycine antagonists BG105123A (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GBGB9812408.4A GB9812408D0 (en)	1998-06-10	1998-06-10	Heterocyclic compounds
GBGB9812410.0A GB9812410D0 (en)	1998-06-10	1998-06-10	Heterocyclic derivatives
PCT/EP1999/003936 WO1999064411A1 (en)	1998-06-10	1999-06-08	Tetrahydroquinoline derivatives as glycine antagonists

Publications (1)

Publication Number	Publication Date
BG105123A true BG105123A (en)	2001-11-30

Family

ID=26313826

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG105123A BG105123A (en)	1998-06-10	2001-01-08	Tetrahydroquinaline derivatives as glycine antagonists

Country Status (33)

Country	Link
US (3)	US6362199B1 (pl)
EP (1)	EP1086093B1 (pl)
JP (1)	JP2002517492A (pl)
KR (1)	KR100586762B1 (pl)
CN (1)	CN1173970C (pl)
AP (1)	AP2000002008A0 (pl)
AR (1)	AR018632A1 (pl)
AT (1)	ATE301650T1 (pl)
AU (1)	AU753867B2 (pl)
BG (1)	BG105123A (pl)
BR (1)	BR9911145A (pl)
CA (1)	CA2334727C (pl)
CO (1)	CO5080785A1 (pl)
CZ (1)	CZ293605B6 (pl)
DE (1)	DE69926632T2 (pl)
DK (1)	DK1086093T3 (pl)
EA (1)	EA003276B1 (pl)
EE (1)	EE200000733A (pl)
ES (1)	ES2249010T3 (pl)
HR (1)	HRP20000845A2 (pl)
HU (1)	HUP0102767A3 (pl)
ID (1)	ID27845A (pl)
IL (2)	IL140062A0 (pl)
IS (1)	IS5746A (pl)
MY (1)	MY125037A (pl)
NO (1)	NO321904B1 (pl)
NZ (1)	NZ508638A (pl)
OA (1)	OA11564A (pl)
PE (1)	PE20000724A1 (pl)
PL (1)	PL197160B1 (pl)
TR (1)	TR200003652T2 (pl)
TW (1)	TWI229079B (pl)
WO (1)	WO1999064411A1 (pl)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MY125037A (en) *	1998-06-10	2006-07-31	Glaxo Wellcome Spa	1,2,3,4 tetrahydroquinoline derivatives
US6455734B1 (en) *	2000-08-09	2002-09-24	Magnesium Diagnostics, Inc.	Antagonists of the magnesium binding defect as therapeutic agents and methods for treatment of abnormal physiological states
GB9929037D0 (en) *	1999-12-08	2000-02-02	Glaxo Wellcome Spa	Heterocyclic derivatives
DE10000311A1 (de)	2000-01-05	2001-07-12	Gruenenthal Gmbh	Aminomethyl-Phonyl-Cyclohexanonderivate
DE10005302A1 (de) *	2000-02-07	2002-01-17	Gruenenthal Gmbh	Substituierte 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate
DE10137488A1 (de) *	2001-08-03	2003-02-20	Gruenenthal Gmbh	Salze substituierter 1,2,3,4-Tetrahydrochinolin-2-carbonsäurederivate
DE10137487A1 (de)	2001-08-03	2003-03-27	Gruenenthal Gmbh	Substituierte 5,6,6a,11b-Tetrahydro-7-oxa-6-aza- benzo[c]fluoren-6-carbonsäurederivate
PL376156A1 (pl) *	2002-10-04	2005-12-27	Millennium Pharmaceuticals, Inc.	Antagoniści receptora PGD2 do leczenia chorób zapalnych
US20090181966A1 (en) *	2002-10-04	2009-07-16	Millennium Pharmaceuticals, Inc.	PGD2 receptor antagonists for the treatment of inflammatory diseases
US7504508B2 (en) *	2002-10-04	2009-03-17	Millennium Pharmaceuticals, Inc.	PGD2 receptor antagonists for the treatment of inflammatory diseases
GB0327912D0 (en) *	2003-12-02	2004-01-07	Glaxo Group Ltd	Medicament
BRPI0608553A2 (pt) *	2005-02-24	2010-01-12	Millennium Pharm Inc	antagonistas de receptor de pgd2 para o tratamento de doenças inflamatórias

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RU2024516C1 (ru) *	1989-02-02	1994-12-15	Яманути Фармасьютикал Ко., Лтд.	Способ получения производного тетрагидробензимидазола или его фармацевтически приемлемой соли
US4902695A (en) *	1989-02-13	1990-02-20	Eli Lilly And Company	Excitatory amino acid receptor antagonists
US5231102A (en) *	1989-03-08	1993-07-27	Merck Sharp & Dohme, Ltd.	Tetrahydroquinoline derivatives useful for neurodegenerative disorders
IL93610A0 (en) *	1989-03-08	1990-12-23	Merck Sharp & Dohme	Tetrahydroquinoline derivatives,their preparation and pharmaceutical compositions containing them
US5529999A (en)	1994-03-04	1996-06-25	Eli Lilly And Company	Antitumor compositions and methods of treatment
CZ292379B6 (cs)	1995-09-29	2003-09-17	Glaxo Wellcome Spa	Tetrahydrochinolinové deriváty, způsob jejich výroby a farmaceutický prostředek s jejich obsahem
GB9617305D0 (en) *	1996-08-17	1996-09-25	Glaxo Wellcome Spa	Heterocyclic compounds
MY125037A (en) *	1998-06-10	2006-07-31	Glaxo Wellcome Spa	1,2,3,4 tetrahydroquinoline derivatives

1999
- 1999-06-07 MY MYPI99002298A patent/MY125037A/en unknown
- 1999-06-08 EA EA200001165A patent/EA003276B1/ru not_active IP Right Cessation
- 1999-06-08 AR ARP990102714A patent/AR018632A1/es active IP Right Grant
- 1999-06-08 PE PE1999000511A patent/PE20000724A1/es not_active Application Discontinuation
- 1999-06-08 WO PCT/EP1999/003936 patent/WO1999064411A1/en not_active Ceased
- 1999-06-08 CA CA002334727A patent/CA2334727C/en not_active Expired - Fee Related
- 1999-06-08 PL PL344694A patent/PL197160B1/pl not_active IP Right Cessation
- 1999-06-08 NZ NZ508638A patent/NZ508638A/en not_active IP Right Cessation
- 1999-06-08 CZ CZ20004587A patent/CZ293605B6/cs not_active IP Right Cessation
- 1999-06-08 DK DK99927911T patent/DK1086093T3/da active
- 1999-06-08 JP JP2000553420A patent/JP2002517492A/ja active Pending
- 1999-06-08 KR KR1020007013994A patent/KR100586762B1/ko not_active Expired - Fee Related
- 1999-06-08 ID IDW20010061A patent/ID27845A/id unknown
- 1999-06-08 US US09/719,188 patent/US6362199B1/en not_active Expired - Fee Related
- 1999-06-08 DE DE69926632T patent/DE69926632T2/de not_active Expired - Lifetime
- 1999-06-08 BR BR9911145-4A patent/BR9911145A/pt not_active Application Discontinuation
- 1999-06-08 ES ES99927911T patent/ES2249010T3/es not_active Expired - Lifetime
- 1999-06-08 CN CNB998094145A patent/CN1173970C/zh not_active Expired - Fee Related
- 1999-06-08 HU HU0102767A patent/HUP0102767A3/hu unknown
- 1999-06-08 AP APAP/P/2000/002008A patent/AP2000002008A0/en unknown
- 1999-06-08 OA OA1200000335A patent/OA11564A/en unknown
- 1999-06-08 HR HR20000845A patent/HRP20000845A2/hr not_active Application Discontinuation
- 1999-06-08 IL IL14006299A patent/IL140062A0/xx active IP Right Grant
- 1999-06-08 CO CO99035699A patent/CO5080785A1/es unknown
- 1999-06-08 EP EP99927911A patent/EP1086093B1/en not_active Expired - Lifetime
- 1999-06-08 AU AU45092/99A patent/AU753867B2/en not_active Ceased
- 1999-06-08 EE EEP200000733A patent/EE200000733A/xx unknown
- 1999-06-08 TR TR2000/03652T patent/TR200003652T2/xx unknown
- 1999-06-08 AT AT99927911T patent/ATE301650T1/de active
- 1999-06-17 TW TW088110159A patent/TWI229079B/zh not_active IP Right Cessation
2000
- 2000-11-30 IS IS5746A patent/IS5746A/is unknown
- 2000-12-04 IL IL140062A patent/IL140062A/en not_active IP Right Cessation
- 2000-12-07 NO NO20006227A patent/NO321904B1/no not_active IP Right Cessation
2001
- 2001-01-08 BG BG105123A patent/BG105123A/xx unknown
- 2001-11-16 US US09/990,513 patent/US6413985B1/en not_active Expired - Fee Related
2002
- 2002-05-14 US US10/145,258 patent/US6495566B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
PL344694A1 (en)	2001-11-19
IL140062A (en)	2007-05-15
HUP0102767A3 (en)	2003-01-28
PL197160B1 (pl)	2008-03-31
HUP0102767A2 (hu)	2001-12-28
ATE301650T1 (de)	2005-08-15
ES2249010T3 (es)	2006-03-16
EE200000733A (et)	2002-06-17
KR100586762B1 (ko)	2006-06-08
CO5080785A1 (es)	2001-09-25
US6413985B1 (en)	2002-07-02
CN1173970C (zh)	2004-11-03
EP1086093B1 (en)	2005-08-10
NZ508638A (en)	2003-08-29
CA2334727A1 (en)	1999-12-16
CA2334727C (en)	2009-08-04
US6362199B1 (en)	2002-03-26
US20020169186A1 (en)	2002-11-14
DK1086093T3 (da)	2005-11-28
ID27845A (id)	2001-04-26
NO20006227L (no)	2001-02-08
NO321904B1 (no)	2006-07-17
HK1034079A1 (en)	2001-10-12
EA003276B1 (ru)	2003-04-24
DE69926632D1 (de)	2005-09-15
BR9911145A (pt)	2001-03-06
IS5746A (is)	2000-11-30
EA200001165A1 (ru)	2001-06-25
IL140062A0 (en)	2002-02-10
TWI229079B (en)	2005-03-11
JP2002517492A (ja)	2002-06-18
CN1311785A (zh)	2001-09-05
AU753867B2 (en)	2002-10-31
TR200003652T2 (tr)	2001-04-20
AR018632A1 (es)	2001-11-28
AP2000002008A0 (en)	2000-12-31
US6495566B2 (en)	2002-12-17
US20020052391A1 (en)	2002-05-02
KR20010052722A (ko)	2001-06-25
WO1999064411A1 (en)	1999-12-16
OA11564A (en)	2004-05-24
AU4509299A (en)	1999-12-30
PE20000724A1 (es)	2000-08-17
MY125037A (en)	2006-07-31
CZ293605B6 (cs)	2004-06-16
DE69926632T2 (de)	2006-01-19
CZ20004587A3 (en)	2001-05-16
EP1086093A1 (en)	2001-03-28
HRP20000845A2 (en)	2001-10-31
NO20006227D0 (no)	2000-12-07

Publication	Publication Date	Title
ATE164575T1 (de)	1998-04-15	Substituierte aromatische verbindungen als c. amp phosphodiesterase-und tnf-hemmer
IL150650A0 (en)	2003-02-12	Piperidine derivatives and pharmaceutical compositions containing the same
IL154893A0 (en)	2003-10-31	Aliphatic nitrogen-containing cyclic compounds, methods for the preparation thereof and pharmaceutical compositions containing the same
DE69332792T2 (de)	2004-01-15	4,1-Benzoxazepinderivate als Squalen-Synthetase Inhibitoren und ihre Verwendung zur Behandlung von Hypercholesterämie und als Fungizide
MY125037A (en)	2006-07-31	1,2,3,4 tetrahydroquinoline derivatives
PT91607A (pt)	1990-03-30	Process for the preparation of substituted beta-diketones and of pharmaceutical compositions containing them
WO1998053790A3 (en)	1999-03-04	Compounds that inhibit the binding of vascular endothelial growth factor to its receptors
ES8404982A1 (es)	1984-05-16	Un procedimiento para preparar guanidino-fenilamidinas heterociclicas sustituidas.
AU624724B2 (en)	1992-06-18	Pyrrolo(2,1-b)thiazole derivatives
TW326439B (en)	1998-02-11	Octahydornaphthalene oxime derivatives for cholesterol biosynthesis inhibition, their preparation and use