BG105602A - Il-5-inhibiting 6-azauracyl derivatives - Google Patents

Il-5-inhibiting 6-azauracyl derivatives

Info

Publication number: BG105602A
Authority: BG; Bulgaria
Prior art keywords: 6alkyl; 4alkyl; optionally substituted; 4alkylc; aryl
Prior art date: 1998-12-18

Application number

BG105602A

Other languages

Bulgarian (bg)

English (en)

Inventor

Eddy Jean Freyne

Frederik DEROOSE

Jean Fernand LACRAMPE

Werner EMBRECHTS

Jerome Michel FORTIN

Original Assignee

Janssen Pharmaceutica N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-12-18

Filing date

2001-06-14

Publication date

2002-01-31

2001-06-14 Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.

2002-01-31 Publication of BG105602A publication Critical patent/BG105602A/xx

Links

101150015560 IL5 gene Proteins 0.000 title 1
230000002401 inhibitory effect Effects 0.000 title 1
125000003118 aryl group Chemical group 0.000 abstract 4
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 3
229910052760 oxygen Inorganic materials 0.000 abstract 3
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
-1 C1-6alkylO Chemical group 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
150000001875 compounds Chemical class 0.000 abstract 2
125000001475 halogen functional group Chemical group 0.000 abstract 2
125000000623 heterocyclic group Chemical group 0.000 abstract 2
125000000896 monocarboxylic acid group Chemical group 0.000 abstract 2
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
150000001204 N-oxides Chemical class 0.000 abstract 1
125000003277 amino group Chemical group 0.000 abstract 1
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
239000000203 mixture Substances 0.000 abstract 1
125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D253/00—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00
- C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
- C07D253/06—1,2,4-Triazines
- C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
- C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D253/075—Two hetero atoms, in positions 3 and 5
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Pulmonology (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

BG105602A 1998-12-18 2001-06-14 Il-5-inhibiting 6-azauracyl derivatives BG105602A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP98204336		1998-12-18
PCT/EP1999/010169 WO2000037451A1 (en)	1998-12-18	1999-12-16	Il-5 inhibiting 6-azauracil derivatives

Publications (1)

Publication Number	Publication Date
BG105602A true BG105602A (en)	2002-01-31

Family

ID=8234494

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG105602A BG105602A (en)	1998-12-18	2001-06-14	Il-5-inhibiting 6-azauracyl derivatives

Country Status (35)

Country	Link
US (1)	US6803364B1 (de)
EP (1)	EP1140873B1 (de)
JP (1)	JP2002533331A (de)
KR (1)	KR100635721B1 (de)
CN (1)	CN100343239C (de)
AR (1)	AR021887A1 (de)
AT (1)	ATE365723T1 (de)
AU (1)	AU773780B2 (de)
BG (1)	BG105602A (de)
BR (1)	BR9916366A (de)
CA (1)	CA2354511A1 (de)
CO (1)	CO5150147A1 (de)
CZ (1)	CZ20012062A3 (de)
DE (1)	DE69936396T2 (de)
DK (1)	DK1140873T3 (de)
EA (1)	EA004806B1 (de)
EE (1)	EE200100320A (de)
ES (1)	ES2289835T3 (de)
HK (1)	HK1042491A1 (de)
HR (1)	HRP20010455A2 (de)
HU (1)	HUP0104641A3 (de)
ID (1)	ID28880A (de)
IL (1)	IL143766A (de)
MY (1)	MY125808A (de)
NO (1)	NO319814B1 (de)
NZ (1)	NZ512748A (de)
PL (1)	PL198205B1 (de)
PT (1)	PT1140873E (de)
SA (1)	SA00201030B1 (de)
SK (1)	SK8152001A3 (de)
TR (1)	TR200101729T2 (de)
TW (1)	TWI249530B (de)
UA (1)	UA73107C2 (de)
WO (1)	WO2000037451A1 (de)
ZA (1)	ZA200104942B (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8466096B2 (en) *	2007-04-26	2013-06-18	Afton Chemical Corporation	1,3,2-dioxaphosphorinane, 2-sulfide derivatives for use as anti-wear additives in lubricant compositions
RU2523651C2 (ru) *	2012-05-22	2014-07-20	Государственное бюджетное образовательное учреждение высшего профессионального образования "Владивостокский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО ВГМУ Минздравсоцразвития России)	Способ дифференцированного контроля базисного противовоспалительного лечения бронхиальной астмы у детей и подростков
RU2506045C1 (ru) *	2012-09-05	2014-02-10	Федеральное государственное бюджетное учреждение "Дальневосточный научный центр физиологии и патологии дыхания" Сибирского отделения РАМН	Способ прогнозирования достижения контроля бронхиальной астмы
CN119161311B (zh) *	2024-11-20	2025-02-11	北京纳百生物科技有限公司	一种地克珠利抗原及其合成方法和应用

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DE2149645A1 (de)	1970-10-07	1972-09-14	Pfizer	2-Phenyl-as-triazin-3.5-(2H,4H)-dione und die Verwendung dieser Verbindungen zur Bekaempfung der Coccidiose
US3912723A (en)	1971-03-29	1975-10-14	Pfizer	2-Phenyl-as-triazine-3,5(2H,4H)diones
US3883528A (en)	1974-04-19	1975-05-13	Pfizer	Preparation of 2(aryl)-as-triazine-3,5(2H,4H)-dione coccidiostats
US4631278A (en)	1984-08-01	1986-12-23	Janssen Pharmaceutica N.V.	Anti-protozoal α-aryl-4-(4,5-dihydro-3,5-dioxo-1,2,4-triazin-2(3H)-yl)-benzeneacetonitrile derivatives, pharmaceutical compositions, and method of use therefor
CA1244024A (en)	1984-08-01	1988-11-01	Gustaaf M. Boeckx	.alpha.- ARYL-4-(4,5-DIHYDRO-3,5-DIOXO-1,2,4-TRIAZIN- 2(3H)-YL)BENZENEACETONITRILES
GB8602342D0 (en)	1986-01-30	1986-03-05	Janssen Pharmaceutica Nv	5 6-dihydro-2-(substituted phenyl)-1 2 4-triazine-3 5(2h 4h)-diones
CA1331757C (en)	1988-02-29	1994-08-30	Janssen Pharmaceutica Naamloze Vennootschap	5-lipoxygenase inhibiting 4-(4-phenyl-1-piperazinyl)phenols
EP0476439A1 (de)	1990-09-18	1992-03-25	Bayer Ag	Substituierte 1,2,4-Triazindione, Verfahren zu ihrer Herstellung, Zwischenprodukte dafür und ihre Verwendung
DE4120138A1 (de)	1991-06-19	1992-12-24	Bayer Ag	Substituierte hexahydro-1,2,4-triazindione, verfahren zu ihrer herstellung, zwischenprodukte dafuer und ihre verwendung
TW263495B (de)	1992-12-23	1995-11-21	Celltech Ltd
GB9304920D0 (en)	1993-03-10	1993-04-28	Celltech Ltd	Chemical compounds
TW403741B (en)	1993-10-15	2000-09-01	Takeda Chemical Industries Ltd	Triazine derivative, production and use thereof
TW332201B (en)	1995-04-06	1998-05-21	Janssen Pharmaceutica Nv	1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives
DE69615601T2 (de)	1995-04-14	2002-07-11	Takeda Schering-Plough Animal Health K.K., Osaka	Verfahren zur Herstellung von Triazinderivate
CN1128141C (zh) *	1996-08-30	2003-11-19	武田舍林-普劳动物保健株式会社	1,2,4－三嗪－3,5－二酮衍生物,其制备和用途
BR9811678A (pt) *	1997-07-10	2000-09-19	Janssen Pharmaceutica Nv	Derivados de 6-azauracila de inibição de il-5
HRP990333A2 (en) *	1997-07-10	2000-04-30	Janssen Pharmaceutica Nv	6-azauracil derivatives as il-5 inhibitors

1999
- 1999-12-16 PL PL349526A patent/PL198205B1/pl not_active IP Right Cessation
- 1999-12-16 DK DK99965509T patent/DK1140873T3/da active
- 1999-12-16 JP JP2000589523A patent/JP2002533331A/ja not_active Withdrawn
- 1999-12-16 EP EP99965509A patent/EP1140873B1/de not_active Expired - Lifetime
- 1999-12-16 HK HK02104206.0A patent/HK1042491A1/zh unknown
- 1999-12-16 ID IDW00200101295A patent/ID28880A/id unknown
- 1999-12-16 CN CNB998146110A patent/CN100343239C/zh not_active Expired - Fee Related
- 1999-12-16 IL IL14376699A patent/IL143766A/xx not_active IP Right Cessation
- 1999-12-16 EA EA200100677A patent/EA004806B1/ru not_active IP Right Cessation
- 1999-12-16 DE DE69936396T patent/DE69936396T2/de not_active Expired - Fee Related
- 1999-12-16 HR HR20010455A patent/HRP20010455A2/hr not_active Application Discontinuation
- 1999-12-16 BR BR9916366-7A patent/BR9916366A/pt not_active Application Discontinuation
- 1999-12-16 AU AU21001/00A patent/AU773780B2/en not_active Ceased
- 1999-12-16 SK SK815-2001A patent/SK8152001A3/sk unknown
- 1999-12-16 KR KR1020017006666A patent/KR100635721B1/ko not_active Expired - Fee Related
- 1999-12-16 NZ NZ512748A patent/NZ512748A/en unknown
- 1999-12-16 US US09/868,384 patent/US6803364B1/en not_active Expired - Fee Related
- 1999-12-16 CA CA002354511A patent/CA2354511A1/en not_active Abandoned
- 1999-12-16 UA UA2001075132A patent/UA73107C2/uk unknown
- 1999-12-16 AT AT99965509T patent/ATE365723T1/de not_active IP Right Cessation
- 1999-12-16 ES ES99965509T patent/ES2289835T3/es not_active Expired - Lifetime
- 1999-12-16 EE EEP200100320A patent/EE200100320A/xx unknown
- 1999-12-16 PT PT99965509T patent/PT1140873E/pt unknown
- 1999-12-16 CZ CZ20012062A patent/CZ20012062A3/cs unknown
- 1999-12-16 TR TR2001/01729T patent/TR200101729T2/xx unknown
- 1999-12-16 HU HU0104641A patent/HUP0104641A3/hu unknown
- 1999-12-16 WO PCT/EP1999/010169 patent/WO2000037451A1/en not_active Ceased
- 1999-12-17 CO CO99079022A patent/CO5150147A1/es unknown
- 1999-12-17 MY MYPI99005536A patent/MY125808A/en unknown
- 1999-12-17 TW TW088122197A patent/TWI249530B/zh not_active IP Right Cessation
- 1999-12-17 AR ARP990106512A patent/AR021887A1/es not_active Application Discontinuation
2000
- 2000-03-05 SA SA00201030A patent/SA00201030B1/ar unknown
2001
- 2001-06-14 BG BG105602A patent/BG105602A/xx unknown
- 2001-06-15 NO NO20012987A patent/NO319814B1/no unknown
- 2001-06-15 ZA ZA200104942A patent/ZA200104942B/en unknown

Also Published As

Publication number	Publication date
CA2354511A1 (en)	2000-06-29
PT1140873E (pt)	2007-10-10
CN1330643A (zh)	2002-01-09
ATE365723T1 (de)	2007-07-15
SA00201030B1 (ar)	2006-10-11
ID28880A (id)	2001-07-12
EP1140873B1 (de)	2007-06-27
JP2002533331A (ja)	2002-10-08
ZA200104942B (en)	2002-06-18
HRP20010455A2 (en)	2002-06-30
NO20012987D0 (no)	2001-06-15
AU773780B2 (en)	2004-06-03
EE200100320A (et)	2002-10-15
PL198205B1 (pl)	2008-06-30
HUP0104641A2 (hu)	2002-04-29
EP1140873A1 (de)	2001-10-10
HUP0104641A3 (en)	2003-01-28
US6803364B1 (en)	2004-10-12
NO20012987L (no)	2001-08-17
NZ512748A (en)	2004-05-28
IL143766A0 (en)	2002-04-21
AR021887A1 (es)	2002-08-07
HK1042491A1 (zh)	2002-08-16
SK8152001A3 (en)	2002-04-04
DK1140873T3 (da)	2007-10-15
DE69936396D1 (de)	2007-08-09
CN100343239C (zh)	2007-10-17
CO5150147A1 (es)	2002-04-29
KR100635721B1 (ko)	2006-10-17
TR200101729T2 (tr)	2001-10-22
NO319814B1 (no)	2005-09-19
EA004806B1 (ru)	2004-08-26
BR9916366A (pt)	2001-09-18
KR20010080617A (ko)	2001-08-22
IL143766A (en)	2005-11-20
DE69936396T2 (de)	2008-06-19
MY125808A (en)	2006-08-30
WO2000037451A1 (en)	2000-06-29
TWI249530B (en)	2006-02-21
CZ20012062A3 (cs)	2002-03-13
ES2289835T3 (es)	2008-02-01
UA73107C2 (en)	2005-06-15
AU2100100A (en)	2000-07-12
EA200100677A1 (ru)	2001-12-24

Publication	Publication Date	Title
BG104738A (en)	2001-04-30	Hiv inhibiting pyrimidine derivatives
IL144826A0 (en)	2002-06-30	Amide compounds and pharmaceutical compositions containing the same
AP1475A (en)	2005-10-03	Trisubstituted 1, 3, 5-triazine derivatives for treatment of HIV infections.
MY119118A (en)	2005-03-31	Thiophenopyrimidines
TW200510431A (en)	2005-03-16	Quinazoline derivatives
HUT74367A (en)	1996-12-30	Fungicidal alpha-aryl-substituted cyclic amide derivatives, fungicid compositions containing these as active ingredients and using thereof
HUP9902714A2 (hu)	1999-12-28	Piridon-karbonsav-származékok és ezek sói, valamint hatóanyagként ilyen vegyületeket tartalmazó antibakteriális szerek
IL101785A0 (en)	1992-12-30	Urea derivatives,processes for the preparation thereof and pharmaceutical compositions containing the same
NZ239305A (en)	1994-08-26	4-benzyl-5-substituted isoxazole derivatives, preparation and herbicidal compositions thereof
BG105571A (en)	2002-01-31	4-(aminomethyl)-piperidine benzamides for treating gastrointestinal disorders
NZ502180A (en)	2000-11-24	6-Azauracil derivatives and their use as IL-5 inhibitors
MXPA04002495A (es)	2004-05-31	Compuestos de imidazopiridin como moduladores del receptor 5-ht4.
BG105602A (en)	2002-01-31	Il-5-inhibiting 6-azauracyl derivatives
MXPA04005155A (es)	2004-08-11	Preparacion de sales farmaceuticas de 4((z) -(4-bromofenil) (etoxiimino)]-1`-((2, 4-dimetil-1 -oxido-3 -piridinil) carbonil]-4` -metil-1, 4`-bipiperidina como antagonistas del receptor ccr5 para el tratamiento de sida y de infecciones de vih relacion
MY118312A (en)	2004-09-30	Angiogenesis inhibiting 5- substituted- 1,2,4- thiadiazolyl derivatives
MY120046A (en)	2005-08-30	Angiogenesis inhibiting thiadiazolyl pyridazine derivatives.
BG106784A (en)	2003-01-31	3-(4,5-dihydroisoxalole-5-yl)benzoylpyrazole
CA2352503A1 (en)	2000-06-02	Il-5 inhibiting 6-azauracil derivatives
ATE500231T1 (de)	2011-03-15	Hiv hemmende pyrimidin derivate
IL84874A (en)	1991-08-16	(((aminoalkyl)amino)-carbonyl)-di(het)areno-(b,e)(1,4)-diazepinones,their preparation and pharmaceutical compositions containing them
IL118379A (en)	1999-12-31	(2-morpholinylmethyl)benzamide derivatives their preparation and pharmaceutical compositions containing them
NZ504299A (en)	2001-01-26	1-aza-2-alkyl-6-aryl-cycloalkane compounds, a process for their preparation and pharmaceutical compositions containing them
PL338009A1 (en)	2000-09-25	2,4,4-three-substituted 1,3-dioxolane based antimycotic agents
KR950704331A (ko)	1995-11-17	세펨 화합물 및 그의 약제학적 조성물(cephem compounds and their pharmaceutical compositions)
TH59860A3 (th)	2003-12-12	ยาที่นุ่มนวลในการยับยั้ง il-5