BG106043A - Site-specific isotopically-labeled proteins, aminoacids, and biochemical precursors - Google Patents

Site-specific isotopically-labeled proteins, aminoacids, and biochemical precursors

Info

Publication number: BG106043A
Authority: BG; Bulgaria
Prior art keywords: site; amino acids; aminoacids; precursors; biochemical precursors
Prior art date: 1999-04-09

Application number

BG106043A

Other languages

Bulgarian (bg)

English (en)

Inventor

Stephen FESIK

David Augeri

Original Assignee

Abbott Laboratories

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-04-09

Filing date

2001-10-24

Publication date

2002-05-31

2001-10-24 Application filed by Abbott Laboratories filed Critical Abbott Laboratories

2002-05-31 Publication of BG106043A publication Critical patent/BG106043A/xx

Links

150000001413 amino acids Chemical class 0.000 title abstract 6
102000004169 proteins and genes Human genes 0.000 title abstract 5
108090000623 proteins and genes Proteins 0.000 title abstract 5
239000002243 precursor Substances 0.000 title abstract 4
235000001014 amino acid Nutrition 0.000 title 1
235000018102 proteins Nutrition 0.000 title 1
229940024606 amino acid Drugs 0.000 abstract 5
FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 abstract 2
239000012634 fragment Substances 0.000 abstract 2
229920001184 polypeptide Polymers 0.000 abstract 2
102000004196 processed proteins & peptides Human genes 0.000 abstract 2
108090000765 processed proteins & peptides Proteins 0.000 abstract 2
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 1
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 1
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 1
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 1
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 1
230000001851 biosynthetic effect Effects 0.000 abstract 1
229910052799 carbon Inorganic materials 0.000 abstract 1
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
229960000310 isoleucine Drugs 0.000 abstract 1
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 1
239000004474 valine Substances 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6489—Metalloendopeptidases (3.4.24)
- C12N9/6491—Matrix metalloproteases [MMP's], e.g. interstitial collagenase (3.4.24.7); Stromelysins (3.4.24.17; 3.2.1.22); Matrilysin (3.4.24.23)
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
- C07B59/001—Acyclic or carbocyclic compounds
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
- C07C229/08—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton the nitrogen atom of the amino group being further bound to hydrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1075—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of amino acids or peptide residues
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/1072—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups
- C07K1/1077—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides by covalent attachment of residues or functional groups by covalent attachment of residues other than amino acids or peptide residues, e.g. sugars, polyols, fatty acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/13—Labelling of peptides
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/06—Alanine; Leucine; Isoleucine; Serine; Homoserine
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/08—Lysine; Diaminopimelic acid; Threonine; Valine
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Analytical Chemistry (AREA)
Biomedical Technology (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Peptides Or Proteins (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Investigating Or Analysing Biological Materials (AREA)

BG106043A 1999-04-09 2001-10-24 Site-specific isotopically-labeled proteins, aminoacids, and biochemical precursors BG106043A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US28951799A	1999-04-09	1999-04-09
PCT/US2000/009296 WO2000061525A1 (en)	1999-04-09	2000-04-07	Site-specific isotopically-labeled proteins, amino acids, and biochemical precursors therefor

Publications (1)

Publication Number	Publication Date
BG106043A true BG106043A (en)	2002-05-31

Family

ID=23111884

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG106043A BG106043A (en)	1999-04-09	2001-10-24	Site-specific isotopically-labeled proteins, aminoacids, and biochemical precursors

Country Status (29)

Country	Link
EP (1)	EP1169282B1 (de)
JP (1)	JP2002541228A (de)
KR (1)	KR100708225B1 (de)
CN (1)	CN1244521C (de)
AR (1)	AR029747A1 (de)
AT (1)	ATE296789T1 (de)
AU (1)	AU777749B2 (de)
BG (1)	BG106043A (de)
BR (1)	BR0009664A (de)
CA (1)	CA2368652C (de)
CO (1)	CO5160349A1 (de)
CZ (1)	CZ20013616A3 (de)
DE (1)	DE60020547T2 (de)
DK (1)	DK1169282T3 (de)
ES (1)	ES2243251T3 (de)
HK (1)	HK1044753B (de)
HU (1)	HUP0200809A3 (de)
IL (2)	IL145536A0 (de)
MX (1)	MXPA01010183A (de)
NO (1)	NO20014691L (de)
NZ (1)	NZ514518A (de)
PL (1)	PL350889A1 (de)
PT (1)	PT1169282E (de)
SI (1)	SI1169282T1 (de)
SK (1)	SK14322001A3 (de)
TR (1)	TR200102842T2 (de)
TW (1)	TWI283659B (de)
WO (1)	WO2000061525A1 (de)
ZA (1)	ZA200107919B (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US10053396B2 (en)	2010-01-06	2018-08-21	Commissariat A L'energie Atomique Et Aux Energies Alternatives	Process for the specific isotopic labeling of methyl groups of Val, Leu and Ile
WO2011083356A1 (en) *	2010-01-06	2011-07-14	Commissariat A L'energie Atomique Et Aux Energies Alternatives	Process for the specific isotopic labeling of methyl groups of val, leu and ile
KR101219684B1 (ko) *	2012-04-27	2013-01-10	건국대학교 산학협력단	정량적 질량분석기법을 이용한 만성골수성 백혈병의 발병 진단방법과 약제 내성 진단방법
EP2695873B1 (de) *	2012-08-08	2016-10-26	Commissariat A L'energie Atomique Et Aux Energies Alternatives	Markierte, chirale alpha-Hydroxy-Ketosäure-Derivate, Verfahren zur Herstellung besagter Derivate und deren Verwendung
CN107793209A (zh) *	2016-08-30	2018-03-13	泰生科技香港有限公司	稳定性同位素标记植物的专用培养基、其制备方法及用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5698401A (en) *	1995-11-14	1997-12-16	Abbott Laboratories	Use of nuclear magnetic resonance to identify ligands to target biomolecules

2000
- 2000-03-28 TW TW089105713A patent/TWI283659B/zh not_active IP Right Cessation
- 2000-04-06 CO CO00025250A patent/CO5160349A1/es unknown
- 2000-04-07 AR ARP000101600A patent/AR029747A1/es not_active Application Discontinuation
- 2000-04-07 PT PT00921858T patent/PT1169282E/pt unknown
- 2000-04-07 CA CA002368652A patent/CA2368652C/en not_active Expired - Fee Related
- 2000-04-07 SK SK1432-2001A patent/SK14322001A3/sk unknown
- 2000-04-07 CN CNB008082510A patent/CN1244521C/zh not_active Expired - Fee Related
- 2000-04-07 HK HK02104717.2A patent/HK1044753B/en not_active IP Right Cessation
- 2000-04-07 PL PL00350889A patent/PL350889A1/xx not_active Application Discontinuation
- 2000-04-07 BR BR0009664-4A patent/BR0009664A/pt not_active IP Right Cessation
- 2000-04-07 DE DE60020547T patent/DE60020547T2/de not_active Expired - Lifetime
- 2000-04-07 JP JP2000610803A patent/JP2002541228A/ja not_active Withdrawn
- 2000-04-07 NZ NZ514518A patent/NZ514518A/en not_active IP Right Cessation
- 2000-04-07 DK DK00921858T patent/DK1169282T3/da active
- 2000-04-07 AU AU42121/00A patent/AU777749B2/en not_active Ceased
- 2000-04-07 CZ CZ20013616A patent/CZ20013616A3/cs unknown
- 2000-04-07 MX MXPA01010183A patent/MXPA01010183A/es active IP Right Grant
- 2000-04-07 EP EP00921858A patent/EP1169282B1/de not_active Expired - Lifetime
- 2000-04-07 TR TR2001/02842T patent/TR200102842T2/xx unknown
- 2000-04-07 WO PCT/US2000/009296 patent/WO2000061525A1/en not_active Ceased
- 2000-04-07 HU HU0200809A patent/HUP0200809A3/hu unknown
- 2000-04-07 SI SI200030724T patent/SI1169282T1/xx unknown
- 2000-04-07 AT AT00921858T patent/ATE296789T1/de active
- 2000-04-07 KR KR1020017012833A patent/KR100708225B1/ko not_active Expired - Fee Related
- 2000-04-07 ES ES00921858T patent/ES2243251T3/es not_active Expired - Lifetime
- 2000-04-07 IL IL14553600A patent/IL145536A0/xx unknown
2001
- 2001-09-21 IL IL145536A patent/IL145536A/en not_active IP Right Cessation
- 2001-09-27 NO NO20014691A patent/NO20014691L/no not_active Application Discontinuation
- 2001-09-27 ZA ZA200107919A patent/ZA200107919B/xx unknown
- 2001-10-24 BG BG106043A patent/BG106043A/xx unknown

Also Published As

Publication number	Publication date
BR0009664A (pt)	2002-01-08
PL350889A1 (en)	2003-02-10
DK1169282T3 (da)	2005-10-03
DE60020547T2 (de)	2006-05-04
TR200102842T2 (tr)	2002-03-21
CA2368652C (en)	2009-11-10
CN1244521C (zh)	2006-03-08
NO20014691D0 (no)	2001-09-27
SI1169282T1 (en)	2005-10-31
HUP0200809A2 (en)	2002-06-29
AU4212100A (en)	2000-11-14
ES2243251T3 (es)	2005-12-01
DE60020547D1 (de)	2005-07-07
CN1353678A (zh)	2002-06-12
MXPA01010183A (es)	2003-07-21
HK1044753A1 (en)	2002-11-01
CA2368652A1 (en)	2000-10-19
JP2002541228A (ja)	2002-12-03
IL145536A (en)	2010-05-31
PT1169282E (pt)	2005-10-31
CZ20013616A3 (cs)	2002-04-17
NO20014691L (no)	2001-12-10
EP1169282B1 (de)	2005-06-01
CO5160349A1 (es)	2002-05-30
HUP0200809A3 (en)	2004-11-29
WO2000061525A1 (en)	2000-10-19
AR029747A1 (es)	2003-07-16
NZ514518A (en)	2003-10-31
KR20010108475A (ko)	2001-12-07
SK14322001A3 (sk)	2002-02-05
ZA200107919B (en)	2003-03-26
KR100708225B1 (ko)	2007-04-17
IL145536A0 (en)	2002-06-30
HK1044753B (en)	2006-03-24
ATE296789T1 (de)	2005-06-15
TWI283659B (en)	2007-07-11
AU777749B2 (en)	2004-10-28
EP1169282A1 (de)	2002-01-09

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SI1077692T1 (en)	2004-10-31	Amino acid stabilized gabapentin and pregabalin preparations and process for preparing the same
NZ527182A (en)	2004-06-25	Neisseria meningitidis antigens and compositions
AU625963B3 (en)	1992-05-22	L-phenylalanyl-tRNA synthetase mutants, a process for the preparation thereof and the use thereof for the in vivo incorporation of non-proteinogenous amino acids into peptides or proteins
ZA989014B (en)	2000-04-03	Process for the microbial production of amino acids of the aspartate and/or glutamate family and means used in the process.
HUT54213A (en)	1991-01-28	Process for the enzymatic removal of n-terminal sequence of proteins
EP0873754A4 (de)	1999-03-24	Aminosäuren zusammensetzungen
GR860081B (en)	1986-04-29	Oligopeptides their intermediates method for their preparation
AU3209097A (en)	1997-12-05	Neuroactive peptides
PL328819A1 (en)	1999-02-15	Improved barstar gene
CA2249180A1 (en)	1997-09-25	Methods for recombinant microbial production of bpi-fusion proteins and bpi-derived peptides
BG106043A (en)	2002-05-31	Site-specific isotopically-labeled proteins, aminoacids, and biochemical precursors
MX9702665A (es)	1997-07-31	Analogos del factor de crecimiento de queratinocitos.
IL122606A0 (en)	1998-08-16	(S)-hydroxy-nitrile-lyase
MY114769A (en)	2003-01-31	Non-splicing variants of gp350/220
AU9026691A (en)	1992-06-11	New human recombinant gamma interferon
AU4876196A (en)	1996-09-18	A process for the preparation of factor ix from biological sources
EP0384731A3 (de)	1991-06-26	Osteogenische Wachstumfaktoren, die aus sich regenerierendem Knochenmark identifiziert werden
WO2001009174A3 (en)	2001-08-30	Plant defensin variants
ATE138936T1 (de)	1996-06-15	Neue peptidderivate, verfahren zu deren herstellung und deren anwendung als heilmittel
CA2259640A1 (en)	1998-02-26	Human glycine transporter
DE69315730D1 (de)	1998-01-29	Verfahren zur Herstellung von Peptiden und neue Zwischenverbindungen dazu
AU2676399A (en)	1999-08-30	Novel cystine knot protein and materials and methods for making it
EP0490383A3 (en)	1993-06-30	Peptides of the hiv-gag protein, their preparation and use
CA2285700A1 (en)	2000-04-13	Renin-active substance
IE790619L (en)	1979-09-02	Psychopharmacological peptides