ATE138936T1 - Neue peptidderivate, verfahren zu deren herstellung und deren anwendung als heilmittel - Google Patents

Neue peptidderivate, verfahren zu deren herstellung und deren anwendung als heilmittel

Info

Publication number: ATE138936T1
Authority: AT; Austria
Prior art keywords: residue; alanine; leucine; isoleucine; valine
Prior art date: 1992-02-12

Application number

AT93400349T

Other languages

English (en)

Inventor

Gilles Hamon

Eve Mahe

Dung Le-Nguyen

Original Assignee

Roussel Uclaf

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-02-12

Filing date

1993-02-11

Publication date

1996-06-15

1993-02-11 Application filed by Roussel Uclaf filed Critical Roussel Uclaf

1996-06-15 Application granted granted Critical

1996-06-15 Publication of ATE138936T1 publication Critical patent/ATE138936T1/de

Links

238000004519 manufacturing process Methods 0.000 title abstract 2
108090000765 processed proteins & peptides Proteins 0.000 title abstract 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 4
QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 abstract 3
CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 abstract 3
AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 abstract 3
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 abstract 3
KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 abstract 3
COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 3
OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 abstract 3
KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 abstract 3
ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 abstract 3
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 3
239000004472 Lysine Substances 0.000 abstract 3
KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 abstract 3
235000004279 alanine Nutrition 0.000 abstract 3
229960003767 alanine Drugs 0.000 abstract 3
235000003704 aspartic acid Nutrition 0.000 abstract 3
229960005261 aspartic acid Drugs 0.000 abstract 3
OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 abstract 3
235000014705 isoleucine Nutrition 0.000 abstract 3
229960000310 isoleucine Drugs 0.000 abstract 3
AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 abstract 3
235000005772 leucine Nutrition 0.000 abstract 3
229960003136 leucine Drugs 0.000 abstract 3
235000018977 lysine Nutrition 0.000 abstract 3
235000008729 phenylalanine Nutrition 0.000 abstract 3
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 3
229960005190 phenylalanine Drugs 0.000 abstract 3
235000002374 tyrosine Nutrition 0.000 abstract 3
OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 abstract 3
229960004441 tyrosine Drugs 0.000 abstract 3
235000014393 valine Nutrition 0.000 abstract 3
229960004295 valine Drugs 0.000 abstract 3
239000004474 valine Substances 0.000 abstract 3
MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 abstract 2
239000004471 Glycine Substances 0.000 abstract 2
XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 abstract 2
MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 abstract 2
125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 abstract 2
235000018417 cysteine Nutrition 0.000 abstract 2
XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 2
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
229960001153 serine Drugs 0.000 abstract 2
235000004400 serine Nutrition 0.000 abstract 2
125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 abstract 2
239000004475 Arginine Substances 0.000 abstract 1
DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 abstract 1
WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 abstract 1
ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 abstract 1
DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 abstract 1
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 abstract 1
QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 abstract 1
QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 abstract 1
235000009697 arginine Nutrition 0.000 abstract 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
235000009582 asparagine Nutrition 0.000 abstract 1
229960001230 asparagine Drugs 0.000 abstract 1
UFWLHIVKHDCSHZ-UHFFFAOYSA-N chembl1595789 Chemical compound NC1=NC(N)=NC(C=2C(=CC=CC=2)O)=N1 UFWLHIVKHDCSHZ-UHFFFAOYSA-N 0.000 abstract 1
125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
235000013922 glutamic acid Nutrition 0.000 abstract 1
239000004220 glutamic acid Substances 0.000 abstract 1
229960002449 glycine Drugs 0.000 abstract 1
125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 abstract 1
125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 abstract 1
229960003646 lysine Drugs 0.000 abstract 1
229940126601 medicinal product Drugs 0.000 abstract 1
BXKNUXDLZJPPBO-UHFFFAOYSA-N tert-butyl 6-[2-chloro-4-(3-methylimidazol-4-yl)anilino]-2-(1-methylpyrazol-4-yl)pyrrolo[3,2-c]pyridine-1-carboxylate Chemical compound C1=NN(C)C=C1C(N(C1=C2)C(=O)OC(C)(C)C)=CC1=CN=C2NC1=CC=C(C=2N(C=NC=2)C)C=C1Cl BXKNUXDLZJPPBO-UHFFFAOYSA-N 0.000 abstract 1
125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/57536—Endothelin, vasoactive intestinal contractor [VIC]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Zoology (AREA)
Genetics & Genomics (AREA)
Toxicology (AREA)
Molecular Biology (AREA)
Endocrinology (AREA)
Vascular Medicine (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)

AT93400349T 1992-02-12 1993-02-11 Neue peptidderivate, verfahren zu deren herstellung und deren anwendung als heilmittel ATE138936T1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR9201557A FR2687156B1 (fr)	1992-02-12	1992-02-12	Nouveaux derives peptidiques, procede de preparation et application a titre de medicaments de ces nouveaux derives.

Publications (1)

Publication Number	Publication Date
ATE138936T1 true ATE138936T1 (de)	1996-06-15

Family

ID=9426558

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT93400349T ATE138936T1 (de)	1992-02-12	1993-02-11	Neue peptidderivate, verfahren zu deren herstellung und deren anwendung als heilmittel

Country Status (10)

Country	Link
US (1)	US5439887A (de)
EP (1)	EP0556124B1 (de)
JP (1)	JPH0649097A (de)
AT (1)	ATE138936T1 (de)
CA (1)	CA2089342A1 (de)
DE (1)	DE69302921T2 (de)
DK (1)	DK0556124T3 (de)
ES (1)	ES2088239T3 (de)
FR (1)	FR2687156B1 (de)
GR (1)	GR3020507T3 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4867986A (en) *	1987-07-17	1989-09-19	Pharmachem Laboratories, Inc.	Dry stabilized microemulsified omega-three acid-containing oils
US5962490A (en)	1987-09-25	1999-10-05	Texas Biotechnology Corporation	Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
US5646130A (en) *	1995-06-30	1997-07-08	Ocean University Of Oingdao	Low molecular weight sulfated polysaccharides and uses thereof
US5977117A (en) *	1996-01-05	1999-11-02	Texas Biotechnology Corporation	Substituted phenyl compounds and derivatives thereof that modulate the activity of endothelin
US5958905A (en)	1996-03-26	1999-09-28	Texas Biotechnology Corporation	Phosphoramidates, phosphinic amides and related compounds and the use thereof to modulate the activity of endothelin
US5804585A (en)	1996-04-15	1998-09-08	Texas Biotechnology Corporation	Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
WO2000018895A1 (en) *	1998-09-25	2000-04-06	The Children's Medical Center Corporation	Short peptides which selectively modulate the activity of protein kinases
CA3056433A1 (en)	2017-03-22	2018-09-27	Pharmain Corporation	Npra agonists, compositions, and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
AU8523191A (en) *	1990-08-08	1992-03-02	Rockefeller University, The	Analogs of endothelin
US5352659A (en) *	1991-02-15	1994-10-04	Takeda Chemical Industries	Endothelin analogs and uses thereof

1992
- 1992-02-12 FR FR9201557A patent/FR2687156B1/fr not_active Expired - Fee Related
1993
- 1993-02-10 US US08/016,023 patent/US5439887A/en not_active Expired - Fee Related
- 1993-02-11 CA CA002089342A patent/CA2089342A1/fr not_active Abandoned
- 1993-02-11 EP EP93400349A patent/EP0556124B1/de not_active Expired - Lifetime
- 1993-02-11 DE DE69302921T patent/DE69302921T2/de not_active Expired - Fee Related
- 1993-02-11 AT AT93400349T patent/ATE138936T1/de not_active IP Right Cessation
- 1993-02-11 ES ES93400349T patent/ES2088239T3/es not_active Expired - Lifetime
- 1993-02-11 DK DK93400349.2T patent/DK0556124T3/da active
- 1993-02-12 JP JP5046032A patent/JPH0649097A/ja not_active Ceased
1996
- 1996-07-11 GR GR950403181T patent/GR3020507T3/el unknown

Also Published As

Publication number	Publication date
DE69302921D1 (de)	1996-07-11
DE69302921T2 (de)	1996-10-31
FR2687156A1 (fr)	1993-08-13
FR2687156B1 (fr)	1994-04-01
CA2089342A1 (fr)	1993-08-13
EP0556124B1 (de)	1996-06-05
JPH0649097A (ja)	1994-02-22
DK0556124T3 (da)	1996-07-29
GR3020507T3 (en)	1996-10-31
US5439887A (en)	1995-08-08
EP0556124A1 (de)	1993-08-18
ES2088239T3 (es)	1996-08-01

Legal Events

Date	Code	Title	Description
1997-01-15	UEP	Publication of translation of european patent specification
2004-11-15	REN	Ceased due to non-payment of the annual fee

Publication	Publication Date	Title
PT93057A (pt)	1990-08-31	Processo para a preparacao de analogos da insulina
ATE95195T1 (de)	1993-10-15	Mikroproteine, verfahren zur herstellung derselben und anwendung dieser mikroproteine als arzneimittel.
EP0873754A4 (de)	1999-03-24	Aminosäuren zusammensetzungen
DE69200644D1 (de)	1994-12-15	Neue Polypeptide mit Affinität zu den Lipopolysacchariden und deren Verwendung.
DE69302921D1 (de)	1996-07-11	Neue Peptidderivate, Verfahren zu deren Herstellung und deren Anwendung als Heilmittel
ATE30919T1 (de)	1987-12-15	Magensekretion hemmende peptidderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel.
ES2135389T3 (es)	1999-11-01	Antagonistas de endotelina.
BG106043A (en)	2002-05-31	Site-specific isotopically-labeled proteins, aminoacids, and biochemical precursors
ES2052447A1 (es)	1994-07-01	Peptidos hemorreguladores.
ATE104663T1 (de)	1994-05-15	Picolylselenobenzamide von aminopyridinen, anilinen und picolylaminen.