BG106734A - Pyrazolo[1,5-d][1,2,4]triazines for enhancing cognition - Google Patents
Pyrazolo[1,5-d][1,2,4]triazines for enhancing cognitionInfo
- Publication number
- BG106734A BG106734A BG106734A BG10673402A BG106734A BG 106734 A BG106734 A BG 106734A BG 106734 A BG106734 A BG 106734A BG 10673402 A BG10673402 A BG 10673402A BG 106734 A BG106734 A BG 106734A
- Authority
- BG
- Bulgaria
- Prior art keywords
- optionally substituted
- heteroaromatic ring
- alkyl
- compounds
- membered heteroaromatic
- Prior art date
Links
- 230000002708 enhancing effect Effects 0.000 title abstract 2
- 230000019771 cognition Effects 0.000 title 1
- APRYYMZGRJPHAI-UHFFFAOYSA-N pyrazolo[1,5-d][1,2,4]triazine Chemical class C1=NN=CN2N=CC=C21 APRYYMZGRJPHAI-UHFFFAOYSA-N 0.000 title 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 5
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 1
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 1
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 150000001602 bicycloalkyls Chemical group 0.000 abstract 1
- 230000003930 cognitive ability Effects 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Psychiatry (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hospice & Palliative Care (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9927874.9A GB9927874D0 (en) | 1999-11-25 | 1999-11-25 | Therapeutic agents |
| GB0009602A GB0009602D0 (en) | 2000-04-18 | 2000-04-18 | Therapeutic agents |
| GB0018651A GB0018651D0 (en) | 2000-07-28 | 2000-07-28 | Therapeutic agents |
| PCT/GB2000/004450 WO2001038331A2 (en) | 1999-11-25 | 2000-11-22 | Pyrazolo[1,5-d][1,2,4]triazines for enhancing cognition |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG106734A true BG106734A (en) | 2003-02-28 |
Family
ID=27255677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG106734A BG106734A (en) | 1999-11-25 | 2002-05-22 | Pyrazolo[1,5-d][1,2,4]triazines for enhancing cognition |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6355638B1 (cs) |
| EP (1) | EP1235829A2 (cs) |
| JP (1) | JP2003514909A (cs) |
| KR (1) | KR20020053091A (cs) |
| CN (1) | CN1391574A (cs) |
| AU (1) | AU1533001A (cs) |
| BG (1) | BG106734A (cs) |
| BR (1) | BR0015126A (cs) |
| CA (1) | CA2391103A1 (cs) |
| CZ (1) | CZ20021813A3 (cs) |
| EA (1) | EA200200599A1 (cs) |
| EE (1) | EE200200260A (cs) |
| HK (1) | HK1046406A1 (cs) |
| HU (1) | HUP0203579A3 (cs) |
| IL (1) | IL149051A0 (cs) |
| MX (1) | MXPA02005233A (cs) |
| NO (1) | NO20022456D0 (cs) |
| PL (1) | PL355637A1 (cs) |
| SK (1) | SK8952002A3 (cs) |
| WO (1) | WO2001038331A2 (cs) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0128499D0 (en) * | 2001-11-28 | 2002-01-23 | Merck Sharp & Dohme | Therapeutic agents |
| EP2298296A1 (en) * | 2009-08-25 | 2011-03-23 | CNRS Centre National De La Recherche Scientifique | Composition and method for treating cognitive impairments in down syndrome subjects |
| US8969349B2 (en) * | 2010-05-26 | 2015-03-03 | Sunovion Pharmaceuticals Inc. | Substituted quinoxalines and quinoxalinones as PDE-10 inhibitors |
| US20150374705A1 (en) * | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| CN107344936B (zh) * | 2016-05-06 | 2022-06-03 | 上海赛默罗生物科技有限公司 | 三唑哒嗪类衍生物、其制备方法、药物组合物和用途 |
| CN107344938B (zh) * | 2016-05-06 | 2022-05-06 | 上海赛默罗生物科技有限公司 | 吡唑-三嗪类衍生物、其制备方法、药物组合物和用途 |
| WO2020257487A1 (en) * | 2019-06-19 | 2020-12-24 | Biomarin Pharmaceutical Inc. | Glycolate oxidase inhibitors for the treatment of disease |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20000029548A (ko) * | 1996-07-25 | 2000-05-25 | 더블유. 지. 콜 | 가바수용체에대한리간드로서의치환된트리아졸로-피리다진유도체 |
| GB9715977D0 (en) * | 1997-07-29 | 1997-10-01 | Merck Sharp & Dohme | Therapeutic agents |
| CA2315219A1 (en) * | 1998-01-14 | 1999-07-22 | Merck Sharp & Dohme Limited | Triazolo-pyridazine derivatives as ligands for gaba receptors |
| GB9806102D0 (en) * | 1998-03-20 | 1998-05-20 | Merck Sharp & Dohme | Therapeutic agents |
| EP1087968A1 (en) * | 1998-06-16 | 2001-04-04 | MERCK SHARP & DOHME LTD. | Triazolo-pyridine derivatives as ligands for gaba receptors |
| ATE371659T1 (de) * | 1998-10-16 | 2007-09-15 | Merck Sharp & Dohme | Pyrazolotriazinderivate als gaba-rezeptorliganden |
-
2000
- 2000-11-21 US US09/717,423 patent/US6355638B1/en not_active Expired - Lifetime
- 2000-11-22 JP JP2001540094A patent/JP2003514909A/ja not_active Withdrawn
- 2000-11-22 EP EP00977692A patent/EP1235829A2/en not_active Withdrawn
- 2000-11-22 AU AU15330/01A patent/AU1533001A/en not_active Abandoned
- 2000-11-22 HK HK02107821.8A patent/HK1046406A1/zh unknown
- 2000-11-22 CA CA002391103A patent/CA2391103A1/en not_active Abandoned
- 2000-11-22 PL PL00355637A patent/PL355637A1/xx not_active Application Discontinuation
- 2000-11-22 WO PCT/GB2000/004450 patent/WO2001038331A2/en not_active Ceased
- 2000-11-22 MX MXPA02005233A patent/MXPA02005233A/es not_active Application Discontinuation
- 2000-11-22 SK SK895-2002A patent/SK8952002A3/sk unknown
- 2000-11-22 BR BR0015126-2A patent/BR0015126A/pt not_active Application Discontinuation
- 2000-11-22 CZ CZ20021813A patent/CZ20021813A3/cs unknown
- 2000-11-22 IL IL14905100A patent/IL149051A0/xx unknown
- 2000-11-22 EE EEP200200260A patent/EE200200260A/xx unknown
- 2000-11-22 KR KR1020027006672A patent/KR20020053091A/ko not_active Withdrawn
- 2000-11-22 EA EA200200599A patent/EA200200599A1/ru unknown
- 2000-11-22 HU HU0203579A patent/HUP0203579A3/hu unknown
- 2000-11-22 CN CN00816013A patent/CN1391574A/zh active Pending
-
2002
- 2002-05-22 BG BG106734A patent/BG106734A/xx unknown
- 2002-05-24 NO NO20022456A patent/NO20022456D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0203579A2 (hu) | 2003-03-28 |
| AU1533001A (en) | 2001-06-04 |
| IL149051A0 (en) | 2002-11-10 |
| KR20020053091A (ko) | 2002-07-04 |
| CA2391103A1 (en) | 2001-05-31 |
| EE200200260A (et) | 2003-06-16 |
| NO20022456L (no) | 2002-05-24 |
| EP1235829A2 (en) | 2002-09-04 |
| BR0015126A (pt) | 2002-07-02 |
| HUP0203579A3 (en) | 2003-07-28 |
| WO2001038331A2 (en) | 2001-05-31 |
| PL355637A1 (en) | 2004-05-04 |
| CZ20021813A3 (cs) | 2002-08-14 |
| WO2001038331A3 (en) | 2001-11-08 |
| JP2003514909A (ja) | 2003-04-22 |
| EA200200599A1 (ru) | 2002-12-26 |
| SK8952002A3 (en) | 2002-10-08 |
| US6355638B1 (en) | 2002-03-12 |
| CN1391574A (zh) | 2003-01-15 |
| MXPA02005233A (es) | 2002-11-07 |
| HK1046406A1 (zh) | 2003-01-10 |
| NO20022456D0 (no) | 2002-05-24 |
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