ATE371659T1 - Pyrazolotriazinderivate als gaba-rezeptorliganden - Google Patents
Pyrazolotriazinderivate als gaba-rezeptorligandenInfo
- Publication number
- ATE371659T1 ATE371659T1 AT99949224T AT99949224T ATE371659T1 AT E371659 T1 ATE371659 T1 AT E371659T1 AT 99949224 T AT99949224 T AT 99949224T AT 99949224 T AT99949224 T AT 99949224T AT E371659 T1 ATE371659 T1 AT E371659T1
- Authority
- AT
- Austria
- Prior art keywords
- receptor ligands
- gaba receptor
- pyrazolotriazine
- derivatives
- pyrazolotriazine derivatives
- Prior art date
Links
- 239000003446 ligand Substances 0.000 title abstract 2
- 102000005915 GABA Receptors Human genes 0.000 title 1
- 108010005551 GABA Receptors Proteins 0.000 title 1
- PEYVWBGHBCDXRT-UHFFFAOYSA-N N1=NNC2=CN=NC2=C1 Chemical class N1=NNC2=CN=NC2=C1 PEYVWBGHBCDXRT-UHFFFAOYSA-N 0.000 title 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 206010010904 Convulsion Diseases 0.000 abstract 1
- 102000027484 GABAA receptors Human genes 0.000 abstract 1
- 108091008681 GABAA receptors Proteins 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000036461 convulsion Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9822716.8A GB9822716D0 (en) | 1998-10-16 | 1998-10-16 | Therapeutic agents |
| GBGB9920092.5A GB9920092D0 (en) | 1999-08-25 | 1999-08-25 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE371659T1 true ATE371659T1 (de) | 2007-09-15 |
Family
ID=26314533
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT99949224T ATE371659T1 (de) | 1998-10-16 | 1999-10-13 | Pyrazolotriazinderivate als gaba-rezeptorliganden |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6476030B1 (de) |
| EP (1) | EP1121361B1 (de) |
| JP (1) | JP2002527519A (de) |
| AT (1) | ATE371659T1 (de) |
| AU (1) | AU760688B2 (de) |
| CA (1) | CA2346289A1 (de) |
| DE (1) | DE69936998T2 (de) |
| ES (1) | ES2291043T3 (de) |
| WO (1) | WO2000023449A1 (de) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9919957D0 (en) | 1999-08-23 | 1999-10-27 | Merck Sharp & Dohme | Therapeutic agents |
| US6355638B1 (en) * | 1999-11-25 | 2002-03-12 | Merck Sharp & Dohme Ltd. | Pyrazolo[1,5-d][1,2,4] triazines for enhancing cognition |
| GB0008696D0 (en) * | 2000-04-07 | 2000-05-31 | Merck Sharp & Dohme | Therapeutic agents |
| GB0210127D0 (en) | 2002-05-02 | 2002-06-12 | Merck Sharp & Dohme | Therapeutic agents |
| GB0210124D0 (en) * | 2002-05-02 | 2002-06-12 | Merck Sharp & Dohme | Therapeutic agents |
| EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
| WO2007025177A2 (en) | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2377530A3 (de) | 2005-10-21 | 2012-06-20 | Braincells, Inc. | Modulation von Neurogenese durch PDE-Hemmung |
| EP1942879A1 (de) | 2005-10-31 | 2008-07-16 | Braincells, Inc. | Gaba-rezeptor-vermittelte modulation von neurogenese |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2021000A2 (de) | 2006-05-09 | 2009-02-11 | Braincells, Inc. | Neurogenese mittels angiotensin-modulation |
| MX2008014320A (es) | 2006-05-09 | 2009-03-25 | Braincells Inc | Neurogenesis mediada por el receptor de 5-hidroxitriptamina. |
| BRPI0716604A2 (pt) * | 2006-09-08 | 2013-04-09 | Braincells Inc | combinaÇÕes contendo um derivado de 4-acilaminopiridina |
| CN102558001B (zh) | 2007-05-22 | 2015-09-23 | 惠氏有限责任公司 | 制造酰肼的改良方法 |
| RS54008B1 (sr) | 2008-04-23 | 2015-10-30 | Gilead Sciences Inc. | 1`-supstituisani karba-nukleozidni analozi za antivirusnu terapiju |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| WO2011035250A1 (en) | 2009-09-21 | 2011-03-24 | Gilead Sciences, Inc. | Processes and intermediates for the preparation of 1'-substituted carba-nucleoside analogs |
| US9090642B2 (en) | 2010-07-19 | 2015-07-28 | Gilead Sciences, Inc. | Methods for the preparation of diasteromerically pure phosphoramidate prodrugs |
| CR20170278A (es) | 2010-07-22 | 2017-09-29 | Gilead Sciences Inc | Métodos y compuestos para tratar infecciones virales por paramyxoviridae |
| ES2536667T3 (es) * | 2010-11-09 | 2015-05-27 | F. Hoffmann-La Roche Ag | Derivados de triazol como ligandos de receptores Gaba |
| CN107141309A (zh) | 2011-01-11 | 2017-09-08 | 桑诺维恩药品公司 | 杂芳基化合物及其使用方法 |
| US20150374705A1 (en) * | 2012-02-14 | 2015-12-31 | Shanghai Institues for Biological Sciences | Substances for treatment or relief of pain |
| TWI767201B (zh) | 2014-10-29 | 2022-06-11 | 美商基利科學股份有限公司 | 絲狀病毒科病毒感染之治療 |
| PL3349758T3 (pl) | 2015-09-16 | 2022-09-12 | Gilead Sciences, Inc. | Sposoby leczenia zakażeń wirusami arenaviridae |
| CN107344938B (zh) * | 2016-05-06 | 2022-05-06 | 上海赛默罗生物科技有限公司 | 吡唑-三嗪类衍生物、其制备方法、药物组合物和用途 |
| CN110869028B (zh) | 2017-03-14 | 2023-01-20 | 吉利德科学公司 | 治疗猫冠状病毒感染的方法 |
| US10836787B2 (en) | 2017-05-01 | 2020-11-17 | Gilead Sciences, Inc. | Crystalline forms of (S)-2-ethylbutyl 2-(((S)-(((2R,3S,4R,5R)-5- (4-aminopyrrolo[2,1-f] [1,2,4]triazin-7-yl)-5-cyano-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy) phosphoryl)amino)propanoate |
| ES3000461T3 (en) | 2017-07-11 | 2025-02-28 | Gilead Sciences Inc | Compositions comprising an rna polymerase inhibitor and cyclodextrin for treating viral infections |
| CN112028891B (zh) * | 2019-07-30 | 2022-07-05 | 厦门宝太生物科技股份有限公司 | 腺苷受体拮抗剂 |
| CN114206852A (zh) | 2019-08-09 | 2022-03-18 | 卡尔维斯塔制药有限公司 | 血浆激肽释放酶抑制剂 |
| CN114641299A (zh) | 2020-01-27 | 2022-06-17 | 吉利德科学公司 | 用于治疗SARS CoV-2感染的方法 |
| CA3169340A1 (en) | 2020-03-12 | 2021-09-16 | Pavel R. Badalov | Methods of preparing 1'-cyano nucleosides |
| EP4132651B1 (de) | 2020-04-06 | 2026-03-18 | Gilead Sciences, Inc. | Inhalationsformulierungen von 1'-cyansubstituierten carbanukleosidanaloga |
| ES3041698T3 (en) | 2020-05-29 | 2025-11-13 | Gilead Sciences Inc | Remdesivir for the treatment of viral infections |
| US11939347B2 (en) | 2020-06-24 | 2024-03-26 | Gilead Sciences, Inc. | 1′-cyano nucleoside analogs and uses thereof |
| DK4204421T3 (da) | 2020-08-27 | 2024-05-27 | Gilead Sciences Inc | Forbindelser og fremgangsmåder til behandling af virale infektioner |
| CN117279917A (zh) * | 2021-05-21 | 2023-12-22 | 成都百裕制药股份有限公司 | 哌嗪衍生物及其在医药上的应用 |
| MX2024010591A (es) | 2022-03-02 | 2024-09-06 | Gilead Sciences Inc | Compuestos y metodos para el tratamiento de infecciones virales. |
| US12357577B1 (en) | 2024-02-02 | 2025-07-15 | Gilead Sciences, Inc. | Pharmaceutical formulations and uses thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9321162D0 (en) | 1993-10-13 | 1993-12-01 | Boots Co Plc | Therapeutic agents |
| EP0915877A1 (de) | 1996-07-25 | 1999-05-19 | MERCK SHARP & DOHME LTD. | Substituierte triazolo-pyridazinderivate als inverse agonisten des gaba-a alpha-5 rezeptor subtyps |
| CZ18199A3 (cs) | 1996-07-25 | 1999-06-16 | Merck Sharp And Dohme Limited | Triazolopyridazinové deriváty, způsob výroby a farmaceutický prostředek |
| GB9713707D0 (en) * | 1997-06-27 | 1997-09-03 | Merck Sharp & Dohme | Therapeutic agents |
| CA2315219A1 (en) * | 1998-01-14 | 1999-07-22 | Merck Sharp & Dohme Limited | Triazolo-pyridazine derivatives as ligands for gaba receptors |
-
1999
- 1999-10-13 JP JP2000577175A patent/JP2002527519A/ja not_active Withdrawn
- 1999-10-13 AT AT99949224T patent/ATE371659T1/de not_active IP Right Cessation
- 1999-10-13 DE DE69936998T patent/DE69936998T2/de not_active Expired - Fee Related
- 1999-10-13 WO PCT/GB1999/003401 patent/WO2000023449A1/en not_active Ceased
- 1999-10-13 US US09/806,879 patent/US6476030B1/en not_active Expired - Fee Related
- 1999-10-13 CA CA002346289A patent/CA2346289A1/en not_active Abandoned
- 1999-10-13 EP EP99949224A patent/EP1121361B1/de not_active Expired - Lifetime
- 1999-10-13 ES ES99949224T patent/ES2291043T3/es not_active Expired - Lifetime
- 1999-10-13 AU AU62199/99A patent/AU760688B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| ES2291043T3 (es) | 2008-02-16 |
| AU760688B2 (en) | 2003-05-22 |
| EP1121361B1 (de) | 2007-08-29 |
| JP2002527519A (ja) | 2002-08-27 |
| AU6219999A (en) | 2000-05-08 |
| CA2346289A1 (en) | 2000-04-27 |
| EP1121361A1 (de) | 2001-08-08 |
| DE69936998D1 (de) | 2007-10-11 |
| US6476030B1 (en) | 2002-11-05 |
| WO2000023449A1 (en) | 2000-04-27 |
| DE69936998T2 (de) | 2008-05-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69936998D1 (de) | Pyrazolotriazinderivate als gaba-rezeptorliganden | |
| DE60012044D1 (de) | Imidazopyridinderivate als liganden für gaba-rezeptoren | |
| MA27119A1 (fr) | Modulateurs tetrahydropyranyle cyclopentyle tetrahydropyrido pyridine de l'activite d'un recepteur de chimiokine | |
| PT841929E (pt) | Quinolonas e sua utilizacao terapeutica | |
| ES2195943T3 (es) | Compuestos heteroaromaticos biciclicos y triciclicos. | |
| DK0915866T3 (da) | Forbedret fremgangsmåde til syntese af beskyttende estere af (S)-3,4-dihydroxysmørsyre | |
| GB0212048D0 (en) | Therapeutic agents | |
| TR199900047T2 (xx) | Gaba resept�rleri ligandlar� olarak ikame triazolo-piridazin t�revleri | |
| EP1501507A4 (de) | Tetrahydropyranyl-cyclopentyl-tetrahydropyridopyridin-modulatoren der chemokin-rezeptor-aktivität | |
| EA199700156A1 (ru) | Производные индола как антагонисты рецептора 5-нт | |
| DE60207416D1 (de) | Imidazotriazin-derivate als gaba-rezeptor-liganden | |
| DE60115282D1 (de) | Imidazotriazin-derivate als liganden für gaba-rezeptoren | |
| DE69823648D1 (de) | 1-phenyl-4-benzylpiperazine: spezifische liganden für den dopamin rezeptor (d4) | |
| NO975663L (no) | Semikarbazoner med CNS aktivitet og farmasöytiske preparater inneholdende de samme | |
| EE200300455A (et) | Imidasopürimidiini derivaadid, nende valmistamisprotsess ja kasutamine ning farmatseutiline kompositsioon | |
| DE69617700D1 (de) | Neue kondensierten isochinoline als dopamin-rezeptor-liganden | |
| DE60235365D1 (de) | Verfahren zur herstellung von 7-amino-syn-3,5-dihydroxyheptansäurederivaten und zwischenverbindungen diesesverfahrens und deren herestellung | |
| AP9801410A0 (en) | Indoline derivatives useful as 5-HT-2C receptor antagonists. | |
| YU59100A (sh) | Postupak za dobijanje pirazolo (4,3-d) pirimidin-7-ona-3-piridilsulfonil jedinjenja i njihova intermedijera | |
| DE69703115D1 (de) | Zwischenprodukte um 2-imidazolin-5onederivate herzustellen. | |
| DE69906243D1 (de) | 2-Indanmethanolderivate und ihre Verwendung als Riechstoffe | |
| DE60002292D1 (de) | (3,4-dihydro-2h-benzo[1,4]oxazinyl-methyl)-3-(1h-indol-3-yl)-alkylamine | |
| MA24904A1 (fr) | Procede de preparation d'intermediaires pesticides | |
| DE69909097D1 (de) | 5-bicycloindolverbindungen | |
| NO20060586L (no) | 7-substituerte-3-nitro-pyrazol[1,5-a]pyrimidiner |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |