BG106846A - Нови хетероарилни производни, тяхното получаване и употреба - Google Patents

Нови хетероарилни производни, тяхното получаване и употреба

Info

Publication number
BG106846A
BG106846A BG106846A BG10684602A BG106846A BG 106846 A BG106846 A BG 106846A BG 106846 A BG106846 A BG 106846A BG 10684602 A BG10684602 A BG 10684602A BG 106846 A BG106846 A BG 106846A
Authority
BG
Bulgaria
Prior art keywords
cr6r7
heteroaryl derivatives
preparation
disorders
compulsive
Prior art date
Application number
BG106846A
Other languages
English (en)
Inventor
Thomas Ruhland
- JENSEN Christian KROG
Ivan Mikkelsen
Mario Rottlaender
Gitte Mikkelsen
Ejner Moltzen
Kim Andersen
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of BG106846A publication Critical patent/BG106846A/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/54—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)

Abstract

Хетероарилните производни, техните енантиомери или смес от тях, или тяхна присъединителна с киселина сол имат формула@@в която Х е -О-, -S- или -CR4R5-; и Y е -CR6R7-, -CR6R7-CR8R9- или -CR6=CR7-; или Х и Y заедно образуват група -CR4=CR5- или -CR4=CR5-CR6R7-; Z e -O- или -S-; W e N, C или СН; n има стойност 2, 3, 4, 5, 6, 7, 8, 9 или 10; m има стойност 2 или 3; А е О или S, като пунктирната линия означава по избор връзка. Съединенията са полезни при лечението на афектни разстройства, например общо чувство за мъчително безпокойство и страх, натраплива компулсивна невроза, депресия, социална фобия, хранителни разстройства както и неврологичниразстройства като психоза.
BG106846A 1999-12-30 2002-06-19 Нови хетероарилни производни, тяхното получаване и употреба BG106846A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA199901884 1999-12-30
PCT/DK2000/000741 WO2001049683A1 (en) 1999-12-30 2000-12-29 Novel heteroaryl derivatives, their preparation and use

Publications (1)

Publication Number Publication Date
BG106846A true BG106846A (bg) 2003-02-28

Family

ID=8108797

Family Applications (1)

Application Number Title Priority Date Filing Date
BG106846A BG106846A (bg) 1999-12-30 2002-06-19 Нови хетероарилни производни, тяхното получаване и употреба

Country Status (22)

Country Link
US (1) US20030050306A1 (bg)
EP (1) EP1246820A1 (bg)
JP (1) JP2003519229A (bg)
KR (1) KR20020063286A (bg)
CN (1) CN1414963A (bg)
AR (1) AR027133A1 (bg)
AU (1) AU2352001A (bg)
BG (1) BG106846A (bg)
BR (1) BR0016954A (bg)
CA (1) CA2395984A1 (bg)
CZ (1) CZ20022280A3 (bg)
EA (1) EA200200733A1 (bg)
HU (1) HUP0204084A3 (bg)
IL (1) IL149993A0 (bg)
IS (1) IS6403A (bg)
NO (1) NO20023188L (bg)
NZ (1) NZ519478A (bg)
PL (1) PL355610A1 (bg)
SK (1) SK9432002A3 (bg)
TR (1) TR200201679T2 (bg)
WO (1) WO2001049683A1 (bg)
ZA (1) ZA200204464B (bg)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE424825T1 (de) 2001-07-20 2009-03-15 Psychogenics Inc Behandlung von hyperaktivitätsstörungen und aufmerksamkeitsdefiziten
TWI320783B (en) 2005-04-14 2010-02-21 Otsuka Pharma Co Ltd Heterocyclic compound
AR055203A1 (es) * 2005-08-31 2007-08-08 Otsuka Pharma Co Ltd Derivados de benzotiofeno con propiedades antipsicoticas
ES2528797T3 (es) 2006-08-21 2015-02-12 Genentech, Inc. Compuestos de aza-benzotiofenilo y métodos de uso
JP4785881B2 (ja) * 2007-02-27 2011-10-05 大塚製薬株式会社 医薬

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK148392D0 (da) * 1992-12-09 1992-12-09 Lundbeck & Co As H Heterocykliske forbindelser
IT1266582B1 (it) * 1993-07-30 1997-01-09 Recordati Chem Pharm Derivati (di)azacicloesanici e diazacicloeptanici
AR022303A1 (es) * 1999-01-22 2002-09-04 Lundbeck & Co As H Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion

Also Published As

Publication number Publication date
NO20023188D0 (no) 2002-07-01
CN1414963A (zh) 2003-04-30
CZ20022280A3 (cs) 2002-10-16
HUP0204084A2 (hu) 2003-03-28
IS6403A (is) 2002-05-31
PL355610A1 (en) 2004-05-04
WO2001049683A1 (en) 2001-07-12
SK9432002A3 (en) 2002-11-06
AU2352001A (en) 2001-07-16
BR0016954A (pt) 2003-04-29
HUP0204084A3 (en) 2005-02-28
CA2395984A1 (en) 2001-07-12
JP2003519229A (ja) 2003-06-17
EA200200733A1 (ru) 2002-12-26
NZ519478A (en) 2004-02-27
US20030050306A1 (en) 2003-03-13
EP1246820A1 (en) 2002-10-09
KR20020063286A (ko) 2002-08-01
ZA200204464B (en) 2003-09-04
NO20023188L (no) 2002-07-01
TR200201679T2 (tr) 2002-10-21
IL149993A0 (en) 2002-12-01
AR027133A1 (es) 2003-03-12

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