|
US4039653A
(en)
*
|
1974-01-23 |
1977-08-02 |
Defoney, Brenman, Mayes & Baron |
Long-acting articles for oral delivery and process
|
|
CH653021A5
(fr)
|
1981-04-24 |
1985-12-13 |
Delalande Sa |
Derives piperidino, piperazino et homopiperazino, n-substitues par un groupe heterocyclique aromatique, leur procede de preparation et composition therapeutique les contenant.
|
|
FR2524312B1
(fr)
*
|
1982-04-01 |
1985-10-04 |
Tech Cuir Centre |
Nouvelles formes de micro-encapsulation de substances medicamenteuses par des couches homogenes de collagene natif
|
|
AU577802B2
(en)
|
1983-10-17 |
1988-10-06 |
Duphar International Research B.V. |
Blood-pressure lowering piperazine derivatives
|
|
EP0189612B1
(de)
|
1984-12-21 |
1992-11-04 |
Duphar International Research B.V |
Arzneimittel mit psychotroper Wirkung
|
|
EP0190472B1
(de)
|
1984-12-21 |
1989-07-12 |
Duphar International Research B.V |
Arzneimittel mit antipsychotischer Wirkung
|
|
GB8521494D0
(en)
*
|
1985-08-29 |
1985-10-02 |
Zyma Sa |
Controlled release tablet
|
|
US4797286A
(en)
*
|
1985-11-12 |
1989-01-10 |
Eli Lilly And Company |
Orally administerable sustained release pharmaceutical formulations
|
|
DE3782525T2
(de)
|
1986-02-27 |
1993-05-27 |
Duphar Int Res |
Aryl-substituierte(n-piperidinyl)methyl und (n-piperazinyl)methylazole mit antipsychotischer wirkung.
|
|
GB8613689D0
(en)
*
|
1986-06-05 |
1986-07-09 |
Euro Celtique Sa |
Pharmaceutical composition
|
|
MX173362B
(es)
|
1987-03-02 |
1994-02-23 |
Pfizer |
Compuestos de piperazinil heterociclicos y procedimiento para su preparacion
|
|
IE74200B1
(en)
|
1987-09-11 |
1997-07-16 |
Duphar Int Res |
Anxiolytically active piperazine derivatives
|
|
US4831031A
(en)
|
1988-01-22 |
1989-05-16 |
Pfizer Inc. |
Aryl piperazinyl-(C2 or C4) alkylene heterocyclic compounds having neuroleptic activity
|
|
IL92544A0
(en)
|
1988-12-08 |
1990-08-31 |
Duphar Int Res |
Piperazine derivatives,their preparation and pharmaceutical compositions containing them
|
|
GB8830312D0
(en)
|
1988-12-28 |
1989-02-22 |
Lundbeck & Co As H |
Heterocyclic compounds
|
|
SE8904361D0
(sv)
|
1989-12-22 |
1989-12-22 |
Astra Ab |
New chroman and thiochroman derivatives
|
|
FR2670491B1
(fr)
|
1990-12-14 |
1993-02-05 |
Adir |
Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant.
|
|
MX9201991A
(es)
|
1991-05-02 |
1992-11-01 |
Jonh Wyeth & Brother Limited |
Derivados de piperazina y procedimiento para su preparacion.
|
|
IT1251144B
(it)
|
1991-07-30 |
1995-05-04 |
Boehringer Ingelheim Italia |
Derivati del benzimidazolone
|
|
GB9125900D0
(en)
|
1991-12-05 |
1992-02-05 |
Wyeth John & Brother Ltd |
Piperazine derivatives
|
|
EP0556889A1
(de)
|
1992-02-18 |
1993-08-25 |
Duphar International Research B.V |
Verfahren zur Herstellung von Aryl(Homo)Piperazine
|
|
FR2692264B1
(fr)
|
1992-06-12 |
1994-08-05 |
Adir |
Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
|
|
DK148392D0
(da)
|
1992-12-09 |
1992-12-09 |
Lundbeck & Co As H |
Heterocykliske forbindelser
|
|
EP0939135A1
(de)
|
1992-12-21 |
1999-09-01 |
Duphar International Research B.V |
Wesentlich saubere hetero-bicyclische Alkohol-Enantiomeren
|
|
RU2118322C1
(ru)
|
1993-07-05 |
1998-08-27 |
Дюфар Интернэшнл Рисерч Б.В. |
2,3-дигидро-1,4-бензодиокси-5-ил-пиперазиновые производные или их соли
|
|
WO1995003801A1
(en)
*
|
1993-07-28 |
1995-02-09 |
Nippon Shinyaku Co., Ltd. |
Antidepressant
|
|
WO1995011243A1
(en)
|
1993-10-19 |
1995-04-27 |
Smithkline Beecham Plc |
Benzanilide derivatives as 5ht-1d receptor antagonists
|
|
EP0650964A1
(de)
|
1993-11-02 |
1995-05-03 |
Duphar International Research B.V |
1- 2H-1-Benzopyran-2-on-8-yl -Piperazin Derivate
|
|
IL112764A0
(en)
|
1994-03-18 |
1995-05-26 |
Ferrer Int |
New chromene derivatives
|
|
FI965238L
(fi)
|
1994-06-29 |
1996-12-27 |
Pfizer |
Aryyli- ja heteroaryylialkoksinaftaleenijohdannaiset
|
|
FR2725623A1
(fr)
*
|
1994-10-18 |
1996-04-19 |
Flamel Tech Sa |
Microcapsules medicamenteuses et/ou nutritionnelles pour administration per os
|
|
EP0710481A1
(de)
|
1994-11-02 |
1996-05-08 |
Duphar International Research B.V |
Verwendung von Flesinoxan zur Wahrnehmungssteigerung
|
|
WO1996017831A1
(de)
|
1994-12-07 |
1996-06-13 |
Byk Gulden Lomberg Chemische Fabrik Gmbh |
Uracilderivate
|
|
US5741789A
(en)
*
|
1995-01-17 |
1998-04-21 |
Eli Lilly And Company |
Compounds having effects on serotonin-related systems
|
|
US6114334A
(en)
|
1995-07-13 |
2000-09-05 |
Knoll Aktiengesellschaft |
Piperazine derivatives as therapeutic agents
|
|
GB9514901D0
(en)
|
1995-07-20 |
1995-09-20 |
American Home Prod |
Piperazine derivatives
|
|
WO1997007120A1
(en)
|
1995-08-11 |
1997-02-27 |
Smithkline Beecham Plc |
Biphenyl(thio)amide and biphenylethan(thi)one derivatives, their preparation and their use as 5-ht1d receptor antagonists
|
|
SE9601110D0
(sv)
|
1996-03-22 |
1996-03-22 |
Astra Ab |
Substituted 1,2,3,4-tetrahydronaphthalene derivatives
|
|
JP3989554B2
(ja)
|
1996-03-29 |
2007-10-10 |
デユフアー・インターナシヨナル・リサーチ・ベー・ブイ |
ピペラジンおよびピペリジン化合物
|
|
US5846982A
(en)
*
|
1996-06-14 |
1998-12-08 |
Eli Lilly And Company |
Inhibition of serotonin reuptake
|
|
DK0932609T3
(da)
|
1996-10-15 |
2003-09-01 |
Wyeth Corp |
Azaheterocyclomethylderivater af 2,3,8,9-tetrahydro-7H-1,4-dioxino[2,3-e]indol-8-on
|
|
JPH10269708A
(ja)
|
1997-03-25 |
1998-10-09 |
Hiroshi Fukuda |
多信号用メモリーシステム
|
|
FR2760014B1
(fr)
|
1997-02-27 |
1999-04-09 |
Adir |
Nouveaux composes de 2-amino indane, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
GB9706089D0
(en)
*
|
1997-03-24 |
1997-05-14 |
Scherer Ltd R P |
Pharmaceutical composition
|
|
DE19730989A1
(de)
*
|
1997-07-18 |
1999-01-21 |
Merck Patent Gmbh |
Piperazin-Derivate
|
|
KR100545329B1
(ko)
|
1997-07-25 |
2006-01-24 |
하. 룬트벡 아크티에 셀스카브 |
인돌 및 2,3-디히드로인돌 유도체, 그들의 제조방법 및 사용
|
|
US5942244A
(en)
*
|
1997-07-31 |
1999-08-24 |
Farmo-Nat Ltd. |
Local oral herbal slow release tablets
|
|
ATE253058T1
(de)
|
1997-09-02 |
2003-11-15 |
Duphar Int Res |
Piperidin- und piperazin derivate als 5-ht1- rezeptor-agonisten
|
|
SE9703376D0
(sv)
*
|
1997-09-18 |
1997-09-18 |
Astra Ab |
A new combination
|
|
SE9703374D0
(sv)
*
|
1997-09-18 |
1997-09-18 |
Astra Ab |
A new combination
|
|
SE9703378D0
(sv)
*
|
1997-09-18 |
1997-09-18 |
Astra Ab |
New compounds
|
|
SE9703375D0
(sv)
*
|
1997-09-18 |
1997-09-18 |
Astra Ab |
A new combination
|
|
TW530054B
(en)
|
1997-09-24 |
2003-05-01 |
Duphar Int Res |
New piperazine and piperidine compounds
|
|
FR2769312B1
(fr)
|
1997-10-03 |
1999-12-03 |
Adir |
Nouveaux composes de l'indanol, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
|
|
IL127497A
(en)
|
1997-12-18 |
2002-07-25 |
Pfizer Prod Inc |
Medicinal products containing piperazinyl-heterocyclic compounds for the treatment of psychiatric disorders
|
|
US6310066B1
(en)
|
1998-04-29 |
2001-10-30 |
American Home Products Corp. |
Antipsychotic indolyl derivatives
|
|
US6387904B2
(en)
|
1998-05-18 |
2002-05-14 |
Pfizer Inc |
Method of treating glaucoma and ischemic retinopathy
|
|
ATE247963T1
(de)
|
1998-05-26 |
2003-09-15 |
Pfizer Prod Inc |
Medikament zur behandlung von glaukoma und ischämischer retinopathie
|
|
GB9812523D0
(en)
*
|
1998-06-10 |
1998-08-05 |
Angeletti P Ist Richerche Bio |
Peptide inhibitors of hepatitis c virus ns3 protease
|
|
WO1999065887A1
(en)
|
1998-06-15 |
1999-12-23 |
American Home Products Corporation |
Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
|
|
US6376494B1
(en)
|
1998-06-15 |
2002-04-23 |
American Home Products Corporation |
Cycloalkyl-substituted aryl-piperazines, piperidines and tetrahydropyridines as serotonergic agents
|
|
UA71590C2
(en)
|
1998-11-13 |
2004-12-15 |
Duphar Int Res |
Piperazine and piperidine derivatives
|
|
US6242448B1
(en)
|
1998-12-17 |
2001-06-05 |
American Home Products Corporation |
Trisubstituted-oxazole derivatives as serotonin ligands
|
|
US6313126B1
(en)
|
1999-01-07 |
2001-11-06 |
American Home Products Corp |
Arylpiperazinyl-cyclohexyl indole derivatives for the treatment of depression
|
|
ES2219302T3
(es)
|
1999-01-07 |
2004-12-01 |
Wyeth |
Derivados de arilpiperazinil-ciclohexilindol para el tratamiento de la depresion.
|
|
AR022303A1
(es)
|
1999-01-22 |
2002-09-04 |
Lundbeck & Co As H |
Derivados de piperidina, tetrahidropiridina y piperazina, su preparacion y utilizacion
|
|
US6306859B1
(en)
|
1999-03-02 |
2001-10-23 |
American Home Products Corporation |
N-substituted imide derivatives with serotonergic activity
|
|
ES2162731B1
(es)
|
1999-06-04 |
2003-02-16 |
Faes Fabrica Espanola De Produ |
Nuevas arilpiperacilnilalquil-3(2h)-piridacinonas.
|
|
EP1204654B1
(de)
|
1999-07-29 |
2003-07-23 |
Eli Lilly And Company |
Benzofurylpiperazine: 5-ht2c serotoninrezeptor agonisten
|
|
ES2198329T3
(es)
|
1999-07-29 |
2004-02-01 |
Eli Lilly And Company |
Agonistas de la serotonina benzofurilpiperazina.
|
|
WO2001014330A2
(en)
|
1999-08-23 |
2001-03-01 |
Solvay Pharmaceuticals B.V. |
Phenylpiperazines as serotonin reuptake inhibitors
|
|
AR027133A1
(es)
|
1999-12-30 |
2003-03-12 |
Lundbeck & Co As H |
Derivados de heteroarilo, su preparacion y uso.
|
|
EP1283838B1
(de)
|
2000-05-12 |
2003-12-03 |
Solvay Pharmaceuticals B.V. |
Piperazin- und piperidinverbindungen
|
|
US20030186838A1
(en)
|
2000-05-12 |
2003-10-02 |
Feenstra Roelof W. |
Use of compounds having combined dopamine d2, 5-ht1a and alpha adrenoreceptor agonistic action for treating cns disorders
|
|
US20020016334A1
(en)
|
2000-07-31 |
2002-02-07 |
Coe Jotham Wadsworth |
Pharmaceutical composition for the treatment of attention deficit hyperactivity disorder (ADHD)
|
|
DE10041574A1
(de)
|
2000-08-24 |
2002-03-07 |
Merck Patent Gmbh |
Chromenonderivate
|
|
DE10043659A1
(de)
|
2000-09-05 |
2002-03-14 |
Merck Patent Gmbh |
Arylpiperazinderivate
|
|
US7034029B2
(en)
*
|
2000-11-02 |
2006-04-25 |
Wyeth |
1-aryl- or 1-alkylsulfonyl-heterocyclylbenzazoles as 5-hydroxytryptamine-6 ligands
|
|
JP4184077B2
(ja)
*
|
2000-11-02 |
2008-11-19 |
ワイス |
5−ヒドロキシトリプトアミン−6リガンドとしての1−アリールまたは1−アルキルスルホニル−ヘテロシクリルベンザゾール
|
|
US6469007B2
(en)
|
2000-11-28 |
2002-10-22 |
Wyeth |
Serotonergic agents
|
|
ES2188344B1
(es)
|
2000-11-29 |
2004-09-16 |
Laboratorios Vita, S.A. |
Compuestos derivados de benzotiofeno, su procedimiento de obtencion y utilizacion de los mismos.
|
|
AR032711A1
(es)
|
2001-02-21 |
2003-11-19 |
Solvay Pharm Bv |
Derivados de fenilpiperazina, un metodo para la preparacion de los mismos y una composicion farmaceutica que los contiene
|
|
MXPA03011769A
(es)
|
2001-06-29 |
2004-04-02 |
Lundbeck & Co As H |
Derivados de heteroarilo novedosos, su preparacion y uso.
|
|
ES2323451T7
(es)
*
|
2001-07-20 |
2011-08-01 |
Psychogenics Inc. |
Tratamiento para el trastorno de hiperactividad con deficit de atencion.
|
|
HU227237B1
(en)
|
2001-09-27 |
2010-12-28 |
Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag |
Substituted alkylpyridazinone derivatives, process for their preparation, pharmaceutical compositions containing them
|
|
ITMI20012060A1
(it)
|
2001-10-05 |
2003-04-05 |
Recordati Chem Pharm |
Nuovi eterocilcli n-acilati
|
|
EP1336406A1
(de)
|
2002-02-14 |
2003-08-20 |
Solvay Pharmaceuticals B.V. |
Partieller Dopamin-D2 Rezeptoragonist plus Substanzen mit Serotonin- und/oder Noradrenalin inhibitorischer Aktivität
|
|
WO2003074518A1
(en)
|
2002-03-06 |
2003-09-12 |
Merck Patent Gmbh |
Thiazole derivatives and their use d2- and 5-ht1a-receptor ligands
|
|
ES2329122T3
(es)
|
2002-03-12 |
2009-11-23 |
Wyeth |
Procedimiento para sintetizar n-aril piperazinas quirales.
|
|
JP4397693B2
(ja)
|
2002-03-12 |
2010-01-13 |
ワイス |
N1−(2’−ピリジル)−1,2−アルカンジアミンスルファミン酸の合成および生物学的に活性なピペラジンの合成におけるその使用
|
|
BR0308347A
(pt)
|
2002-03-12 |
2005-01-25 |
Wyeth Corp |
Processo para fabricação de piperazinas 1,4-dissubstituìdas quirais
|
|
PT1506179E
(pt)
|
2002-05-13 |
2006-06-30 |
Hoffmann La Roche |
Derivados de benzoxazina como moduladores de 5-ht6 e suas utilizacoes
|
|
US20040072839A1
(en)
|
2002-06-14 |
2004-04-15 |
Amedeo Leonardi |
1-Phenylalkylpiperazines
|
|
US20040002500A1
(en)
|
2002-06-28 |
2004-01-01 |
Fabre Kramer Pharmaceutical, Inc. |
Methods for treating attention deficit disorder
|
|
US7067518B2
(en)
|
2002-09-05 |
2006-06-27 |
Wyeth |
Pyridinyl-methyl-ethyl cyclohexanecarboxamides as serotonergic agents
|
|
US7153849B2
(en)
|
2002-09-12 |
2006-12-26 |
Wyeth |
Antidepressant arylpiperazine derivatives of hetrocycle-fused benzodioxans
|
|
PL377770A1
(pl)
|
2002-11-08 |
2006-02-20 |
F. Hoffmann-La Roche Ag |
Podstawione benzoksazynony i ich zastosowanie
|
|
HU227592B1
(en)
|
2002-11-13 |
2011-09-28 |
Egis Gyogyszergyar Nyilvanosan Muekoedoe Reszvenytarsasag |
Use of substituted alkyl-piridazinone derivatives for the treatment of memory decline and learning malfunctions
|
|
US20040147581A1
(en)
|
2002-11-18 |
2004-07-29 |
Pharmacia Corporation |
Method of using a Cox-2 inhibitor and a 5-HT1A receptor modulator as a combination therapy
|
|
GB0227240D0
(en)
|
2002-11-21 |
2002-12-31 |
Glaxo Group Ltd |
Compounds
|
|
DE10259244A1
(de)
|
2002-12-17 |
2004-07-01 |
Merck Patent Gmbh |
N-(Indolethyl-)cycloamin-Verbindungen
|
|
US20050004105A1
(en)
|
2003-01-29 |
2005-01-06 |
Emer Leahy |
Treatment for a attention-deficit hyperactivity disorder
|
|
KR100751604B1
(ko)
|
2003-03-03 |
2007-08-22 |
에프. 호프만-라 로슈 아게 |
5-ht6 조절자로서 사용되는 2,5- 및 2,6-치환된테트라하이드로아이소퀴놀린
|
|
MXPA05012320A
(es)
|
2003-05-16 |
2006-01-30 |
Pfizer Prod Inc |
Tratamientos de trastornos bipolares y sintomas asociados.
|
|
CA2525868A1
(en)
|
2003-05-16 |
2004-11-25 |
Pfizer Products Inc. |
Anxiety treatments with ziprasidone
|
|
EP1633360A1
(de)
|
2003-05-16 |
2006-03-15 |
Pfizer Products Incorporated |
Behandlung von psychotischen und depressiven erkrankungen
|
|
MXPA05012325A
(es)
|
2003-05-16 |
2006-01-30 |
Pfizer Prod Inc |
Procedimiento para potenciar la cognicion usando zipirasidona.
|
|
US20050065158A1
(en)
|
2003-07-16 |
2005-03-24 |
Pfizer Inc. |
Treatment of sexual dysfunction
|
|
GB0316915D0
(en)
|
2003-07-18 |
2003-08-20 |
Glaxo Group Ltd |
Compounds
|
|
US7435738B2
(en)
|
2003-08-18 |
2008-10-14 |
Solvay Pharmaceuticals, Inc. |
Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate)
|
|
US7160888B2
(en)
|
2003-08-22 |
2007-01-09 |
Warner Lambert Company Llc |
[1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia
|
|
ATE371653T1
(de)
|
2003-12-09 |
2007-09-15 |
Hoffmann La Roche |
Benzoxazinderivate und deren verwendungen
|
|
WO2005063296A2
(en)
|
2003-12-23 |
2005-07-14 |
Pfizer Products Inc. |
Therapeutic combination for cognition enhancement and psychotic disorders
|