BG107330A - Substituted imidazoles as tafia inhibitors - Google Patents

Substituted imidazoles as tafia inhibitors

Info

Publication number: BG107330A
Authority: BG; Bulgaria
Prior art keywords: tafia inhibitors; substituted imidazoles; compounds; tafia; inhibitors
Prior art date: 2000-08-17

Application number

BG107330A

Other languages

Bulgarian (bg)

English (en)

Inventor

Charlotte ALLERTON

Julian Blagg

Mark Bunnage

John Steele

Original Assignee

Pfizer Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-17

Filing date

2002-11-28

Publication date

2003-06-30

2000-08-17 Priority claimed from GB0020346A external-priority patent/GB0020346D0/en

2000-11-09 Priority claimed from GB0027409A external-priority patent/GB0027409D0/en

2000-12-04 Priority claimed from GB0029556A external-priority patent/GB0029556D0/en

2002-11-28 Application filed by Pfizer Inc. filed Critical Pfizer Inc.

2003-06-30 Publication of BG107330A publication Critical patent/BG107330A/xx

Links

239000003112 inhibitor Substances 0.000 title abstract 2
150000002460 imidazoles Chemical class 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
201000001320 Atherosclerosis Diseases 0.000 abstract 1
101800004538 Bradykinin Proteins 0.000 abstract 1
QXZGBUJJYSLZLT-UHFFFAOYSA-N H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg-OH Natural products NC(N)=NCCCC(N)C(=O)N1CCCC1C(=O)N1C(C(=O)NCC(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CO)C(=O)N2C(CCC2)C(=O)NC(CC=2C=CC=CC=2)C(=O)NC(CCCN=C(N)N)C(O)=O)CCC1 QXZGBUJJYSLZLT-UHFFFAOYSA-N 0.000 abstract 1
102100035792 Kininogen-1 Human genes 0.000 abstract 1
206010028980 Neoplasm Diseases 0.000 abstract 1
QXZGBUJJYSLZLT-FDISYFBBSA-N bradykinin Chemical compound NC(=N)NCCC[C@H](N)C(=O)N1CCC[C@H]1C(=O)N1[C@H](C(=O)NCC(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CO)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)CCC1 QXZGBUJJYSLZLT-FDISYFBBSA-N 0.000 abstract 1
201000011510 cancer Diseases 0.000 abstract 1
230000002500 effect on skin Effects 0.000 abstract 1
230000002708 enhancing effect Effects 0.000 abstract 1
230000003176 fibrotic effect Effects 0.000 abstract 1
208000027866 inflammatory disease Diseases 0.000 abstract 1
230000037390 scarring Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Dermatology (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Reproductive Health (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Physical Education & Sports Medicine (AREA)
Hematology (AREA)
Orthopedic Medicine & Surgery (AREA)
Rheumatology (AREA)
Surgery (AREA)
Endocrinology (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Gynecology & Obstetrics (AREA)
Psychiatry (AREA)
Pregnancy & Childbirth (AREA)

BG107330A 2000-08-17 2002-11-28 Substituted imidazoles as tafia inhibitors BG107330A (en)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
GB0020346A GB0020346D0 (en)	2000-08-17	2000-08-17	Pharmaceuticals
GB0027409A GB0027409D0 (en)	2000-11-09	2000-11-09	Pharmaceuticals
GB0029556A GB0029556D0 (en)	2000-12-04	2000-12-04	Pharmaceuticals
PCT/IB2001/001425 WO2002014285A1 (fr)	2000-08-17	2001-08-08	Imidazoles substitues utilises comme inhibiteurs tafia

Publications (1)

Publication Number	Publication Date
BG107330A true BG107330A (en)	2003-06-30

Family

ID=27255849

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG107330A BG107330A (en)	2000-08-17	2002-11-28	Substituted imidazoles as tafia inhibitors

Country Status (38)

Country	Link
EP (1)	EP1311488B1 (fr)
JP (2)	JP4119746B2 (fr)
KR (1)	KR20030022412A (fr)
CN (1)	CN1443173A (fr)
AP (1)	AP1375A (fr)
AR (1)	AR035580A1 (fr)
AT (1)	ATE447557T1 (fr)
AU (1)	AU2001276605A1 (fr)
BG (1)	BG107330A (fr)
BR (1)	BR0113289A (fr)
CA (1)	CA2419633C (fr)
CY (1)	CY1109693T1 (fr)
CZ (1)	CZ2003388A3 (fr)
DE (1)	DE60140368D1 (fr)
DK (1)	DK1311488T3 (fr)
DO (1)	DOP2001000233A (fr)
EA (1)	EA005532B1 (fr)
EE (1)	EE200300070A (fr)
ES (1)	ES2334101T3 (fr)
HR (1)	HRP20030103A2 (fr)
HU (1)	HUP0303763A3 (fr)
IL (1)	IL153225A0 (fr)
IS (1)	IS6638A (fr)
MA (1)	MA26940A1 (fr)
MX (1)	MXPA03001425A (fr)
NO (1)	NO20030706L (fr)
NZ (1)	NZ522823A (fr)
OA (1)	OA12362A (fr)
PA (1)	PA8525401A1 (fr)
PE (1)	PE20020352A1 (fr)
PL (1)	PL361054A1 (fr)
PT (1)	PT1311488E (fr)
SI (1)	SI1311488T1 (fr)
SK (1)	SK1732003A3 (fr)
SV (1)	SV2002000602A (fr)
TN (1)	TNSN01126A1 (fr)
UY (1)	UY26889A1 (fr)
WO (1)	WO2002014285A1 (fr)

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SE0103272D0 (sv)	2001-09-28	2001-09-28	Astrazeneca Ab	Chemical compounds
CN1620291A (zh) *	2002-01-22	2005-05-25	美国辉瑞有限公司	作为tafia抑制剂的3－(咪唑基)－2－烷氧基丙酸
US6713496B2 (en)	2002-01-22	2004-03-30	Pfizer Inc	3-(imidazolyl)-2-alkoxypropanoic acids
JP2005516972A (ja)	2002-01-22	2005-06-09	ファイザー・インク	血栓疾患の治療のためのｔａｆｉ−ａ阻害剤として使用される３−（イミダゾリル）−２−アミノプロピオン酸
ATE453865T1 (de) *	2003-04-29	2010-01-15	Univ Zuerich	An einem biomolekül gebundenen n epsilon- und/oder n alpha derivatisiertem und organisch- geschütztem l-histidin zur hoch-effizienter markierung mit (m(h2o)3(co)3)+ mittels fac koordinierung
SE0302853D0 (sv) *	2003-10-29	2003-10-29	Astrazeneca Ab	Chemical compounds
JP2007509898A (ja) *	2003-11-03	2007-04-19	プロビオドルグエージー	神経障害治療に有用な組合せ
WO2005051384A1 (fr) *	2003-11-25	2005-06-09	Pfizer Limited	Compositions pharmaceutiques stabilisees
JP2008536923A (ja) *	2005-04-18	2008-09-11	バイエル・シェーリング・ファルマ・アクチェンゲゼルシャフト	心筋の再灌流の増強およびｐｃｉの容易化のためのｔａｆｉ阻害剤の使用
DE102005049385A1 (de) *	2005-10-15	2007-04-19	Sanofi-Aventis Deutschland Gmbh	Imidazolderivate als Inhibitoren von TAFIa
WO2008067909A2 (fr) *	2006-12-06	2008-06-12	Sanofi-Aventis	Dérivés d'urée et de sulfamides utilisés comme inhibiteurs de tafi-a
EP2262783A2 (fr) *	2008-02-21	2010-12-22	Sanofi-Aventis	Sondes d'imagerie à liaison covalente
WO2010050525A1 (fr) *	2008-10-29	2010-05-06	大正製薬株式会社	Composé ayant une activité inhibitrice des tafia
FR2947266B1 (fr) *	2009-06-26	2011-06-17	Servier Lab	Nouveaux derives d'acide 2-mercaptocyclopentanecarboxylique, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
ES2643132T3 (es)	2010-03-18	2017-11-21	Daiichi Sankyo Company, Limited	Derivado de imidazol cicloalquilo sustituido
ES2608779T3 (es) *	2010-03-18	2017-04-17	Daiichi Sankyo Company, Limited	Derivado de ácido ciclopropanocarboxílico
KR20170034950A (ko) *	2011-05-17	2017-03-29	조인트 스톡 컴퍼니 “파르마신세즈”	부착과정의 예방과 치료를 위한 p38 MAP 키나아제 저해제 조성물
DK2734508T3 (en) *	2011-07-22	2018-05-22	Cambrex Karlskoga Ab	NEW PROCEDURES FOR THE PREPARATION OF 4-SUBSTITUTED IMIDAZOLS
WO2013039202A1 (fr) *	2011-09-15	2013-03-21	第一三共株式会社	Nouveau dérivé d'acide acrylique
RU2015156612A (ru)	2013-06-10	2017-07-17	Санофи	Макроциклические производные мочевины в качестве ингибиторов tafia, их получение и их применение в качестве фармацевтических средств
KR102667385B1 (ko)	2015-10-07	2024-05-21	미토브리지, 인크.	Ppar 효능제, 화합물, 제약 조성물, 및 그의 사용 방법
FR3046793B1 (fr) *	2016-01-14	2018-01-05	Les Laboratoires Servier	Nouveaux derives de phosphinanes et azaphosphinanes, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
KR20180123038A (ko) *	2016-03-29	2018-11-14	다이이찌 산쿄 가부시키가이샤	염증성 장질환 치료제
JP6925367B2 (ja) *	2016-04-13	2021-08-25	ミトブリッジ，インコーポレーテッド	Ｐｐａｒアゴニスト、化合物、医薬組成物、及びその使用方法
CN113943255B (zh) *	2020-07-17	2024-08-06	深圳信立泰药业股份有限公司	一种手性3-(4-环丙基-2,5-二氧杂咪唑啉-4-基)丙酸的制备方法

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JPS6163661A (ja) *	1984-09-05	1986-04-01	Microbial Chem Res Found	ヒスタジン関連化合物
US5993815A (en) *	1996-11-08	1999-11-30	University Of Vermont	Methods and compositions for inhibiting the activation of thrombin-activatable fibrinolysis inhibitor (TAFI)
SE9901572D0 (sv) *	1999-05-03	1999-05-03	Astra Ab	New compounds

2001
- 2001-08-08 AT AT01954264T patent/ATE447557T1/de active
- 2001-08-08 SK SK173-2003A patent/SK1732003A3/sk unknown
- 2001-08-08 CA CA2419633A patent/CA2419633C/fr not_active Expired - Fee Related
- 2001-08-08 NZ NZ522823A patent/NZ522823A/en unknown
- 2001-08-08 PT PT01954264T patent/PT1311488E/pt unknown
- 2001-08-08 CN CN01813131A patent/CN1443173A/zh active Pending
- 2001-08-08 CZ CZ2003388A patent/CZ2003388A3/cs unknown
- 2001-08-08 EP EP01954264A patent/EP1311488B1/fr not_active Expired - Lifetime
- 2001-08-08 IL IL15322501A patent/IL153225A0/xx unknown
- 2001-08-08 EA EA200201239A patent/EA005532B1/ru not_active IP Right Cessation
- 2001-08-08 EE EEP200300070A patent/EE200300070A/xx unknown
- 2001-08-08 DK DK01954264T patent/DK1311488T3/da active
- 2001-08-08 MX MXPA03001425A patent/MXPA03001425A/es active IP Right Grant
- 2001-08-08 PL PL36105401A patent/PL361054A1/xx not_active Application Discontinuation
- 2001-08-08 ES ES01954264T patent/ES2334101T3/es not_active Expired - Lifetime
- 2001-08-08 AU AU2001276605A patent/AU2001276605A1/en not_active Abandoned
- 2001-08-08 JP JP2002519428A patent/JP4119746B2/ja not_active Expired - Fee Related
- 2001-08-08 KR KR10-2003-7002279A patent/KR20030022412A/ko not_active Ceased
- 2001-08-08 WO PCT/IB2001/001425 patent/WO2002014285A1/fr not_active Ceased
- 2001-08-08 HU HU0303763A patent/HUP0303763A3/hu unknown
- 2001-08-08 OA OA1200300039A patent/OA12362A/fr unknown
- 2001-08-08 DE DE60140368T patent/DE60140368D1/de not_active Expired - Lifetime
- 2001-08-08 HR HR20030103A patent/HRP20030103A2/hr not_active Application Discontinuation
- 2001-08-08 SI SI200130950T patent/SI1311488T1/sl unknown
- 2001-08-08 BR BR0113289-0A patent/BR0113289A/pt not_active Application Discontinuation
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- 2001-08-15 UY UY26889A patent/UY26889A1/es not_active Application Discontinuation
- 2001-08-16 TN TNTNSN01126A patent/TNSN01126A1/fr unknown
- 2001-08-16 AP APAP/P/2001/002250A patent/AP1375A/en active
- 2001-08-16 SV SV2001000602A patent/SV2002000602A/es unknown
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2002
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- 2002-11-28 BG BG107330A patent/BG107330A/xx unknown
2003
- 2003-02-04 MA MA27025A patent/MA26940A1/fr unknown
- 2003-02-14 NO NO20030706A patent/NO20030706L/no not_active Application Discontinuation
2008
- 2008-02-27 JP JP2008045382A patent/JP4778531B2/ja not_active Expired - Fee Related
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Also Published As

Publication number	Publication date
NZ522823A (en)	2004-11-26
JP2004506044A (ja)	2004-02-26
HRP20030103A2 (en)	2003-04-30
AP2001002250A0 (en)	2001-09-30
JP4119746B2 (ja)	2008-07-16
EA200201239A1 (ru)	2003-08-28
HUP0303763A2 (hu)	2004-04-28
NO20030706D0 (no)	2003-02-14
CY1109693T1 (el)	2014-08-13
CA2419633C (fr)	2011-05-10
SI1311488T1 (sl)	2010-01-29
AU2001276605A1 (en)	2002-02-25
TNSN01126A1 (fr)	2005-11-10
MXPA03001425A (es)	2003-06-06
PA8525401A1 (es)	2002-04-25
MA26940A1 (fr)	2004-12-20
EE200300070A (et)	2005-02-15
IL153225A0 (en)	2003-07-06
KR20030022412A (ko)	2003-03-15
PE20020352A1 (es)	2002-05-11
WO2002014285A1 (fr)	2002-02-21
CN1443173A (zh)	2003-09-17
EP1311488A1 (fr)	2003-05-21
ATE447557T1 (de)	2009-11-15
DE60140368D1 (de)	2009-12-17
EP1311488B1 (fr)	2009-11-04
SK1732003A3 (en)	2004-08-03
DK1311488T3 (da)	2010-01-04
UY26889A1 (es)	2002-03-22
CA2419633A1 (fr)	2002-02-21
ES2334101T3 (es)	2010-03-05
BR0113289A (pt)	2003-06-17
HUP0303763A3 (en)	2004-06-28
SV2002000602A (es)	2002-10-24
PL361054A1 (en)	2004-09-20
AR035580A1 (es)	2004-06-16
JP2008169224A (ja)	2008-07-24
OA12362A (en)	2004-04-07
NO20030706L (no)	2003-04-15
CZ2003388A3 (cs)	2004-03-17
IS6638A (is)	2002-11-28
DOP2001000233A (es)	2002-05-15
JP4778531B2 (ja)	2011-09-21
PT1311488E (pt)	2009-12-30
EA005532B1 (ru)	2005-04-28
AP1375A (en)	2005-03-03

Publication	Publication Date	Title
BG107330A (en)	2003-06-30	Substituted imidazoles as tafia inhibitors
BG105800A (en)	2002-03-29	Benzoheterocycles and their use as mek inhibitors
BG106585A (en)	2003-03-31	Kinase inhibitors as therapeutic agents
YU3902A (sh)	2006-01-16	Imidazoimidazoli i triazoli kao anti-inflamatorna sredstva
HK1049656A1 (zh)	2003-05-23	Fab i抑制剂
PL372926A1 (en)	2005-08-08	Piperidine-pyridazones and phthalazones as pde4 inhibitors
EG25017A (en)	2011-05-25	N-alkyl-4-methyleneamino-3-hydroxy-2-pyridones as antimicrobials.
EP1171428A4 (fr)	2004-09-15	Inhibiteurs de fab i
DE60121345D1 (de)	2006-08-17	Alkylierte imidazopyridinderivate
PL365116A1 (en)	2004-12-27	Prodrugs of imidazopyridine derivatives
ATE265455T1 (de)	2004-05-15	Tetrahydropyridoverbindungen
MY128164A (en)	2007-01-31	Compounds
NO20015892L (no)	2001-12-19	Inhibitorer av metallproteinaser
PL377176A1 (pl)	2006-01-23	N-Sulfonylo-4-metylenoamino-3-hydroksy-2-pirydony
DE60011677D1 (en)	2004-07-22	Tryptase-inhibitoren
PT1244614E (pt)	2004-10-29	Inibidores de triptase
AU2003259159A1 (en)	2004-02-25	N-aryl-2-oxazolidinones and their derivatives
DE60216920D1 (en)	2007-02-01	Tryptase-inhibitoren
IL150978A0 (en)	2003-02-12	Nitroacridine/tumor inhibitor compositions
DE60220504D1 (en)	2007-07-19	Tryptasehemmer
DE60120398D1 (de)	2006-07-20	Imidazopyridin-8-one
ITBO20000360A0 (it)	2000-06-16	Apparecchiatura di elettrostimolazione del corpo umano .