BG107360A - Стабилизиран фармацевтично ефективен състав и фармацевтична форма, която го съдържа - Google Patents

Стабилизиран фармацевтично ефективен състав и фармацевтична форма, която го съдържа Download PDF

Info

Publication number: BG107360A
Authority: BG; Bulgaria
Prior art keywords: substance; hmg; coa reductase; reductase inhibitor; crystallization
Prior art date: 2000-06-09

Application number

BG107360A

Other languages

Bulgarian (bg)

English (en)

Inventor

Zlatko Pflaum

Janez Kere

Original Assignee

Lek Pharmaceuticals D.D.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-09

Filing date

2002-12-06

Publication date

2003-11-28

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26318615&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG107360(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2002-12-06 Application filed by Lek Pharmaceuticals D.D. filed Critical Lek Pharmaceuticals D.D.

2003-11-28 Publication of BG107360A publication Critical patent/BG107360A/bg

Links

239000000470 constituent Substances 0.000 title 1
239000000203 mixture Substances 0.000 claims abstract description 68
229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims abstract description 58
239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims abstract description 58
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 53
239000000126 substance Substances 0.000 claims abstract description 50
239000006172 buffering agent Substances 0.000 claims abstract description 42
239000013543 active substance Substances 0.000 claims abstract description 40
TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 claims abstract description 25
229960002965 pravastatin Drugs 0.000 claims abstract description 25
TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims abstract description 25
238000000034 method Methods 0.000 claims abstract description 16
239000003795 chemical substances by application Substances 0.000 claims abstract description 11
XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims abstract description 10
XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims abstract description 10
229960005370 atorvastatin Drugs 0.000 claims abstract description 10
239000011230 binding agent Substances 0.000 claims abstract description 7
239000000945 filler Substances 0.000 claims abstract description 6
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical group CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 78
230000003113 alkalizing effect Effects 0.000 claims description 40
VWBQYTRBTXKKOG-IYNICTALSA-M pravastatin sodium Chemical compound [Na+].C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC([O-])=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 VWBQYTRBTXKKOG-IYNICTALSA-M 0.000 claims description 27
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-1 inorganic acid salts Chemical class 0.000 claims description 24
238000002288 cocrystallisation Methods 0.000 claims description 19
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ZGGHKIMDNBDHJB-NRFPMOEYSA-M (3R,5S)-fluvastatin sodium Chemical compound [Na+].C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 ZGGHKIMDNBDHJB-NRFPMOEYSA-M 0.000 claims description 7
SEERZIQQUAZTOL-ANMDKAQQSA-N cerivastatin Chemical compound COCC1=C(C(C)C)N=C(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC(O)=O)=C1C1=CC=C(F)C=C1 SEERZIQQUAZTOL-ANMDKAQQSA-N 0.000 claims description 7
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239000008240 homogeneous mixture Substances 0.000 claims description 7
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 6
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238000000975 co-precipitation Methods 0.000 claims description 2
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229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 abstract description 5
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AJLFOPYRIVGYMJ-UHFFFAOYSA-N SJ000287055 Natural products C12C(OC(=O)C(C)CC)CCC=C2C=CC(C)C1CCC1CC(O)CC(=O)O1 AJLFOPYRIVGYMJ-UHFFFAOYSA-N 0.000 abstract description 2
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238000006731 degradation reaction Methods 0.000 abstract description 2
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PCZOHLXUXFIOCF-BXMDZJJMSA-N lovastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 PCZOHLXUXFIOCF-BXMDZJJMSA-N 0.000 abstract description 2
QLJODMDSTUBWDW-UHFFFAOYSA-N lovastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(C)C=C21 QLJODMDSTUBWDW-UHFFFAOYSA-N 0.000 abstract description 2
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AJLFOPYRIVGYMJ-INTXDZFKSA-N mevastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=CCC[C@@H]([C@H]12)OC(=O)[C@@H](C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 AJLFOPYRIVGYMJ-INTXDZFKSA-N 0.000 abstract description 2
BOZILQFLQYBIIY-UHFFFAOYSA-N mevastatin hydroxy acid Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CCC=C21 BOZILQFLQYBIIY-UHFFFAOYSA-N 0.000 abstract description 2
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239000013078 crystal Substances 0.000 description 27
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CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 6
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238000002560 therapeutic procedure Methods 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Chemical class OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
239000001069 triethyl citrate Substances 0.000 description 1
VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
235000013769 triethyl citrate Nutrition 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Inorganic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Oil, Petroleum & Natural Gas (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pulmonology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)
Medicines Containing Plant Substances (AREA)

BG107360A 2000-06-09 2002-12-06 Стабилизиран фармацевтично ефективен състав и фармацевтична форма, която го съдържа BG107360A (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/IB2000/000773 WO2001093860A1 (en)	2000-06-09	2000-06-09	Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
US09/591,322 US6531507B1 (en)	2000-06-09	2000-06-09	Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same

Publications (1)

Publication Number	Publication Date
BG107360A true BG107360A (bg)	2003-11-28

Family

ID=26318615

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG107360A BG107360A (bg)	2000-06-09	2002-12-06	Стабилизиран фармацевтично ефективен състав и фармацевтична форма, която го съдържа

Country Status (19)

Country	Link
US (1)	US6531507B1 (de)
EP (1)	EP1292293B1 (de)
JP (1)	JP2004501121A (de)
AT (1)	ATE260101T1 (de)
AU (2)	AU2000249434B2 (de)
BG (1)	BG107360A (de)
CA (1)	CA2412326A1 (de)
CZ (1)	CZ20023826A3 (de)
DE (1)	DE60008608T2 (de)
ES (1)	ES2215050T3 (de)
HR (1)	HRP20020950A2 (de)
HU (1)	HUP0301325A3 (de)
NO (1)	NO20025784L (de)
PL (1)	PL362764A1 (de)
RU (1)	RU2246943C2 (de)
SI (1)	SI1292293T1 (de)
SK (1)	SK16982002A3 (de)
UA (1)	UA70410C2 (de)
WO (1)	WO2001093860A1 (de)

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US8163797B2 (en) *	2003-12-31	2012-04-24	Actavis Elizabeth Llc	Method of treating with stable pravastatin formulation
US20080242725A1 (en) *	2004-03-01	2008-10-02	Janez Kerc	Pharmaceutical Composition
CA2560252C (en)	2004-03-17	2009-08-04	Ranbaxy Laboratories Limited	Process for the production of atorvastatin calcium in amorphous form
US7491263B2 (en) *	2004-04-05	2009-02-17	Technology Innovation, Llc	Storage assembly
KR100598326B1 (ko) *	2004-04-10	2006-07-10	한미약품 주식회사	ＨＭＧ-ＣｏＡ 환원효소 억제제의 경구투여용 서방형 제제및 이의 제조방법
US20090042979A1 (en) *	2004-08-06	2009-02-12	Transform Pharmaceuticals Inc.	Novel Statin Pharmaceutical Compositions and Related Methods of Treatment
NZ552390A (en) *	2004-08-06	2010-01-29	Transform Pharmaceuticals Inc	Novel fenofibrate formulations and related methods of treatment
EP1786414A4 (de) *	2004-08-06	2008-04-09	Transform Pharmaceuticals Inc	Neue pharmazeutische statin-zusammensetzungen und relevante behandlungsverfahren
WO2006054308A2 (en)	2004-11-22	2006-05-26	Dexcel Pharma Technologies Ltd.	Stable atorvastatin formulations
AU2006208293A1 (en) *	2005-01-24	2006-08-03	Palmetto Pharmaceuticals, Llc	Methods of treating various conditions by administration of sustained release L-arginine
US20080182887A1 (en) *	2005-02-22	2008-07-31	Sun Pharmaceutical Industries Limited	Stable Oral Pharmaceutical Composition
US20060229277A1 (en) *	2005-04-08	2006-10-12	Orbus Pharma, Inc.	Stabilized pharmaceutical compositions comprising an HMG-CoA reductase inhibitor
JP4813841B2 (ja) *	2005-07-25	2011-11-09	キユーピー株式会社	プラバスタチンナトリウムの製造方法
EP1940391A4 (de) *	2005-08-05	2010-01-20	Orbus Pharma Inc	Stabilisierte pharmazeutische zusammensetzungen mit verlängerter freisetzung mit einem hmg-coa-reduktase-hemmer
WO2007020079A2 (en) *	2005-08-17	2007-02-22	Synthon B.V.	Orally disintegratable simvastatin tablets
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2000
- 2000-06-09 HR HRP20020950 patent/HRP20020950A2/hr not_active Application Discontinuation
- 2000-06-09 SK SK1698-2002A patent/SK16982002A3/sk not_active Application Discontinuation
- 2000-06-09 AU AU2000249434A patent/AU2000249434B2/en not_active Ceased
- 2000-06-09 HU HU0301325A patent/HUP0301325A3/hu unknown
- 2000-06-09 DE DE60008608T patent/DE60008608T2/de not_active Expired - Lifetime
- 2000-06-09 RU RU2002134764/15A patent/RU2246943C2/ru not_active IP Right Cessation
- 2000-06-09 PL PL00362764A patent/PL362764A1/xx not_active Application Discontinuation
- 2000-06-09 WO PCT/IB2000/000773 patent/WO2001093860A1/en not_active Ceased
- 2000-06-09 JP JP2002501433A patent/JP2004501121A/ja active Pending
- 2000-06-09 CZ CZ20023826A patent/CZ20023826A3/cs unknown
- 2000-06-09 ES ES00931486T patent/ES2215050T3/es not_active Expired - Lifetime
- 2000-06-09 EP EP00931486A patent/EP1292293B1/de not_active Revoked
- 2000-06-09 US US09/591,322 patent/US6531507B1/en not_active Expired - Fee Related
- 2000-06-09 AT AT00931486T patent/ATE260101T1/de active
- 2000-06-09 SI SI200030324T patent/SI1292293T1/xx unknown
- 2000-06-09 CA CA002412326A patent/CA2412326A1/en not_active Abandoned
- 2000-06-09 AU AU4943400A patent/AU4943400A/xx active Pending
- 2000-09-06 UA UA2002119464A patent/UA70410C2/uk unknown
2002
- 2002-12-02 NO NO20025784A patent/NO20025784L/no not_active Application Discontinuation
- 2002-12-06 BG BG107360A patent/BG107360A/bg unknown

Also Published As

Publication number	Publication date
NO20025784D0 (no)	2002-12-02
AU2000249434B2 (en)	2006-02-02
DE60008608T2 (de)	2004-12-30
PL362764A1 (en)	2004-11-02
EP1292293A1 (de)	2003-03-19
ES2215050T3 (es)	2004-10-01
SK16982002A3 (sk)	2003-04-01
NO20025784L (no)	2002-12-02
UA70410C2 (en)	2004-10-15
HUP0301325A2 (hu)	2003-11-28
CZ20023826A3 (cs)	2003-04-16
US6531507B1 (en)	2003-03-11
JP2004501121A (ja)	2004-01-15
EP1292293B1 (de)	2004-02-25
WO2001093860A1 (en)	2001-12-13
HUP0301325A3 (en)	2004-03-01
AU4943400A (en)	2001-12-17
CA2412326A1 (en)	2001-12-13
SI1292293T1 (en)	2004-06-30
DE60008608D1 (de)	2004-04-01
HRP20020950A2 (en)	2004-12-31
RU2246943C2 (ru)	2005-02-27
ATE260101T1 (de)	2004-03-15

Publication	Publication Date	Title
BG107360A (bg)	2003-11-28	Стабилизиран фармацевтично ефективен състав и фармацевтична форма, която го съдържа
AU2000249434A1 (en)	2002-03-07	Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
KR100638307B1 (ko)	2006-10-25	ＨＭＧ-ＣｏＡ 환원효소 억제제를 포함하는 안정한 약학적조제물
JP2004501121A5 (de)	2007-08-02
SK282991B6 (sk)	2003-01-09	Stabilizovaná farmaceutická kompozícia na báze kyseliny (E)- 3,5-dihydroxy-7-[4'-4''-fluórfenyl-2'-cyklopropylchinolin-3'yl]- 6-hepténovej
CA2692862C (en)	2013-11-12	Stable compositions
EA027869B1 (ru)	2017-09-29	Стабилизированная композиция такролимуса
US6806290B2 (en)	2004-10-19	Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
EP1296672B2 (de)	2018-10-24	Stabilisiertes arzneimittel und arzneizubereitung