ES2215050T3 - Composicion estabilizada farmaceuticamente eficaz y formulacion farmaceutica que la comprende. - Google Patents

Composicion estabilizada farmaceuticamente eficaz y formulacion farmaceutica que la comprende.

Info

Publication number: ES2215050T3
Authority: ES; Spain
Prior art keywords: substance; hmg; inhibitor; coa reductase; basifying
Prior art date: 2000-06-09
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

ES00931486T

Other languages

English (en)

Spanish (es)

Inventor

Zlatko Pflaum

Janez Kere

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Lek Pharmaceuticals dd

Original Assignee

Lek Pharmaceuticals and Chemical Co dd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-09

Filing date

2000-06-09

Publication date

2004-10-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26318615&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2215050(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2000-06-09 Application filed by Lek Pharmaceuticals and Chemical Co dd filed Critical Lek Pharmaceuticals and Chemical Co dd

2004-10-01 Application granted granted Critical

2004-10-01 Publication of ES2215050T3 publication Critical patent/ES2215050T3/es

2020-06-09 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 75
239000008194 pharmaceutical composition Substances 0.000 title claims description 49
239000000126 substance Substances 0.000 claims abstract description 52
239000006172 buffering agent Substances 0.000 claims abstract description 38
229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims abstract description 22
239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims abstract description 22
238000000975 co-precipitation Methods 0.000 claims abstract description 12
238000002288 cocrystallisation Methods 0.000 claims abstract description 12
239000008240 homogeneous mixture Substances 0.000 claims abstract description 6
239000003112 inhibitor Substances 0.000 claims description 40
TUZYXOIXSAXUGO-UHFFFAOYSA-N Pravastatin Natural products C1=CC(C)C(CCC(O)CC(O)CC(O)=O)C2C(OC(=O)C(C)CC)CC(O)C=C21 TUZYXOIXSAXUGO-UHFFFAOYSA-N 0.000 claims description 36
229960002965 pravastatin Drugs 0.000 claims description 36
TUZYXOIXSAXUGO-PZAWKZKUSA-N pravastatin Chemical compound C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC(O)=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 TUZYXOIXSAXUGO-PZAWKZKUSA-N 0.000 claims description 36
239000013543 active substance Substances 0.000 claims description 35
102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 claims description 32
108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 claims description 32
150000003839 salts Chemical class 0.000 claims description 29
239000011734 sodium Substances 0.000 claims description 23
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 22
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239000003795 chemical substances by application Substances 0.000 claims description 17
238000000034 method Methods 0.000 claims description 16
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VWBQYTRBTXKKOG-IYNICTALSA-M pravastatin sodium Chemical compound [Na+].C1=C[C@H](C)[C@H](CC[C@@H](O)C[C@@H](O)CC([O-])=O)[C@H]2[C@@H](OC(=O)[C@@H](C)CC)C[C@H](O)C=C21 VWBQYTRBTXKKOG-IYNICTALSA-M 0.000 claims description 15
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XUKUURHRXDUEBC-KAYWLYCHSA-N Atorvastatin Chemical compound C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CC[C@@H](O)C[C@@H](O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-KAYWLYCHSA-N 0.000 claims description 11
XUKUURHRXDUEBC-UHFFFAOYSA-N Atorvastatin Natural products C=1C=CC=CC=1C1=C(C=2C=CC(F)=CC=2)N(CCC(O)CC(O)CC(O)=O)C(C(C)C)=C1C(=O)NC1=CC=CC=C1 XUKUURHRXDUEBC-UHFFFAOYSA-N 0.000 claims description 11
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ZGGHKIMDNBDHJB-NRFPMOEYSA-M (3R,5S)-fluvastatin sodium Chemical compound [Na+].C12=CC=CC=C2N(C(C)C)C(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)=C1C1=CC=C(F)C=C1 ZGGHKIMDNBDHJB-NRFPMOEYSA-M 0.000 claims description 6
239000011230 binding agent Substances 0.000 claims description 6
229960003765 fluvastatin Drugs 0.000 claims description 6
239000000470 constituent Substances 0.000 claims description 5
239000003960 organic solvent Substances 0.000 claims description 5
238000002425 crystallisation Methods 0.000 claims description 4
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238000001556 precipitation Methods 0.000 claims description 4
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239000013078 crystal Substances 0.000 description 25
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 24
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 24
230000006641 stabilisation Effects 0.000 description 20
238000011105 stabilization Methods 0.000 description 20
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 15
238000009472 formulation Methods 0.000 description 14
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239000004615 ingredient Substances 0.000 description 11
-1 alkyl ketones Chemical class 0.000 description 10
230000000694 effects Effects 0.000 description 10
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
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CABVTRNMFUVUDM-VRHQGPGLSA-N (3S)-3-hydroxy-3-methylglutaryl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)C[C@@](O)(CC(O)=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 CABVTRNMFUVUDM-VRHQGPGLSA-N 0.000 description 8
BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 8
102000004316 Oxidoreductases Human genes 0.000 description 8
108090000854 Oxidoreductases Proteins 0.000 description 8
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239000000243 solution Substances 0.000 description 8
239000006185 dispersion Substances 0.000 description 7
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 6
239000000945 filler Substances 0.000 description 6
239000002904 solvent Substances 0.000 description 6
DVLFYONBTKHTER-UHFFFAOYSA-N 3-(N-morpholino)propanesulfonic acid Chemical compound OS(=O)(=O)CCCN1CCOCC1 DVLFYONBTKHTER-UHFFFAOYSA-N 0.000 description 5
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 5
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 5
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 5
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239000012298 atmosphere Substances 0.000 description 5
238000001914 filtration Methods 0.000 description 5
239000012535 impurity Substances 0.000 description 5
150000002596 lactones Chemical class 0.000 description 5
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 5
239000010452 phosphate Substances 0.000 description 5
230000001681 protective effect Effects 0.000 description 5
235000019698 starch Nutrition 0.000 description 5
239000004094 surface-active agent Substances 0.000 description 5
GFIWSSUBVYLTRF-UHFFFAOYSA-N 2-[2-(2-hydroxyethylamino)ethylamino]ethanol Chemical compound OCCNCCNCCO GFIWSSUBVYLTRF-UHFFFAOYSA-N 0.000 description 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 4
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 4
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230000007613 environmental effect Effects 0.000 description 4
239000002609 medium Substances 0.000 description 4
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OTXHZHQQWQTQMW-UHFFFAOYSA-N (diaminomethylideneamino)azanium;hydrogen carbonate Chemical compound OC([O-])=O.N[NH2+]C(N)=N OTXHZHQQWQTQMW-UHFFFAOYSA-N 0.000 description 3
ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
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BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical group [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 description 3
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 3
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
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238000006243 chemical reaction Methods 0.000 description 3
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
238000006731 degradation reaction Methods 0.000 description 3
238000010586 diagram Methods 0.000 description 3
FSBVERYRVPGNGG-UHFFFAOYSA-N dimagnesium dioxido-bis[[oxido(oxo)silyl]oxy]silane hydrate Chemical compound O.[Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O FSBVERYRVPGNGG-UHFFFAOYSA-N 0.000 description 3
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LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 3
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YIWUKEYIRIRTPP-UHFFFAOYSA-N 2-ethylhexan-1-ol Chemical compound CCCCC(CC)CO YIWUKEYIRIRTPP-UHFFFAOYSA-N 0.000 description 2
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
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CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 2
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HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 2
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239000011591 potassium Substances 0.000 description 2
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QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 2
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230000004584 weight gain Effects 0.000 description 1
235000019786 weight gain Nutrition 0.000 description 1
XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Inorganic Chemistry (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oil, Petroleum & Natural Gas (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Pulmonology (AREA)
Diabetes (AREA)
Hematology (AREA)
Obesity (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicines Containing Plant Substances (AREA)

ES00931486T 2000-06-09 2000-06-09 Composicion estabilizada farmaceuticamente eficaz y formulacion farmaceutica que la comprende. Expired - Lifetime ES2215050T3 (es)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
PCT/IB2000/000773 WO2001093860A1 (en)	2000-06-09	2000-06-09	Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
US09/591,322 US6531507B1 (en)	2000-06-09	2000-06-09	Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same

Publications (1)

Publication Number	Publication Date
ES2215050T3 true ES2215050T3 (es)	2004-10-01

Family

ID=26318615

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES00931486T Expired - Lifetime ES2215050T3 (es)	2000-06-09	2000-06-09	Composicion estabilizada farmaceuticamente eficaz y formulacion farmaceutica que la comprende.

Country Status (19)

Country	Link
US (1)	US6531507B1 (de)
EP (1)	EP1292293B1 (de)
JP (1)	JP2004501121A (de)
AT (1)	ATE260101T1 (de)
AU (2)	AU4943400A (de)
BG (1)	BG107360A (de)
CA (1)	CA2412326A1 (de)
CZ (1)	CZ20023826A3 (de)
DE (1)	DE60008608T2 (de)
ES (1)	ES2215050T3 (de)
HR (1)	HRP20020950A2 (de)
HU (1)	HUP0301325A3 (de)
NO (1)	NO20025784L (de)
PL (1)	PL362764A1 (de)
RU (1)	RU2246943C2 (de)
SI (1)	SI1292293T1 (de)
SK (1)	SK16982002A3 (de)
UA (1)	UA70410C2 (de)
WO (1)	WO2001093860A1 (de)

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US20060029668A1 (en) *	2002-10-24	2006-02-09	Ron Eyal S	Sustained release L-arginine formulations and methods of manufacture and use
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US7655692B2 (en) *	2003-06-12	2010-02-02	Pfizer Inc.	Process for forming amorphous atorvastatin
CA2540202A1 (en) *	2003-09-29	2005-04-21	Enos Pharmaceuticals, Inc.	Sustained release l-arginine formulations and methods of manufacture and use
US8163797B2 (en) *	2003-12-31	2012-04-24	Actavis Elizabeth Llc	Method of treating with stable pravastatin formulation
WO2005084669A1 (en) *	2004-03-01	2005-09-15	Lek Pharmaceuticals D.D.	Pharmaceutical composition
WO2005092852A1 (en)	2004-03-17	2005-10-06	Ranbaxy Laboratories Limited	Process for the production of atorvastatin calcium in amorphous form
US7491263B2 (en) *	2004-04-05	2009-02-17	Technology Innovation, Llc	Storage assembly
KR100598326B1 (ko) *	2004-04-10	2006-07-10	한미약품 주식회사	ＨＭＧ-ＣｏＡ 환원효소 억제제의 경구투여용 서방형 제제및 이의 제조방법
NZ552390A (en) *	2004-08-06	2010-01-29	Transform Pharmaceuticals Inc	Novel fenofibrate formulations and related methods of treatment
JP2008509154A (ja) *	2004-08-06	2008-03-27	トランスフオーム・フアーマシユーチカルズ・インコーポレーテツド	新規なスタチン薬剤組成物および関連治療方法
US20090042979A1 (en) *	2004-08-06	2009-02-12	Transform Pharmaceuticals Inc.	Novel Statin Pharmaceutical Compositions and Related Methods of Treatment
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WO2006081147A1 (en) *	2005-01-24	2006-08-03	Enos Pharmaceuticals, Inc.	Methods of treating various conditions by administration of sustained release l-arginine
WO2006123358A2 (en) *	2005-02-22	2006-11-23	Sun Pharmaceutical Industries Limited	Stabilized atorvastatin-containing formulation
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JP4813841B2 (ja) *	2005-07-25	2011-11-09	キユーピー株式会社	プラバスタチンナトリウムの製造方法
WO2007016757A1 (en) *	2005-08-05	2007-02-15	Orbus Pharma Inc.	Stabilized extended release pharmeceutical compositions comprising an hmg-coa reductase inhibitor
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KR20080094837A (ko) *	2006-02-24	2008-10-24	테바 파마슈티컬 인더스트리즈 리미티드	플루바스타틴 나트륨 약학 조성물
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2000
- 2000-06-09 CZ CZ20023826A patent/CZ20023826A3/cs unknown
- 2000-06-09 WO PCT/IB2000/000773 patent/WO2001093860A1/en not_active Ceased
- 2000-06-09 AU AU4943400A patent/AU4943400A/xx active Pending
- 2000-06-09 AT AT00931486T patent/ATE260101T1/de active
- 2000-06-09 SI SI200030324T patent/SI1292293T1/xx unknown
- 2000-06-09 AU AU2000249434A patent/AU2000249434B2/en not_active Ceased
- 2000-06-09 EP EP00931486A patent/EP1292293B1/de not_active Revoked
- 2000-06-09 JP JP2002501433A patent/JP2004501121A/ja active Pending
- 2000-06-09 US US09/591,322 patent/US6531507B1/en not_active Expired - Fee Related
- 2000-06-09 CA CA002412326A patent/CA2412326A1/en not_active Abandoned
- 2000-06-09 DE DE60008608T patent/DE60008608T2/de not_active Expired - Lifetime
- 2000-06-09 SK SK1698-2002A patent/SK16982002A3/sk not_active Application Discontinuation
- 2000-06-09 HU HU0301325A patent/HUP0301325A3/hu unknown
- 2000-06-09 RU RU2002134764/15A patent/RU2246943C2/ru not_active IP Right Cessation
- 2000-06-09 ES ES00931486T patent/ES2215050T3/es not_active Expired - Lifetime
- 2000-06-09 HR HRP20020950 patent/HRP20020950A2/hr not_active Application Discontinuation
- 2000-06-09 PL PL00362764A patent/PL362764A1/xx not_active Application Discontinuation
- 2000-09-06 UA UA2002119464A patent/UA70410C2/uk unknown
2002
- 2002-12-02 NO NO20025784A patent/NO20025784L/no not_active Application Discontinuation
- 2002-12-06 BG BG107360A patent/BG107360A/bg unknown

Also Published As

Publication number	Publication date
ATE260101T1 (de)	2004-03-15
EP1292293B1 (de)	2004-02-25
HUP0301325A2 (hu)	2003-11-28
NO20025784D0 (no)	2002-12-02
JP2004501121A (ja)	2004-01-15
PL362764A1 (en)	2004-11-02
US6531507B1 (en)	2003-03-11
DE60008608T2 (de)	2004-12-30
UA70410C2 (en)	2004-10-15
CZ20023826A3 (cs)	2003-04-16
SK16982002A3 (sk)	2003-04-01
NO20025784L (no)	2002-12-02
HRP20020950A2 (en)	2004-12-31
WO2001093860A1 (en)	2001-12-13
EP1292293A1 (de)	2003-03-19
AU2000249434B2 (en)	2006-02-02
CA2412326A1 (en)	2001-12-13
HUP0301325A3 (en)	2004-03-01
AU4943400A (en)	2001-12-17
DE60008608D1 (de)	2004-04-01
RU2246943C2 (ru)	2005-02-27
SI1292293T1 (en)	2004-06-30
BG107360A (bg)	2003-11-28

Publication	Publication Date	Title
ES2215050T3 (es)	2004-10-01	Composicion estabilizada farmaceuticamente eficaz y formulacion farmaceutica que la comprende.
AU2000249434A1 (en)	2002-03-07	Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
ES2299265T3 (es)	2008-05-16	Formulacion farmaceutica estable que incluye pravastatina o atorvastatina.
JP2004501121A5 (de)	2007-08-02
SK282991B6 (sk)	2003-01-09	Stabilizovaná farmaceutická kompozícia na báze kyseliny (E)- 3,5-dihydroxy-7-[4'-4''-fluórfenyl-2'-cyklopropylchinolin-3'yl]- 6-hepténovej
JP5722034B2 (ja)	2015-05-20	１種または複数のＨＭＧ−ＣｏＡレダクターゼ阻害剤を含む安定的な医薬組成物
US6806290B2 (en)	2004-10-19	Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
CN101412690A (zh)	2009-04-22	西洛多辛的药用酸加成盐及其制备方法和药物应用
IE57886B1 (en)	1993-05-05	Improvements in or relating to cephalosporin derivatives
EP1296672B1 (de)	2008-12-31	Stabilisiertes arzneimittel und arzneizubereitung
ES2281594T3 (es)	2007-10-01	Procedimiento para la preparacion de adsorbatos de atorvastatina en polvo de flujo libre.
CN101461799B (zh)	2011-06-29	一种稳定的普伐他汀药物组合物及其制备方法
ES2972617T3 (es)	2024-06-13	Nueva forma de sulfonamida de isoquinolina
PT1796730E (pt)	2010-10-26	Produto farmacêutico que contém leucotrieno b4 (ltb4) estabilizado
RU2008128454A (ru)	2010-02-10	Фармацевтическая композиция и лекарственная форма фенофибрата с улучшенной биодоступностью