BG107752A - Соли на изотиазол-4-карбоксамид и тяхното приложение като антихиперпролиферативни агенти - Google Patents

Соли на изотиазол-4-карбоксамид и тяхното приложение като антихиперпролиферативни агенти Download PDF

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Publication number
BG107752A
BG107752A BG107752A BG10775203A BG107752A BG 107752 A BG107752 A BG 107752A BG 107752 A BG107752 A BG 107752A BG 10775203 A BG10775203 A BG 10775203A BG 107752 A BG107752 A BG 107752A
Authority
BG
Bulgaria
Prior art keywords
salt
isothiazole
ray diffraction
bromo
ureido
Prior art date
Application number
BG107752A
Other languages
Bulgarian (bg)
English (en)
Inventor
Thomas G. Gant
Glenn R. Williams
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of BG107752A publication Critical patent/BG107752A/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
BG107752A 2000-11-28 2003-04-22 Соли на изотиазол-4-карбоксамид и тяхното приложение като антихиперпролиферативни агенти BG107752A (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25351300P 2000-11-28 2000-11-28
PCT/IB2001/002193 WO2002044158A1 (en) 2000-11-28 2001-11-19 Salts of a isothiazole-4-carboxamide and their use as anti-hyperproliferation agents

Publications (1)

Publication Number Publication Date
BG107752A true BG107752A (bg) 2004-01-30

Family

ID=22960587

Family Applications (1)

Application Number Title Priority Date Filing Date
BG107752A BG107752A (bg) 2000-11-28 2003-04-22 Соли на изотиазол-4-карбоксамид и тяхното приложение като антихиперпролиферативни агенти

Country Status (49)

Country Link
US (1) US6831091B2 (cs)
EP (1) EP1337521B1 (cs)
JP (2) JP2004514714A (cs)
KR (2) KR20030059275A (cs)
CN (1) CN1231474C (cs)
AP (1) AP2001002358A0 (cs)
AR (1) AR031512A1 (cs)
AT (1) ATE340786T1 (cs)
AU (2) AU2002214204B2 (cs)
BG (1) BG107752A (cs)
BR (1) BR0115621A (cs)
CA (1) CA2430065C (cs)
CR (1) CR6963A (cs)
CY (1) CY1106240T1 (cs)
CZ (1) CZ20031315A3 (cs)
DE (1) DE60123461T2 (cs)
DK (1) DK1337521T3 (cs)
DO (1) DOP2001000288A (cs)
EA (1) EA005859B1 (cs)
EC (1) ECSP034628A (cs)
EE (1) EE200300247A (cs)
ES (1) ES2271086T3 (cs)
GE (1) GEP20053652B (cs)
GT (1) GT200100237A (cs)
HN (1) HN2001000268A (cs)
HR (1) HRP20030408A2 (cs)
HU (1) HUP0302553A3 (cs)
IL (1) IL155371A0 (cs)
IS (1) IS6788A (cs)
MA (1) MA26960A1 (cs)
MX (1) MXPA03004714A (cs)
MY (1) MY136686A (cs)
NO (1) NO325187B1 (cs)
NZ (1) NZ525788A (cs)
OA (1) OA12532A (cs)
PA (1) PA8533801A1 (cs)
PE (1) PE20020591A1 (cs)
PL (1) PL362079A1 (cs)
PT (1) PT1337521E (cs)
SI (1) SI1337521T1 (cs)
SK (1) SK5862003A3 (cs)
SV (1) SV2002000748A (cs)
TN (1) TNSN01167A1 (cs)
TW (1) TWI287542B (cs)
UA (1) UA74221C2 (cs)
UY (1) UY27039A1 (cs)
WO (1) WO2002044158A1 (cs)
YU (1) YU36403A (cs)
ZA (1) ZA200303341B (cs)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA60365C2 (uk) * 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
US8124630B2 (en) 1999-01-13 2012-02-28 Bayer Healthcare Llc ω-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
EP2298311B1 (en) 1999-01-13 2012-05-09 Bayer HealthCare LLC w-Carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors
US7351834B1 (en) 1999-01-13 2008-04-01 Bayer Pharmaceuticals Corporation ω-Carboxyaryl substituted diphenyl ureas as raf kinase inhibitors
WO2003068229A1 (en) 2002-02-11 2003-08-21 Bayer Pharmaceuticals Corporation Pyridine, quinoline, and isoquinoline n-oxides as kinase inhibitors
DK1478358T3 (da) 2002-02-11 2013-10-07 Bayer Healthcare Llc Sorafenibtosylat til behandling af sygdomme kendetegnet ved unormal angiogenese
CA2493701A1 (en) * 2002-07-25 2004-02-05 Pfizer Products Inc. Isothiazole derivatives useful as anticancer agents
EA200500234A1 (ru) * 2002-08-19 2005-08-25 Пфайзер Продактс Инк. Комбинированная терапия гиперпролиферативных болезней
EP1636585B2 (en) 2003-05-20 2012-06-13 Bayer HealthCare LLC Diaryl ureas with kinase inhibiting activity
PL1663978T3 (pl) 2003-07-23 2008-04-30 Bayer Healthcare Llc Fluoropodstawiony omega-karboksyarylodifenylomocznik do leczenia i profilaktyki chorób i stanów
RU2317295C1 (ru) * 2003-10-27 2008-02-20 Мерк Энд Ко., Инк. Соль антагониста ccr-2
US7572914B2 (en) 2003-12-19 2009-08-11 Takeda Pharmaceutical Company Limited Kinase inhibitors
WO2005102327A1 (en) * 2004-04-20 2005-11-03 Pfizer Products Inc. Dosage forms and methods of treatment using vegfr inhibitors
US7838524B2 (en) 2004-04-30 2010-11-23 Bayer Healthcare Llc Substituted pyrazolyl urea derivatives useful in the treatment of cancer
TW200538104A (en) * 2004-05-17 2005-12-01 Pfizer Prod Inc Phenyl derivatives for the treatment of abnormal cell growth
WO2006023931A2 (en) 2004-08-18 2006-03-02 Takeda San Diego, Inc. Kinase inhibitors
EP1812439B2 (en) 2004-10-15 2017-12-06 Takeda Pharmaceutical Company Limited Kinase inhibitors
US8119655B2 (en) 2005-10-07 2012-02-21 Takeda Pharmaceutical Company Limited Kinase inhibitors
MY150647A (en) 2006-06-16 2014-02-14 Lundbeck & Co As H 1-[2-(2,4-dimethylphenylsulfanyl)-phenyl] piperazine as a compound with combined serotonin reuptake, 5-ht3 and 5-ht1a activity for the treatment of cognitive impairment
US7932390B2 (en) 2006-06-29 2011-04-26 Hoffman-La Roche Inc. Substituted thieno[3,2-C]pyridine carboxylic acid derivatives
JP2010505962A (ja) 2006-10-09 2010-02-25 武田薬品工業株式会社 キナーゼ阻害剤
MX2010001636A (es) 2007-08-14 2010-03-15 Hoffmann La Roche Derivados de pirazolo[3,4-d]-pirimidina como agentes antiproliferativos.
WO2011073521A1 (en) 2009-12-15 2011-06-23 Petri Salven Methods for enriching adult-derived endothelial progenitor cells and uses thereof
SG187592A1 (en) 2010-07-23 2013-03-28 Univ Boston Anti-despr inhibitors as therapeutics for inhibition of pathological angiogenesis and tumor cell invasiveness and for molecular imaging and targeted delivery
KR102433489B1 (ko) * 2013-03-14 2022-08-17 팬옵티카, 인크. 눈의 후안부로의 약물 전달을 위한 안구용 제제
AU2015317531B2 (en) * 2014-09-17 2020-11-19 Panoptica, Inc. Ocular formulations for drug-delivery and protection of the anterior segment of the eye
KR20250121146A (ko) * 2022-12-28 2025-08-11 비양 테라퓨틱스 컴퍼니 리미티드 단백질 티로신 키나제 억제제 및 이의 의약적 용도
WO2026002126A1 (zh) * 2024-06-27 2026-01-02 苏州必扬医药科技有限公司 一种蛋白酪氨酸激酶抑制剂及其眼用制剂
WO2026002142A1 (zh) * 2024-06-27 2026-01-02 苏州必扬医药科技有限公司 一种蛋白酪氨酸激酶抑制剂的半琥珀酸盐晶型
WO2026002133A1 (zh) * 2024-06-27 2026-01-02 苏州必扬医药科技有限公司 一种蛋白酪氨酸激酶抑制剂的盐型

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA60365C2 (uk) * 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця

Also Published As

Publication number Publication date
IL155371A0 (en) 2003-11-23
NZ525788A (en) 2004-11-26
YU36403A (sh) 2006-08-17
MA26960A1 (fr) 2004-12-20
DE60123461T2 (de) 2007-02-15
WO2002044158A1 (en) 2002-06-06
EE200300247A (et) 2003-10-15
AR031512A1 (es) 2003-09-24
UY27039A1 (es) 2002-07-31
AU1420402A (en) 2002-06-11
HN2001000268A (es) 2002-01-30
MXPA03004714A (es) 2003-08-19
CA2430065A1 (en) 2002-06-06
EA005859B1 (ru) 2005-06-30
EP1337521B1 (en) 2006-09-27
ES2271086T3 (es) 2007-04-16
HUP0302553A2 (hu) 2003-11-28
HUP0302553A3 (en) 2009-03-30
NO20032388L (no) 2003-07-18
HK1059085A1 (en) 2004-06-18
PT1337521E (pt) 2006-12-29
AP2001002358A0 (en) 2001-12-31
PL362079A1 (en) 2004-10-18
KR20050116401A (ko) 2005-12-12
TNSN01167A1 (fr) 2005-11-10
TWI287542B (en) 2007-10-01
CY1106240T1 (el) 2011-06-08
MY136686A (en) 2008-11-28
PA8533801A1 (es) 2002-10-31
JP4971946B2 (ja) 2012-07-11
CN1231474C (zh) 2005-12-14
DK1337521T3 (da) 2007-01-29
GT200100237A (es) 2002-07-03
GEP20053652B (en) 2005-11-10
CN1476439A (zh) 2004-02-18
US20020151573A1 (en) 2002-10-17
IS6788A (is) 2003-04-14
KR20030059275A (ko) 2003-07-07
EA200300424A1 (ru) 2003-10-30
UA74221C2 (uk) 2005-11-15
DE60123461D1 (de) 2006-11-09
SI1337521T1 (sl) 2006-12-31
BR0115621A (pt) 2003-09-02
DOP2001000288A (es) 2002-12-15
US6831091B2 (en) 2004-12-14
ATE340786T1 (de) 2006-10-15
JP2004514714A (ja) 2004-05-20
SV2002000748A (es) 2002-12-02
OA12532A (en) 2006-06-02
EP1337521A1 (en) 2003-08-27
CR6963A (es) 2003-11-25
AU2002214204B2 (en) 2007-05-24
NO325187B1 (no) 2008-02-11
CA2430065C (en) 2008-05-20
ECSP034628A (es) 2003-07-25
HRP20030408A2 (en) 2003-08-31
CZ20031315A3 (cs) 2004-04-14
NO20032388D0 (no) 2003-05-27
ZA200303341B (en) 2004-04-30
JP2008056692A (ja) 2008-03-13
PE20020591A1 (es) 2002-07-06
SK5862003A3 (en) 2004-05-04

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