BG107788A - Фармацевтични състави на nmda рецепторен агонист - Google Patents

Фармацевтични състави на nmda рецепторен агонист Download PDF

Info

Publication number: BG107788A
Authority: BG; Bulgaria
Prior art keywords: pharmaceutical composition; composition; disease; pharmaceutically acceptable; free
Prior art date: 2000-12-13

Application number

BG107788A

Other languages

Bulgarian (bg)

English (en)

Inventor

Jinyang Hong

Yesook Kim

Original Assignee

Pfizer Products Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-13

Filing date

2003-05-09

Publication date

2004-01-30

2003-05-09 Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.

2004-01-30 Publication of BG107788A publication Critical patent/BG107788A/bg

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 35
239000003706 n methyl dextro aspartic acid receptor stimulating agent Substances 0.000 title abstract 2
238000000034 method Methods 0.000 claims abstract description 19
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210000003169 central nervous system Anatomy 0.000 claims abstract description 11
206010015037 epilepsy Diseases 0.000 claims abstract description 10
208000006011 Stroke Diseases 0.000 claims abstract description 8
208000023105 Huntington disease Diseases 0.000 claims abstract description 7
206010046543 Urinary incontinence Diseases 0.000 claims abstract description 7
238000001356 surgical procedure Methods 0.000 claims abstract description 7
208000030507 AIDS Diseases 0.000 claims abstract description 6
206010012289 Dementia Diseases 0.000 claims abstract description 6
208000019695 Migraine disease Diseases 0.000 claims abstract description 6
208000005314 Multi-Infarct Dementia Diseases 0.000 claims abstract description 6
208000028017 Psychotic disease Diseases 0.000 claims abstract description 6
208000030886 Traumatic Brain injury Diseases 0.000 claims abstract description 6
201000004810 Vascular dementia Diseases 0.000 claims abstract description 6
239000002249 anxiolytic agent Substances 0.000 claims abstract description 6
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230000000302 ischemic effect Effects 0.000 claims abstract description 6
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208000013016 Hypoglycemia Diseases 0.000 claims abstract description 5
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239000000203 mixture Substances 0.000 claims description 57
150000001875 compounds Chemical class 0.000 claims description 54
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229910052760 oxygen Inorganic materials 0.000 claims description 18
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
238000000354 decomposition reaction Methods 0.000 claims description 14
XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 14
QEMSVZNTSXPFJA-HNAYVOBHSA-N 1-[(1s,2s)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]-4-phenylpiperidin-4-ol Chemical compound C1([C@H](O)[C@H](C)N2CCC(O)(CC2)C=2C=CC=CC=2)=CC=C(O)C=C1 QEMSVZNTSXPFJA-HNAYVOBHSA-N 0.000 claims description 12
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 12
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 12
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JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 claims description 9
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239000007864 aqueous solution Substances 0.000 claims description 9
229910001431 copper ion Inorganic materials 0.000 claims description 9
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KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 8
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical group OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 7
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239000000047 product Substances 0.000 description 5
239000012086 standard solution Substances 0.000 description 5
KQKFQBTWXOGINC-UHFFFAOYSA-N 4-phenylpiperidin-4-ol Chemical compound C=1C=CC=CC=1C1(O)CCNCC1 KQKFQBTWXOGINC-UHFFFAOYSA-N 0.000 description 4
XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
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HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 description 4
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239000004480 active ingredient Substances 0.000 description 4
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WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
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LKGCPYOBWLSCTK-UHFFFAOYSA-N methanesulfonic acid;trihydrate Chemical compound O.O.O.CS(O)(=O)=O LKGCPYOBWLSCTK-UHFFFAOYSA-N 0.000 description 3
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238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 2
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ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 2
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 2
DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 2
238000004458 analytical method Methods 0.000 description 2
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WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
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238000004128 high performance liquid chromatography Methods 0.000 description 2
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239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 description 2
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239000003002 pH adjusting agent Substances 0.000 description 2
229960003330 pentetic acid Drugs 0.000 description 2
MBYLVOKEDDQJDY-UHFFFAOYSA-N tris(2-aminoethyl)amine Chemical compound NCCN(CCN)CCN MBYLVOKEDDQJDY-UHFFFAOYSA-N 0.000 description 2
KWDXGALCQUZREM-VKHMYHEASA-N (2s)-2-(methoxyamino)butanedioic acid Chemical group CON[C@H](C(O)=O)CC(O)=O KWDXGALCQUZREM-VKHMYHEASA-N 0.000 description 1
OBDVFOBWBHMJDG-UHFFFAOYSA-N 3-mercapto-1-propanesulfonic acid Chemical compound OS(=O)(=O)CCCS OBDVFOBWBHMJDG-UHFFFAOYSA-N 0.000 description 1
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206010012335 Dependence Diseases 0.000 description 1
RPNUMPOLZDHAAY-UHFFFAOYSA-N Diethylenetriamine Chemical compound NCCNCCN RPNUMPOLZDHAAY-UHFFFAOYSA-N 0.000 description 1
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DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 1
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SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
VKWVKRZCWUQLHV-UHFFFAOYSA-N hex-3-ene-1,6-diamine Chemical group NCCC=CCCN VKWVKRZCWUQLHV-UHFFFAOYSA-N 0.000 description 1
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Classifications

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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Epidemiology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Oil, Petroleum & Natural Gas (AREA)
Inorganic Chemistry (AREA)
Urology & Nephrology (AREA)
Dermatology (AREA)
Diabetes (AREA)
Psychology (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Addiction (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Hydrogenated Pyridines (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

BG107788A 2000-12-13 2003-05-09 Фармацевтични състави на nmda рецепторен агонист BG107788A (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US25537200P	2000-12-13	2000-12-13
PCT/IB2001/002359 WO2002047685A2 (en)	2000-12-13	2001-12-05	Nmda receptor agonist pharmaceutical compositions

Publications (1)

Publication Number	Publication Date
BG107788A true BG107788A (bg)	2004-01-30

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ID=22968017

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Application Number	Title	Priority Date	Filing Date
BG107788A BG107788A (bg)	2000-12-13	2003-05-09	Фармацевтични състави на nmda рецепторен агонист

Country Status (41)

Country	Link
US (2)	US6635270B2 (de)
EP (1)	EP1347760B1 (de)
JP (1)	JP2004515529A (de)
KR (1)	KR100533407B1 (de)
CN (1)	CN1273135C (de)
AP (1)	AP1235A (de)
AR (1)	AR035607A1 (de)
AT (1)	ATE296629T1 (de)
AU (2)	AU1845402A (de)
BG (1)	BG107788A (de)
BR (1)	BR0116085A (de)
CA (1)	CA2431172A1 (de)
CZ (1)	CZ20031543A3 (de)
DE (1)	DE60111265T2 (de)
DO (1)	DOP2001000300A (de)
DZ (1)	DZ3484A1 (de)
EA (1)	EA006489B1 (de)
EC (1)	ECSP034655A (de)
EE (1)	EE200300284A (de)
ES (1)	ES2239648T3 (de)
GE (1)	GEP20053568B (de)
HR (1)	HRP20030473A2 (de)
HU (1)	HUP0400645A2 (de)
IL (1)	IL155810A0 (de)
IS (1)	IS6811A (de)
MA (1)	MA26970A1 (de)
MX (1)	MXPA03005257A (de)
NO (1)	NO20032678L (de)
NZ (1)	NZ525742A (de)
OA (1)	OA12414A (de)
PA (1)	PA8534901A1 (de)
PE (1)	PE20020710A1 (de)
PL (1)	PL362080A1 (de)
PT (1)	PT1347760E (de)
SK (1)	SK6982003A3 (de)
TN (1)	TNSN01173A1 (de)
UA (1)	UA73619C2 (de)
UY (1)	UY27068A1 (de)
WO (1)	WO2002047685A2 (de)
YU (1)	YU41103A (de)
ZA (1)	ZA200303892B (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
HRP20150037T4 (hr)	2003-04-08	2022-09-02	Progenics Pharmaceuticals, Inc.	Farmaceutske formulacije koje sadrže metilnaltrekson
TW200800959A (en) *	2005-06-10	2008-01-01	Wyeth Corp	Piperazine-piperidine antagonists and agonists of the 5-HT1a receptor
TW200808740A (en) *	2006-06-09	2008-02-16	Wyeth Corp	Succinate salts of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline and crystalline forms thereof
TW200808741A (en) *	2006-06-09	2008-02-16	Wyeth Corp	6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline hydrochloric acid salts
TW200811144A (en) *	2006-06-09	2008-03-01	Wyeth Corp	Crystalline forms of 6-methoxy-8-[4-(1-(5-fluoro)-quinolin-8-yl-piperidin-4-yl)-piperazin-1-yl]-quinoline
TWI489984B (zh)	2006-08-04	2015-07-01	Wyeth Corp	用於非經腸道傳輸化合物之配方及其用途
AR063984A1 (es) *	2006-11-28	2009-03-04	Wyeth Corp	Metabolitos de 5-fluoro-8-{4-[4-(6-metoxiquinolin-8-il)piperazin-1-il]piperidin-1-il}quinolina, metodos de preparacion, su uso en la fabricacion de medicamentos para el tratamiento de trastornos relacionados con 5-ht1a, composicion farmaceutica que los comprende, compuestos radioetiquetados derivado
TW200901974A (en)	2007-01-16	2009-01-16	Wyeth Corp	Compounds, compositions, and methods of making and using them
CN101317844B (zh) *	2007-06-08	2010-11-17	章劲夫	化合物(+)-5-甲基-10，11-二氢-5H-二苯并〔a，d〕环庚烯-5，10-亚胺在制备避孕药物中的应用
JP5702288B2 (ja)	2008-09-18	2015-04-15	ノースウエスタンユニバーシティ	Ｎｍｄａレセプターモジュレータ及びその用途
US8951968B2 (en)	2009-10-05	2015-02-10	Northwestern University	Methods of treating depression and other related diseases
AU2011215704B2 (en)	2010-02-11	2015-07-23	Northwestern University	Secondary structure stabilized NMDA receptor modulators and uses thereof
KR101692275B1 (ko)	2010-02-11	2017-01-04	노오쓰웨스턴 유니버시티	２차 구조 안정화된 ｎｍｄａ 수용체 조절제 및 그의 용도
CN102586243A (zh) *	2012-03-08	2012-07-18	中国人民解放军军事医学科学院放射与辐射医学研究所	一种预防电磁辐射致脑损伤的标志物
WO2014078568A1 (en)	2012-11-14	2014-05-22	The Johns Hopkins University	Methods and compositions for treating schizophrenia
LT2951183T (lt)	2013-01-29	2019-05-27	Aptinyx Inc.	Spiro-laktamo nmda receptorių moduliatoriai ir jų panaudojimas
CA2899010A1 (en)	2013-01-29	2014-08-07	Naurex, Inc.	Spiro-lactam nmda receptor modulators and uses thereof
MX375286B (es)	2013-01-29	2025-03-06	Aptinyx Inc	Moduladores de receptores nmda de espiro-lactama y sus usos.
CA2898863A1 (en)	2013-01-29	2014-08-07	Naurex, Inc.	Spiro-lactam nmda receptor modulators and uses thereof
AU2014212501A1 (en)	2013-01-29	2015-07-30	Aptinyx, Inc.	Spiro-lactam NMDA receptor modulators and uses thereof
MX2016008369A (es)	2013-12-23	2016-12-15	Samyang Biopharmaceuticals	Composicion farmaceutica que incluye palonosetron.
JP6823083B2 (ja)	2016-05-19	2021-01-27	アプティニックスインコーポレイテッド	スピロラクタム系ｎｍｄａ受容体モジュレーターおよびその使用
WO2017201285A1 (en)	2016-05-19	2017-11-23	Aptinyx Inc.	Spiro-lactam nmda receptor modulators and uses thereof
AU2017306158B2 (en)	2016-08-01	2021-10-14	Aptinyx Inc.	Spiro-lactam and bis-spiro-lactam NMDA receptor modulators and uses thereof
MX385336B (es)	2016-08-01	2025-03-18	Aptinyx Inc	Moduladores del receptor nmda espiro-lactam y uso de los mismos.
EA201990424A1 (ru)	2016-08-01	2019-08-30	Аптиникс Инк.	Спиролактамовые модуляторы nmda-рецептора и их применение
PE20190504A1 (es)	2016-08-01	2019-04-10	Aptinyx Inc	Moduladores del receptor nmda espiro-lactam y uso de los mismos
ES2974090T3 (es)	2016-08-01	2024-06-25	Tenacia Biotechnology Hong Kong Co Ltd	Moduladores de NMDA de espirolactama y métodos de uso de los mismos
JP7210599B2 (ja)	2018-01-31	2023-01-23	アプティニックスインコーポレイテッド	スピロラクタム系ｎｍｄａ受容体修飾因子およびその使用
US12012413B2 (en)	2019-11-11	2024-06-18	Tenacia Biotechnology (Hong Kong) Co., Limited	Methods of treating painful diabetic peripheral neuropathy

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5272160A (en)	1989-05-17	1993-12-21	Pfizer Inc	2-piperidino-1-alkanol derivatives as antiischemic agents
US5710168A (en)	1991-10-23	1998-01-20	Pfizer Inc.	2-piperidino-1-alkanol derivatives as neuroprotective agents
ATE215072T1 (de) *	1995-08-11	2002-04-15	Pfizer	(1s,2s)-1-(4-hydroxyphenyl)-2-(4-hydroxy-4- phenylpiperidin-1-yl)-1-propanol-methansulfonat trihydrat
TW450807B (en) *	1995-09-15	2001-08-21	Pfizer	Pharmaceutical compositions for treating tinnitus comprising neuroprotective agents

2001
- 2001-05-12 UA UA2003065485A patent/UA73619C2/uk unknown
- 2001-12-05 SK SK698-2003A patent/SK6982003A3/sk unknown
- 2001-12-05 AU AU1845402A patent/AU1845402A/xx active Pending
- 2001-12-05 ES ES01270205T patent/ES2239648T3/es not_active Expired - Lifetime
- 2001-12-05 GE GE5171A patent/GEP20053568B/en unknown
- 2001-12-05 PT PT01270205T patent/PT1347760E/pt unknown
- 2001-12-05 WO PCT/IB2001/002359 patent/WO2002047685A2/en not_active Ceased
- 2001-12-05 AT AT01270205T patent/ATE296629T1/de not_active IP Right Cessation
- 2001-12-05 EE EEP200300284A patent/EE200300284A/xx unknown
- 2001-12-05 CZ CZ20031543A patent/CZ20031543A3/cs unknown
- 2001-12-05 EP EP01270205A patent/EP1347760B1/de not_active Expired - Lifetime
- 2001-12-05 MX MXPA03005257A patent/MXPA03005257A/es active IP Right Grant
- 2001-12-05 YU YU41103A patent/YU41103A/sh unknown
- 2001-12-05 PL PL01362080A patent/PL362080A1/xx not_active Application Discontinuation
- 2001-12-05 OA OA1200300145A patent/OA12414A/en unknown
- 2001-12-05 JP JP2002549256A patent/JP2004515529A/ja active Pending
- 2001-12-05 KR KR10-2003-7007874A patent/KR100533407B1/ko not_active Expired - Fee Related
- 2001-12-05 EA EA200300514A patent/EA006489B1/ru not_active IP Right Cessation
- 2001-12-05 AU AU2002218454A patent/AU2002218454B2/en not_active Ceased
- 2001-12-05 CN CNB018203922A patent/CN1273135C/zh not_active Expired - Fee Related
- 2001-12-05 BR BR0116085-0A patent/BR0116085A/pt not_active IP Right Cessation
- 2001-12-05 US US10/010,827 patent/US6635270B2/en not_active Expired - Fee Related
- 2001-12-05 HR HR20030473A patent/HRP20030473A2/hr not_active Application Discontinuation
- 2001-12-05 HU HU0400645A patent/HUP0400645A2/hu unknown
- 2001-12-05 NZ NZ525742A patent/NZ525742A/en unknown
- 2001-12-05 CA CA002431172A patent/CA2431172A1/en not_active Abandoned
- 2001-12-05 DZ DZ013484A patent/DZ3484A1/fr active
- 2001-12-05 DE DE60111265T patent/DE60111265T2/de not_active Expired - Fee Related
- 2001-12-05 IL IL15581001A patent/IL155810A0/xx unknown
- 2001-12-10 DO DO2001000300A patent/DOP2001000300A/es unknown
- 2001-12-11 AR ARP010105748A patent/AR035607A1/es unknown
- 2001-12-11 PE PE2001001235A patent/PE20020710A1/es not_active Application Discontinuation
- 2001-12-12 TN TNTNSN01173A patent/TNSN01173A1/fr unknown
- 2001-12-12 UY UY27068A patent/UY27068A1/es not_active Application Discontinuation
- 2001-12-13 AP APAP/P/2001/002376A patent/AP1235A/en active
- 2001-12-13 PA PA20018534901A patent/PA8534901A1/es unknown
2003
- 2003-05-08 IS IS6811A patent/IS6811A/is unknown
- 2003-05-09 BG BG107788A patent/BG107788A/bg unknown
- 2003-05-20 ZA ZA200303892A patent/ZA200303892B/en unknown
- 2003-06-03 MA MA27191A patent/MA26970A1/fr unknown
- 2003-06-12 NO NO20032678A patent/NO20032678L/no not_active Application Discontinuation
- 2003-06-13 EC EC2003004655A patent/ECSP034655A/es unknown
- 2003-08-19 US US10/643,441 patent/US20040039022A1/en not_active Abandoned

Also Published As

Publication number	Publication date
WO2002047685A2 (en)	2002-06-20
SK6982003A3 (en)	2004-08-03
NO20032678D0 (no)	2003-06-12
AU1845402A (en)	2002-06-24
YU41103A (sh)	2006-05-25
KR20030070060A (ko)	2003-08-27
NO20032678L (no)	2003-06-12
BR0116085A (pt)	2003-12-23
CN1273135C (zh)	2006-09-06
GEP20053568B (en)	2005-07-11
DZ3484A1 (fr)	2002-06-20
EP1347760A2 (de)	2003-10-01
AP2001002376A0 (en)	2001-12-31
AU2002218454B2 (en)	2005-10-27
TNSN01173A1 (fr)	2005-11-10
EA200300514A1 (ru)	2003-10-30
KR100533407B1 (ko)	2005-12-02
DOP2001000300A (es)	2002-05-30
JP2004515529A (ja)	2004-05-27
IL155810A0 (en)	2003-12-23
US20040039022A1 (en)	2004-02-26
CN1479617A (zh)	2004-03-03
AP1235A (en)	2004-01-06
UY27068A1 (es)	2002-07-31
US6635270B2 (en)	2003-10-21
PE20020710A1 (es)	2002-08-09
PT1347760E (pt)	2005-09-30
OA12414A (en)	2006-04-18
DE60111265D1 (de)	2005-07-07
US20020111366A1 (en)	2002-08-15
PL362080A1 (en)	2004-10-18
UA73619C2 (en)	2005-08-15
MXPA03005257A (es)	2003-09-25
ZA200303892B (en)	2004-05-20
EE200300284A (et)	2003-10-15
EP1347760B1 (de)	2005-06-01
CZ20031543A3 (cs)	2004-06-16
PA8534901A1 (es)	2002-08-26
IS6811A (is)	2003-05-08
CA2431172A1 (en)	2002-06-20
EA006489B1 (ru)	2005-12-29
WO2002047685A3 (en)	2002-08-15
MA26970A1 (fr)	2004-12-20
HRP20030473A2 (en)	2005-04-30
DE60111265T2 (de)	2006-05-04
HK1059575A1 (en)	2004-07-09
ATE296629T1 (de)	2005-06-15
ECSP034655A (es)	2003-07-25
NZ525742A (en)	2005-07-29
ES2239648T3 (es)	2005-10-01
HUP0400645A2 (hu)	2004-06-28
AR035607A1 (es)	2004-06-16

Publication	Publication Date	Title
EP1347760B1 (de)	2005-06-01	Pharmazeutische zusammensetzungen mit nmda-rezeptor-agonist
AU2002218454A1 (en)	2002-08-29	NMDA receptor agonist pharmaceutical compositions
KR101408336B1 (ko)	2014-06-20	아세틸시스테인 조성물 및 그의 용도
JP5522877B2 (ja)	2014-06-18	モキシフロキサシン／塩化ナトリウム製剤
JP6736765B2 (ja)	2020-08-05	ベンダムスチン溶液製剤
JPWO2008023807A1 (ja)	2010-01-14	安定化された医薬組成物
AU2019215801B2 (en)	2024-09-19	Parenteral formulations and uses thereof
JP7857158B2 (ja)	2026-05-12	透析患者に適用される注射用医薬組成物
WO2013108180A1 (en)	2013-07-25	Aqueous paracetamol composition for injection
TW200808690A (en)	2008-02-16	Aqueous pharmaceutical formulation of 4-[((4-carboxybutyl)-{2-[(4-phenethylbenzyl)oxy]-phenethyl}amino)methyl]benzoic acid
WO2004098614A1 (ja)	2004-11-18	メチルコバラミン含有凍結乾燥製剤及びその製造方法
JP3668225B2 (ja)	2005-07-06	Ｏｃｔ製剤
EP0365363B1 (de)	1993-04-14	Parenteral anzuwendende 1-Diphenylmethyl-4-[(2-(4-methylphenyl)-5-methyl-1H-imidazol-4-yl)-methyl]-piperazin enthaltende Zubereitungen
JPWO2006004028A1 (ja)	2008-04-24	キノロン含有医薬組成物
KR20220062368A (ko)	2022-05-16	p-보로노페닐알라닌을 함유하는 주사액제의 석출 방지 방법
CN114423458A (zh)	2022-04-29	含有对二羟硼基苯丙氨酸的注射液剂
NZ562158A (en)	2011-04-29	Stannsoporfin compositions and administration
HK1059575B (en)	2006-12-08	Nmda receptor agonist pharmaceutical compositions
EP1864664A1 (de)	2007-12-12	Pharmazeutische zubereitung
HK40063208A (en)	2022-06-17	Method for preventing precipitation of injectable solution containing p-boronophenylalanine
HK1101347A1 (en)	2007-10-18	Fasudil-containing preparation and method of improving stability thereof