BG108032A - Азолови съединения като противогъбични средства - Google Patents

Азолови съединения като противогъбични средства Download PDF

Info

Publication number: BG108032A
Authority: BG; Bulgaria
Prior art keywords: group; alkyl; alkoxy; hydrogen; carboxyl
Prior art date: 2000-12-26

Application number

BG108032A

Other languages

Bulgarian (bg)

English (en)

Inventor

Mohammad Salman

Rita Katoch

Ashwani Verma

Jitendra Sattigeri

Ashok Rattan

Original Assignee

Ranbaxy Laboratories Limited

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-26

Filing date

2003-07-25

Publication date

2004-12-30

2003-07-25 Application filed by Ranbaxy Laboratories Limited filed Critical Ranbaxy Laboratories Limited

2004-12-30 Publication of BG108032A publication Critical patent/BG108032A/bg

Links

230000000843 anti-fungal effect Effects 0.000 title abstract description 13
150000003851 azoles Chemical class 0.000 title abstract description 9
229940121375 antifungal agent Drugs 0.000 title description 14
150000001875 compounds Chemical class 0.000 claims abstract description 66
208000031888 Mycoses Diseases 0.000 claims abstract description 19
238000000034 method Methods 0.000 claims abstract description 19
206010017533 Fungal infection Diseases 0.000 claims abstract description 17
238000002360 preparation method Methods 0.000 claims abstract description 9
-1 diastereomers Chemical class 0.000 claims description 80
229910052739 hydrogen Inorganic materials 0.000 claims description 43
239000001257 hydrogen Substances 0.000 claims description 43
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 31
239000003814 drug Substances 0.000 claims description 28
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 27
125000003118 aryl group Chemical group 0.000 claims description 26
229940079593 drug Drugs 0.000 claims description 26
125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims description 25
125000004435 hydrogen atom Chemical class [H]* 0.000 claims description 25
125000000217 alkyl group Chemical group 0.000 claims description 24
229910052736 halogen Inorganic materials 0.000 claims description 22
150000002367 halogens Chemical class 0.000 claims description 22
HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 20
150000003839 salts Chemical class 0.000 claims description 20
125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims description 18
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 16
239000002243 precursor Substances 0.000 claims description 15
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 15
125000003626 1,2,4-triazol-1-yl group Chemical group [*]N1N=C([H])N=C1[H] 0.000 claims description 14
125000004182 2-chlorophenyl group Chemical group [H]C1=C([H])C(Cl)=C(*)C([H])=C1[H] 0.000 claims description 13
125000001424 substituent group Chemical group 0.000 claims description 13
150000001204 N-oxides Chemical class 0.000 claims description 12
239000002207 metabolite Substances 0.000 claims description 12
125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims description 11
125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims description 11
CFHGBZLNZZVTAY-UHFFFAOYSA-N lawesson's reagent Chemical class C1=CC(OC)=CC=C1P1(=S)SP(=S)(C=2C=CC(OC)=CC=2)S1 CFHGBZLNZZVTAY-UHFFFAOYSA-N 0.000 claims description 10
125000004800 4-bromophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Br 0.000 claims description 9
ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 9
WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 9
ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 9
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims description 9
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229910052794 bromium Inorganic materials 0.000 claims description 9
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125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 9
125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 9
125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 claims description 8
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LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 7
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PEUPUKDBCPLDIH-UHFFFAOYSA-N 1,2,4-triazole Chemical group C1=NC=N[N]1 PEUPUKDBCPLDIH-UHFFFAOYSA-N 0.000 claims 1
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XRECTZIEBJDKEO-UHFFFAOYSA-N flucytosine Chemical compound NC1=NC(=O)NC=C1F XRECTZIEBJDKEO-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

BG108032A 2000-12-26 2003-07-25 Азолови съединения като противогъбични средства BG108032A (bg)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IN1197DE2000		2000-12-26

Publications (1)

Publication Number	Publication Date
BG108032A true BG108032A (bg)	2004-12-30

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ID=11097140

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Country Status (18)

Country	Link
US (1)	US6710049B2 (fr)
EP (1)	EP1347758A1 (fr)
JP (1)	JP2004518667A (fr)
CN (1)	CN1489465A (fr)
AR (1)	AR035525A1 (fr)
BG (1)	BG108032A (fr)
BR (1)	BR0116570A (fr)
CA (1)	CA2433259A1 (fr)
CZ (1)	CZ20032028A3 (fr)
EA (1)	EA200300725A1 (fr)
EC (1)	ECSP034673A (fr)
HU (1)	HUP0400725A2 (fr)
MA (1)	MA26066A1 (fr)
MX (1)	MXPA03005899A (fr)
PL (1)	PL362051A1 (fr)
SK (1)	SK9522003A3 (fr)
WO (1)	WO2002051408A1 (fr)
ZA (1)	ZA200304980B (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IN191819B (fr) *	2001-07-19	2004-01-03	Ranbaxy Lab Ltd
WO2004018485A1 (fr) *	2002-08-26	2004-03-04	Ranbaxy Laboratories Limited	Dérivés d'azole utilisés comme agents antifongiques
WO2007047394A2 (fr) *	2005-10-13	2007-04-26	Epix Delaware, Inc.	Derives de thiotriazolyle
PL2623499T3 (pl) *	2010-10-01	2015-09-30	Taisho Pharmaceutical Co Ltd	Pochodne 1,2,4-triazolonu

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB567981A (en)	1943-03-30	1945-03-13	Malcolm Edward Johnson	Improvements in or relating to control valves for vehicle servo brakes
TW218017B (fr)	1992-04-28	1993-12-21	Takeda Pharm Industry Co Ltd
CA2134417A1 (fr) *	1993-12-22	1995-06-23	Katsumi Itoh	Derives azotes optiquement actifs leur production et leur utilisation
US5677464A (en)	1994-05-31	1997-10-14	Takeda Chemical Industries, Ltd.	Production of optically active triazole compounds and their intermediates
TW318841B (fr)	1995-02-17	1997-11-01	Takeda Pharm Industry Co Ltd
DE19620407A1 (de) *	1996-05-21	1997-11-27	Bayer Ag	Thiocyano-triazolyl-Derivate
PL365072A1 (en)	2000-03-07	2004-12-27	Ranbaxy Laboratories Limited	Azole compounds as therapeutic agents for fungal infections

2001
- 2001-12-21 MX MXPA03005899A patent/MXPA03005899A/es not_active Application Discontinuation
- 2001-12-21 CN CNA018225721A patent/CN1489465A/zh active Pending
- 2001-12-21 US US10/026,235 patent/US6710049B2/en not_active Expired - Fee Related
- 2001-12-21 HU HU0400725A patent/HUP0400725A2/hu unknown
- 2001-12-21 PL PL01362051A patent/PL362051A1/xx not_active Application Discontinuation
- 2001-12-21 BR BR0116570-4A patent/BR0116570A/pt not_active Application Discontinuation
- 2001-12-21 JP JP2002552553A patent/JP2004518667A/ja active Pending
- 2001-12-21 EA EA200300725A patent/EA200300725A1/ru unknown
- 2001-12-21 SK SK952-2003A patent/SK9522003A3/sk unknown
- 2001-12-21 CA CA002433259A patent/CA2433259A1/fr not_active Abandoned
- 2001-12-21 EP EP01272204A patent/EP1347758A1/fr not_active Withdrawn
- 2001-12-21 WO PCT/IB2001/002620 patent/WO2002051408A1/fr not_active Ceased
- 2001-12-21 CZ CZ20032028A patent/CZ20032028A3/cs unknown
- 2001-12-26 AR ARP010106040A patent/AR035525A1/es unknown
2003
- 2003-06-26 ZA ZA200304980A patent/ZA200304980B/en unknown
- 2003-06-26 MA MA27214A patent/MA26066A1/fr unknown
- 2003-06-26 EC EC2003004673A patent/ECSP034673A/es unknown
- 2003-07-25 BG BG108032A patent/BG108032A/bg unknown

Also Published As

Publication number	Publication date
AR035525A1 (es)	2004-06-02
EA200300725A1 (ru)	2004-04-29
ZA200304980B (en)	2004-04-28
US20020119984A1 (en)	2002-08-29
CZ20032028A3 (cs)	2003-11-12
CA2433259A1 (fr)	2002-07-04
SK9522003A3 (en)	2003-12-02
CN1489465A (zh)	2004-04-14
BR0116570A (pt)	2005-04-12
JP2004518667A (ja)	2004-06-24
WO2002051408A1 (fr)	2002-07-04
MA26066A1 (fr)	2004-04-01
HUP0400725A2 (hu)	2004-07-28
MXPA03005899A (es)	2004-01-26
PL362051A1 (en)	2004-10-18
US6710049B2 (en)	2004-03-23
EP1347758A1 (fr)	2003-10-01
ECSP034673A (es)	2003-08-29

Publication	Publication Date	Title
EP2536697B1 (fr)	2016-10-19	Nouveaux dérivés de triazole antifongiques
WO2002089809A1 (fr)	2002-11-14	Utilisations medicales d'hydrazones et d'hydrazines
JPS58185571A (ja)	1983-10-29	新規トリアゾ−ル誘導体及びそれからなる抗真菌剤
US20060178415A1 (en)	2006-08-10	Azole derivatives as antifungal agents
EP0829478A2 (fr)	1998-03-18	Dérivés de N-benzylimidazolium et N-benzyltriazolium, leur préparation et leur utilisation comme agents anti-fongiques et anti-mycotiques
BG108032A (bg)	2004-12-30	Азолови съединения като противогъбични средства
JPS59164782A (ja)	1984-09-17	置換１，３−ジアゾリル−２−プロパノ−ル類、その製法および抗糸状菌剤
US20050131041A1 (en)	2005-06-16	Azole derivatives as antifungal agents
KR100252433B1 (ko)	2000-08-01	엔-벤질아졸륨 유도체
JPWO1997024333A1 (ja)	1999-01-26	糖尿病性合併症の予防・治療剤
JP2001508080A (ja)	2001-06-19	アミノ酸エステル含有アゾール抗真菌剤
US20040242896A1 (en)	2004-12-02	Azole compounds as anti-fungal agents
RU2345769C2 (ru)	2009-02-10	Комбинация вориконазола и противогрибкового ингибитора cyp2c19
JP2016527228A (ja)	2016-09-08	新規抗マラリア薬
EP2799430B1 (fr)	2016-07-20	Dérivé de diphénylméthyl pipérazine et composition pharmaceutique l'utilisant
JPS6084284A (ja)	1985-05-13	抗真菌性トリアゾ−ル誘導体
WO2002090350A1 (fr)	2002-11-14	Nouveaux derives d'azole ou de triazole, leur procede de preparation et leur application comme medicaments anti-fongiques
CN114181225B (zh)	2023-08-08	一种含笑内酯衍生物及其药物组合物、制备方法和用途
AU2002217365A1 (en)	2002-07-08	Azole compounds as anti-fungals agents
US20050261330A1 (en)	2005-11-24	Derivatives of 2,2,4-trisubstituted tetrahydrofuran an antifungal agents
JPH01149780A (ja)	1989-06-12	新規なアゾリルメチルカルビノール類
EP1409461B1 (fr)	2011-02-23	Nouveaux derives d'azole ou de triazole, leur procede de preparation et leur application comme fongicides
JPH08253475A (ja)	1996-10-01	２，３−ジヒドロベンゾ［ｂ］チオフェン誘導体
CA2015013A1 (fr)	1990-11-02	Compose de triazole, preparation antimycotique le contenant, et methode de prevention et(ou) de traitement des mycoses profondes par l'utilisation dudit compose