BG108072A - The use of epothilone derivatives for the treatment of refractory tumors - Google Patents

The use of epothilone derivatives for the treatment of refractory tumors

Info

Publication number: BG108072A
Authority: BG; Bulgaria
Prior art keywords: treatment; epothilone; derivatives; epothilone derivatives; refractory tumors
Prior art date: 2001-02-20

Application number

BG108072A

Other languages

Bulgarian (bg)

English (en)

Inventor

Francis Lee

Original Assignee

Bristol-Myers Squibb Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-20

Filing date

2003-08-07

Publication date

2005-04-30

2003-08-07 Application filed by Bristol-Myers Squibb Company filed Critical Bristol-Myers Squibb Company

2005-04-30 Publication of BG108072A publication Critical patent/BG108072A/xx

Links

206010028980 Neoplasm Diseases 0.000 title abstract 3
150000003883 epothilone derivatives Chemical class 0.000 title abstract 3
238000000034 method Methods 0.000 abstract 2
241000124008 Mammalia Species 0.000 abstract 1
229940123237 Taxane Drugs 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
229930013356 epothilone Natural products 0.000 abstract 1
238000011275 oncology therapy Methods 0.000 abstract 1
DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 abstract 1
238000002560 therapeutic procedure Methods 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Plural Heterocyclic Compounds (AREA)

BG108072A 2001-02-20 2003-08-07 The use of epothilone derivatives for the treatment of refractory tumors BG108072A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US26985801P	2001-02-20	2001-02-20

Publications (1)

Publication Number	Publication Date
BG108072A true BG108072A (en)	2005-04-30

Family

ID=23028941

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG108072A BG108072A (en)	2001-02-20	2003-08-07	The use of epothilone derivatives for the treatment of refractory tumors

Country Status (18)

Country	Link
US (1)	US6727276B2 (pl)
EP (1)	EP1368030A1 (pl)
JP (1)	JP2004522771A (pl)
KR (1)	KR20040028720A (pl)
CN (1)	CN1610549A (pl)
BG (1)	BG108072A (pl)
BR (1)	BR0207316A (pl)
CA (1)	CA2438598A1 (pl)
EE (1)	EE200300397A (pl)
HU (1)	HUP0400041A2 (pl)
IL (1)	IL157128A0 (pl)
IS (1)	IS6917A (pl)
MX (1)	MXPA03007423A (pl)
NO (1)	NO20033682D0 (pl)
PL (1)	PL363363A1 (pl)
RU (1)	RU2003128312A (pl)
WO (1)	WO2002066033A1 (pl)
ZA (1)	ZA200306237B (pl)

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US6780620B1 (en) *	1998-12-23	2004-08-24	Bristol-Myers Squibb Company	Microbial transformation method for the preparation of an epothilone
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CA2440555A1 (en) *	2001-03-14	2002-09-19	Bristol-Myers Squibb Company	Combination of epothilone analogs and chemotherapeutic agents for the treatment of proliferative diseases
TW200403994A (en) *	2002-04-04	2004-03-16	Bristol Myers Squibb Co	Oral administration of EPOTHILONES
TW200400191A (en) *	2002-05-15	2004-01-01	Bristol Myers Squibb Co	Pharmaceutical compositions and methods of using C-21 modified epothilone derivatives
US7384964B2 (en) *	2002-08-23	2008-06-10	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto, analogues and uses thereof
US7649006B2 (en)	2002-08-23	2010-01-19	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
US6921769B2 (en)	2002-08-23	2005-07-26	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto and analogues thereof
WO2004018478A2 (en) *	2002-08-23	2004-03-04	Sloan-Kettering Institute For Cancer Research	Synthesis of epothilones, intermediates thereto, analogues and uses thereof
AU2003279911A1 (en)	2002-10-09	2004-05-04	Kosan Biosciences, Inc.	Therapeutic formulations
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EP1824458A1 (en) *	2004-11-18	2007-08-29	Bristol-Myers Squibb Company	Enteric coated bead comprising epothilone or an epothilone analog, and preparation and administration thereof
JP2008536479A (ja)	2005-02-11	2008-09-11	ユニバーシティオブサザンカリフォルニア	ジスルフィド架橋を有するタンパク質の発現法
JP4954983B2 (ja)	2005-05-18	2012-06-20	ファーマサイエンス・インコーポレイテッド	Ｂｉｒドメイン結合化合物
US8008256B2 (en) *	2006-05-01	2011-08-30	University Of Southern California	Combination therapy for treatment of cancer
SG10201407457UA (en)	2006-05-16	2014-12-30	Pharmascience Inc	Iap bir domain binding compounds
US8802394B2 (en)	2008-11-13	2014-08-12	Radu O. Minea	Method of expressing proteins with disulfide bridges with enhanced yields and activity
MX340870B (es)	2010-02-12	2016-07-27	Pharmascience Inc	Compuestos de unión del dominio de repetición de inhibidores de proteínas de apoptosis de baculovirus.
CN103037903A (zh)	2010-05-18	2013-04-10	天蓝制药公司	用于治疗自身免疫性疾病或其它疾病的组合物和方法
CN110105368B (zh) *	2019-05-09	2022-01-07	上海大学	去氧紫杉烷类似物及其制备方法

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DE19639456A1 (de)	1996-09-25	1998-03-26	Biotechnolog Forschung Gmbh	Epothilon-Derivate, Herstellung und Mittel
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DE19645362A1 (de)	1996-10-28	1998-04-30	Ciba Geigy Ag	Verfahren zur Herstellung von Epothilon A und B und Derivaten
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DE19645361A1 (de)	1996-08-30	1998-04-30	Ciba Geigy Ag	Zwischenprodukte innerhalb der Totalsynthese von Epothilon A und B, Teil II
JP4274583B2 (ja)	1996-11-18	2009-06-10	ゲゼルシャフト・フュア・ビオテクノロギッシェ・フォルシュンク・ミット・ベシュレンクテル・ハフツング（ゲー・ベー・エフ）	エポチロンｃ，ｄ，ｅ及びｆ、製造と薬剤
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ES2184307T3 (es)	1997-07-16	2003-04-01	Schering Ag	Derivados de tiazol, procedimiento para su preparacion y su utilizacion.
CA2299608A1 (en)	1997-08-09	1999-02-18	Schering Aktiengesellschaft	New epothilone derivatives, method for producing same and their pharmaceutical use
US6365749B1 (en)	1997-12-04	2002-04-02	Bristol-Myers Squibb Company	Process for the preparation of ring-opened epothilone intermediates which are useful for the preparation of epothilone analogs
MY125921A (en)	1998-02-05	2006-08-30	Novartis Ag	Compositions containing organic compounds
US6194181B1 (en)	1998-02-19	2001-02-27	Novartis Ag	Fermentative preparation process for and crystal forms of cytostatics
JP2002504540A (ja)	1998-02-25	2002-02-12	スローン−ケッタリングインスティトゥートフォアキャンサーリサーチ	エポチロンの合成、その中間体およびそのアナログ
FR2775187B1 (fr)	1998-02-25	2003-02-21	Novartis Ag	Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
US6380395B1 (en)	1998-04-21	2002-04-30	Bristol-Myers Squibb Company	12, 13-cyclopropane epothilone derivatives
WO2000000485A1 (de)	1998-06-30	2000-01-06	Schering Aktiengesellschaft	Epothilon-derivate, verfahren zu deren herstellung, zwischenprodukte und ihre pharmazeutische verwendung
KR100851418B1 (ko)	1998-11-20	2008-08-08	코산 바이오사이언시즈, 인코포레이티드	에포틸론 및 에포틸론 유도체의 생산을 위한 재조합 방법 및 물질
AU2795000A (en)	1998-12-22	2000-07-12	Novartis Ag	Epothilone derivatives and their use as antitumor agents
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WO2000050423A1 (en) *	1999-02-22	2000-08-31	Gesellschaft Fuer Biotechnologische Forschung Mbh (Gbf)	C-21 modified epothilones
US6211412B1 (en)	1999-03-29	2001-04-03	The University Of Kansas	Synthesis of epothilones
PE20010116A1 (es)	1999-04-30	2001-02-15	Schering Ag	Derivados de 6-alquenil-, 6-alquinil- y 6-epoxi-epotilona, procedimientos para su preparacion

2002
- 2002-02-06 MX MXPA03007423A patent/MXPA03007423A/es unknown
- 2002-02-06 WO PCT/US2002/004247 patent/WO2002066033A1/en not_active Ceased
- 2002-02-06 RU RU2003128312/14A patent/RU2003128312A/ru not_active Application Discontinuation
- 2002-02-06 EP EP02724940A patent/EP1368030A1/en not_active Withdrawn
- 2002-02-06 HU HU0400041A patent/HUP0400041A2/hu unknown
- 2002-02-06 CN CNA028052447A patent/CN1610549A/zh active Pending
- 2002-02-06 BR BR0207316-1A patent/BR0207316A/pt not_active Application Discontinuation
- 2002-02-06 JP JP2002565591A patent/JP2004522771A/ja active Pending
- 2002-02-06 PL PL02363363A patent/PL363363A1/pl not_active Application Discontinuation
- 2002-02-06 CA CA002438598A patent/CA2438598A1/en not_active Abandoned
- 2002-02-06 IL IL15712802A patent/IL157128A0/xx unknown
- 2002-02-06 KR KR10-2003-7010872A patent/KR20040028720A/ko not_active Withdrawn
- 2002-02-06 EE EEP200300397A patent/EE200300397A/xx unknown
- 2002-02-08 US US10/071,988 patent/US6727276B2/en not_active Expired - Fee Related
2003
- 2003-08-07 BG BG108072A patent/BG108072A/xx unknown
- 2003-08-12 ZA ZA200306237A patent/ZA200306237B/en unknown
- 2003-08-18 IS IS6917A patent/IS6917A/is unknown
- 2003-08-19 NO NO20033682A patent/NO20033682D0/no not_active Application Discontinuation

Also Published As

Publication number	Publication date
HUP0400041A2 (hu)	2004-04-28
KR20040028720A (ko)	2004-04-03
JP2004522771A (ja)	2004-07-29
CN1610549A (zh)	2005-04-27
IL157128A0 (en)	2004-02-08
ZA200306237B (en)	2004-12-23
US20020165257A1 (en)	2002-11-07
RU2003128312A (ru)	2005-02-10
PL363363A1 (pl)	2004-11-15
MXPA03007423A (es)	2003-11-18
US6727276B2 (en)	2004-04-27
CA2438598A1 (en)	2002-08-29
IS6917A (is)	2003-08-18
NO20033682L (no)	2003-08-19
WO2002066033A1 (en)	2002-08-29
NO20033682D0 (no)	2003-08-19
BR0207316A (pt)	2004-02-10
EE200300397A (et)	2003-12-15
EP1368030A1 (en)	2003-12-10

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