BG108379A - Използване на енантиомерно чист есциталопрам - Google Patents

Използване на енантиомерно чист есциталопрам Download PDF

Info

Publication number: BG108379A
Authority: BG; Bulgaria
Prior art keywords: escitalopram; treatment; pharmaceutical composition; disorder; disorders
Prior art date: 2001-05-01

Application number

BG108379A

Other languages

Bulgarian (bg)

English (en)

Inventor

Connie Sanchez

Jensen Jesper Lyng

Arne Mork

Original Assignee

H. Lundbeck A/S

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-05-01

Filing date

2003-11-24

Publication date

2004-11-30

2003-11-24 Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S

2004-11-30 Publication of BG108379A publication Critical patent/BG108379A/bg

Links

WSEQXVZVJXJVFP-FQEVSTJZSA-N escitalopram Chemical compound C1([C@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-FQEVSTJZSA-N 0.000 title claims abstract description 52
229960004341 escitalopram Drugs 0.000 title claims abstract description 52
238000011282 treatment Methods 0.000 claims abstract description 31
208000020401 Depressive disease Diseases 0.000 claims abstract description 18
239000003814 drug Substances 0.000 claims abstract description 7
208000015238 neurotic disease Diseases 0.000 claims abstract description 7
206010029333 Neurosis Diseases 0.000 claims abstract description 6
208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims abstract description 3
208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims abstract description 3
208000032841 Bulimia Diseases 0.000 claims abstract description 3
206010006550 Bulimia nervosa Diseases 0.000 claims abstract description 3
208000008589 Obesity Diseases 0.000 claims abstract description 3
206010036618 Premenstrual syndrome Diseases 0.000 claims abstract description 3
208000031674 Traumatic Acute Stress disease Diseases 0.000 claims abstract description 3
208000022531 anorexia Diseases 0.000 claims abstract description 3
208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims abstract description 3
208000010877 cognitive disease Diseases 0.000 claims abstract description 3
206010061428 decreased appetite Diseases 0.000 claims abstract description 3
208000024732 dysthymic disease Diseases 0.000 claims abstract description 3
235000020824 obesity Nutrition 0.000 claims abstract description 3
208000019899 phobic disease Diseases 0.000 claims abstract description 3
208000011117 substance-related disease Diseases 0.000 claims abstract description 3
208000026331 Disruptive, Impulse Control, and Conduct disease Diseases 0.000 claims abstract 2
208000030814 Eating disease Diseases 0.000 claims abstract 2
208000019454 Feeding and Eating disease Diseases 0.000 claims abstract 2
208000030990 Impulse-control disease Diseases 0.000 claims abstract 2
208000026345 acute stress disease Diseases 0.000 claims abstract 2
235000014632 disordered eating Nutrition 0.000 claims abstract 2
WSEQXVZVJXJVFP-HXUWFJFHSA-N (R)-citalopram Chemical compound C1([C@@]2(C3=CC=C(C=C3CO2)C#N)CCCN(C)C)=CC=C(F)C=C1 WSEQXVZVJXJVFP-HXUWFJFHSA-N 0.000 claims description 21
239000008194 pharmaceutical composition Substances 0.000 claims description 16
229940124834 selective serotonin reuptake inhibitor Drugs 0.000 claims description 13
238000011221 initial treatment Methods 0.000 claims description 4
150000003891 oxalate salts Chemical class 0.000 claims description 4
239000004480 active ingredient Substances 0.000 claims description 3
206010013663 drug dependence Diseases 0.000 claims description 2
208000013403 hyperactivity Diseases 0.000 claims 1
208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 5
208000035475 disorder Diseases 0.000 abstract description 2
208000024714 major depressive disease Diseases 0.000 abstract 2
206010013654 Drug abuse Diseases 0.000 abstract 1
230000000694 effects Effects 0.000 description 18
229960001653 citalopram Drugs 0.000 description 12
229940068196 placebo Drugs 0.000 description 11
239000000902 placebo Substances 0.000 description 11
QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 description 8
230000004044 response Effects 0.000 description 7
208000019906 panic disease Diseases 0.000 description 6
208000019901 Anxiety disease Diseases 0.000 description 5
206010041250 Social phobia Diseases 0.000 description 5
208000024891 symptom Diseases 0.000 description 5
208000021384 Obsessive-Compulsive disease Diseases 0.000 description 4
230000036506 anxiety Effects 0.000 description 4
208000011688 Generalised anxiety disease Diseases 0.000 description 3
206010033664 Panic attack Diseases 0.000 description 3
208000028552 Treatment-Resistant Depressive disease Diseases 0.000 description 3
238000010171 animal model Methods 0.000 description 3
230000001430 anti-depressive effect Effects 0.000 description 3
239000000935 antidepressant agent Substances 0.000 description 3
230000008859 change Effects 0.000 description 3
208000029364 generalized anxiety disease Diseases 0.000 description 3
230000006872 improvement Effects 0.000 description 3
230000000144 pharmacologic effect Effects 0.000 description 3
208000028173 post-traumatic stress disease Diseases 0.000 description 3
206010010904 Convulsion Diseases 0.000 description 2
201000001880 Sexual dysfunction Diseases 0.000 description 2
229940079593 drug Drugs 0.000 description 2
230000005764 inhibitory process Effects 0.000 description 2
230000003389 potentiating effect Effects 0.000 description 2
239000012896 selective serotonin reuptake inhibitor Substances 0.000 description 2
231100000872 sexual dysfunction Toxicity 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 description 1
208000008811 Agoraphobia Diseases 0.000 description 1
206010034912 Phobia Diseases 0.000 description 1
229940123445 Tricyclic antidepressant Drugs 0.000 description 1
230000009471 action Effects 0.000 description 1
229940005513 antidepressants Drugs 0.000 description 1
230000003542 behavioural effect Effects 0.000 description 1
230000008901 benefit Effects 0.000 description 1
230000008499 blood brain barrier function Effects 0.000 description 1
210000001218 blood-brain barrier Anatomy 0.000 description 1
230000001684 chronic effect Effects 0.000 description 1
229940066010 citalopram 40 mg Drugs 0.000 description 1
125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 description 1
201000010099 disease Diseases 0.000 description 1
229940041201 escitalopram 10 mg Drugs 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
238000001727 in vivo Methods 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
238000000034 method Methods 0.000 description 1
239000000203 mixture Substances 0.000 description 1
208000030212 nutrition disease Diseases 0.000 description 1
238000001050 pharmacotherapy Methods 0.000 description 1
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
208000020016 psychiatric disease Diseases 0.000 description 1
230000009467 reduction Effects 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
229940126570 serotonin reuptake inhibitor Drugs 0.000 description 1
239000003772 serotonin uptake inhibitor Substances 0.000 description 1
208000019116 sleep disease Diseases 0.000 description 1
201000001716 specific phobia Diseases 0.000 description 1
230000035882 stress Effects 0.000 description 1
230000001629 suppression Effects 0.000 description 1
239000003029 tricyclic antidepressant agent Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Engineering & Computer Science (AREA)
Biomedical Technology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pain & Pain Management (AREA)
Hematology (AREA)
Obesity (AREA)
Diabetes (AREA)
Child & Adolescent Psychology (AREA)
Hospice & Palliative Care (AREA)
Addiction (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)

BG108379A 2001-05-01 2003-11-24 Използване на енантиомерно чист есциталопрам BG108379A (bg)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DKPA200100684		2001-05-01

Publications (1)

Publication Number	Publication Date
BG108379A true BG108379A (bg)	2004-11-30

Family

ID=8160464

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG108379A BG108379A (bg)	2001-05-01	2003-11-24	Използване на енантиомерно чист есциталопрам

Country Status (25)

Country	Link
US (7)	US20040198809A1 (pl)
EP (1)	EP1385503A1 (pl)
JP (1)	JP2004527551A (pl)
KR (2)	KR20100012089A (pl)
CN (1)	CN1509169A (pl)
AR (1)	AR033308A1 (pl)
AT (1)	AT10974U1 (pl)
BG (1)	BG108379A (pl)
BR (1)	BR0208283A (pl)
CA (1)	CA2445843A1 (pl)
CZ (1)	CZ20033267A3 (pl)
EA (1)	EA200301195A1 (pl)
HR (1)	HRP20030744A2 (pl)
HU (1)	HUP0400054A3 (pl)
IL (1)	IL158031A0 (pl)
IS (1)	IS6954A (pl)
ME (1)	MEP5908A (pl)
MX (1)	MXPA03008777A (pl)
NO (1)	NO20034538L (pl)
PL (1)	PL367480A1 (pl)
SK (1)	SK14612003A3 (pl)
UA (1)	UA82828C2 (pl)
WO (1)	WO2002087566A1 (pl)
YU (1)	YU85303A (pl)
ZA (1)	ZA200307102B (pl)

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AR021155A1 (es) *	1999-07-08	2002-06-12	Lundbeck & Co As H	Tratamiento de desordenes neuroticos
CA2445843A1 (en) *	2001-05-01	2002-11-07	H. Lundbeck A/S	The use of enantiomeric pure escitalopram
NZ540281A (en) *	2002-12-23	2008-07-31	Lundbeck & Co As H	Escitalopram hydrobromide and a method for the preparation thereof
US20050037983A1 (en) *	2003-03-11	2005-02-17	Timothy Dinan	Compositions and methods for the treatment of depression and other affective disorders
AR047553A1 (es) *	2003-07-04	2006-01-25	Lundbeck & Co As H	La combinacion de un inhibidor de reabsorcion de serotonina y agomelatina
PT1691811E (pt) *	2003-12-11	2014-10-30	Sunovion Pharmaceuticals Inc	Combinação de um sedativo e de um modulador de neurotransmissores e métodos para melhorar a qualidade do sono e tratamento da depressão
NZ549100A (en) *	2004-03-05	2010-02-26	Lundbeck & Co As H	Crystalline composition containing escitalopram oxalate
US20050196453A1 (en)	2004-03-05	2005-09-08	H. Lundbeck A/S	Crystalline composition containing escitalopram
TWI358407B (en) *	2005-06-22	2012-02-21	Lundbeck & Co As H	Crystalline base of escitalopram and orodispersibl
AU2006304889A1 (en) *	2005-10-14	2007-04-26	H. Lundbeck A/S	Stable pharmaceutical formulations containing escitalopram and bupropion
KR20080080094A (ko) *	2005-10-14	2008-09-02	하. 룬트벡 아크티에 셀스카브	에스시탈로프람 및 부프로피온의 저용량 조합물을 이용한중추신경계 장애의 치료 방법
US20070134322A1 (en) *	2005-12-14	2007-06-14	Forest Laboratories, Inc.	Modified and pulsatile release pharmaceutical formulations of escitalopram
CN100353939C (zh) *	2006-01-05	2007-12-12	昆明积大制药有限公司	含西酞普兰和环糊精的抗抑郁口服药用组合物
TW200812993A (en) *	2006-05-02	2008-03-16	Lundbeck & Co As H	New uses of escitalopram
US20070259952A1 (en) *	2006-05-02	2007-11-08	H. Lundbeck A/S	Uses of escitalopram
US8252336B2 (en) *	2006-10-20	2012-08-28	Ratiopharm Gmbh	Escitalopram and solid pharmaceutical composition comprising the same
US20100003313A1 (en) *	2006-10-27	2010-01-07	Hisamitsu Pharmaceutical Co.,Inc.	Adhesive skin patch
EP2017271A1 (en)	2007-07-06	2009-01-21	Aurobindo Pharma Limited	Process for the preparation of escitalopram
ES2653852T3 (es) *	2007-08-03	2018-02-09	Richter Gedeon Nyrt.	Composiciones farmacéuticas que contienen ligandos del receptor de dopamina y procedimientos de tratamiento usando ligandos del receptor de dopamina
CA2713598C (en) *	2008-01-31	2016-07-05	Takeda Pharmaceutical Company Limited	Prophylactic or therapeutic agent for attention deficit/hyperactivity disorder
ITMI20080768A1 (it) *	2008-04-24	2009-10-25	Abiogen Pharma Spa	Procedimento per la preparazione di un composto in forma cristallina di 3-benzil-2-metil-2,3,3a,4,5,6,7,7a-ottaidro-benzo[d]isossazol-4-one
WO2010098230A1 (ja) *	2009-02-27	2010-09-02	久光製薬株式会社	経皮投与製剤
US20180071269A1 (en)	2015-08-12	2018-03-15	Tianxin Wang	Therapeutical methods, formulations and nutraceutical formulations
CA2982898C (en) *	2015-05-13	2023-08-29	A. Carlsson Research Ab	Combination of dopamine stabilizing agent and an anti-depressive agent to treat a disorder characterized by debilitating fatigue

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IL145615A0 (en) *	1999-04-14	2002-06-30	Lundbeck & Co As H	Method for the preparation of citalopram
AR021155A1 (es) *	1999-07-08	2002-06-12	Lundbeck & Co As H	Tratamiento de desordenes neuroticos
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UA77650C2 (en) *	1999-12-06	2007-01-15	Lundbeck & Co As H	Use of serotonin reuptake inhibitor in combination with deramcyclane
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US6469064B2 (en) *	2000-04-24	2002-10-22	Aryx Therapeutics	Materials and methods for the treatment of depression
CA2445843A1 (en) *	2001-05-01	2002-11-07	H. Lundbeck A/S	The use of enantiomeric pure escitalopram

2002
- 2002-05-01 CA CA002445843A patent/CA2445843A1/en not_active Abandoned
- 2002-05-01 HU HU0400054A patent/HUP0400054A3/hu unknown
- 2002-05-01 MX MXPA03008777A patent/MXPA03008777A/es unknown
- 2002-05-01 ME MEP-59/08A patent/MEP5908A/xx unknown
- 2002-05-01 CZ CZ20033267A patent/CZ20033267A3/cs unknown
- 2002-05-01 HR HR20030744A patent/HRP20030744A2/xx not_active Application Discontinuation
- 2002-05-01 WO PCT/DK2002/000281 patent/WO2002087566A1/en not_active Ceased
- 2002-05-01 BR BR0208283-7A patent/BR0208283A/pt not_active IP Right Cessation
- 2002-05-01 SK SK1461-2003A patent/SK14612003A3/sk not_active Application Discontinuation
- 2002-05-01 IL IL15803102A patent/IL158031A0/xx unknown
- 2002-05-01 US US10/468,685 patent/US20040198809A1/en not_active Abandoned
- 2002-05-01 KR KR1020097027003A patent/KR20100012089A/ko not_active Ceased
- 2002-05-01 PL PL02367480A patent/PL367480A1/pl not_active Application Discontinuation
- 2002-05-01 CN CNA028092309A patent/CN1509169A/zh active Pending
- 2002-05-01 EP EP02724141A patent/EP1385503A1/en not_active Withdrawn
- 2002-05-01 KR KR10-2003-7014286A patent/KR20040030609A/ko not_active Ceased
- 2002-05-01 EA EA200301195A patent/EA200301195A1/ru unknown
- 2002-05-01 UA UA2003098415A patent/UA82828C2/xx unknown
- 2002-05-01 JP JP2002584912A patent/JP2004527551A/ja active Pending
- 2002-05-01 YU YU85303A patent/YU85303A/sh unknown
- 2002-05-02 AR ARP020101612A patent/AR033308A1/es unknown
2003
- 2003-08-20 US US10/644,577 patent/US20040198810A1/en not_active Abandoned
- 2003-08-20 US US10/644,579 patent/US20040192765A1/en not_active Abandoned
- 2003-08-20 US US10/644,588 patent/US20040192766A1/en not_active Abandoned
- 2003-08-20 US US10/644,587 patent/US20040198811A1/en not_active Abandoned
- 2003-08-20 US US10/644,576 patent/US20040192764A1/en not_active Abandoned
- 2003-09-11 ZA ZA200307102A patent/ZA200307102B/xx unknown
- 2003-09-15 IS IS6954A patent/IS6954A/is unknown
- 2003-10-09 NO NO20034538A patent/NO20034538L/no not_active Application Discontinuation
- 2003-11-24 BG BG108379A patent/BG108379A/bg unknown
2007
- 2007-09-12 US US11/853,949 patent/US20080004338A1/en not_active Abandoned
2008
- 2008-03-21 AT AT0017508U patent/AT10974U1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
EA200301195A1 (ru)	2004-04-29
CA2445843A1 (en)	2002-11-07
EP1385503A1 (en)	2004-02-04
UA82828C2 (en)	2008-05-26
HUP0400054A2 (hu)	2004-04-28
US20040198809A1 (en)	2004-10-07
AT10974U1 (de)	2010-02-15
MXPA03008777A (es)	2004-02-12
BR0208283A (pt)	2004-03-09
HUP0400054A3 (en)	2007-03-28
IL158031A0 (en)	2004-03-28
NO20034538D0 (no)	2003-10-09
US20040192765A1 (en)	2004-09-30
IS6954A (is)	2003-09-15
YU85303A (sh)	2006-05-25
KR20040030609A (ko)	2004-04-09
SK14612003A3 (sk)	2004-04-06
PL367480A1 (pl)	2005-02-21
US20040192766A1 (en)	2004-09-30
JP2004527551A (ja)	2004-09-09
MEP5908A (xx)	2010-02-10
CZ20033267A3 (en)	2004-06-16
US20080004338A1 (en)	2008-01-03
US20040198811A1 (en)	2004-10-07
CN1509169A (zh)	2004-06-30
WO2002087566A1 (en)	2002-11-07
KR20100012089A (ko)	2010-02-05
ZA200307102B (en)	2004-09-13
US20040198810A1 (en)	2004-10-07
AR033308A1 (es)	2003-12-10
NO20034538L (no)	2003-10-09
HRP20030744A2 (en)	2005-06-30
US20040192764A1 (en)	2004-09-30

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