BG108424A - Pyrrolidineoxadiazole and pyrrolidinethiadiazole derivatives - Google Patents

Pyrrolidineoxadiazole and pyrrolidinethiadiazole derivatives

Info

Publication number: BG108424A
Authority: BG; Bulgaria
Prior art keywords: compounds; well; derivatives; relates; pyrrolidinethiadiazole
Prior art date: 2001-06-18

Application number

BG108424A

Other languages

Bulgarian (bg)

English (en)

Inventor

Matthias Schwarz

Anna Quattropani

Patrick Page

Russell Thomas

Vincent Pomel

Original Assignee

Applied Research Systems Ars Holding N.V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-18

Filing date

2003-12-08

Publication date

2005-03-31

2003-12-08 Application filed by Applied Research Systems Ars Holding N.V. filed Critical Applied Research Systems Ars Holding N.V.

2005-03-31 Publication of BG108424A publication Critical patent/BG108424A/xx

Links

150000001875 compounds Chemical class 0.000 abstract 4
150000003235 pyrrolidines Chemical class 0.000 abstract 2
UGUHFDPGDQDVGX-UHFFFAOYSA-N 1,2,3-thiadiazole Chemical group C1=CSN=N1 UGUHFDPGDQDVGX-UHFFFAOYSA-N 0.000 abstract 1
208000005171 Dysmenorrhea Diseases 0.000 abstract 1
206010013935 Dysmenorrhoea Diseases 0.000 abstract 1
XNOPRXBHLZRZKH-UHFFFAOYSA-N Oxytocin Natural products N1C(=O)C(N)CSSCC(C(=O)N2C(CCC2)C(=O)NC(CC(C)C)C(=O)NCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C(C)CC)NC(=O)C1CC1=CC=C(O)C=C1 XNOPRXBHLZRZKH-UHFFFAOYSA-N 0.000 abstract 1
101800000989 Oxytocin Proteins 0.000 abstract 1
102000004279 Oxytocin receptors Human genes 0.000 abstract 1
108090000876 Oxytocin receptors Proteins 0.000 abstract 1
102100031951 Oxytocin-neurophysin 1 Human genes 0.000 abstract 1
208000005107 Premature Birth Diseases 0.000 abstract 1
208000006399 Premature Obstetric Labor Diseases 0.000 abstract 1
206010036590 Premature baby Diseases 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
230000006806 disease prevention Effects 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
230000001404 mediated effect Effects 0.000 abstract 1
238000000034 method Methods 0.000 abstract 1
WCPAKWJPBJAGKN-UHFFFAOYSA-N oxadiazole Chemical group C1=CON=N1 WCPAKWJPBJAGKN-UHFFFAOYSA-N 0.000 abstract 1
XNOPRXBHLZRZKH-DSZYJQQASA-N oxytocin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@H](N)C(=O)N1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(N)=O)=O)[C@@H](C)CC)C1=CC=C(O)C=C1 XNOPRXBHLZRZKH-DSZYJQQASA-N 0.000 abstract 1
229960001723 oxytocin Drugs 0.000 abstract 1
239000008194 pharmaceutical composition Substances 0.000 abstract 1
-1 preterm labor Chemical compound 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/06—Antiabortive agents; Labour repressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Diabetes (AREA)
Gynecology & Obstetrics (AREA)
Pregnancy & Childbirth (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

BG108424A 2001-06-18 2003-12-08 Pyrrolidineoxadiazole and pyrrolidinethiadiazole derivatives BG108424A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP01113632		2001-06-18

Publications (1)

Publication Number	Publication Date
BG108424A true BG108424A (en)	2005-03-31

Family

ID=8177641

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG108424A BG108424A (en)	2001-06-18	2003-12-08	Pyrrolidineoxadiazole and pyrrolidinethiadiazole derivatives

Country Status (26)

Country	Link
US (2)	US7115639B2 (fr)
EP (1)	EP1444225B1 (fr)
JP (1)	JP4426284B2 (fr)
KR (1)	KR20040030678A (fr)
CN (1)	CN100564378C (fr)
AR (1)	AR036108A1 (fr)
AU (1)	AU2002319237B2 (fr)
BG (1)	BG108424A (fr)
BR (1)	BR0211030A (fr)
CA (1)	CA2449578C (fr)
CZ (1)	CZ20033475A3 (fr)
EA (1)	EA006212B1 (fr)
EE (1)	EE200400022A (fr)
ES (1)	ES2397305T3 (fr)
HR (1)	HRP20031017A2 (fr)
HU (1)	HUP0400238A2 (fr)
IL (1)	IL159219A0 (fr)
MX (1)	MXPA03011441A (fr)
MY (1)	MY128890A (fr)
NO (1)	NO20035399L (fr)
PL (1)	PL367275A1 (fr)
RS (1)	RS99503A (fr)
SK (1)	SK15552003A3 (fr)
UA (1)	UA75145C2 (fr)
WO (1)	WO2002102799A2 (fr)
ZA (1)	ZA200309402B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR20040030678A (ko)	2001-06-18	2004-04-09	어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이.	피롤리딘 옥사디아졸 및 티아디아졸 유도체
DE602004024170D1 (de) *	2003-02-27	2009-12-31	Merck Serono Sa Coinsins	Pyrrolidin-derivate als oxytocin antagonisten
DE602005003803T2 (de) *	2004-02-26	2008-12-24	Laboratoires Serono S.A., Coinsins	Verfahren zur herstellung von pyrrolidinoximen
PL1879573T3 (pl)	2005-05-10	2013-05-31	Incyte Holdings Corp	Modulatory 2,3-dioksygenazy indoloaminy i sposoby ich zastosowania
US8450351B2 (en)	2005-12-20	2013-05-28	Incyte Corporation	N-hydroxyamidinoheterocycles as modulators of indoleamine 2,3-dioxygenase
CL2007002650A1 (es)	2006-09-19	2008-02-08	Incyte Corp	Compuestos derivados de heterociclo n-hidroxiamino; composicion farmaceutica, util para tratar cancer, infecciones virales y desordenes neurodegenerativos entre otras.
WO2008036642A2 (fr) *	2006-09-19	2008-03-27	Incyte Corporation	N-hydroxyamidinohétérocycles en tant que modulateurs d'indoléamine 2,3-dioxygénase
JP5465720B2 (ja)	2008-07-08	2014-04-09	インサイト・コーポレイション	インドールアミン２，３−ジオキシゲナーゼの阻害剤としての１，２，５−オキサジアゾール
EP2845850A1 (fr) *	2013-09-10	2015-03-11	ObsEva S.A.	Dérivés de pyrrolidine comme antagonistes des récepteurs V1a de vasopressine/oxytocine
ES2799582T3 (es)	2013-11-08	2020-12-18	Incyte Holdings Corp	Proceso para la síntesis de un inhibidor de indoleamina 2,3-dioxigenasa
EP2886107A1 (fr)	2013-12-17	2015-06-24	ObsEva S.A.	Formules orales de dérivés de pyrrolydine
EP3753921A1 (fr)	2014-07-02	2020-12-23	ObsEva S.A.	Cristallin (3z,5s)-5-(hydroxyméthyl)-1-[(2?-méthyl-1,1?-biphényl-4-yl)carbonyl]pyrrolidin-3-one o-méthyloxime et ses procédés d'utilisation
TW202435864A (zh)	2023-02-09	2024-09-16	大陸商上海葆正醫藥科技有限公司	亞胺化合物及其製備方法和應用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2722190B1 (fr) *	1994-07-05	1996-10-04	Sanofi Sa	Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant
CA2210138A1 (fr)	1995-01-24	1996-08-01	Peter D. Williams	Antagonistes tocolytiques des recepteurs de l'oxytocine
US5756497A (en)	1996-03-01	1998-05-26	Merck & Co., Inc.	Tocolytic oxytocin receptor antagonists
FR2757157B1 (fr) *	1996-12-13	1999-12-31	Sanofi Sa	Derives d'indolin-2-one, procede pour leur preparation et compositions pharmaceutiques les contenant
EP1176959B1 (fr) *	1999-05-05	2006-03-08	Merck & Co., Inc.	Prolines en tant qu'agents antimicrobiens
DK1268419T3 (da)	2000-03-27	2006-10-02	Applied Research Systems	Farmaceutisk aktive pyrrolidinderivater som BAX-inhibitorer
DE60120661T2 (de) *	2000-03-27	2007-07-05	Applied Research Systems Ars Holding N.V.	Pharmazeutisch wirksame pyrrolidin-derivate als bax-inhibitoren
AU1401902A (en) *	2000-10-17	2002-04-29	Applied Research Systems	Pharmaceutically active sulfanilide derivatives
EP1829861A3 (fr) *	2001-03-20	2009-01-21	Laboratoires Serono SA	Dérivés estérifiés de la pyrrolidine effectifs comme antagonistes de l'oxytocine
KR20040030678A (ko)	2001-06-18	2004-04-09	어플라이드 리서치 시스템스 에이알에스 홀딩 엔.브이.	피롤리딘 옥사디아졸 및 티아디아졸 유도체
ES2249636T3 (es) *	2001-12-20	2006-04-01	Applied Research Systems Ars Holding N.V.	Triazoles como antagonistas de la oxitocina.
UA78058C2 (en) *	2002-07-05	2007-02-15	Applied Research Systems	Pyrrolidine derivative as oxitocin antagonists

2002
- 2002-06-14 KR KR10-2003-7016485A patent/KR20040030678A/ko not_active Ceased
- 2002-06-14 US US10/480,992 patent/US7115639B2/en not_active Expired - Fee Related
- 2002-06-14 EP EP02748785A patent/EP1444225B1/fr not_active Expired - Lifetime
- 2002-06-14 BR BR0211030-0A patent/BR0211030A/pt not_active IP Right Cessation
- 2002-06-14 HR HR20031017A patent/HRP20031017A2/xx not_active Application Discontinuation
- 2002-06-14 CN CNB028159446A patent/CN100564378C/zh not_active Expired - Fee Related
- 2002-06-14 EE EEP200400022A patent/EE200400022A/xx unknown
- 2002-06-14 CA CA2449578A patent/CA2449578C/fr not_active Expired - Fee Related
- 2002-06-14 PL PL02367275A patent/PL367275A1/xx not_active Application Discontinuation
- 2002-06-14 JP JP2003506272A patent/JP4426284B2/ja not_active Expired - Fee Related
- 2002-06-14 IL IL15921902A patent/IL159219A0/xx unknown
- 2002-06-14 EA EA200400049A patent/EA006212B1/ru not_active IP Right Cessation
- 2002-06-14 MX MXPA03011441A patent/MXPA03011441A/es active IP Right Grant
- 2002-06-14 SK SK1555-2003A patent/SK15552003A3/sk not_active Application Discontinuation
- 2002-06-14 CZ CZ20033475A patent/CZ20033475A3/cs unknown
- 2002-06-14 AU AU2002319237A patent/AU2002319237B2/en not_active Ceased
- 2002-06-14 HU HU0400238A patent/HUP0400238A2/hu unknown
- 2002-06-14 ES ES02748785T patent/ES2397305T3/es not_active Expired - Lifetime
- 2002-06-14 WO PCT/EP2002/006629 patent/WO2002102799A2/fr not_active Ceased
- 2002-06-14 RS YU99503A patent/RS99503A/sr unknown
- 2002-06-14 UA UA20031211897A patent/UA75145C2/uk unknown
- 2002-06-18 MY MYPI20022260A patent/MY128890A/en unknown
- 2002-06-21 AR ARP020102353A patent/AR036108A1/es unknown
2003
- 2003-12-03 ZA ZA200309402A patent/ZA200309402B/en unknown
- 2003-12-04 NO NO20035399A patent/NO20035399L/no unknown
- 2003-12-08 BG BG108424A patent/BG108424A/xx unknown
2006
- 2006-06-09 US US11/449,802 patent/US20060229343A1/en not_active Abandoned

Also Published As

Publication number	Publication date
US20060229343A1 (en)	2006-10-12
KR20040030678A (ko)	2004-04-09
JP4426284B2 (ja)	2010-03-03
NO20035399D0 (no)	2003-12-04
CN1639155A (zh)	2005-07-13
WO2002102799A3 (fr)	2003-04-03
NO20035399L (no)	2004-02-17
HRP20031017A2 (en)	2004-04-30
US20040220238A1 (en)	2004-11-04
US7115639B2 (en)	2006-10-03
EP1444225A2 (fr)	2004-08-11
UA75145C2 (en)	2006-03-15
EE200400022A (et)	2004-04-15
JP2004534804A (ja)	2004-11-18
BR0211030A (pt)	2004-06-22
HK1074204A1 (zh)	2005-11-04
IL159219A0 (en)	2004-06-01
CZ20033475A3 (en)	2004-05-12
AU2002319237B2 (en)	2008-01-03
CA2449578A1 (fr)	2002-12-27
SK15552003A3 (sk)	2004-05-04
EA200400049A1 (ru)	2004-08-26
EA006212B1 (ru)	2005-10-27
CA2449578C (fr)	2011-12-13
HUP0400238A2 (hu)	2004-07-28
RS99503A (sr)	2006-12-15
AR036108A1 (es)	2004-08-11
ZA200309402B (en)	2004-12-03
CN100564378C (zh)	2009-12-02
PL367275A1 (en)	2005-02-21
WO2002102799A2 (fr)	2002-12-27
ES2397305T3 (es)	2013-03-06
MXPA03011441A (es)	2004-07-01
MY128890A (en)	2007-02-28
EP1444225B1 (fr)	2012-10-10

Publication	Publication Date	Title
IL155333A0 (en)	2003-11-23	Sulfanilide derivatives for use in medicine, certain such new derivatives and their preparation
TW200745111A (en)	2007-12-16	New compounds
BG108424A (en)	2005-03-31	Pyrrolidineoxadiazole and pyrrolidinethiadiazole derivatives
MXPA02007942A (es)	2004-09-10	Derivados de pirrolopirimidinona, procesos de preparacion y uso.
WO2003048164A3 (fr)	2003-10-16	Antagonistes du recepteur a2a de l'adenosine
SE0104340D0 (sv)	2001-12-20	New compounds
AU2007276804A1 (en)	2008-01-31	Inhibitors of undecaprenyl pyrophosphate synthase
NO20093464L (no)	2001-11-02	Nye medikamentblandinger basert pa anti-cholinergisk effektive forbindelser og beta-mimetika
WO2005011654A3 (fr)	2005-04-14	Derives de pyridyle et utilisation de ceux-ci en tant qu'agents therapeutiques
JP2002540156A (ja)	2002-11-26	抗ウイルス治療用チアジアゾリルウレアまたはチオウレア誘導体
CA2468649A1 (fr)	2003-06-12	Antagonistes du recepteur a2a d'adenosine
ZA200408283B (en)	2006-05-31	7-aryl-3,9-diazabicyclo (3.3.1)non-6-ene derivatives and their use as renin inhibitors in the treatment of hypertension, cardivascular or rental diseases
WO2002088100A3 (fr)	2003-05-30	3-piperidinopropiophenones dopees et produits pharmaceutiques contenant ces composes
SE9901573D0 (sv)	1999-05-03	New compounds
EA200201026A1 (ru)	2003-02-27	Фармацевтически активные производные пирролидина
DE60008399D1 (de)	2004-03-25	Carbonsäuren und acylsulfonamide, solche verbindungen enthaltende zubereitungen und behandlungsmethoden
AU2002359162A1 (en)	2003-07-15	Use of oxindole derivatives in the treatment of dementia related diseases, alzheimer's disease and conditions associated with glycogen synthase kinase-3
SE0102440D0 (sv)	2001-07-05	New compound
TW200606164A (en)	2006-02-16	New compounds
SI1458381T1 (sl)	2006-04-30	Triazoli kot oksitocinski antagonisti
TW200800984A (en)	2008-01-01	New compounds
SE9901572D0 (sv)	1999-05-03	New compounds
EP1613328B8 (fr)	2009-06-10	Utilisation de derives de carbamazepine dans le traitement de l'agitation chez des patients atteints de demence
Lu et al.	2003	Design and synthesis of highly potent HIV protease inhibitors with activity against resistant virus
AP9801417A0 (en)	1998-12-31	Piperidine acetic acid derivatives and their use in the treatment of thrombotic disorders.