BG27902A3 - Метод за получаване на n-(метокси-метил-фуриметил)-6,7-бензоморфани и морфипани - Google Patents

Метод за получаване на n-(метокси-метил-фуриметил)-6,7-бензоморфани и морфипани

Info

Publication number
BG27902A3
BG27902A3 BG028037A BG2803774A BG27902A3 BG 27902 A3 BG27902 A3 BG 27902A3 BG 028037 A BG028037 A BG 028037A BG 2803774 A BG2803774 A BG 2803774A BG 27902 A3 BG27902 A3 BG 27902A3
Authority
BG
Bulgaria
Prior art keywords
benzomorphanes
morphipanes
furimethyl
methoxy
methyl
Prior art date
Application number
BG028037A
Other languages
English (en)
Inventor
Herbert Merz
Adolf Longbein
Gerhard Walter
Klaus Stokhaus
Original Assignee
C.H.Boehringer Sohn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C.H.Boehringer Sohn filed Critical C.H.Boehringer Sohn
Publication of BG27902A3 publication Critical patent/BG27902A3/bg

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Метод за получаване на охарактеризирани и доказани в описанието n-(метоксиметил-фурилметил)-6, 7-бензоморфани и -морфинани с обща формула........ Патентните претенции са формулирани в 2 точки
BG028037A 1973-10-27 1974-10-25 Метод за получаване на n-(метокси-метил-фуриметил)-6,7-бензоморфани и морфипани BG27902A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19732354002 DE2354002A1 (de) 1973-10-27 1973-10-27 Neue n-(methoxymethyl-furylmethyl)6,7-benzomorphane und -morphinane, deren saeureadditionssalze, ihre verwendung als arzneimittel und verfahren zu deren herstellung

Publications (1)

Publication Number Publication Date
BG27902A3 true BG27902A3 (bg) 1980-01-15

Family

ID=5896658

Family Applications (3)

Application Number Title Priority Date Filing Date
BG028038A BG27903A3 (bg) 1973-10-27 1974-10-25 Метод за получаване на n-(метокси-метил-фурилметил)-6,7-бензоморфани и морфипани и техните присъединителни с киселина соли
BG028037A BG27902A3 (bg) 1973-10-27 1974-10-25 Метод за получаване на n-(метокси-метил-фуриметил)-6,7-бензоморфани и морфипани
BG028036A BG27901A3 (bg) 1973-10-27 1974-10-25 Метод за получаване на n-(метокси-метил-фурил-метил)-6-7-бензоморфани и бензоморфинапи

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BG028038A BG27903A3 (bg) 1973-10-27 1974-10-25 Метод за получаване на n-(метокси-метил-фурилметил)-6,7-бензоморфани и морфипани и техните присъединителни с киселина соли

Family Applications After (1)

Application Number Title Priority Date Filing Date
BG028036A BG27901A3 (bg) 1973-10-27 1974-10-25 Метод за получаване на n-(метокси-метил-фурил-метил)-6-7-бензоморфани и бензоморфинапи

Country Status (27)

Country Link
US (1) US3981874A (bg)
JP (1) JPS5738590B2 (bg)
AT (6) AT335632B (bg)
BE (1) BE821505A (bg)
BG (3) BG27903A3 (bg)
CA (1) CA1056377A (bg)
CH (6) CH609340A5 (bg)
CS (3) CS171195B2 (bg)
DD (1) DD115909A5 (bg)
DE (1) DE2354002A1 (bg)
DK (1) DK138325C (bg)
ES (6) ES431054A1 (bg)
FI (1) FI62079C (bg)
FR (1) FR2248838B1 (bg)
GB (1) GB1482552A (bg)
HU (1) HU176479B (bg)
IE (1) IE41528B1 (bg)
IL (1) IL45938A (bg)
NL (1) NL7413980A (bg)
NO (1) NO140859C (bg)
PH (1) PH11894A (bg)
PL (3) PL92053B1 (bg)
RO (5) RO65656A (bg)
SE (1) SE422791B (bg)
SU (6) SU511005A3 (bg)
YU (5) YU36949B (bg)
ZA (1) ZA746790B (bg)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1513961A (en) * 1975-02-25 1978-06-14 Acf Chemiefarma Nv 6,7-benzomorphans method for their preparation and intermediates
US4208523A (en) * 1978-11-30 1980-06-17 Sterling Drug Inc. 11-Lower-alkyl-, 11-phenyl-lower-alkyl- and 11-cyclo-lower-alkyl-lower-alkyl-hexahydro-2,6-methano-3-benzazocines
JP5470557B2 (ja) 2007-07-26 2014-04-16 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１型の阻害剤の合成
TW200927115A (en) 2007-11-16 2009-07-01 Boehringer Ingelheim Int Aryl-and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use
US8440658B2 (en) 2007-12-11 2013-05-14 Vitae Pharmaceuticals, Inc. Cyclic urea inhibitors of 11β-hydroxysteroid dehydrogenase 1
TW200934490A (en) 2008-01-07 2009-08-16 Vitae Pharmaceuticals Inc Lactam inhibitors of 11 &abgr;-hydroxysteroid dehydrogenase 1
WO2009094169A1 (en) 2008-01-24 2009-07-30 Vitae Pharmaceuticals, Inc. Cyclic carbazate and semicarbazide inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5538239B2 (ja) * 2008-02-12 2014-07-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ベンゾモルファン及び関連骨格の尿素誘導体、そのような化合物を含む医薬ならびにそれらの使用
US8598160B2 (en) 2008-02-15 2013-12-03 Vitae Pharmaceuticals, Inc. Cycloalkyl lactame derivatives as inhibitors of 11-beta-hydroxysteroid dehydrogenase 1
RU2531272C2 (ru) 2008-05-01 2014-10-20 Вайтаи Фармасьютиклз, Инк. Циклические ингибиторы 11бета-гидроксистероид-дегидрогеназы 1
EP2291370B1 (en) 2008-05-01 2013-11-27 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
JP5696037B2 (ja) 2008-05-01 2015-04-08 ヴァイティー ファーマシューティカルズ，インコーポレイテッド １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター
AR071719A1 (es) 2008-05-13 2010-07-07 Boehringer Ingelheim Int Derivados aliciclicos de acido carboxilico de benzomorfanos y estructuras relacionadas, medicamentos que contienen dichos compuestos y su uso.procesos de obtencion
WO2010010157A2 (en) 2008-07-25 2010-01-28 Boehringer Ingelheim International Gmbh INHIBITORS OF 11beta-HYDROXYSTEROID DEHYDROGENASE 1
NZ590495A (en) 2008-07-25 2012-10-26 Vitae Pharmaceuticals Inc Dihydropyridin-phenyl-3-oxazinan-2-ones as inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8680093B2 (en) 2009-04-30 2014-03-25 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11beta-hydroxysteroid dehydrogenase 1
US8927539B2 (en) 2009-06-11 2015-01-06 Vitae Pharmaceuticals, Inc. Cyclic inhibitors of 11β-hydroxysteroid dehydrogenase 1 based on the 1,3-oxazinan-2-one structure
AR078887A1 (es) 2009-11-06 2011-12-07 Boehringer Ingelheim Int Derivados arilo y heteroarilcarbonilo de hexahidroindenopiridina y octahidrobenzoquinolina y composiciones farmaceuticas que los contienen.
WO2011159760A1 (en) 2010-06-16 2011-12-22 Vitae Pharmaceuticals, Inc. Substituted 5-,6- and 7-membered heterocycles, medicaments containing such compounds, and their use
TWI537258B (zh) 2010-11-05 2016-06-11 百靈佳殷格翰國際股份有限公司 六氫茚并吡啶及八氫苯并喹啉之芳基－及雜環芳基羰基衍生物
WO2013025664A1 (en) 2011-08-17 2013-02-21 Boehringer Ingelheim International Gmbh Indenopyridine derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632591A (en) * 1968-07-19 1972-01-04 Sterling Drug Inc 1 2 3 4 5 6 - hexahydro-3-(cycloaliphatic or cycloaliphatic 11-dimethyl-2 alkyl)-66-methano-3-benzazocines
US3833595A (en) * 1968-12-26 1974-09-03 Sumitomo Chemical Co 2-aroylalkyl benzomorphans
CS166802B2 (bg) * 1971-02-08 1976-03-29 Boehringer Sohn Ingelheim

Also Published As

Publication number Publication date
YU36949B (en) 1984-08-31
BG27901A3 (bg) 1980-01-15
GB1482552A (en) 1977-08-10
DE2354002A1 (de) 1975-05-07
RO65657A (ro) 1980-06-15
RO65655A (ro) 1980-06-15
ATA828974A (de) 1976-08-15
YU285174A (en) 1982-06-18
AT336202B (de) 1977-04-25
PH11894A (en) 1978-08-29
RO65658A (fr) 1979-07-15
IL45938A0 (en) 1974-12-31
YU36519B (en) 1984-02-29
IE41528L (en) 1975-04-27
SU578870A3 (ru) 1977-10-30
CH609046A5 (bg) 1979-02-15
PL92052B1 (bg) 1977-03-31
NO140859C (no) 1979-11-28
RO65656A (ro) 1980-06-15
IE41528B1 (en) 1980-01-30
SU508193A3 (ru) 1976-03-25
SE7413485L (bg) 1975-04-28
RO65659A (ro) 1980-06-15
ATA828574A (de) 1976-07-15
US3981874A (en) 1976-09-21
YU36950B (en) 1984-08-31
AT335634B (de) 1977-03-25
FR2248838B1 (bg) 1977-11-04
JPS5071679A (bg) 1975-06-13
FI314174A7 (bg) 1975-04-28
AT335632B (de) 1977-03-25
ES431058A1 (es) 1976-10-16
FR2248838A1 (bg) 1975-05-23
DK138325B (da) 1978-08-14
DK138325C (da) 1979-01-22
BG27903A3 (bg) 1980-01-15
YU36952B (en) 1984-08-31
CH609047A5 (bg) 1979-02-15
SE422791B (sv) 1982-03-29
CS171196B2 (bg) 1976-10-29
AT335633B (de) 1977-03-25
FI62079B (fi) 1982-07-30
ATA828774A (de) 1976-07-15
DK559874A (bg) 1975-06-23
CH609685A5 (bg) 1979-03-15
JPS5738590B2 (bg) 1982-08-16
CS171194B2 (bg) 1976-10-29
YU36951B (en) 1984-08-31
ES431055A1 (es) 1976-10-16
IL45938A (en) 1977-12-30
NL7413980A (nl) 1975-04-29
YU285474A (en) 1982-06-18
HU176479B (en) 1981-03-28
ES431056A1 (es) 1976-10-16
PL92086B1 (bg) 1977-03-31
ZA746790B (en) 1976-06-30
FI62079C (fi) 1982-11-10
NO140859B (no) 1979-08-20
AT335076B (de) 1977-02-25
CA1056377A (en) 1979-06-12
AT335631B (de) 1977-03-25
SU511005A3 (ru) 1976-04-15
YU285674A (en) 1982-06-18
CS171195B2 (bg) 1976-10-29
ATA828674A (de) 1976-07-15
ATA828874A (de) 1976-06-15
PL92053B1 (bg) 1977-03-31
SU512707A3 (ru) 1976-04-30
YU285374A (en) 1982-06-18
NO743845L (bg) 1975-05-26
CH609686A5 (bg) 1979-03-15
DD115909A5 (bg) 1975-10-20
SU510999A3 (ru) 1976-04-15
SU508192A3 (ru) 1976-03-25
CH609340A5 (bg) 1979-02-28
ATA829074A (de) 1976-07-15
ES431057A1 (es) 1976-10-16
BE821505A (fr) 1975-04-25
YU285274A (en) 1982-02-25
CH609048A5 (bg) 1979-02-15
ES431054A1 (es) 1976-10-16
ES431059A1 (es) 1976-10-16

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