BG42675A3 - Метод за получаване на 20-амино-макролидни производни - Google Patents

Метод за получаване на 20-амино-макролидни производни

Info

Publication number: BG42675A3
Authority: BG; Bulgaria
Prior art keywords: amino; preparation; macrolide derivatives; macrolide; derivatives
Prior art date: 1982-09-13

Application number

BG062310A

Other languages

Bulgarian (bg)

English (en)

Inventor

Manuel Debono

Herbert Kirst

Original Assignee

Eli Lilly And Company

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-09-13

Filing date

1983-09-08

Publication date

1988-01-15

1983-09-08 Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company

1988-01-15 Publication of BG42675A3 publication Critical patent/BG42675A3/xx

Links

239000003120 macrolide antibiotic agent Substances 0.000 title abstract 2
QRPHLEPFYLNRDA-NLGRAQRVSA-N 2-[(4r,5s,6s,7r,9r,11e,13e,15r,16r)-6-[(2r,3r,4s,5s,6r)-4-(dimethylamino)-3,5-dihydroxy-6-methyloxan-2-yl]oxy-16-ethyl-4-hydroxy-15-[[(2r,3r,4r,5r,6r)-5-hydroxy-3,4-dimethoxy-6-methyloxan-2-yl]oxymethyl]-5,9,13-trimethyl-2,10-dioxo-1-oxacyclohexadeca-11,1 Chemical compound O([C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@@H]1O[C@H](C)[C@@H](O)[C@H](N(C)C)[C@H]1O QRPHLEPFYLNRDA-NLGRAQRVSA-N 0.000 abstract 1
CFMSCYSETWZXRS-UHFFFAOYSA-N Lactenocin Natural products O=CCC1CC(C)C(=O)C=CC(C)=CC(COC2C(C(O)C(O)C(C)O2)OC)C(CC)OC(=O)CC(O)C(C)C1OC1OC(C)C(O)C(N(C)C)C1O CFMSCYSETWZXRS-UHFFFAOYSA-N 0.000 abstract 1
229930194936 Tylosin Natural products 0.000 abstract 1
239000004182 Tylosin Substances 0.000 abstract 1
239000003242 anti bacterial agent Substances 0.000 abstract 1
244000052616 bacterial pathogen Species 0.000 abstract 1
CFMSCYSETWZXRS-SNPFKJFCSA-N lactenocin Chemical compound O([C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@@H]1[C@H]([C@@H](O)[C@@H](O)[C@@H](C)O1)OC)CC)C1O[C@@H](C)[C@@H](O)[C@@H](N(C)C)[C@@H]1O CFMSCYSETWZXRS-SNPFKJFCSA-N 0.000 abstract 1
UFUYRGNJTFAODM-HQCAVAADSA-N macrocin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](O)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 UFUYRGNJTFAODM-HQCAVAADSA-N 0.000 abstract 1
WBPYTXDJUQJLPQ-VMXQISHHSA-N tylosin Chemical compound O([C@@H]1[C@@H](C)O[C@H]([C@@H]([C@H]1N(C)C)O)O[C@@H]1[C@@H](C)[C@H](O)CC(=O)O[C@@H]([C@H](/C=C(\C)/C=C/C(=O)[C@H](C)C[C@@H]1CC=O)CO[C@H]1[C@@H]([C@H](OC)[C@H](O)[C@@H](C)O1)OC)CC)[C@H]1C[C@@](C)(O)[C@@H](O)[C@H](C)O1 WBPYTXDJUQJLPQ-VMXQISHHSA-N 0.000 abstract 1
229960004059 tylosin Drugs 0.000 abstract 1
235000019375 tylosin Nutrition 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Communicable Diseases (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Fodder In General (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

BG062310A 1982-09-13 1983-09-08 Метод за получаване на 20-амино-макролидни производни BG42675A3 (bg)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US41724782A	1982-09-13	1982-09-13

Publications (1)

Publication Number	Publication Date
BG42675A3 true BG42675A3 (bg)	1988-01-15

Family

ID=23653182

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG062310A BG42675A3 (bg)	1982-09-13	1983-09-08	Метод за получаване на 20-амино-макролидни производни

Country Status (34)

Country	Link
EP (1)	EP0103465B1 (fr)
JP (1)	JPS5973598A (fr)
KR (1)	KR850000961B1 (fr)
AR (1)	AR241595A1 (fr)
AT (1)	AT381707B (fr)
AU (1)	AU561147B2 (fr)
BG (1)	BG42675A3 (fr)
CA (1)	CA1243310A (fr)
CS (1)	CS259862B2 (fr)
CY (1)	CY1417A (fr)
DD (1)	DD210284A5 (fr)
DE (1)	DE3366097D1 (fr)
DK (1)	DK153555C (fr)
EG (1)	EG16287A (fr)
ES (2)	ES8604596A1 (fr)
FI (1)	FI73222C (fr)
GB (1)	GB2127017B (fr)
GR (1)	GR79067B (fr)
HK (1)	HK21888A (fr)
HU (1)	HU194271B (fr)
IE (1)	IE55916B1 (fr)
IL (1)	IL69666A (fr)
LU (1)	LU90240I2 (fr)
MY (1)	MY8700756A (fr)
NL (1)	NL950001I2 (fr)
NZ (1)	NZ205501A (fr)
PH (1)	PH23242A (fr)
PL (2)	PL142251B1 (fr)
PT (1)	PT77335B (fr)
RO (1)	RO89235A (fr)
SG (1)	SG99287G (fr)
SU (1)	SU1375135A3 (fr)
UA (1)	UA6045A1 (fr)
ZA (1)	ZA836741B (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS59181294A (ja) *	1983-03-30	1984-10-15	Satoshi Omura	抗生物質ｐｔｌ−４４８とその誘導体およびそれらの製造方法
US4921947A (en) *	1986-03-31	1990-05-01	Eli Lilly And Company	Process for preparing macrolide derivatives
EP0262903A3 (fr) *	1986-09-29	1988-11-02	Eli Lilly And Company	Dérivés acylés des composés tylosine et desmycosine modifiés en position 20
US4820694A (en) *	1986-09-29	1989-04-11	Eli Lilly And Company	Modifications of 3-O-demethylmycinose in macrocin and lactenocin
US5354708A (en) *	1992-06-04	1994-10-11	Taskar Nikhil R	Method of nitrogen doping of II-VI semiconductor compounds during epitaxial growth using an amine
TW226373B (fr) *	1992-07-15	1994-07-11	Pfizer
ES2076107B1 (es) *	1993-09-20	1996-04-01	Pfizer	Derivados de antibioticos macrolidos de anillos de 16 miembros.
AU3121095A (en) *	1994-09-22	1996-04-09	Pfizer Inc.	Antibiotic macrolides
EP0778283A3 (fr) *	1995-12-05	1998-01-28	Pfizer Inc.	Macrolides antibiotiques
US6605599B1 (en)	1997-07-08	2003-08-12	Bristol-Myers Squibb Company	Epothilone derivatives
DK0948967T3 (da) *	1998-03-02	2005-02-14	Lilly Co Eli	Behandling af virussygdom hos svin
EP2019112A1 (fr)	2007-07-26	2009-01-28	Intervet International BV	Formules à l'état solide de macrolide
JP5323696B2 (ja)	2006-07-28	2013-10-23	インターベツト・インターナシヨナル・ベー・ベー	マクロライド合成方法
RU2478630C2 (ru) *	2007-12-07	2013-04-10	ЭЙСАН Ар ЭНД Ди МЕНЕДЖМЕНТ КО., ЛТД.	Промежуточные соединения и способы получения зеараленоновых макролидных аналогов
HUE037868T2 (hu) *	2013-05-23	2018-09-28	Bayer Animal Health Gmbh	Tilozin-származékok és eljárás elõállításukra
CN103880903B (zh) *	2014-03-21	2016-06-15	烟台万润药业有限公司	一种泰乐菌素类大环内酯及其衍生物的制备方法
CN117304241B (zh) *	2023-11-30	2024-03-01	中国农业科学院饲料研究所	一种大环内酯类化合物及其制备方法与应用
CN117510561B (zh) *	2023-11-30	2024-04-02	中国农业科学院饲料研究所	一种泰乐菌素衍生物及其制备方法与应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IE32839B1 (en) *	1967-12-04	1973-12-28	Lilly Co Eli	Urea-antibiotic adducts and process for preparing the same
US4279896A (en) *	1980-06-23	1981-07-21	Schering Corporation	Novel 20-imino macrolide antibacterial agents
JPS58146595A (ja) *	1982-02-25	1983-09-01	Satoshi Omura	マクロライド系抗生物質

1983
- 1983-09-05 AU AU18710/83A patent/AU561147B2/en not_active Expired
- 1983-09-05 IL IL69666A patent/IL69666A/xx not_active IP Right Cessation
- 1983-09-06 NZ NZ205501A patent/NZ205501A/en unknown
- 1983-09-07 AR AR83294140A patent/AR241595A1/es active
- 1983-09-07 GR GR72394A patent/GR79067B/el unknown
- 1983-09-07 PH PH29508A patent/PH23242A/en unknown
- 1983-09-08 DE DE8383305241T patent/DE3366097D1/de not_active Expired
- 1983-09-08 SU SU833641764A patent/SU1375135A3/ru active
- 1983-09-08 CY CY141783A patent/CY1417A/xx unknown
- 1983-09-08 GB GB08324044A patent/GB2127017B/en not_active Expired
- 1983-09-08 BG BG062310A patent/BG42675A3/xx unknown
- 1983-09-08 EP EP83305241A patent/EP0103465B1/fr not_active Expired
- 1983-09-08 AT AT0320683A patent/AT381707B/de not_active IP Right Cessation
- 1983-09-08 UA UA3641764A patent/UA6045A1/uk unknown
- 1983-09-09 RO RO83112026A patent/RO89235A/fr unknown
- 1983-09-09 FI FI833229A patent/FI73222C/fi not_active IP Right Cessation
- 1983-09-11 EG EG557/83A patent/EG16287A/xx active
- 1983-09-12 PL PL1983250619A patent/PL142251B1/pl unknown
- 1983-09-12 CA CA000436451A patent/CA1243310A/fr not_active Expired
- 1983-09-12 PL PL1983243718A patent/PL142304B1/pl unknown
- 1983-09-12 KR KR1019830004273A patent/KR850000961B1/ko not_active Expired
- 1983-09-12 DD DD83254748A patent/DD210284A5/de unknown
- 1983-09-12 ZA ZA836741A patent/ZA836741B/xx unknown
- 1983-09-12 ES ES525544A patent/ES8604596A1/es not_active Expired
- 1983-09-12 HU HU833167A patent/HU194271B/hu unknown
- 1983-09-12 IE IE2131/83A patent/IE55916B1/en not_active IP Right Cessation
- 1983-09-12 DK DK413783A patent/DK153555C/da not_active IP Right Cessation
- 1983-09-13 CS CS836653A patent/CS259862B2/cs unknown
- 1983-09-13 JP JP58169127A patent/JPS5973598A/ja active Granted
- 1983-09-13 PT PT77335A patent/PT77335B/pt unknown
1985
- 1985-10-31 ES ES548472A patent/ES8607336A1/es not_active Expired
1987
- 1987-11-11 SG SG992/87A patent/SG99287G/en unknown
- 1987-12-30 MY MY756/87A patent/MY8700756A/xx unknown
1988
- 1988-03-24 HK HK218/88A patent/HK21888A/en not_active IP Right Cessation
1995
- 1995-01-10 NL NL950001C patent/NL950001I2/nl unknown
1998
- 1998-05-06 LU LU90240C patent/LU90240I2/fr unknown

Also Published As

Publication number	Publication date
NL950001I1 (nl)	1995-02-16
PT77335B (en)	1986-05-19
DK153555C (da)	1988-12-05
DK413783A (da)	1984-03-14
NL950001I2 (nl)	1997-05-01
DK153555B (da)	1988-07-25
IL69666A0 (en)	1983-12-30
UA6045A1 (uk)	1994-12-29
AR241595A1 (es)	1992-09-30
FI73222B (fi)	1987-05-29
SU1375135A3 (ru)	1988-02-15
KR850000961B1 (ko)	1985-07-02
ES8604596A1 (es)	1986-02-01
CA1243310A (fr)	1988-10-18
GR79067B (fr)	1984-10-02
MY8700756A (en)	1987-12-31
EP0103465B1 (fr)	1986-09-10
ZA836741B (en)	1984-04-25
DE3366097D1 (en)	1986-10-16
AU561147B2 (en)	1987-04-30
IE832131L (en)	1984-03-13
PH23242A (en)	1989-06-06
PL142251B1 (en)	1987-10-31
PL250619A1 (en)	1985-07-30
RO89235A (fr)	1986-03-15
NZ205501A (en)	1985-09-13
CS259862B2 (en)	1988-11-15
HUT35272A (en)	1985-06-28
ATA320683A (de)	1986-04-15
HK21888A (en)	1988-03-31
KR840005734A (ko)	1984-11-15
GB2127017B (en)	1986-01-15
EG16287A (en)	1987-04-30
ES8607336A1 (es)	1986-06-01
IL69666A (en)	1987-10-20
JPH021840B2 (fr)	1990-01-12
FI73222C (fi)	1987-09-10
PT77335A (en)	1983-10-01
PL243718A1 (en)	1985-04-09
AU1871083A (en)	1984-03-22
GB8324044D0 (en)	1983-10-12
DD210284A5 (de)	1984-06-06
EP0103465A1 (fr)	1984-03-21
FI833229A7 (fi)	1984-03-14
CY1417A (en)	1988-04-22
SG99287G (en)	1988-09-23
LU90240I2 (fr)	1998-07-06
HU194271B (en)	1988-01-28
PL142304B1 (en)	1987-10-31
AT381707B (de)	1986-11-25
IE55916B1 (en)	1991-02-27
ES548472A0 (es)	1986-06-01
JPS5973598A (ja)	1984-04-25
CS665383A2 (en)	1988-04-15
GB2127017A (en)	1984-04-04
FI833229A0 (fi)	1983-09-09
DK413783D0 (da)	1983-09-12
ES525544A0 (es)	1986-02-01

Publication	Publication Date	Title
BG42675A3 (bg)	1988-01-15	Метод за получаване на 20-амино-макролидни производни
ATE30237T1 (de)	1987-10-15	Epi-derivat von azahomoerythromycin a und zwischenprodukte.
BG44205A3 (en)	1988-10-14	Method for preparing of antibiotic s541
EA199901016A1 (ru)	2000-06-26	9-оксим-производные эритромицина
NZ335825A (en)	2001-01-26	Use of azithromycin for treating atherosclerosis
IE811297L (en)	1981-12-12	Macrolide antibiotics
EA200100396A1 (ru)	2001-10-22	Новые макролидные антибиотики
ATE66001T1 (de)	1991-08-15	Makrolid-antibiotikaderivate.
RO85833A (fr)	1984-11-25	Procede pour la preparation des derives de 20-aminothylosine
MD1788G2 (ro)	2002-05-31	Derivaţi de 9-O-oximă ai Eritromicinei A, compoziţie farmaceutică pe baza lor şi metodă de tratament al bolilor infecţioase
IL57853A (en)	1983-06-15	Sisomycin derivatives,their production and pharmaceutical compositions and fodder containing them
FI842523A0 (fi)	1984-06-21	Antacyklinderivat, deras mikrobiologiska framstaellningsfoerfarande och deras anvaendning som cellgifter.
ES2080140T3 (es)	1996-02-01	Derivados de eritromicina.
ES8602942A1 (es)	1985-12-01	Un procedimiento para preparar el compuesto antibacteriano dificidina.
ES442505A1 (es)	1977-05-16	Procedimiento de preparacion de la 4-0-n2',6'-diamino-2',3',6' - tridesoxi-alfa, d-ribohexopiranosiln6-0 - n3" - metila-mino-3",4",6"tridesoxi alfa,d-xilohexopiranosiln2-desoxies- treptamina.
IL69093A (en)	1986-09-30	Method for preparing 20-deoxo-23-de(mycinosyloxy)tylosin antibiotics,the novel 20-deoxo-23-de(mycinoslyloxy)tylosin derivatives,their use as intermediates and pharmaceutical compositions containing them
ES8300773A1 (es)	1982-11-01	"un procedimiento para la preparacion de derivados de metoxicefalosporinas".
BG42676A3 (en)	1988-01-15	Method for preparang derivatives of 6- aminoalkyl- penicillanic acid
TR200003249T2 (tr)	2001-03-21	2''-Deoksi higromisin türevleri
ES2082806T3 (es)	1996-04-01	Derivados quimicos de los antibioticos alfa- y beta-ll-e19020.
ES464924A1 (es)	1978-09-01	Un procedimiento para la preparacion de derivados de olean- domicina.
GR3003852T3 (fr)	1993-03-16
DK0874863T3 (da)	2003-05-26	3-deoxy-3-descladinose-derivater fra erythromycin A og B
IT8119082A0 (it)	1981-01-09	Antibiotici macrolidici semisintetici,procedimento microbiologico per la loro preparazione e relatico microorganismo,intermedio per la loro preparazione e composizioni farmaceutiche che li contengono