BG45047A3 - Метод за получаване на изопеницилин н синтетазна активност в гостоприемникова клетка - Google Patents

Метод за получаване на изопеницилин н синтетазна активност в гостоприемникова клетка

Info

Publication number
BG45047A3
BG45047A3 BG074576A BG7457686A BG45047A3 BG 45047 A3 BG45047 A3 BG 45047A3 BG 074576 A BG074576 A BG 074576A BG 7457686 A BG7457686 A BG 7457686A BG 45047 A3 BG45047 A3 BG 45047A3
Authority
BG
Bulgaria
Prior art keywords
host cell
isopenicillin
synthetase activity
obtaining
encoding
Prior art date
Application number
BG074576A
Other languages
Bulgarian (bg)
English (en)
Inventor
Thomas Ingolia
Stephen Queener
Suellen Samson
Paul Skatrud
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of BG45047A3 publication Critical patent/BG45047A3/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/93—Ligases (6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C12N15/69—Increasing the copy number of the vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
BG074576A 1985-04-22 1986-04-18 Метод за получаване на изопеницилин н синтетазна активност в гостоприемникова клетка BG45047A3 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US72587085A 1985-04-22 1985-04-22
US79938485A 1985-11-18 1985-11-18

Publications (1)

Publication Number Publication Date
BG45047A3 true BG45047A3 (bg) 1989-03-15

Family

ID=27111238

Family Applications (2)

Application Number Title Priority Date Filing Date
BG074576A BG45047A3 (bg) 1985-04-22 1986-04-18 Метод за получаване на изопеницилин н синтетазна активност в гостоприемникова клетка
BG078442A BG45219A3 (bg) 1985-04-22 1986-04-18 Метод за получаване на вектор на рекомбинантна днк,съдържащ част от изопеницилин синтеза на цефалоспориум акремониум

Family Applications After (1)

Application Number Title Priority Date Filing Date
BG078442A BG45219A3 (bg) 1985-04-22 1986-04-18 Метод за получаване на вектор на рекомбинантна днк,съдържащ част от изопеницилин синтеза на цефалоспориум акремониум

Country Status (14)

Country Link
EP (1) EP0200425B1 (fr)
JP (1) JPH0787788B2 (fr)
KR (1) KR860008287A (fr)
CN (1) CN86102604A (fr)
AU (2) AU592791B2 (fr)
BG (2) BG45047A3 (fr)
CA (1) CA1309673C (fr)
DE (1) DE3683080D1 (fr)
DK (1) DK178386A (fr)
ES (3) ES8800344A1 (fr)
FI (1) FI95810C (fr)
HU (1) HU202279B (fr)
IE (1) IE58780B1 (fr)
IL (1) IL78531A0 (fr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2687995B2 (ja) 1980-04-03 1997-12-08 バイオゲン インコーポレイテッド Ｄｎａ配列、組替えｄｎａ分子およびヒト繊維芽細胞インターフェロン様ポリペプチドの製造方法
GB8508800D0 (en) * 1985-04-04 1985-05-09 Glaxo Group Ltd Microbiological process
US4892819A (en) * 1985-11-25 1990-01-09 Eli Lilly And Company Recombinant DNA expression vectors and DNA compounds that encode isopenicillin N synthetase from penicillium chrysogenum
DE3789880T2 (de) * 1986-01-31 1994-09-08 Beecham Group Plc Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen.
IL85535A (en) * 1987-03-04 1994-02-27 Lilly Co Eli Recombinant dna expression vectors and dna compounds that encode deacetoxycephalosporin c synthetase and deacetylcephalosporin c synthetase
GB2208077A (en) * 1987-04-24 1989-02-22 Antibioticos Sa Isopenicillin n synthetase gene derived from aspergillus nidulans
AU1975988A (en) * 1987-08-10 1989-02-16 Governers Of The University Of Alberta, The Cloning and nucleotide sequence determination of the isopenicillin n. synthetase gene from streptomyces clauvigerus
US4885252A (en) * 1987-09-08 1989-12-05 Eli Lilly And Company Recombinant DNA expression vectors and DNA compounds that encode isopenicillin N synthetase from aspergillus nidulans
US4950603A (en) * 1987-11-02 1990-08-21 Eli Lilly And Company Recombinant DNA expression vectors and DNA compounds that encode isopenicillin N synthetase from Streptomyces lipmanii
US6258555B1 (en) 1987-12-09 2001-07-10 Beecham Group P.L.C. DNA encoding ACV synthetase
GB8728811D0 (en) * 1987-12-09 1988-01-27 Beecham Group Plc Novel substance
KR0171897B1 (ko) * 1989-12-27 1999-02-01 후지사와 도모끼찌로 7-아미노세펨 화합물 또는 그 염류의 제조 방법
DE69131238T2 (de) * 1990-01-12 1999-11-11 Glaxo Group Ltd., Greenford Für ein Enzym der Antibiotika-Biosynthese kodierende DNA-Sequenz
EP0783581B1 (fr) * 1994-09-28 2006-07-26 Novozymes A/S Procede de production de metabolites secondaires
DE19755302A1 (de) * 1997-12-12 1999-06-17 Hoechst Marion Roussel De Gmbh Neuer Transkriptionsfaktor CPCR1 zur Regulation des Isopenicillin N-Synthetase-Gens (pcbC) und des AC-/ACV-Synthetase-Gens (pcbAB)
EP1165546A2 (fr) * 1999-04-02 2002-01-02 Du Pont Pharmaceuticals Company Nouveaux inhibiteurs de lactame de metalloproteases matricielles, de tnf-alpha, et de l'aggrecanase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3330003A1 (de) * 1982-10-21 1984-10-31 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig Dna-sequenz und dna-strukturen und sie verwendendes verfahren zur herstellung von penicillin-acylase
CA1278540C (fr) * 1983-07-22 1991-01-02 Eli Lilly And Company Gene modifie conferant une resistance a un antibiotique
US4762786A (en) * 1984-09-27 1988-08-09 Eli Lilly And Company Vectors and conditions which allow genetic transformation of cephalosporium
GB8508800D0 (en) * 1985-04-04 1985-05-09 Glaxo Group Ltd Microbiological process
US4892819A (en) * 1985-11-25 1990-01-09 Eli Lilly And Company Recombinant DNA expression vectors and DNA compounds that encode isopenicillin N synthetase from penicillium chrysogenum

Also Published As

Publication number Publication date
CA1309673C (fr) 1992-11-03
IL78531A0 (en) 1986-08-31
ES554218A0 (es) 1987-11-01
EP0200425A2 (fr) 1986-11-05
CN86102604A (zh) 1986-11-26
DK178386D0 (da) 1986-04-18
ES8802585A1 (es) 1988-08-16
AU592791B2 (en) 1990-01-25
EP0200425A3 (en) 1988-07-06
DK178386A (da) 1986-10-23
ES8800344A1 (es) 1987-11-01
BG45219A3 (bg) 1989-04-14
ES8900142A1 (es) 1989-01-16
KR860008287A (ko) 1986-11-14
EP0200425B1 (fr) 1991-12-27
AU5643186A (en) 1986-10-30
IE58780B1 (en) 1993-11-17
FI95810C (fi) 1996-03-25
ES557829A0 (es) 1989-01-16
FI861653A0 (fi) 1986-04-18
AU619596B2 (en) 1992-01-30
IE861029L (en) 1986-10-22
FI861653A7 (fi) 1986-10-23
DE3683080D1 (de) 1992-02-06
FI95810B (fi) 1995-12-15
HU202279B (en) 1991-02-28
JPH0787788B2 (ja) 1995-09-27
ES557658A0 (es) 1988-08-16
HUT40705A (en) 1987-01-28
AU4234789A (en) 1990-01-11
JPS61254192A (ja) 1986-11-11

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