BG47036A3 - Метод за получаване на монохидрат на бета - лактамов антибиотик 1- карбацефалоспорин - Google Patents

Метод за получаване на монохидрат на бета - лактамов антибиотик 1- карбацефалоспорин

Info

Publication number
BG47036A3
BG47036A3 BG085594A BG8559488A BG47036A3 BG 47036 A3 BG47036 A3 BG 47036A3 BG 085594 A BG085594 A BG 085594A BG 8559488 A BG8559488 A BG 8559488A BG 47036 A3 BG47036 A3 BG 47036A3
Authority
BG
Bulgaria
Prior art keywords
monohydrate
carbacephalosporin
lactam antibiotic
obtaining beta
beta
Prior art date
Application number
BG085594A
Other languages
English (en)
Inventor
Carol Pasini
Original Assignee
Eli Lilly And Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Company filed Critical Eli Lilly And Company
Publication of BG47036A3 publication Critical patent/BG47036A3/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D463/00—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D463/10—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D463/14—Heterocyclic compounds containing 1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. carbacephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with hetero atoms directly attached in position 7
    • C07D463/16—Nitrogen atoms
    • C07D463/18—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof
    • C07D463/20—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D463/22—Nitrogen atoms further acylated by radicals derived from carboxylic acids or by nitrogen or sulfur analogues thereof with the acylating radicals further substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen further substituted by nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Методът намира приложение във фармацевтичната промишленост. Монохидратът е стабилен в широки граници на влажност и има високо обемно тегло. 1 претенция
BG085594A 1987-10-06 1988-10-04 Метод за получаване на монохидрат на бета - лактамов антибиотик 1- карбацефалоспорин BG47036A3 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10576687A 1987-10-06 1987-10-06

Publications (1)

Publication Number Publication Date
BG47036A3 true BG47036A3 (bg) 1990-04-16

Family

ID=22307671

Family Applications (1)

Application Number Title Priority Date Filing Date
BG085594A BG47036A3 (bg) 1987-10-06 1988-10-04 Метод за получаване на монохидрат на бета - лактамов антибиотик 1- карбацефалоспорин

Country Status (32)

Country Link
EP (1) EP0311366B1 (bg)
JP (1) JP2641745B2 (bg)
KR (1) KR970002637B1 (bg)
CN (1) CN1029966C (bg)
AR (1) AR248407A1 (bg)
AT (1) ATE103916T1 (bg)
AU (1) AU598155B2 (bg)
BG (1) BG47036A3 (bg)
CA (1) CA1334970C (bg)
CS (1) CS270594B2 (bg)
DD (1) DD273634A5 (bg)
DE (1) DE3888913T2 (bg)
DK (1) DK170070B1 (bg)
EG (1) EG18529A (bg)
ES (1) ES2063049T3 (bg)
FI (1) FI884554L (bg)
HK (1) HK15497A (bg)
HU (1) HU206348B (bg)
IE (1) IE62108B1 (bg)
IL (1) IL87905A (bg)
MX (1) MX13277A (bg)
MY (1) MY104063A (bg)
NO (1) NO884416L (bg)
NZ (1) NZ226450A (bg)
OA (1) OA08958A (bg)
PH (1) PH31002A (bg)
PL (1) PL152022B1 (bg)
PT (1) PT88662B (bg)
SU (1) SU1731058A3 (bg)
UA (1) UA19149A (bg)
YU (1) YU46699B (bg)
ZA (1) ZA887409B (bg)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD280112A5 (de) * 1987-10-07 1990-06-27 ����@����@���@��������@���������@�������@�������k�� Verfahren zur herstellung kristalliner formen eines 1-carbacephalosporins
CA2002596A1 (en) * 1988-11-14 1990-05-14 Thomas M. Eckrich Hydrates of b-lactam antibiotic
CA2002597C (en) * 1988-11-14 1999-03-23 Thomas M. Eckrich Solvates of b-lactam antibiotic
CA2034592C (en) * 1990-01-26 2001-06-05 Ralph R. Pfeiffer Crystalline hydrochloride of new beta-lactam antibiotic and process therefor
US5352782A (en) * 1993-06-04 1994-10-04 Eli Lilly And Company Process for preparing crystalline β-lactam monohydrate
US5399686A (en) * 1993-06-04 1995-03-21 Eli Lilly And Company Loracarbef isopropanolate and a process for converting loracarbef isopropanolate to loracarbef monohydrate
US5374719A (en) * 1993-06-04 1994-12-20 Eli Lilly And Company Process for converting loracarbef dihydrate to loracarbef monohydrate
US5550231A (en) * 1993-06-15 1996-08-27 Eli Lilly And Company Loracarbef hydrochloride C1-C3 alcohol solvates and uses thereof
US5412094A (en) * 1993-06-28 1995-05-02 Eli Lilly And Company Bicyclic beta-lactam/paraben complexes
US5580977A (en) * 1995-03-01 1996-12-03 Eli Lilly And Company Process for preparing loracarbef monohydrate
US6001996A (en) * 1995-05-11 1999-12-14 Eli Lilly And Company Complexes of cephalosporins and carbacephalosporins with parabens
US6982251B2 (en) 2000-12-20 2006-01-03 Schering Corporation Substituted 2-azetidinones useful as hypocholesterolemic agents
US7071181B2 (en) 2001-01-26 2006-07-04 Schering Corporation Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors
IL156445A0 (en) 2001-01-26 2004-01-04 Schering Corp Combinations of peroxisome proliferator-activated receptor (ppar) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications
AR035533A1 (es) 2001-01-26 2004-06-02 Schering Corp Uso de por lo menos un inhibidor de la absorcion de los esteroles o sus sales, solvatos, prodrogas farmaceuticamente aceptables o mezclas de los mismos para la preparacion de un medicamento para el tratamiento de la sitosterolemia, composiciones farmaceuticas, el uso de dichas composiciones para la
US7056906B2 (en) 2001-09-21 2006-06-06 Schering Corporation Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women
MXPA04002573A (es) 2001-09-21 2004-06-18 Schering Corp Tratamiento de xantoma con derivados de azetidinona como inhibidores de la absorcion de esterol.
US7053080B2 (en) 2001-09-21 2006-05-30 Schering Corporation Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors
WO2004043457A1 (en) 2002-11-06 2004-05-27 Schering Corporation Cholesterol absorptions inhibitors for the treatment of autoimmune disorders
US7459442B2 (en) 2003-03-07 2008-12-02 Schering Corporation Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof
JP2006519869A (ja) 2003-03-07 2006-08-31 シェーリング　コーポレイション 置換アゼチジノン化合物、置換アゼチジノン化合物を調製するためのプロセス、それらの処方物および使用
EP1601668B1 (en) 2003-03-07 2008-08-27 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia
CA2517572C (en) 2003-03-07 2011-12-13 Schering Corporation Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3655656A (en) * 1970-06-04 1972-04-11 Lilly Co Eli Crystalline cephalexin monohydrate
JPS5672698A (en) * 1979-11-14 1981-06-16 Kyowa Hakko Kogyo Co Ltd Preparation of optically active cephalosporin analogue
DD280112A5 (de) * 1987-10-07 1990-06-27 ����@����@���@��������@���������@�������@�������k�� Verfahren zur herstellung kristalliner formen eines 1-carbacephalosporins

Also Published As

Publication number Publication date
YU46699B (sh) 1994-04-05
DE3888913T2 (de) 1994-08-11
DD273634A5 (de) 1989-11-22
DK553788A (da) 1989-04-07
DE3888913D1 (de) 1994-05-11
IE883015L (en) 1989-04-06
FI884554A7 (fi) 1989-04-07
IL87905A0 (en) 1989-03-31
CN1029966C (zh) 1995-10-11
PL275093A1 (en) 1989-05-02
AR248407A1 (es) 1995-08-18
NO884416D0 (no) 1988-10-05
DK553788D0 (da) 1988-10-04
NZ226450A (en) 1990-05-28
AU598155B2 (en) 1990-06-14
HUT48884A (en) 1989-07-28
PT88662A (pt) 1988-11-01
CA1334970C (en) 1995-03-28
HK15497A (en) 1997-02-14
SU1731058A3 (ru) 1992-04-30
PT88662B (pt) 1992-12-31
MX13277A (es) 1993-11-01
FI884554A0 (fi) 1988-10-04
EP0311366A1 (en) 1989-04-12
FI884554L (fi) 1989-04-07
JPH01128983A (ja) 1989-05-22
NO884416L (no) 1989-04-07
ATE103916T1 (de) 1994-04-15
MY104063A (en) 1993-11-30
KR970002637B1 (ko) 1997-03-07
CS270594B2 (en) 1990-07-12
HU206348B (en) 1992-10-28
CN1032793A (zh) 1989-05-10
PH31002A (en) 1997-12-23
EG18529A (en) 1993-04-30
PL152022B1 (en) 1990-10-31
AU2337288A (en) 1989-04-06
IE62108B1 (en) 1994-12-14
CS666688A2 (en) 1989-11-14
YU184588A (en) 1990-02-28
JP2641745B2 (ja) 1997-08-20
UA19149A (uk) 1997-12-25
OA08958A (en) 1990-11-30
KR890006644A (ko) 1989-06-15
IL87905A (en) 1992-06-21
ZA887409B (en) 1990-06-27
EP0311366B1 (en) 1994-04-06
ES2063049T3 (es) 1995-01-01
DK170070B1 (da) 1995-05-15

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