BG49721A3 - Метод за получаване на полипептид, имащ активността на животински хормон на растежа - Google Patents

Метод за получаване на полипептид, имащ активността на животински хормон на растежа

Info

Publication number
BG49721A3
BG49721A3 BG066214A BG6621484A BG49721A3 BG 49721 A3 BG49721 A3 BG 49721A3 BG 066214 A BG066214 A BG 066214A BG 6621484 A BG6621484 A BG 6621484A BG 49721 A3 BG49721 A3 BG 49721A3
Authority
BG
Bulgaria
Prior art keywords
polypeptide
activity
growth hormone
animal growth
host
Prior art date
Application number
BG066214A
Other languages
English (en)
Inventor
Haim Aviv
Marian Gorecki
Avigdor Levanon
Amos Oppenheim
Tikva Vogel
Elisha Zeelon
Menachem Zeevi
Original Assignee
Bio- Technology General Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BG080683A priority Critical patent/BG49718A3/bg
Application filed by Bio- Technology General Corp filed Critical Bio- Technology General Corp
Publication of BG49721A3 publication Critical patent/BG49721A3/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0089—Oxidoreductases (1.) acting on superoxide as acceptor (1.15)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C12N15/73—Expression systems using phage (lambda) regulatory sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/806—Antigenic peptides or proteins
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/825—Bacteria
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/12—Growth hormone, growth factor other than t-cell or b-cell growth factor, and growth hormone releasing factor; related peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Endocrinology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Feed For Specific Animals (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Fodder In General (AREA)

Abstract

Методът ще намери приложение в областта на медицината. По него се получава полипептид, имащ активността на животински хормон на растежа, който осигурява изразяването и свръхизразяването на хормона до количества, надвишващи 20 % от общия клетъчен белтък. По метода в гостоприемник еsснеriснiа соli се внася плазмид, който съдържа информация за продуциране на желания полипептид, съдържащ термолабилния репресор сi, така че при повишаване на температурата на гостоприемника до температурата, при която репресорът се разрушава, в гостоприемника се осъществява експресия на днк-кодиращ полипептид и той е продуциран.20 претенции, 15 фигури
BG066214A 1983-07-15 1984-07-12 Метод за получаване на полипептид, имащ активността на животински хормон на растежа BG49721A3 (bg)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BG080683A BG49718A3 (bg) 1983-07-15 1984-07-02 Метод за получаване на полипептид със супероксиддисмутазна активност

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US51418883A 1983-07-15 1983-07-15

Publications (1)

Publication Number Publication Date
BG49721A3 true BG49721A3 (bg) 1992-01-15

Family

ID=24046152

Family Applications (2)

Application Number Title Priority Date Filing Date
BG080683A BG49718A3 (bg) 1983-07-15 1984-07-02 Метод за получаване на полипептид със супероксиддисмутазна активност
BG066214A BG49721A3 (bg) 1983-07-15 1984-07-12 Метод за получаване на полипептид, имащ активността на животински хормон на растежа

Family Applications Before (1)

Application Number Title Priority Date Filing Date
BG080683A BG49718A3 (bg) 1983-07-15 1984-07-02 Метод за получаване на полипептид със супероксиддисмутазна активност

Country Status (22)

Country Link
US (3) US4871835A (bg)
EP (3) EP0131843B1 (bg)
JP (3) JPH0687780B2 (bg)
AT (2) ATE136934T1 (bg)
AU (2) AU577298B2 (bg)
BG (2) BG49718A3 (bg)
BR (1) BR8403523A (bg)
CA (1) CA1254527A (bg)
CZ (1) CZ282867B6 (bg)
DD (2) DD240217A5 (bg)
DE (2) DE3486425T2 (bg)
DK (1) DK347184A (bg)
ES (2) ES534321A0 (bg)
FI (1) FI90564C (bg)
HK (1) HK128095A (bg)
HU (1) HU209878B (bg)
IE (2) IE64174B1 (bg)
IL (8) IL72396A (bg)
NZ (2) NZ208897A (bg)
RO (1) RO91332B (bg)
SK (1) SK278576B6 (bg)
ZA (1) ZA845345B (bg)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340926A (en) * 1983-03-25 1994-08-23 Celltech, Limited Process for the recovery of recombinantly produced protein from insoluble aggregate
US5236828A (en) * 1983-07-06 1993-08-17 Papas Takis S Plasmid pJL6
BG49718A3 (bg) * 1983-07-15 1992-01-15 Bio- Technology General Corp Метод за получаване на полипептид със супероксиддисмутазна активност
US5670371A (en) * 1983-07-15 1997-09-23 Bio-Technology General Corp. Bacterial expression of superoxide dismutase
US5332805A (en) * 1984-02-03 1994-07-26 Celltech Limited Process for the recovery of recombinantly produced chymosin from insoluble aggregate
EP0159123B1 (en) * 1984-03-06 1992-01-15 Eli Lilly And Company Vectors for expressing bovine growth hormone derivatives
CA1340597C (en) * 1984-08-27 1999-06-22 Haim Aviv Expression vectors containing pl promoter, and engineered restriction site for convenient replacement of ribosomal binding site, plasmids containing the vectors, hosts containing the plasmids and related methods
US5112744A (en) * 1984-08-27 1992-05-12 Bio-Technology General Corp. Plasmids for the production of human Cu-Zn superoxide dismutase, bacterial hosts containing the plasmids and methods for production and recovery of such superoxide dismutase
CA1267615A (en) * 1984-08-27 1990-04-10 Dan Hadary Method for recovering purified growth hormones from genetically engineered microorganisms
US5143836A (en) * 1984-08-27 1992-09-01 Bio-Technology General Corp. Plasmids for expression of human superoxide dismutase (SOD) analogs containing lambda pl promoter with engineered restriction site for substituting ribosomal binding sites and methods of use thereof
US6030611A (en) * 1984-08-27 2000-02-29 Bio-Technology General Corp. Therapeutic SOD compositions and uses thereof
US5759816A (en) * 1984-08-27 1998-06-02 Bio-Technology General Corp. Expression vectors containing λPL promoter and T1 T2 rRNA termination sequence plasmids containing the vectors hosts containing the plasmids and related methods
US5162217A (en) * 1984-08-27 1992-11-10 Bio-Technology General Corp. Plasmids for expression of human superoxide dismutase (SOD) analogs containing lambda PL promoter with engineered restriction site for substituting ribosomal binding sites and methods of use thereof
US4743546A (en) * 1985-02-13 1988-05-10 Biotechnica International, Inc. Controlled gene excision
US4861868A (en) 1985-02-22 1989-08-29 Monsanto Company Production of proteins in procaryotes
FR2579223B1 (fr) * 1985-03-25 1988-12-09 Genetica Procede de preparation microbiologique de la serum-albumine humaine
ATE76435T1 (de) 1985-06-26 1992-06-15 Upjohn Co Solubilisation und oxidation von somatotropin aus transformierten mikroorganismen.
US4788144A (en) * 1985-06-28 1988-11-29 International Minerals & Chemical Corp. Fermentation process for the high level production of swine growth
US4762784A (en) * 1985-07-15 1988-08-09 International Minerals & Chemical Corp. Fermemtation process for the high level production of bovine growth hormone
US4874703A (en) * 1985-08-26 1989-10-17 Eli Lilly And Company Expression vectors for use in E. coli
WO1987001708A2 (en) * 1985-09-18 1987-03-26 The Upjohn Company Enhanced bioactivity of mammalian somatotropin through selective deamidation
US5631227A (en) * 1985-09-18 1997-05-20 The Upjohn Company Somatotropin analogs
JPH07110232B2 (ja) * 1985-10-14 1995-11-29 株式会社日立製作所 遺伝子組換え大腸菌の遺伝子生産物を採取する方法および装置
US6610520B1 (en) 1985-11-22 2003-08-26 Bio-Technology General Corp. Gene encoding human manganese superoxide dismutase and recombinant polypeptide encoded thereby
IE59498B1 (en) * 1985-11-22 1994-03-09 Bio Technology General Corp Human manganese superoxide dismutase analog, plasmid for its expression and method of recovering it in enzymatically active form
ES2019874B3 (es) * 1986-10-08 1991-07-16 Upjohn Co Bioactividad mejorada de somatotropina de mamiferos mediante desamidacion selectiva.
US5089406A (en) * 1987-01-07 1992-02-18 Allied-Signal Inc. Method of producing a gene cassette coding for polypeptides with repeating amino acid sequences
GB8701848D0 (en) * 1987-01-28 1987-03-04 Celltech Ltd Polypeptides
WO1988006186A2 (en) * 1987-02-19 1988-08-25 The Upjohn Company cDNAs ENCODING SOMATOTROPIN, EXPRESSION VECTORS AND HOSTS
US5240837A (en) * 1987-02-19 1993-08-31 The Upjohn Company CDNAS encoding somatotropin, expression vectors and hosts
US5104796A (en) * 1987-04-06 1992-04-14 International Minerals & Chemical Corp. High titer production of human somatomedin c
US5047504A (en) * 1987-04-28 1991-09-10 Amgen, Inc. Method for purifying granulocyte-macrophage colony stimulating factor
US4966841A (en) * 1987-05-22 1990-10-30 The Board Of Regents Of The University Of Washington Enhanced vector production and expression of recombinant DNA products
US5030563A (en) * 1987-07-07 1991-07-09 Genetics Institute, Inc. Bacterial hypersecretion using mutant repressor sequence
US5079345A (en) * 1988-08-19 1992-01-07 Eli Lilly And Company Proteins having growth hormone anabolic properties with reduced effect on carbohydrate metabolism
DE68919647T2 (de) * 1988-10-26 1995-05-11 American Cyanamid Co Verfahren zur Verringerung des Aggregatinhaltes in Wachstumshormonen gleichenden Stoffen.
US6780613B1 (en) 1988-10-28 2004-08-24 Genentech, Inc. Growth hormone variants
EP0397834B1 (en) * 1988-10-28 2000-02-02 Genentech, Inc. Method for identifying active domains and amino acid residues in polypeptides and hormone variants
EP0441889A1 (fr) * 1988-11-07 1991-08-21 Commission des Communautés Européennes Hormone de croissance humaine modifiee
US4975529A (en) * 1989-08-18 1990-12-04 Monsanto Company Method of folding somatotropins
US6583115B1 (en) 1989-10-12 2003-06-24 Ohio University/Edison Biotechnology Institute Methods for treating acromegaly and giantism with growth hormone antagonists
US5958879A (en) * 1989-10-12 1999-09-28 Ohio University/Edison Biotechnology Institute Growth hormone receptor antagonists and methods of reducing growth hormone activity in a mammal
IE912345A1 (en) * 1990-08-03 1992-02-12 Pharmacia Ab Treatment of human lactation failure
US5612198A (en) * 1990-09-04 1997-03-18 The Salk Institute Production of insulin-like growth factor-1 in methylotrophic yeast cells
ES2083152T3 (es) * 1990-11-30 1996-04-01 Monoclonetics Int Metodos para el diagnostico de dolores cronicos lumbares y cervicales.
US5844097A (en) * 1990-11-30 1998-12-01 Monoclonetics International, Inc. Methods for the diagnosis of peripheral nerve damage
US5231178A (en) * 1991-01-16 1993-07-27 The Salk Institute Biotechnology/Industrial Associates, Inc. Method for the purification of intact, correctly-folded insulin-like growth factor-1
JP3417558B2 (ja) * 1991-05-10 2003-06-16 ジェネンテク，インコーポレイテッド 配位子作用薬および拮抗薬の選択
US5395761A (en) * 1991-11-27 1995-03-07 Eli Lilly And Company Plasmid pHKY334, an expression vector for EK-BGH and host cells transformed therewith
ZA94169B (en) * 1993-01-26 1994-09-07 Lilly Co Eli Non-denaturing potency assay for bovine somatotropin
AU693478B2 (en) * 1994-11-10 1998-07-02 Metabolic Pharmaceuticals Limited Treatment of obesity
US20020142965A1 (en) * 1994-11-15 2002-10-03 Metabolic Pharmaceuticals, Ltd. Treatment of obesity
US6335319B1 (en) 1994-11-15 2002-01-01 Metabolic Pharmaceuticals, Inc. Treatment of obesity
AU5881996A (en) * 1995-06-07 1996-12-30 Ohio University/Edison Biotechnology Institute Methods of treatment using growth hormone antagonists
KR970006498A (ko) * 1995-07-31 1997-02-21 유충식 활성형 인성장호르몬의 정제 방법
DK0851925T3 (da) * 1995-09-21 2005-11-28 Genentech Inc Humane Væksthormonvarianter
US5849293A (en) * 1996-01-11 1998-12-15 Cornell Research Foundation, Inc. Use of human transferrin in controlling insulin levels
ATE216723T1 (de) 1996-02-13 2002-05-15 Japan Chem Res Hormones de croissance humaines mutantes et leur utilisation
BR9811755A (pt) * 1997-09-08 2000-08-29 Metabolic Pharmaceutical Ltd Peptìdeo, processo para o tratamento da obesidade em um animal, uso de um peptìdeo, e, composição farmacêutica
DE19951765A1 (de) * 1999-10-27 2001-05-03 Thomas Schweder Wirts-Vektor-Systeme zur Überproduktion von thermolabilen Enzymen psychrophiler Organismen
KR100400638B1 (ko) * 2000-12-06 2003-10-08 주식회사 엘지생명과학 재조합 인간 성장호르몬 유사체의 분리방법
DK1368483T3 (da) 2001-03-09 2012-11-05 Genentech Inc Fremgangsmåde til fremstilling af polypeptider
DE60332358D1 (de) * 2002-09-09 2010-06-10 Hanall Pharmaceutical Co Ltd Protease-resistente modifizierte interferon alpha polypeptide
US7998930B2 (en) 2004-11-04 2011-08-16 Hanall Biopharma Co., Ltd. Modified growth hormones
WO2006121569A2 (en) 2005-04-08 2006-11-16 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
US20080260820A1 (en) * 2007-04-19 2008-10-23 Gilles Borrelly Oral dosage formulations of protease-resistant polypeptides
EP2446898A1 (en) 2010-09-30 2012-05-02 Laboratorios Del. Dr. Esteve, S.A. Use of growth hormone to enhance the immune response in immunosuppressed patients

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GR68404B (bg) * 1979-06-01 1981-12-29 Univ California
US4342832A (en) * 1979-07-05 1982-08-03 Genentech, Inc. Method of constructing a replicable cloning vehicle having quasi-synthetic genes
US4426323A (en) * 1980-01-10 1984-01-17 Ionics, Incorporated Selected recovery of proteins from fermentation broths
US4443539A (en) * 1980-02-05 1984-04-17 The Upjohn Company Process for preparing bovine growth hormone
IL59690A (en) * 1980-03-24 1983-11-30 Yeda Res & Dev Production of bovine growth hormone by microorganisms and modified microorganisms adapted to produce it
EP0041767B1 (en) * 1980-06-06 1993-03-03 Biogen, Inc. Improved vectors and methods for making such vectors and for expressing cloned genes
US4352443A (en) * 1980-06-24 1982-10-05 U.S. Cap & Closure, Inc. Dispenser having a trigger-bulb pump
JPS6045848B2 (ja) * 1980-07-31 1985-10-12 株式会社林原生物化学研究所 ヒト成長ホルモンの製造方法
IE52755B1 (en) * 1980-08-26 1988-02-17 Univ California Bovine pre-growth and growth hormone
DE3231658A1 (bg) 1981-01-21 1983-11-17
EP0061250A3 (en) * 1981-03-23 1983-09-28 Biogen N.V. Improved process for recovering products produced by host organisms
NZ201918A (en) * 1981-09-18 1987-04-30 Genentech Inc N-terminal methionyl analogues of bovine growth hormone
US4436815A (en) * 1981-11-27 1984-03-13 Eli Lilly And Company Method for stabilizing and selecting recombinant DNA containing host cells
US4665160A (en) * 1982-03-22 1987-05-12 Genentech, Inc. Novel human growth hormone like protein HGH-V encoded in the human genome
IE55163B1 (en) * 1982-06-07 1990-06-20 Celltech Ltd A process for the preparation of chymosin
EP0103395A3 (en) * 1982-08-17 1985-05-22 Biogen N.V. Dna sequences, recombinant dna molecules and processes for producing bovine growth hormone-like polypeptides in high yield
EP0111814A3 (en) * 1982-12-16 1985-08-14 Mgi Pharma, Inc. The cloning and expression of nucleotide sequences encoding bovine growth hormone
US4512922A (en) * 1982-12-22 1985-04-23 Genentech, Inc. Purification and activity assurance of precipitated heterologous proteins
WO1984002534A1 (en) * 1982-12-23 1984-07-05 Us Commerce Human growth hormone produced by recombinant dna in mouse cells
US4728609A (en) * 1983-01-10 1988-03-01 Hoffmann-La-Roche Inc. Recombinant growth hormone releasing factor
JPS59145876A (ja) * 1983-02-09 1984-08-21 株式会社リコー 開閉体用のヒンジ
AU574064B2 (en) * 1983-03-07 1988-06-30 F. Hoffmann-La Roche Ag Growth hormone releasing factor analogues
EP0122080B1 (en) * 1983-03-25 1989-09-13 Celltech Limited A process for the production of a protein
US4755465A (en) * 1983-04-25 1988-07-05 Genentech, Inc. Secretion of correctly processed human growth hormone in E. coli and Pseudomonas
BG49718A3 (bg) * 1983-07-15 1992-01-15 Bio- Technology General Corp Метод за получаване на полипептид със супероксиддисмутазна активност
AU587176B2 (en) * 1984-02-14 1989-08-10 Mycogen Plant Science, Inc. Transfer vector
US4767709A (en) * 1984-06-28 1988-08-30 The Johns Hopkins University Growth-related hormones
DE3426532A1 (de) * 1984-07-18 1986-01-30 Gesellschaft für Biotechnologische Forschung mbH (GBF), 3300 Braunschweig Verwendung einer dna-sequenz zur expression sowie dna-struktur und expressionsvektor mit der dna-sequenz
CA1340597C (en) * 1984-08-27 1999-06-22 Haim Aviv Expression vectors containing pl promoter, and engineered restriction site for convenient replacement of ribosomal binding site, plasmids containing the vectors, hosts containing the plasmids and related methods
US4612367A (en) * 1985-04-08 1986-09-16 Eli Lilly And Company Process for purifying growth hormone-like materials
US4677196A (en) * 1985-09-06 1987-06-30 International Minerals & Chemical Corp. Purification and activation of proteins from insoluble inclusion bodies
US4656255A (en) * 1985-09-09 1987-04-07 International Minerals & Chemical Corp. Protein recovery

Also Published As

Publication number Publication date
DE3485003D1 (de) 1991-10-10
SK524684A3 (en) 1997-10-08
DD240217A5 (de) 1986-10-22
ES8602947A1 (es) 1985-12-01
BG49718A3 (bg) 1992-01-15
EP0131843A1 (en) 1985-01-23
ATE136934T1 (de) 1996-05-15
FI842842A0 (fi) 1984-07-13
DE3486425T2 (de) 1996-10-17
IL108108A0 (en) 1994-04-12
IE64174B1 (en) 1995-07-12
IL91826A (en) 1992-05-25
HUT34543A (en) 1985-03-28
FI842842A7 (fi) 1985-01-16
JP3146161B2 (ja) 2001-03-12
EP0691406A1 (en) 1996-01-10
CZ282867B6 (cs) 1997-11-12
SK278576B6 (en) 1997-10-08
IL101629A0 (en) 1992-12-30
US4831120A (en) 1989-05-16
JPH0799990A (ja) 1995-04-18
JPS6091986A (ja) 1985-05-23
US4871835A (en) 1989-10-03
IL91826A0 (en) 1990-06-10
AU1977788A (en) 1988-12-22
IL72396A0 (en) 1984-11-30
IE841818L (en) 1985-01-15
HU209878B (en) 1994-11-28
JPH09131190A (ja) 1997-05-20
AU577298B2 (en) 1988-09-22
EP0319049A2 (en) 1989-06-07
ZA845345B (en) 1985-03-27
ES534321A0 (es) 1985-12-01
IL112178A0 (en) 1995-03-15
AU615663B2 (en) 1991-10-10
ES544976A0 (es) 1986-01-16
JP2568376B2 (ja) 1997-01-08
DD229427A5 (de) 1985-11-06
BR8403523A (pt) 1985-06-25
EP0319049B1 (en) 1996-04-17
HK128095A (en) 1995-08-18
FI90564B (fi) 1993-11-15
NZ208897A (en) 1990-06-26
IL72396A (en) 1992-05-25
IL91828A0 (en) 1990-06-10
IE922469A1 (en) 1985-01-15
NZ227962A (en) 1990-06-26
CZ524684A3 (en) 1997-07-16
US4997916A (en) 1991-03-05
DK347184D0 (da) 1984-07-13
EP0319049A3 (en) 1990-01-03
AU3034584A (en) 1985-01-17
RO91332A (ro) 1987-04-30
JPH0687780B2 (ja) 1994-11-09
DE3486425D1 (de) 1996-05-23
ES8604252A1 (es) 1986-01-16
CA1254527A (en) 1989-05-23
DK347184A (da) 1985-01-16
IL91828A (en) 1992-05-25
FI90564C (fi) 1994-02-25
ATE66959T1 (de) 1991-09-15
RO91332B (ro) 1987-05-01
EP0131843B1 (en) 1991-09-04

Similar Documents

Publication Publication Date Title
BG49721A3 (bg) Метод за получаване на полипептид, имащ активността на животински хормон на растежа
MY102472A (en) Preparation of funtional human urokinase proteins.
DE3064888D1 (en) Aqueous solutions of proteins stable against denaturization, process for their manufacture, and their utilization
BG46601A3 (bg) Метод за получаване на авермектинови производни
NL990034I1 (nl) DNA dat codeert voor humane tumor necrosis faktor en humane tumor necrosis faktor polypeptide.
BG44877A3 (bg) Метод за експресия на ген,кодиращ човешки имунен интерферон
FI823758A7 (fi) Toiminnalliset valkuaisainehydrolysaatit, niiden valmistusmenetelmä, näiden valkuaisainehydrolysaattien käyttö elintarvikkeiden lisäaineina sekä näitä valkuaisaineita sisältävät elielintarvikkeet.
IT1232827B (it) Proteine biologicamente attive, formulazioni che le contengono e metodo per prepararle ed applicarle
PT82978B (pt) Processo para a producao de hormonas de crescimento recombinantes bio-activas secas
ATE44652T1 (de) Zubereitung mit gehalt an stabilisiertes polypeptid mit gamma-interferon aktivitaet.
ATE49600T1 (de) Kristallinisches kalzium-pseudomonat und verwendung.
DE3686130D1 (de) Geschmackskontrolle von proteinhydrolysaten.
FI872147A7 (fi) Kalarehu, menetelmä sen valmistamiseksi sekä ruokintamenetelmä.
NO865191L (no) Gm-csf-protein, derivater derav og fremstilling og anvendelse av slike proteiner.
IT8319385A0 (it) Prodotti di cioccolato con maggiore contenuto di proteine eprocedimento per la produzione diprodotti di tipo siffatto.
IT8483359A0 (it) Procedimento per ottenere lapreparazione di concentrati e nutrimenti proteici dal sangue animale.
FI942442A0 (fi) Proteiinien tuotto 7B2-proteiinia käyttäen
FI850814A7 (fi) Proteiineja, farmaseuttisia seoksia, geenejä, vektoreita, isäntäorgan ismeja ja menetelmiä niiden tuottamiseksi.
DE68909465D1 (de) Behandlung von pferdeviehbestand.
ATE47955T1 (de) Lagerstabile saure naehrmittelsosse, die faserige proteinkomplexe enthaelt.
ATE45675T1 (de) Verwendung von interferon gamma (ifn-gamma) zur herstellung von praeparationen zur behandlung rheumatischer erkrankungen.
Barrett Adult body temperatures and the development of endothermy in the puffin Fratercula arctica, razorbill, Alca torda and guillemot Uria aalge.
GB1387606A (en) Triazolobenzodiazepines
DE3686688D1 (de) Verwendung von sulfanilamido quinoxalinen zur behandlung von neoplastischen krankheiten.
ATE74161T1 (de) Expressionsplasmide die vollstaendige cdna-sequenz von kalbsprochymosin enthaltend.