BG50610A3 - Метод за получаване на производни на 1н,3н-пирол/1,2-с/ тиазол-7-карбоксамид - Google Patents
Метод за получаване на производни на 1н,3н-пирол/1,2-с/ тиазол-7-карбоксамидInfo
- Publication number
- BG50610A3 BG50610A3 BG092844A BG9284490A BG50610A3 BG 50610 A3 BG50610 A3 BG 50610A3 BG 092844 A BG092844 A BG 092844A BG 9284490 A BG9284490 A BG 9284490A BG 50610 A3 BG50610 A3 BG 50610A3
- Authority
- BG
- Bulgaria
- Prior art keywords
- alkyl
- phenyl
- radical
- hydroxyalkyl
- pyridyl
- Prior art date
Links
- UXXNOOGXRXCGEO-UHFFFAOYSA-N 3,4-dihydro-2h-pyran-2-ol Chemical class OC1CCC=CO1 UXXNOOGXRXCGEO-UHFFFAOYSA-N 0.000 title 1
- -1 -OH Chemical group 0.000 abstract 11
- 125000000217 alkyl group Chemical group 0.000 abstract 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 8
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 4
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 239000002131 composite material Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000004076 pyridyl group Chemical group 0.000 abstract 3
- 150000003254 radicals Chemical class 0.000 abstract 3
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- MDFFNEOEWAXZRQ-UHFFFAOYSA-N aminyl Chemical group [NH2] MDFFNEOEWAXZRQ-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- RSEBUVRVKCANEP-UHFFFAOYSA-N 2-pyrroline Chemical class C1CC=CN1 RSEBUVRVKCANEP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 abstract 1
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 210000002249 digestive system Anatomy 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 125000002183 isoquinolinyl group Chemical group C1(=NC=CC2=CC=CC=C12)* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- KHUXNRRPPZOJPT-UHFFFAOYSA-N phenoxy radical Chemical group O=C1C=C[CH]C=C1 KHUXNRRPPZOJPT-UHFFFAOYSA-N 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 125000005493 quinolyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
- BRNULMACUQOKMR-UHFFFAOYSA-N thiomorpholine Chemical compound C1CSCCN1 BRNULMACUQOKMR-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Получените съединения намират приложение в медицината за лечение на алергични заболявания, възпалителни процеси, както и на заболявания на храносмилателната система. По метода се получават производни на 1н, 3н-пирол/1,2-с/тиазол-7-карбоксамида с обща формула в която r1 е водороден или халогенен атом, алкилов, алкилокси, сf3, nн2, алкиламино, диалкиламино, -он, -сn, фенилов или феноксирадикал; аr е фенилов, нафтилов, пиридилов, хинолилов, изохинолилов, тиенилов, евентуално заместени с халогенен атом, алкилов, алкилокси, сf3, nн2, алкиламино, диалкиламино, -он или сn радикал, като р е цяло число 0, 1 или 2, и z е валентна връзка, а r2 е н, или z е валентна връзка и r2 е пиридилов, хиноклидинилов, 3-пиролидинилов, 3или 4-пиперидилов радикал, евентуално заместени с алкилов, хидроксиалкилов, фенилов или фенилалкилов радикал, или z е с1-4 алкиленов радикал и r2 е 2-, 3или 4-пиридилов, 3-хиноклидинилов, 2-пиролидинилов, 2-, 3или 4-пиперидилов радикал, евентуално заместени с алкилов, хидроксиалкилов, фенилов или фенилалкилов радикал, или е групата соn/r3//r4/, в която r3 и r4 образуват заедно с азотния атом пиперазинов цикъл, евентуално заместен с алкилов, хидроксиалкилов, пиридилов, фенилов или фенилалкилов радикал, или r3 е водороден атом, алкилов, фенилов или фенилалкилов радикал или групата /сн2/nn/r5/r6, където n е цяло число от 1 до 4, а r5 и r6 означават водороден атом, алкилов, фенилов, фенилалкилов радикал, или r5 и r6 образуват морфолинов, тиоморфолинов, пиролидинов, пиперидинов или пиперазинов пръстен, евентуално заместен с алкилов, хидроксиалкилов, пиридилов, фенилов, фенилалкилов или фенилкарбонилов радикал, и r4 е /сн2/nn/r5//r6/, където r5, r6 и n имат дадените по-горе значения, или z е с1-4 алкиленов радикал, а r2 е n/r3/ /r4/ или n/r5//r6/, като r3, r4, r5 и r6 имат дадените по-горе значения, при условие, че във всички споменати по-горе значения алкиловите радикали и алкиловата част съдържат от 1 до 4 въглеродни ат
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR8903510A FR2644456B1 (fr) | 1989-03-17 | 1989-03-17 | Nouveaux derives du 1h, 3h-pyrrolo(1,2-c)thiazolecarboxamide-7, leur preparation et les compositions pharmaceutiques qui les contiennent |
| BG091500A BG51159A3 (bg) | 1989-03-17 | 1990-03-16 | Метод за получаване на производни на 1н,3н-пирол (1,2-с)тиазол-7-карбоксамида |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BG50610A3 true BG50610A3 (bg) | 1992-09-15 |
Family
ID=25663358
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG9284390A BG51455A3 (en) | 1989-03-17 | 1990-03-06 | Process for the preparation derivatives of 1h-3h-pyrol/1,2-c/thiazole-7-carboxamide |
| BG092844A BG50610A3 (bg) | 1989-03-17 | 1990-03-16 | Метод за получаване на производни на 1н,3н-пирол/1,2-с/ тиазол-7-карбоксамид |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG9284390A BG51455A3 (en) | 1989-03-17 | 1990-03-06 | Process for the preparation derivatives of 1h-3h-pyrol/1,2-c/thiazole-7-carboxamide |
Country Status (1)
| Country | Link |
|---|---|
| BG (2) | BG51455A3 (bg) |
-
1990
- 1990-03-06 BG BG9284390A patent/BG51455A3/xx unknown
- 1990-03-16 BG BG092844A patent/BG50610A3/bg unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BG51455A3 (en) | 1993-05-14 |
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