BG50942A3 - Method for production of chymopapain - Google Patents

Method for production of chymopapain

Info

Publication number
BG50942A3
BG50942A3 BG084338A BG8433888A BG50942A3 BG 50942 A3 BG50942 A3 BG 50942A3 BG 084338 A BG084338 A BG 084338A BG 8433888 A BG8433888 A BG 8433888A BG 50942 A3 BG50942 A3 BG 50942A3
Authority
BG
Bulgaria
Prior art keywords
chymopapain
sephadex
derived
production
cystein
Prior art date
Application number
BG084338A
Other languages
Bulgarian (bg)
Inventor
Laszlo Polgar
Jozsef Gaal
Sandor Virag
Laszlo Jozsa
Tibor Vizkeleti
Bence Asboth
Erzsebet Fejer
Original Assignee
Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. filed Critical Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.
Priority to BG084338A priority Critical patent/BG50942A3/en
Publication of BG50942A3 publication Critical patent/BG50942A3/en

Links

Landscapes

  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

This method is used in medicine for extracting medical agents for the treatment of inter-vertebra disc hernia. The product is highly active and is derived in a simple way : the raw chymopapain is dissolved in water containing a phosphate or acetate buffer, with a pH between 5 and 7, in the presence of a reducer, such as cystein or sodium bisulphite. The derived pure solution is subjected to gel chromatography in a column in proportion between the length and diameter in the 5:1 and 50:1 range and containing sephadex G-50 or sephadex G-25, after which the chymopapain fractions are gathered and lyophilised.
BG084338A 1986-12-08 1988-06-01 Method for production of chymopapain BG50942A3 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BG084338A BG50942A3 (en) 1986-12-08 1988-06-01 Method for production of chymopapain

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU865090A HU196624B (en) 1986-12-08 1986-12-08 Process for producing chymopapain with high specific activity
BG084338A BG50942A3 (en) 1986-12-08 1988-06-01 Method for production of chymopapain

Publications (1)

Publication Number Publication Date
BG50942A3 true BG50942A3 (en) 1992-12-15

Family

ID=10969645

Family Applications (1)

Application Number Title Priority Date Filing Date
BG084338A BG50942A3 (en) 1986-12-08 1988-06-01 Method for production of chymopapain

Country Status (5)

Country Link
BG (1) BG50942A3 (en)
CS (1) CS271346B2 (en)
CU (1) CU22158A3 (en)
DD (1) DD270723A5 (en)
HU (1) HU196624B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8909836D0 (en) * 1989-04-28 1989-06-14 Boots Co Plc Therapeutic agent
CN1320111C (en) * 2004-08-09 2007-06-06 王美岭 Process for preparing papain

Also Published As

Publication number Publication date
HU196624B (en) 1988-12-28
CS377388A2 (en) 1989-12-13
CS271346B2 (en) 1990-09-12
CU22158A3 (en) 1994-01-31
DD270723A5 (en) 1989-08-09

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