BG50942A3 - Метод за получаване на химопапаин - Google Patents

Метод за получаване на химопапаин

Info

Publication number
BG50942A3
BG50942A3 BG084338A BG8433888A BG50942A3 BG 50942 A3 BG50942 A3 BG 50942A3 BG 084338 A BG084338 A BG 084338A BG 8433888 A BG8433888 A BG 8433888A BG 50942 A3 BG50942 A3 BG 50942A3
Authority
BG
Bulgaria
Prior art keywords
chymopapain
sephadex
derived
production
cystein
Prior art date
Application number
BG084338A
Other languages
English (en)
Inventor
Laszlo Polgar
Jozsef Gaal
Sandor Virag
Laszlo Jozsa
Tibor Vizkeleti
Bence Asboth
Erzsebet Fejer
Original Assignee
Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. filed Critical Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.
Priority to BG084338A priority Critical patent/BG50942A3/bg
Publication of BG50942A3 publication Critical patent/BG50942A3/bg

Links

Landscapes

  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)

Abstract

Методът намира приложение в медицината за получаване на лекарствено средство за лечение на херния на междупрешленния диск. Продуктът е с висока активност и се получава по опростен начин, като суровият химопапаин се разтваря във вода, съдържаща фосфатен или ацетатен буфер с рн между 5 и 7 в присъствие на редуктор, като цистеин или натриев бисулфит. Полученият чист разтвор се подлага на гелна хроматография в колона със съотношение между дължината и диаметъра й в границите между 5:1 и 50:1 и съдържаща sернаdех g-50 или sернаdех g 25, след което фракциите от химопапаин се събират и лиофилизират.2 претенции, 1 фигура
BG084338A 1986-12-08 1988-06-01 Метод за получаване на химопапаин BG50942A3 (bg)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BG084338A BG50942A3 (bg) 1986-12-08 1988-06-01 Метод за получаване на химопапаин

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU865090A HU196624B (en) 1986-12-08 1986-12-08 Process for producing chymopapain with high specific activity
BG084338A BG50942A3 (bg) 1986-12-08 1988-06-01 Метод за получаване на химопапаин

Publications (1)

Publication Number Publication Date
BG50942A3 true BG50942A3 (bg) 1992-12-15

Family

ID=10969645

Family Applications (1)

Application Number Title Priority Date Filing Date
BG084338A BG50942A3 (bg) 1986-12-08 1988-06-01 Метод за получаване на химопапаин

Country Status (5)

Country Link
BG (1) BG50942A3 (bg)
CS (1) CS271346B2 (bg)
CU (1) CU22158A3 (bg)
DD (1) DD270723A5 (bg)
HU (1) HU196624B (bg)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8909836D0 (en) * 1989-04-28 1989-06-14 Boots Co Plc Therapeutic agent
CN1320111C (zh) * 2004-08-09 2007-06-06 王美岭 一种制备木瓜凝乳酶的方法

Also Published As

Publication number Publication date
CS377388A2 (en) 1989-12-13
CS271346B2 (en) 1990-09-12
HU196624B (en) 1988-12-28
CU22158A3 (es) 1994-01-31
DD270723A5 (de) 1989-08-09

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