BG60716B1 - Specific binding agents - Google Patents

Specific binding agents Download PDF

Info

Publication number
BG60716B1
BG60716B1 BG97607A BG9760793A BG60716B1 BG 60716 B1 BG60716 B1 BG 60716B1 BG 97607 A BG97607 A BG 97607A BG 9760793 A BG9760793 A BG 9760793A BG 60716 B1 BG60716 B1 BG 60716B1
Authority
BG
Bulgaria
Prior art keywords
human antibody
ser
tyr
altered
altered human
Prior art date
Application number
BG97607A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG97607A (bg
Inventor
Martine E Verhoeyen
Original Assignee
Unilever Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Unilever Nv filed Critical Unilever Nv
Publication of BG97607A publication Critical patent/BG97607A/bg
Publication of BG60716B1 publication Critical patent/BG60716B1/bg

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
    • C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
  • Nonmetallic Welding Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
BG97607A 1990-09-07 1993-04-05 Specific binding agents BG60716B1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB909019553A GB9019553D0 (en) 1990-09-07 1990-09-07 Specific binding agents
PCT/GB1991/001511 WO1992004380A1 (fr) 1990-09-07 1991-09-05 Agents de liaison specifiques

Publications (2)

Publication Number Publication Date
BG97607A BG97607A (bg) 1994-03-31
BG60716B1 true BG60716B1 (en) 1996-01-31

Family

ID=10681827

Family Applications (1)

Application Number Title Priority Date Filing Date
BG97607A BG60716B1 (en) 1990-09-07 1993-04-05 Specific binding agents

Country Status (18)

Country Link
US (2) US6204366B1 (fr)
EP (1) EP0483961B1 (fr)
JP (2) JP3514456B2 (fr)
KR (1) KR930702526A (fr)
AT (1) ATE233279T1 (fr)
AU (1) AU653167B2 (fr)
BG (1) BG60716B1 (fr)
CA (1) CA2090961C (fr)
DE (1) DE69133200T2 (fr)
DK (1) DK0483961T3 (fr)
ES (1) ES2193129T3 (fr)
FI (2) FI113873B (fr)
GB (1) GB9019553D0 (fr)
HU (2) HU9300609D0 (fr)
NO (2) NO314595B1 (fr)
RO (1) RO113432B1 (fr)
UA (1) UA46691C2 (fr)
WO (1) WO1992004380A1 (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6800738B1 (en) 1991-06-14 2004-10-05 Genentech, Inc. Method for making humanized antibodies
WO1994004679A1 (fr) * 1991-06-14 1994-03-03 Genentech, Inc. Procede pour fabriquer des anticorps humanises
EP0590058B1 (fr) 1991-06-14 2003-11-26 Genentech, Inc. ANTICORP HUMANISE specifique pour heregulin
WO1993011794A1 (fr) * 1991-12-13 1993-06-24 Xoma Corporation Procedes et matieres de preparation de domaines variables d'anticorps modifies et leurs utilisations therapeutiques
US5869619A (en) * 1991-12-13 1999-02-09 Xoma Corporation Modified antibody variable domains
WO1994011508A2 (fr) * 1992-11-13 1994-05-26 Cancer Research Fund Of Contra Costa Polypeptides presentant une specificite par rapport aux neoplasies, kit et procedes diagnostiques, therapeutiques et de vaccination
US5804187A (en) 1992-11-16 1998-09-08 Cancer Research Fund Of Contra Costa Modified antibodies with human milk fat globule specificity
US5792852A (en) * 1992-11-16 1998-08-11 Cancer Research Fund Of Contra Costa Polynucleotides encoding modified antibodies with human milk fat globule specificity
JPH09503901A (ja) * 1992-11-16 1997-04-22 キャンサー リサーチ ファンド オブ コントラ コスタ 広範な新生物特異性を有するペプチドおよびアンチセンスペプチド
US6281335B1 (en) * 1993-10-08 2001-08-28 Coulter Corporation Hybridoma and anti-KC-4 humanized monoclonal antibody
JPH07203974A (ja) * 1994-01-13 1995-08-08 Tosoh Corp 癌特異的ムチンを認識する抗体の遺伝子断片等
EP0781847A1 (fr) * 1995-11-06 1997-07-02 MERCK PATENT GmbH Anticorps monoclonal humanisé
WO1999025379A1 (fr) * 1997-11-14 1999-05-27 Euro-Celtique, S.A. Anticorps modifies a capacite amelioree de declenchement d'une reponse anti-idiotype
GB2360771A (en) * 2000-03-28 2001-10-03 Antisoma Res Ltd Compounds for targeting
WO2001074905A1 (fr) * 2000-04-03 2001-10-11 Antisoma Research Limited Composes de ciblage
US20040143101A1 (en) * 2001-04-02 2004-07-22 Soltis Daniel A. Immunoglobulin construct containing anti-mucin variable domain sequences for eliciting an anti-idiotype anti-tumor response
GB0200657D0 (en) * 2002-01-12 2002-02-27 Antisoma Plc Cancer treatment
EP1513879B1 (fr) * 2002-06-03 2018-08-22 Genentech, Inc. Bibliotheques de phages et anticorps synthetiques
US20040059093A1 (en) * 2002-07-16 2004-03-25 Stuart Bussell Methods to construct multimeric DNA and polymeric protein sequences as direct fusions or with linkers
JP2007501011A (ja) * 2003-08-01 2007-01-25 ジェネンテック・インコーポレーテッド 制限多様性配列を有する結合型ポリペプチド
GB0519398D0 (en) * 2005-09-23 2005-11-02 Antisoma Plc Biological materials and uses thereof
EP1957531B1 (fr) 2005-11-07 2016-04-13 Genentech, Inc. Polypeptides de liaison comprenant des sequences diversifiees et des sequences consensus hypervariables vh/vl
WO2007064919A2 (fr) * 2005-12-02 2007-06-07 Genentech, Inc. Polypeptides de liaison avec des sequences de diversite limitees
PH12013500703A1 (en) 2010-10-13 2013-05-20 Janssen Biotech Inc Human oncostatin m antibodies and methods of use
US20140079722A1 (en) * 2011-03-09 2014-03-20 Centrose, Llc Extracellular targeted drug conjugates
RU2493165C1 (ru) * 2012-02-28 2013-09-20 Общество с ограниченной ответственностью "Технофарма" Наноантитело, специфически связывающее белок muc1, способ детекции белка muc1 с помощью наноантител
KR102103366B1 (ko) 2012-04-30 2020-04-22 바이오테라, 인크. β-글루칸 면역치료 방법

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8607679D0 (en) * 1986-03-27 1986-04-30 Winter G P Recombinant dna product
CA1339204C (fr) * 1987-01-07 1997-08-05 Joyce Taylor-Papadimitriou Polypeptides, anticorps et sondes a noyau de mucine
JPH02500329A (ja) * 1987-05-21 1990-02-08 クリエイテイブ・バイオマリキユールズ・インコーポレーテツド ターゲット化多機能蛋白質
WO1989007268A1 (fr) * 1988-02-08 1989-08-10 John Muir Cancer & Aging Institute Anticorps monoclonal specifique a un nouvel antigene de surface a glycoproteines du type mucines qui se trouvent sur des cellules carcinomateuses humaines
EP0442926A1 (fr) * 1988-11-10 1991-08-28 Imperial Cancer Research Technology Limited Polypeptides
CA2003211A1 (fr) 1988-11-17 1990-05-17 Pei-Xiang Xing Anticorps monoclonaux
US5075219A (en) * 1989-04-05 1991-12-24 John Muir Cancer & Aging Institute Monoclonal antibody which recognizes a specific glycoprotein of a human milk-fat globule membrane mucin antigen and said mucin antigen
KR970007782B1 (ko) * 1989-11-17 1997-05-16 유니레버 엔 브이 특이적 결합제

Also Published As

Publication number Publication date
ATE233279T1 (de) 2003-03-15
EP0483961B1 (fr) 2003-02-26
RO113432B1 (ro) 1998-07-30
FI113873B (fi) 2004-06-30
EP0483961A1 (fr) 1992-05-06
CA2090961A1 (fr) 1992-03-08
FI930984L (fi) 1993-03-05
US20020086978A1 (en) 2002-07-04
CA2090961C (fr) 2004-01-20
AU653167B2 (en) 1994-09-22
NO20014822D0 (no) 2001-10-04
KR930702526A (ko) 1993-09-09
BG97607A (bg) 1994-03-31
JPH06500468A (ja) 1994-01-20
NO20014822L (no) 1993-05-05
AU8495391A (en) 1992-03-30
UA46691C2 (uk) 2002-06-17
ES2193129T3 (es) 2003-11-01
GB9019553D0 (en) 1990-10-24
NO314595B1 (no) 2003-04-14
NO930825L (no) 1993-05-05
DK0483961T3 (da) 2003-06-23
FI930984A0 (fi) 1993-03-05
DE69133200T2 (de) 2003-11-20
HU9300609D0 (en) 1993-05-28
FI114611B (fi) 2004-11-30
JP3514456B2 (ja) 2004-03-31
DE69133200D1 (de) 2003-04-03
NO930825D0 (no) 1993-03-05
HUT67796A (en) 1995-04-28
NO315239B1 (no) 2003-08-04
US6204366B1 (en) 2001-03-20
WO1992004380A1 (fr) 1992-03-19
JP2003061689A (ja) 2003-03-04

Similar Documents

Publication Publication Date Title
CA2090961C (fr) Agents liants specifiques
RU2112037C1 (ru) Гибридное моноклональное антитело, взаимодействующее с cd4-антигеном т-хелперных клеток человека, и способ его получения
US5891996A (en) Humanized and chimeric monoclonal antibodies that recognize epidermal growth factor receptor (EGF-R); diagnostic and therapeutic use
US5712120A (en) Method for obtaining modified immunoglobulins with reduced immunogenicity of murine antibody variable domains, compositions containing them
KR100516133B1 (ko) 항-인간항원 수용체의 신규한 제조방법 및 용도
JPH06506927A (ja) Ｐｅｍムチン縦列繰り返し配列特異性単クローン抗体の最小識別単位
CA2087095A1 (fr) Domaines associatifs
KR970007782B1 (ko) 특이적 결합제
CN112480250B (zh) 一种抗人骨桥蛋白的抗体及其应用
CA2080260C (fr) Anticorps monoclonaux contre des antigenes associes aux tumeurs, procedes de preparation et utilisation de ceux-ci
JP2024534706A (ja) 二重特異性抗体及びその使用
WO1997019113A2 (fr) Anticorps monoclonaux antiidiotypiques (ab2) et leurs utilisations
RU2102479C1 (ru) Химерное моноклональное антитело, взаимодействующее с человеческой плацентарной щелочной фосфатазой, вариабельная область тяжелой гамма-цепи химерного моноклонального антитела, вариабельная область легкой k-цепи химерного моноклонального антитела, фрагмент кднк, кодирующий вариабельную область тяжелой гамма-цепи химерного моноклонального антитела и фрагмент кднк, кодирующий вариабельную область легкой k-цепи химерного моноклонального антитела
JPH09278799A (ja) 抗エメリン抗体及び該抗体を用いたエメリンの測定方法