BG61080B1 - Модифициран биологичен материал - Google Patents

Модифициран биологичен материал Download PDF

Info

Publication number: BG61080B1
Authority: BG; Bulgaria
Prior art keywords: complement; cells; species; recipient; tissue
Prior art date: 1989-10-12

Application number

BG96329A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG96329A (bg

Inventor

David J White

Alan F Williams

Original Assignee

Imutran Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-10-12

Filing date

1992-05-12

Publication date

1996-10-31

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26296038&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG61080(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1989-10-12 Priority claimed from GB898922987A external-priority patent/GB8922987D0/en

1990-08-06 Priority claimed from GB909017198A external-priority patent/GB9017198D0/en

1992-05-12 Application filed by Imutran Ltd filed Critical Imutran Ltd

1993-12-24 Publication of BG96329A publication Critical patent/BG96329A/bg

1996-10-31 Publication of BG61080B1 publication Critical patent/BG61080B1/bg

Links

Classifications

- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
- A01K2267/025—Animal producing cells or organs for transplantation
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases

Landscapes

Life Sciences & Earth Sciences (AREA)
Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Genetics & Genomics (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Zoology (AREA)
General Health & Medical Sciences (AREA)
Biotechnology (AREA)
Bioinformatics & Cheminformatics (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
General Engineering & Computer Science (AREA)
Environmental Sciences (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Cell Biology (AREA)
Immunology (AREA)
Microbiology (AREA)
Plant Pathology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Gastroenterology & Hepatology (AREA)
Animal Husbandry (AREA)
Biodiversity & Conservation Biology (AREA)
Toxicology (AREA)
Physics & Mathematics (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Transplantation (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Materials For Medical Uses (AREA)

BG96329A 1989-10-12 1992-05-12 Модифициран биологичен материал BG61080B1 (bg)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB898922987A GB8922987D0 (en)	1989-10-12	1989-10-12	Modified biological material
GB909017198A GB9017198D0 (en)	1990-08-06	1990-08-06	Modified biological material
PCT/GB1990/001575 WO1991005855A1 (en)	1989-10-12	1990-10-12	Modified biological material

Publications (2)

Publication Number	Publication Date
BG96329A BG96329A (bg)	1993-12-24
BG61080B1 true BG61080B1 (bg)	1996-10-31

Family

ID=26296038

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG96329A BG61080B1 (bg)	1989-10-12	1992-05-12	Модифициран биологичен материал

Country Status (27)

Country	Link
US (1)	US6495735B1 (2)
EP (2)	EP0495852B1 (2)
JP (1)	JP3302358B2 (2)
KR (2)	KR920702410A (2)
CN (2)	CN1122719C (2)
AT (1)	ATE139562T1 (2)
AU (1)	AU654116B2 (2)
BG (1)	BG61080B1 (2)
CA (1)	CA2067235A1 (2)
CY (1)	CY1996A (2)
DE (2)	DE69027535T2 (2)
DK (1)	DK0495852T3 (2)
ES (1)	ES2060561T3 (2)
FI (1)	FI921618A7 (2)
GR (2)	GR940300004T1 (2)
HK (1)	HK48497A (2)
HU (1)	HUT64584A (2)
IE (1)	IE75345B1 (2)
IL (2)	IL95970A0 (2)
IN (1)	IN171948B (2)
MY (1)	MY107433A (2)
NO (2)	NO303502B1 (2)
NZ (2)	NZ248153A (2)
PT (2)	PT95580B (2)
RO (1)	RO109863B1 (2)
SG (1)	SG72614A1 (2)
WO (1)	WO1991005855A1 (2)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5705732A (en) *	1989-06-12	1998-01-06	Oklahoma Medical Research Foundation	Universal donor cells
JP2750220B2 (ja) *	1989-07-21	1998-05-13	ワシントンユニバーシティ	組換え産生したヒト細胞膜補助因子タンパク（ｍｃｐ）
US5846715A (en) *	1990-05-11	1998-12-08	The Austin Research Institute	CD46 variants
EP0537171B1 (en) *	1990-05-11	2002-09-18	The Austin Research Institute	CD46 isoforms
DE69233010T2 (de) *	1991-07-15	2004-02-19	Oklahoma Medical Research Foundation, Oklahoma	Universale spenderzellen
US6916654B1 (en) *	1992-06-29	2005-07-12	Oklahoma Medical Research Foundation	Universal donor cells
JPH08501451A (ja) *	1992-09-22	1996-02-20	ディーエヌエックスバイオセラピューティックス、インコーポレーテッド	異種移植臓器移植片の事前適応化、その他を目的とする膜間転移によるタンパク質の供給法
US5627264A (en) *	1994-03-03	1997-05-06	Alexion Pharmaceuticals, Inc.	Chimeric complement inhibitor proteins
WO1996006165A1 (en) *	1994-08-19	1996-02-29	The General Hospital Corporation	Genetically engineered swine cells
CA2227584A1 (en)	1995-08-04	1997-02-20	The General Hospital Corporation	Transgenic swine and swine cells having human hla genes
US6166288A (en) *	1995-09-27	2000-12-26	Nextran Inc.	Method of producing transgenic animals for xenotransplantation expressing both an enzyme masking or reducing the level of the gal epitope and a complement inhibitor
AU1933897A (en) *	1996-03-22	1997-10-17	Imutran Limited	Surfaces which prevent or reduce complement activation
DE69833545T2 (de)	1997-03-26	2006-12-14	Imperial College Innovations Ltd.	In der zellmembran verankertes antikoagulant-fusionsprotein
ATE313256T1 (de)	1997-07-14	2006-01-15	Nippon Meat Packers	Transgene schweine
WO1999022759A1 (en) *	1997-10-31	1999-05-14	Walter Reed Army Institute Of Research	Method of inhibiting side effects of pharmaceutical compositions containing amphiphilic vehicles or drug carrier molecules
SE523817C2 (sv)	1999-02-05	2004-05-18	Corline Systems Ab	Användning av ett koagulationsförebyggande ämne i samband med transplantation av insulinproducerande celler
GB9905503D0 (en)	1999-03-10	1999-05-05	Adprotech Plc	Novel compound formulations and methods of delivery
CA2533259C (en) *	2003-07-21	2014-01-28	Lifecell Corporation	Acellular tissue matrices made from galactose .alpha.-1,3-galactose-deficient tissue
EP2464219B1 (en)	2009-08-14	2019-10-23	Revivicor, Inc.	Multi-transgenic pigs for diabetes treatment
US9420770B2 (en)	2009-12-01	2016-08-23	Indiana University Research & Technology Corporation	Methods of modulating thrombocytopenia and modified transgenic pigs
WO2012031273A2 (en)	2010-09-03	2012-03-08	Stem Centrx, Inc.	Novel modulators and methods of use
CA2827348C (en)	2011-02-14	2021-02-23	Revivicor, Inc.	Genetically modified pigs for xenotransplantation of vascularized xenografts and derivatives thereof
ES2846758T3 (es)	2013-11-04	2021-07-29	Lifecell Corp	Métodos para eliminar la alfa-galactosa
CN114686427B (zh) *	2022-05-23	2022-07-29	中国人民解放军总医院第一医学中心	一种脾脏调节型b淋巴细胞及其制备方法与应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1982004443A1 (en) *	1981-06-12	1982-12-23	Ohio Univ	Genetic transformation of zygotes
US4431636A (en)	1982-05-24	1984-02-14	American Cyanamid Company	Bis(4-O-polyhexaose-thio)-phenyl ureas and method of use
US5109113A (en) *	1986-05-02	1992-04-28	Genentech, Inc.	Membrane anchor fusion polypeptides
JPS62104594A (ja) *	1985-10-31	1987-05-15	Terumo Corp	クエン酸塩利用能検査用培地組成物
JPH0742235B2 (ja) *	1985-11-08	1995-05-10	三共株式会社	自己免疫性疾病の予防・治療剤
IL82390A0 (en) *	1986-05-02	1987-10-30	Genentech Inc	Nucleic acid and methods for the synthesis of novel daf compositions
GB8615942D0 (en) *	1986-06-30	1986-08-06	Animal & Food Research Council	Peptide production
IL89790A (en) *	1988-04-01	2002-05-23	Johns Hopking University	Nucleic acid sequences that encode and cells that produce cr1 protein and methods of production and purification
DE3830271A1 (de)	1988-09-06	1990-03-15	Goetze Otto	Mittel mit immunsuppressiver wirkung
US5573940A (en) *	1989-06-12	1996-11-12	Oklahoma Medical Research Foundation	Cells expressing high levels of CD59

1990
- 1990-10-12 WO PCT/GB1990/001575 patent/WO1991005855A1/en not_active Ceased
- 1990-10-12 FI FI921618A patent/FI921618A7/fi not_active Application Discontinuation
- 1990-10-12 AU AU65392/90A patent/AU654116B2/en not_active Ceased
- 1990-10-12 IL IL95970A patent/IL95970A0/xx unknown
- 1990-10-12 MY MYPI90001781A patent/MY107433A/en unknown
- 1990-10-12 NZ NZ248153A patent/NZ248153A/en unknown
- 1990-10-12 NZ NZ235657A patent/NZ235657A/en unknown
- 1990-10-12 HU HU9201240A patent/HUT64584A/hu unknown
- 1990-10-12 JP JP51427990A patent/JP3302358B2/ja not_active Ceased
- 1990-10-12 CA CA002067235A patent/CA2067235A1/en not_active Abandoned
- 1990-10-12 PT PT95580A patent/PT95580B/pt not_active IP Right Cessation
- 1990-10-12 EP EP90915320A patent/EP0495852B1/en not_active Expired - Lifetime
- 1990-10-12 DK DK90915320.7T patent/DK0495852T3/da active
- 1990-10-12 DE DE69027535T patent/DE69027535T2/de not_active Expired - Fee Related
- 1990-10-12 IN IN872/CAL/90A patent/IN171948B/en unknown
- 1990-10-12 DE DE90915320T patent/DE495852T1/de active Pending
- 1990-10-12 RO RO92-200502A patent/RO109863B1/ro unknown
- 1990-10-12 CN CN90108275A patent/CN1122719C/zh not_active Expired - Fee Related
- 1990-10-12 AT AT90915320T patent/ATE139562T1/de not_active IP Right Cessation
- 1990-10-12 CN CNA021302499A patent/CN1491624A/zh active Pending
- 1990-10-12 KR KR1019920700843A patent/KR920702410A/ko not_active Ceased
- 1990-10-12 ES ES90915320T patent/ES2060561T3/es not_active Expired - Lifetime
- 1990-10-12 KR KR1019997005897A patent/KR100317106B1/ko not_active Expired - Fee Related
- 1990-10-12 SG SG1996001903A patent/SG72614A1/en unknown
- 1990-10-12 EP EP95118520A patent/EP0709459A3/en not_active Withdrawn
- 1990-10-12 IE IE364990A patent/IE75345B1/en not_active IP Right Cessation
1992
- 1992-04-10 NO NO921438A patent/NO303502B1/no active IP Right Review Request
- 1992-05-12 BG BG96329A patent/BG61080B1/bg unknown
1994
- 1994-02-28 GR GR940300004T patent/GR940300004T1/el unknown
- 1994-11-21 US US08/347,210 patent/US6495735B1/en not_active Expired - Lifetime
1996
- 1996-07-15 PT PT101896A patent/PT101896B/pt not_active IP Right Cessation
- 1996-08-07 GR GR960402106T patent/GR3020741T3/el unknown
1997
- 1997-04-17 HK HK48497A patent/HK48497A/en not_active IP Right Cessation
- 1997-05-07 IL IL12079597A patent/IL120795A0/xx unknown
- 1997-09-05 CY CY199697A patent/CY1996A/xx unknown
1998
- 1998-05-11 NO NO982131A patent/NO982131D0/no unknown

Also Published As

Publication number	Publication date
JPH05503074A (ja)	1993-05-27
DE495852T1 (de)	1994-03-31
PT95580B (pt)	1999-05-31
CN1491624A (zh)	2004-04-28
HUT64584A (en)	1994-01-28
HK48497A (en)	1997-04-25
DE69027535T2 (de)	1996-11-28
IE903649A1 (en)	1991-04-24
NO982131L (no)	1992-04-10
SG72614A1 (en)	2000-05-23
KR920702410A (ko)	1992-09-04
ES2060561T3 (es)	1996-08-01
IE75345B1 (en)	1997-08-27
EP0709459A3 (en)	1999-01-07
EP0495852B1 (en)	1996-06-19
HU9201240D0 (en)	1992-06-29
IL95970A0 (en)	1992-05-25
JP3302358B2 (ja)	2002-07-15
FI921618L (fi)	1992-04-10
US6495735B1 (en)	2002-12-17
EP0495852A1 (en)	1992-07-29
MY107433A (en)	1995-12-30
NO921438L (no)	1992-04-10
BG96329A (bg)	1993-12-24
EP0709459A2 (en)	1996-05-01
CN1122719C (zh)	2003-10-01
NO303502B1 (no)	1998-07-20
ATE139562T1 (de)	1996-07-15
PT101896B (pt)	2003-01-31
CN1051199A (zh)	1991-05-08
IL120795A0 (en)	1997-09-30
GR940300004T1 (en)	1994-02-28
DE69027535D1 (de)	1996-07-25
FI921618A0 (fi)	1992-04-10
FI921618A7 (fi)	1992-04-10
WO1991005855A1 (en)	1991-05-02
DK0495852T3 (da)	1996-07-15
NO921438D0 (no)	1992-04-10
AU6539290A (en)	1991-05-16
AU654116B2 (en)	1994-10-27
KR100317106B1 (ko)	2001-12-22
NO982131D0 (no)	1998-05-11
NZ248153A (en)	1997-07-27
PT95580A (pt)	1991-09-13
RO109863B1 (ro)	1995-06-30
GR3020741T3 (en)	1996-11-30
PT101896A (pt)	1998-02-27
CY1996A (en)	1997-09-05
CA2067235A1 (en)	1991-04-13
ES2060561T1 (es)	1994-12-01
IN171948B (2)	1993-02-13
NZ235657A (en)	1994-05-26

Publication	Publication Date	Title
McCurry et al.	1995	Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury
EP0495852B1 (en)	1996-06-19	Modified biological material
US5652373A (en)	1997-07-29	Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
Loveland et al.	2004	Characterization of a CD46 transgenic pig and protection of transgenic kidneys against hyperacute rejection in non‐immunosuppressed baboons
Watanabe et al.	2020	Intra‐bone bone marrow transplantation from hCD47 transgenic pigs to baboons prolongs chimerism to> 60 days and promotes increased porcine lung transplant survival
US5849288A (en)	1998-12-15	Method for production of monoclonal antibodies in chimeric mice or rats having xenogeneic antibody-producing cells
US5866757A (en)	1999-02-02	Engraftment and development of xenogeneic cells in normal mammals having reconstituted hematopoetic deficient immune systems
Ljunggren et al.	1995	MHC class I expression and CD8+ T cell development in TAP1/β2-microglobulin double mutant mice
AU2003265415A1 (en)	2004-03-03	Alpha(1,3)-GALACTOSYLTRANSFERASE NULL CELLS, METHODS OF SELECTING AND Alpha(1,3)-GALACTOSYLTRANSFERASE NULL SWINE PRODUCED THEREFROM
US5663481A (en)	1997-09-02	Animal model of the human immune system
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