BG62839B1 - Фармацевтични аерозолни състави - Google Patents

Фармацевтични аерозолни състави Download PDF

Info

Publication number: BG62839B1
Authority: BG; Bulgaria
Prior art keywords: composition according; factor; hydrogen; drug; surfactant
Prior art date: 1994-09-28

Application number

BG101347A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG101347A (en

Inventor

Li Li-Bovet

Keith A. Johnson

Original Assignee

Glaxo Wellcome Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-09-28

Filing date

1997-03-21

Publication date

2000-09-29

1997-03-21 Application filed by Glaxo Wellcome Inc. filed Critical Glaxo Wellcome Inc.

1997-12-30 Publication of BG101347A publication Critical patent/BG101347A/xx

2000-09-29 Publication of BG62839B1 publication Critical patent/BG62839B1/bg

Links

239000000203 mixture Substances 0.000 title claims abstract description 78
239000008249 pharmaceutical aerosol Substances 0.000 title claims abstract description 10
239000004094 surface-active agent Substances 0.000 claims abstract description 47
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 25
239000001257 hydrogen Substances 0.000 claims abstract description 23
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 22
-1 chloro hydrogen fluoride Chemical compound 0.000 claims abstract description 22
239000002245 particle Substances 0.000 claims abstract description 5
239000003814 drug Substances 0.000 claims description 54
229940079593 drug Drugs 0.000 claims description 45
239000003380 propellant Substances 0.000 claims description 42
GIIZNNXWQWCKIB-UHFFFAOYSA-N Serevent Chemical compound C1=C(O)C(CO)=CC(C(O)CNCCCCCCOCCCCC=2C=CC=CC=2)=C1 GIIZNNXWQWCKIB-UHFFFAOYSA-N 0.000 claims description 23
NDAUXUAQIAJITI-UHFFFAOYSA-N albuterol Chemical compound CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 NDAUXUAQIAJITI-UHFFFAOYSA-N 0.000 claims description 17
229960002052 salbutamol Drugs 0.000 claims description 17
WMWTYOKRWGGJOA-CENSZEJFSA-N fluticasone propionate Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(OC(=O)CC)[C@@]2(C)C[C@@H]1O WMWTYOKRWGGJOA-CENSZEJFSA-N 0.000 claims description 16
229960004017 salmeterol Drugs 0.000 claims description 16
229960000289 fluticasone propionate Drugs 0.000 claims description 15
238000000034 method Methods 0.000 claims description 15
LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical group FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 claims description 12
229960002714 fluticasone Drugs 0.000 claims description 9
150000003254 radicals Chemical class 0.000 claims description 8
KYKAJFCTULSVSH-UHFFFAOYSA-N chloro(fluoro)methane Chemical compound F[C]Cl KYKAJFCTULSVSH-UHFFFAOYSA-N 0.000 claims description 7
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125000001153 fluoro group Chemical group F* 0.000 claims description 6
NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 claims description 6
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KUVIULQEHSCUHY-XYWKZLDCSA-N Beclometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)COC(=O)CC)(OC(=O)CC)[C@@]1(C)C[C@@H]2O KUVIULQEHSCUHY-XYWKZLDCSA-N 0.000 claims description 5
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IMZMKUWMOSJXDT-UHFFFAOYSA-N cromoglycic acid Chemical compound O1C(C(O)=O)=CC(=O)C2=C1C=CC=C2OCC(O)COC1=CC=CC2=C1C(=O)C=C(C(O)=O)O2 IMZMKUWMOSJXDT-UHFFFAOYSA-N 0.000 claims description 5
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OHMHBGPWCHTMQE-UHFFFAOYSA-N 2,2-dichloro-1,1,1-trifluoroethane Chemical compound FC(F)(F)C(Cl)Cl OHMHBGPWCHTMQE-UHFFFAOYSA-N 0.000 claims description 3
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229910052731 fluorine Inorganic materials 0.000 claims description 3
239000011737 fluorine Substances 0.000 claims description 3
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 3
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YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 claims description 2
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125000002252 acyl group Chemical group 0.000 claims description 2
125000004429 atom Chemical group 0.000 claims description 2
125000001246 bromo group Chemical group Br* 0.000 claims description 2
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125000004433 nitrogen atom Chemical group N* 0.000 claims description 2
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WVLAAKXASPCBGT-UHFFFAOYSA-N reproterol Chemical compound C1=2C(=O)N(C)C(=O)N(C)C=2N=CN1CCCNCC(O)C1=CC(O)=CC(O)=C1 WVLAAKXASPCBGT-UHFFFAOYSA-N 0.000 claims description 2
229920006395 saturated elastomer Polymers 0.000 claims description 2
229910052799 carbon Inorganic materials 0.000 claims 1
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125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
150000002431 hydrogen Chemical class 0.000 claims 1
125000004417 unsaturated alkyl group Chemical group 0.000 claims 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract description 3
229910000040 hydrogen fluoride Inorganic materials 0.000 abstract 2
KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 abstract 1
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BNPSSFBOAGDEEL-UHFFFAOYSA-N albuterol sulfate Chemical compound OS(O)(=O)=O.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1.CC(C)(C)NCC(O)C1=CC=C(O)C(CO)=C1 BNPSSFBOAGDEEL-UHFFFAOYSA-N 0.000 description 17
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239000000126 substance Substances 0.000 description 13
HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 12
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XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 9
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JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 6
MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 description 6
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KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 4
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
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CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 4
239000013543 active substance Substances 0.000 description 4
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XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 4
238000004458 analytical method Methods 0.000 description 4
ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 description 4
NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 description 3
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210000001331 nose Anatomy 0.000 description 1
229960002969 oleic acid Drugs 0.000 description 1
235000021313 oleic acid Nutrition 0.000 description 1
239000004006 olive oil Substances 0.000 description 1
235000008390 olive oil Nutrition 0.000 description 1
230000003287 optical effect Effects 0.000 description 1
229960002657 orciprenaline Drugs 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
GIPDEPRRXIBGNF-KTKRTIGZSA-N oxolan-2-ylmethyl (z)-octadec-9-enoate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC1CCCO1 GIPDEPRRXIBGNF-KTKRTIGZSA-N 0.000 description 1
125000006353 oxyethylene group Chemical group 0.000 description 1
238000005192 partition Methods 0.000 description 1
150000002960 penicillins Chemical class 0.000 description 1
XDRYMKDFEDOLFX-UHFFFAOYSA-N pentamidine Chemical compound C1=CC(C(=N)N)=CC=C1OCCCCCOC1=CC=C(C(N)=N)C=C1 XDRYMKDFEDOLFX-UHFFFAOYSA-N 0.000 description 1
229960004448 pentamidine Drugs 0.000 description 1
229960000395 phenylpropanolamine Drugs 0.000 description 1
DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 description 1
150000008105 phosphatidylcholines Chemical class 0.000 description 1
239000006223 plastic coating Substances 0.000 description 1
229920001084 poly(chloroprene) Polymers 0.000 description 1
229940068918 polyethylene glycol 400 Drugs 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
239000000843 powder Substances 0.000 description 1
238000001556 precipitation Methods 0.000 description 1
229960005205 prednisolone Drugs 0.000 description 1
OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
108090000765 processed proteins & peptides Proteins 0.000 description 1
239000000047 product Substances 0.000 description 1
239000001294 propane Substances 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
102000004169 proteins and genes Human genes 0.000 description 1
108090000623 proteins and genes Proteins 0.000 description 1
MIXMJCQRHVAJIO-TZHJZOAOSA-N qk4dys664x Chemical compound O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O.C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O MIXMJCQRHVAJIO-TZHJZOAOSA-N 0.000 description 1
239000010453 quartz Substances 0.000 description 1
238000004064 recycling Methods 0.000 description 1
229960001457 rimiterol Drugs 0.000 description 1
IYMMESGOJVNCKV-SKDRFNHKSA-N rimiterol Chemical compound C([C@@H]1[C@@H](O)C=2C=C(O)C(O)=CC=2)CCCN1 IYMMESGOJVNCKV-SKDRFNHKSA-N 0.000 description 1
239000005060 rubber Substances 0.000 description 1
229940021597 salmeterol and fluticasone Drugs 0.000 description 1
229930195734 saturated hydrocarbon Natural products 0.000 description 1
239000000565 sealant Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
229940035044 sorbitan monolaurate Drugs 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
229940035049 sorbitan monooleate Drugs 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
229940012831 stearyl alcohol Drugs 0.000 description 1
229960005322 streptomycin Drugs 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
229940124530 sulfonamide Drugs 0.000 description 1
150000003456 sulfonamides Chemical class 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
239000002600 sunflower oil Substances 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
229940065721 systemic for obstructive airway disease xanthines Drugs 0.000 description 1
239000006068 taste-masking agent Substances 0.000 description 1
235000019364 tetracycline Nutrition 0.000 description 1
150000003522 tetracyclines Chemical class 0.000 description 1
229940040944 tetracyclines Drugs 0.000 description 1
229940072958 tetrahydrofurfuryl oleate Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
229960002117 triamcinolone acetonide Drugs 0.000 description 1
YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
238000002604 ultrasonography Methods 0.000 description 1
229950000339 xinafoate Drugs 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/10—Phosphatides, e.g. lecithin

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Pulmonology (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Biochemistry (AREA)
Epidemiology (AREA)
Molecular Biology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Otolaryngology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)
Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)

BG101347A 1994-09-28 1997-03-21 Фармацевтични аерозолни състави BG62839B1 (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB9419536A GB9419536D0 (en)	1994-09-28	1994-09-28	Medicaments
PCT/IB1995/000866 WO1996009816A1 (fr)	1994-09-28	1995-09-27	Medicaments

Publications (2)

Publication Number	Publication Date
BG101347A BG101347A (en)	1997-12-30
BG62839B1 true BG62839B1 (bg)	2000-09-29

Family

ID=10762008

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG101347A BG62839B1 (bg)	1994-09-28	1997-03-21	Фармацевтични аерозолни състави

Country Status (32)

Country	Link
US (1)	US5849265A (fr)
EP (1)	EP0783302B1 (fr)
JP (1)	JPH10506887A (fr)
KR (1)	KR100375469B1 (fr)
CN (1)	CN1084614C (fr)
AP (1)	AP742A (fr)
AT (1)	ATE187063T1 (fr)
AU (1)	AU707922B2 (fr)
BG (1)	BG62839B1 (fr)
BR (1)	BR9509108A (fr)
CZ (1)	CZ286356B6 (fr)
DE (1)	DE69513671T2 (fr)
DK (1)	DK0783302T3 (fr)
EE (1)	EE03380B1 (fr)
ES (1)	ES2140706T3 (fr)
FI (1)	FI971279L (fr)
GB (1)	GB9419536D0 (fr)
GE (1)	GEP20002140B (fr)
GR (1)	GR3032245T3 (fr)
HU (1)	HU221856B1 (fr)
IS (1)	IS1991B (fr)
MD (1)	MD1900C2 (fr)
MX (1)	MX9702149A (fr)
NO (1)	NO313658B1 (fr)
NZ (1)	NZ292995A (fr)
OA (1)	OA10603A (fr)
PL (1)	PL181453B1 (fr)
RO (1)	RO118564B1 (fr)
RU (1)	RU2157188C2 (fr)
SK (1)	SK281519B6 (fr)
UA (1)	UA47412C2 (fr)
WO (1)	WO1996009816A1 (fr)

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US6406745B1 (en)	1999-06-07	2002-06-18	Nanosphere, Inc.	Methods for coating particles and particles produced thereby
GB0009606D0 (en) *	2000-04-18	2000-06-07	Glaxo Group Ltd	Therapeutic combinations
US6451287B1 (en)	2000-05-26	2002-09-17	Smithkline Beecham Corporation	Fluorinated copolymer surfactants and use thereof in aerosol compositions
GB0016876D0 (en) *	2000-07-11	2000-08-30	Astrazeneca Ab	Novel formulation
US6759398B2 (en)	2000-08-05	2004-07-06	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative
US6858596B2 (en) *	2000-08-05	2005-02-22	Smithkline Beecham Corporation	Formulation containing anti-inflammatory androstane derivative
US6777399B2 (en) *	2000-08-05	2004-08-17	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
GB0019172D0 (en) *	2000-08-05	2000-09-27	Glaxo Group Ltd	Novel compounds
US6858593B2 (en) *	2000-08-05	2005-02-22	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
US6777400B2 (en) *	2000-08-05	2004-08-17	Smithkline Beecham Corporation	Anti-inflammatory androstane derivative compositions
US6787532B2 (en) *	2000-08-05	2004-09-07	Smithkline Beecham Corporation	Formulation containing anti-inflammatory androstane derivatives
US6750210B2 (en) *	2000-08-05	2004-06-15	Smithkline Beecham Corporation	Formulation containing novel anti-inflammatory androstane derivative
SI1775305T1 (sl) *	2000-08-05	2015-01-30	Glaxo Group Limited	S-fluorometil ester 6alfa,9alfa-difluoro-17alfa-((2-furanilkarboksil)oksi)- 11beta-hidroksi-16alfa-metil-3-okso-androst-1,4-dien-17-karbotiojske kisline kot protivnetno sredstvo
US7217409B2 (en)	2000-09-22	2007-05-15	Smithkline Beecham Corporation	Alkanoic acid derivatives
GB0106046D0 (en)	2001-03-12	2001-05-02	Glaxo Group Ltd	Canister
UA77656C2 (en) *	2001-04-07	2007-01-15	Glaxo Group Ltd	S-fluoromethyl ester of 6-alpha, 9-alpha-difluoro-17-alpha-[(2-furanylcarbonyl)oxy]-11-beta-hydroxy-16- alpha-methyl-3-oxoandrosta-1,4-dien-17-beta-carbothioacid as anti-inflammatory agent
US6667344B2 (en)	2001-04-17	2003-12-23	Dey, L.P.	Bronchodilating compositions and methods
KR100831534B1 (ko) *	2001-04-30	2008-05-22	글락소 그룹 리미티드	17.알파 위치에 시클릭 에스테르기를 지닌 항염증성의안드로스탄의 17.베타.-카르보티오에이트 에스테르 유도체
ES2307751T3 (es) *	2001-06-12	2008-12-01	Glaxo Group Limited	Nuevos esteres heterociclicos centi-inflamatorios 17 alfa de derivados 17 beta de carbotioato de androstano.
GB0118364D0 (en) *	2001-07-27	2001-09-19	Glaxo Group Ltd	Compounds
ES2293157T3 (es) *	2001-08-03	2008-03-16	Glaxo Group Limited	Compuestos tensioactivos y uso de los mismos.
GB0125127D0 (en)	2001-10-19	2001-12-12	Glaxo Group Ltd	Compounds
JP2003221335A (ja)	2001-10-26	2003-08-05	Dey Lp	慢性閉塞性肺疾患の症状を緩和するためのアルブテロールおよびイプラトロピウム吸入溶液、システム、キットおよび方法
US20030140920A1 (en) *	2001-10-26	2003-07-31	Dey L.P.	Albuterol inhalation soultion, system, kit and method for relieving symptoms of pediatric asthma
US6702997B2 (en)	2001-10-26	2004-03-09	Dey, L.P.	Albuterol inhalation solution, system, kit and method for relieving symptoms of pediatric asthma
US20030191151A1 (en) *	2001-10-26	2003-10-09	Imtiaz Chaudry	Albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease
US20030203930A1 (en) *	2001-10-26	2003-10-30	Imtiaz Chaudry	Albuterol and ipratropium inhalation solution, system, kit and method for relieving symptoms of chronic obstructive pulmonary disease
US20050175545A1 (en) *	2002-02-04	2005-08-11	Keith Biggadike	Formulation for inhalation comprising a glucocorticoid and a beta 2-adrenoreceptor agonist
GB0202635D0 (en) *	2002-02-05	2002-03-20	Glaxo Wellcome Mfg Pte Ltd	Formulation containing novel anti-inflammatory androstane derivative
CA2474626A1 (fr) *	2002-02-13	2003-08-21	Glaxo Group Limited	Composes d'acide carboxylique a utiliser comme agents de surface
GB0205327D0 (en) *	2002-03-06	2002-04-17	Glaxo Group Ltd	compounds
GB2389530B (en) *	2002-06-14	2007-01-10	Cipla Ltd	Pharmaceutical compositions
TWI359675B (en)	2003-07-10	2012-03-11	Dey L P	Bronchodilating β-agonist compositions
AU2004264941B2 (en)	2003-08-11	2008-11-27	Glaxo Group Limited	Pharmaceutical metered dose inhaler and methods relating thereto
EP1658105B1 (fr)	2003-08-29	2018-03-14	Glaxo Group Limited	Aerosol-doseur pharmaceutique et procedes associes
US7030255B2 (en) *	2004-03-09	2006-04-18	Lyondell Chemical Technology, L.P.	Oxidation process with in-situ H202 generation and polymer-encapsulated catalysts therefor
EP1949891A1 (fr)	2004-10-12	2008-07-30	Generics (UK) Limited	Procédé pour la préparation de formules à suspension pour aérosol, caractérisé en ce que les particles soient formées par précipitation à l'intérieur d'un récipient
DE602005009012D1 (de) *	2004-10-12	2008-09-25	Generics Uk Ltd	Rmulierungen, worin die partikel durch präzipition in einem aerosolbehälter gebildet werden
GB0507165D0 (en) *	2005-04-08	2005-05-18	Glaxo Group Ltd	Novel crystalline pharmaceutical product
GB0615108D0 (en) *	2006-07-28	2006-09-06	Glaxo Group Ltd	Novel formulations
WO2008097664A1 (fr)	2007-02-11	2008-08-14	Map Pharmaceuticals, Inc.	Procédé d'administration thérapeutique de dhe pour procurer un soulagement rapide de la migraine tout en minimisant le profil des effets secondaires
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1994
- 1994-09-28 GB GB9419536A patent/GB9419536D0/en active Pending
1995
- 1995-09-27 JP JP8511571A patent/JPH10506887A/ja not_active Ceased
- 1995-09-27 US US08/809,764 patent/US5849265A/en not_active Expired - Fee Related
- 1995-09-27 RU RU97106511/14A patent/RU2157188C2/ru not_active IP Right Cessation
- 1995-09-27 AP APAP/P/1997/000951A patent/AP742A/en active
- 1995-09-27 PL PL95319342A patent/PL181453B1/pl not_active IP Right Cessation
- 1995-09-27 BR BR9509108A patent/BR9509108A/pt not_active IP Right Cessation
- 1995-09-27 EP EP95932166A patent/EP0783302B1/fr not_active Expired - Lifetime
- 1995-09-27 MD MD97-0134A patent/MD1900C2/ro not_active IP Right Cessation
- 1995-09-27 AT AT95932166T patent/ATE187063T1/de not_active IP Right Cessation
- 1995-09-27 MX MX9702149A patent/MX9702149A/es not_active IP Right Cessation
- 1995-09-27 AU AU35321/95A patent/AU707922B2/en not_active Ceased
- 1995-09-27 GE GEAP19953636A patent/GEP20002140B/en unknown
- 1995-09-27 HU HU9702260A patent/HU221856B1/hu not_active IP Right Cessation
- 1995-09-27 RO RO97-00561A patent/RO118564B1/ro unknown
- 1995-09-27 CN CN95196444A patent/CN1084614C/zh not_active Expired - Fee Related
- 1995-09-27 SK SK393-97A patent/SK281519B6/sk unknown
- 1995-09-27 UA UA97031255A patent/UA47412C2/uk unknown
- 1995-09-27 CZ CZ1997936A patent/CZ286356B6/cs not_active IP Right Cessation
- 1995-09-27 EE EE9700061A patent/EE03380B1/xx not_active IP Right Cessation
- 1995-09-27 WO PCT/IB1995/000866 patent/WO1996009816A1/fr not_active Ceased
- 1995-09-27 ES ES95932166T patent/ES2140706T3/es not_active Expired - Lifetime
- 1995-09-27 KR KR1019970702014A patent/KR100375469B1/ko not_active Expired - Fee Related
- 1995-09-27 DE DE69513671T patent/DE69513671T2/de not_active Expired - Fee Related
- 1995-09-27 DK DK95932166T patent/DK0783302T3/da active
- 1995-09-27 NZ NZ292995A patent/NZ292995A/xx unknown
- 1995-09-27 FI FI971279A patent/FI971279L/fi not_active Application Discontinuation
1997
- 1997-03-10 IS IS4438A patent/IS1991B/is unknown
- 1997-03-21 OA OA60982A patent/OA10603A/en unknown
- 1997-03-21 BG BG101347A patent/BG62839B1/bg unknown
- 1997-03-25 NO NO19971422A patent/NO313658B1/no unknown
1999
- 1999-12-22 GR GR990403333T patent/GR3032245T3/el unknown

Also Published As

Publication number	Publication date
BR9509108A (pt)	1998-07-14
SK281519B6 (sk)	2001-04-09
OA10603A (en)	2002-08-30
EE03380B1 (et)	2001-04-16
EE9700061A (et)	1997-08-15
RU2157188C2 (ru)	2000-10-10
MD1900C2 (ro)	2002-12-31
MX9702149A (es)	1998-04-30
KR970705981A (ko)	1997-11-03
US5849265A (en)	1998-12-15
FI971279A7 (fi)	1997-03-26
CZ93697A3 (en)	1997-08-13
PL181453B1 (pl)	2001-07-31
WO1996009816A1 (fr)	1996-04-04
FI971279A0 (fi)	1997-03-26
FI971279L (fi)	1997-03-26
BG101347A (en)	1997-12-30
EP0783302A1 (fr)	1997-07-16
MD1900B2 (en)	2002-04-30
NO971422L (no)	1997-05-23
GEP20002140B (en)	2000-06-25
AP742A (en)	1999-04-26
GR3032245T3 (en)	2000-04-27
AP9700951A0 (en)	1997-04-30
IS1991B (is)	2005-02-15
EP0783302B1 (fr)	1999-12-01
PL319342A1 (en)	1997-08-04
CN1168630A (zh)	1997-12-24
DE69513671T2 (de)	2000-04-06
DK0783302T3 (da)	2000-05-29
MD970134A (en)	1999-02-28
GB9419536D0 (en)	1994-11-16
HUT77377A (hu)	1998-04-28
UA47412C2 (uk)	2002-07-15
SK39397A3 (en)	1997-10-08
AU707922B2 (en)	1999-07-22
NO971422D0 (no)	1997-03-25
RO118564B1 (ro)	2003-07-30
DE69513671D1 (de)	2000-01-05
NZ292995A (en)	1998-10-28
IS4438A (is)	1997-03-10
ATE187063T1 (de)	1999-12-15
AU3532195A (en)	1996-04-19
CZ286356B6 (cs)	2000-03-15
KR100375469B1 (ko)	2003-10-17
JPH10506887A (ja)	1998-07-07
HU221856B1 (hu)	2003-02-28
ES2140706T3 (es)	2000-03-01
CN1084614C (zh)	2002-05-15
NO313658B1 (no)	2002-11-11

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BG62839B1 (bg)	2000-09-29	Фармацевтични аерозолни състави
AU663906C (en)	1993-07-19	Medicaments
US5955439A (en)	1999-09-21	Pharmaceutical aerosol containing at least one sugar
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US5736124A (en)	1998-04-07	Aerosol formulations containing P134a and particulate medicament
RU2179037C2 (ru)	2002-02-10	Баллон для доставки фармацевтического состава, дозирующий ингалятор
JP3675474B2 (ja)	2005-07-27	医薬
EP0616524A1 (fr)	1994-09-28	Medicaments
JP2004536884A5 (fr)	2006-01-05
JP2004536884A (ja)	2004-12-09	界面活性剤として使用するための化合物
CA2200986C (fr)	2007-03-06	Medicaments
HK1111611A (en)	2008-08-15	Medicaments