BG63159B1 - Производни на заместени 4-бифенил-4-хидрокси-маслени киселини като инхибитори на матрични металопротеази - Google Patents

Производни на заместени 4-бифенил-4-хидрокси-маслени киселини като инхибитори на матрични металопротеази Download PDF

Info

Publication number: BG63159B1
Authority: BG; Bulgaria
Prior art keywords: carbon atoms; phenyl; hydroxy; chlorophenyl; ring
Prior art date: 1996-10-31

Application number

BG103426A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG103426A (en

Inventor

Harold Kluender

Susan Bjorge

Lisa Zadjura

William Brubaker

Original Assignee

Bayer Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-31

Filing date

1999-05-21

Publication date

2001-05-31

1999-05-21 Application filed by Bayer Corporation filed Critical Bayer Corporation

2000-01-31 Publication of BG103426A publication Critical patent/BG103426A/xx

2001-05-31 Publication of BG63159B1 publication Critical patent/BG63159B1/bg

Links

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- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
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- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
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- C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
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- C07C59/40—Unsaturated compounds
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- C07C59/40—Unsaturated compounds
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- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

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BG103426A 1996-10-31 1999-05-21 Производни на заместени 4-бифенил-4-хидрокси-маслени киселини като инхибитори на матрични металопротеази BG63159B1 (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US3026496P	1996-10-31	1996-10-31
PCT/US1997/019960 WO1998022436A1 (en)	1996-10-31	1997-10-30	Substituted 4-biphenyl-4-hydroxybutyric acid derivatives as matrix metalloprotease inhibitors

Publications (2)

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BG103426A BG103426A (en)	2000-01-31
BG63159B1 true BG63159B1 (bg)	2001-05-31

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BG103426A BG63159B1 (bg)	1996-10-31	1999-05-21	Производни на заместени 4-бифенил-4-хидрокси-маслени киселини като инхибитори на матрични металопротеази

Country Status (29)

Country	Link
US (1)	US5939583A (de)
EP (1)	EP0937036B1 (de)
JP (1)	JP2001505877A (de)
KR (1)	KR20000052899A (de)
CN (1)	CN1140508C (de)
AR (1)	AR009137A1 (de)
AT (1)	ATE210112T1 (de)
AU (1)	AU731830B2 (de)
BG (1)	BG63159B1 (de)
BR (1)	BR9712707A (de)
CA (1)	CA2268770A1 (de)
CZ (1)	CZ148599A3 (de)
DE (1)	DE69708909T2 (de)
DK (1)	DK0937036T3 (de)
EE (1)	EE03745B1 (de)
ES (1)	ES2167021T3 (de)
HU (1)	HUP9904664A3 (de)
ID (1)	ID18712A (de)
IL (1)	IL129420A (de)
MY (1)	MY117687A (de)
NO (1)	NO312629B1 (de)
PL (1)	PL333112A1 (de)
PT (1)	PT937036E (de)
SK (1)	SK58399A3 (de)
TR (1)	TR199900945T2 (de)
TW (1)	TW464642B (de)
UA (1)	UA57047C2 (de)
WO (1)	WO1998022436A1 (de)
ZA (1)	ZA979756B (de)

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HK1043981A1 (zh)	1998-12-30	2002-10-04	拜尔公司	取代的4-聯芳基丁酸和5-聯芳基戊酸衍生物作為治療呼吸疾病的基質金屬蛋白酶抑制劑的用途
EP1031349A1 (de) *	1999-02-25	2000-08-30	Bayer Aktiengesellschaft	Verwendung von substituierten 4-Biarylbuttersäuren und 5-Biarylpentansäuren zur Behandlung von zerebralen Krankheiten
DE10058163C2 (de) *	2000-11-22	2003-07-10	Bebig Isotopen Und Medizintech	Verfahren und Applikator zum Positionieren und/oder Auswerfen von Strahlenquellen über Hohlnadeln in biologisches Gewebe
PE20030701A1 (es)	2001-12-20	2003-08-21	Schering Corp	Compuestos para el tratamiento de trastornos inflamatorios
US20040225077A1 (en)	2002-12-30	2004-11-11	Angiotech International Ag	Drug delivery from rapid gelling polymer composition
US8460243B2 (en)	2003-06-10	2013-06-11	Abbott Diabetes Care Inc.	Glucose measuring module and insulin pump combination
US7722536B2 (en)	2003-07-15	2010-05-25	Abbott Diabetes Care Inc.	Glucose measuring device integrated into a holster for a personal area network device
CA3110101A1 (en)	2004-06-04	2005-12-15	Abbott Diabetes Care Inc.	Systems and methods for managing diabetes care data
KR101274309B1 (ko) *	2005-02-22	2013-06-13	랜박시 래보러터리스 리미티드	천식 및 기타 질병의 치료를 위한 기질 메탈로프로테나제저해제로서 5-페닐-펜탄산 유도체
US7414142B2 (en)	2005-09-19	2008-08-19	Wyeth	5-aryl-indan-1-one oximes and analogs useful as progesterone receptor modulators
US7319152B2 (en)	2005-09-19	2008-01-15	Wyeth	5-Aryl-indan-1-one and analogs useful as progesterone receptor modulators
SG160363A1 (en) *	2006-04-17	2010-04-29	Sumitomo Chemical Company Limt	Ester of cyclic carboxylic acid
BRPI0715231A2 (pt) *	2006-08-22	2013-06-25	Ranbaxy Lab Ltd	compostos, composiÇÕes farmacÊuticas e seus usos, auxiliar quiral e seu uso e processos para preparar um composto
US10136845B2 (en)	2011-02-28	2018-11-27	Abbott Diabetes Care Inc.	Devices, systems, and methods associated with analyte monitoring devices and devices incorporating the same
JP6804352B2 (ja) *	2017-03-22	2020-12-23	大阪瓦斯株式会社	コラゲナーゼｍｍｐ１及び３の産生抑制剤

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GB1040735A (en) *	1964-07-23	1966-09-01	British Drug Houses Ltd	4-aryl-3-hydroxybutyric acid and esters, amides and salts thereof
US4021479A (en) *	1971-03-17	1977-05-03	Boehringer Ingelheim Gmbh	Derivatives of 4-(4-biphenylyl)-butyric acid
ES446581A1 (es) *	1975-04-04	1977-06-16	Boots Co Ltd	Un procedimiento para preparar acidos 2-arilpropionicos.
US4151302A (en) *	1975-06-28	1979-04-24	Merck Patent Gesellschaft Mit Beschrankter Haftung	Araliphatic dihalogen compounds composition and method of use
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JPS60169462A (ja) *	1984-02-15	1985-09-02	Sumitomo Chem Co Ltd	光学活性なフエニルセリン誘導体の製造法
CA1223602A (en) *	1983-05-25	1987-06-30	Naohito Ohashi	Process for producing 3-(3,4-dihydroxyphenyl) serine
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US5789434A (en) *	1994-11-15	1998-08-04	Bayer Corporation	Derivatives of substituted 4-biarylbutyric acid as matrix metalloprotease inhibitors

1997
- 1997-10-29 MY MYPI97005143A patent/MY117687A/en unknown
- 1997-10-30 AR ARP970105054A patent/AR009137A1/es unknown
- 1997-10-30 CZ CZ991485A patent/CZ148599A3/cs unknown
- 1997-10-30 DK DK97945585T patent/DK0937036T3/da active
- 1997-10-30 PT PT97945585T patent/PT937036E/pt unknown
- 1997-10-30 KR KR1019990703763A patent/KR20000052899A/ko not_active Ceased
- 1997-10-30 DE DE69708909T patent/DE69708909T2/de not_active Expired - Fee Related
- 1997-10-30 JP JP52367798A patent/JP2001505877A/ja active Pending
- 1997-10-30 EE EEP199900180A patent/EE03745B1/xx not_active IP Right Cessation
- 1997-10-30 ES ES97945585T patent/ES2167021T3/es not_active Expired - Lifetime
- 1997-10-30 IL IL12942097A patent/IL129420A/xx not_active IP Right Cessation
- 1997-10-30 BR BR9712707-8A patent/BR9712707A/pt unknown
- 1997-10-30 UA UA99052950A patent/UA57047C2/uk unknown
- 1997-10-30 AU AU51024/98A patent/AU731830B2/en not_active Ceased
- 1997-10-30 HU HU9904664A patent/HUP9904664A3/hu unknown
- 1997-10-30 WO PCT/US1997/019960 patent/WO1998022436A1/en not_active Ceased
- 1997-10-30 ZA ZA9709756A patent/ZA979756B/xx unknown
- 1997-10-30 US US08/960,921 patent/US5939583A/en not_active Expired - Fee Related
- 1997-10-30 AT AT97945585T patent/ATE210112T1/de not_active IP Right Cessation
- 1997-10-30 CA CA002268770A patent/CA2268770A1/en not_active Abandoned
- 1997-10-30 TW TW086116305A patent/TW464642B/zh not_active IP Right Cessation
- 1997-10-30 PL PL97333112A patent/PL333112A1/xx unknown
- 1997-10-30 EP EP97945585A patent/EP0937036B1/de not_active Expired - Lifetime
- 1997-10-30 TR TR1999/00945T patent/TR199900945T2/xx unknown
- 1997-10-30 SK SK583-99A patent/SK58399A3/sk unknown
- 1997-10-30 CN CNB971809100A patent/CN1140508C/zh not_active Expired - Fee Related
- 1997-10-31 ID IDP973569A patent/ID18712A/id unknown
1999
- 1999-04-27 NO NO19991994A patent/NO312629B1/no not_active IP Right Cessation
- 1999-05-21 BG BG103426A patent/BG63159B1/bg unknown

Also Published As

Publication number	Publication date
IL129420A (en)	2003-09-17
NO312629B1 (no)	2002-06-10
NO991994D0 (no)	1999-04-27
KR20000052899A (ko)	2000-08-25
US5939583A (en)	1999-08-17
AU5102498A (en)	1998-06-10
SK58399A3 (en)	2000-01-18
ES2167021T3 (es)	2002-05-01
UA57047C2 (uk)	2003-06-16
NO991994L (no)	1999-06-15
EE03745B1 (et)	2002-06-17
DE69708909T2 (de)	2002-04-11
EP0937036A1 (de)	1999-08-25
CN1140508C (zh)	2004-03-03
MY117687A (en)	2004-07-31
IL129420A0 (en)	2000-02-17
AU731830B2 (en)	2001-04-05
EP0937036B1 (de)	2001-12-05
BG103426A (en)	2000-01-31
TR199900945T2 (xx)	1999-07-21
BR9712707A (pt)	1999-10-26
ATE210112T1 (de)	2001-12-15
CA2268770A1 (en)	1998-05-28
CZ148599A3 (cs)	1999-11-17
AR009137A1 (es)	2000-03-08
EE9900180A (et)	1999-12-15
PL333112A1 (en)	1999-11-08
WO1998022436A1 (en)	1998-05-28
ZA979756B (en)	1999-11-01
ID18712A (id)	1998-04-30
HUP9904664A3 (en)	2001-03-28
TW464642B (en)	2001-11-21
CN1241177A (zh)	2000-01-12
PT937036E (pt)	2002-05-31
JP2001505877A (ja)	2001-05-08
DK0937036T3 (da)	2002-04-02
HUP9904664A2 (hu)	2000-05-28
DE69708909D1 (en)	2002-01-17

Publication	Publication Date	Title
EP0937036B1 (de)	2001-12-05	Substituierte 4-biphenyl-4-hydroxybuttersäurederivate als matrix metallprotease inhibitoren
EP0671911A1 (de)	1995-09-20	Carboxypeptidyl-derivate als antidegenerative wirkstoffe
JP3354941B2 (ja)	2002-12-09	マトリックス・メタロプロテアーゼ阻害物質としての置換４―アリール酪酸誘導体
JP3524556B2 (ja)	2004-05-10	２―（ω―アロイルアルキル）―４―ビアリール−オキソ酪酸によるマトリックスメタロプロテアーゼの阻害
US5863915A (en)	1999-01-26	Substituted 4-arylbutyric acid derivatives as matrix metalloprotease
JP3090957B2 (ja)	2000-09-25	アセチレン含有化合物によるマトリックスメタロプロテアーゼの阻害
JP3417951B2 (ja)	2003-06-16	マトリックスメタロプロテアーゼ阻害剤としての置換されたオキシ酪酸
JP3305328B2 (ja)	2002-07-22	置換フェンアルキル化合物によるマトリックスプロテアーゼの阻害
US5804581A (en)	1998-09-08	Inhibition of matrix metalloproteases by substituted phenalkyl compounds
EP1217994A2 (de)	2002-07-03	Verwendung von substituierten 4-biarylbuttersäure- und 5-biarylpentansäurederivate zur behandlung der multiplen sklerose
US5932577A (en)	1999-08-03	Substituted oxobutyric acids as matrix metalloprotease inhibitors
MXPA99003734A (en)	2000-05-01	Substituted 4-biphenyl-4-hydroxybutyric acid derivatives as matrix metalloprotease inhibitors
US5932763A (en)	1999-08-03	Inhibition of matrix metalloproteases by 2-(ω-arolalkyl)-4-biaryl-4-oxobutyric acids
NZ335433A (en)	2001-04-27	Substituted 4-biphenyl-4-hydroxybutyric acid derivatives as matrix metalloprotease inhibitors and their use and manufacture as medicaments
HK1023112A (en)	2000-09-01	Substituted 4-biphenyl-4-hydroxybutyric acid derivatives as matrix metalloprotease
EP1087761A2 (de)	2001-04-04	Verwendung von substituierten 4-biarylbuttersäuren und 5-biarylpentansäuren zur behandlung von zerebralen krankheiten