BG63208B1 - Бициклични тахикининови антагонисти, тяхното приготовляване и използуване в фармацевтични състави - Google Patents

Бициклични тахикининови антагонисти, тяхното приготовляване и използуване в фармацевтични състави Download PDF

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Publication number: BG63208B1
Authority: BG; Bulgaria
Prior art keywords: cyclo; dap; seq; leu; asp
Prior art date: 1995-03-13

Application number

BG101849A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG101849A (en

Inventor

Federico Arcamone

Carlo Maggi

Laura Quartara

Danilo Giannotti

Original Assignee

A. Menarini Industrie Farmaceutiche Riunite S.R.L.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-03-13

Filing date

1997-08-22

Publication date

2001-06-29

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11351134&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG63208(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1997-08-22 Application filed by A. Menarini Industrie Farmaceutiche Riunite S.R.L. filed Critical A. Menarini Industrie Farmaceutiche Riunite S.R.L.

1998-04-30 Publication of BG101849A publication Critical patent/BG101849A/xx

2001-06-29 Publication of BG63208B1 publication Critical patent/BG63208B1/bg

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BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
NHOWLEZFTHYCTP-UHFFFAOYSA-N benzylhydrazine Chemical compound NNCC1=CC=CC=C1 NHOWLEZFTHYCTP-UHFFFAOYSA-N 0.000 description 1
UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 description 1
230000004071 biological effect Effects 0.000 description 1
239000004044 bronchoconstricting agent Substances 0.000 description 1
230000002741 bronchospastic effect Effects 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
UHBYWPGGCSDKFX-UHFFFAOYSA-N carboxyglutamic acid Chemical compound OC(=O)C(N)CC(C(O)=O)C(O)=O UHBYWPGGCSDKFX-UHFFFAOYSA-N 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
229940125904 compound 1 Drugs 0.000 description 1
125000006165 cyclic alkyl group Chemical group 0.000 description 1
150000001923 cyclic compounds Chemical class 0.000 description 1
201000003146 cystitis Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
208000035475 disorder Diseases 0.000 description 1
238000010494 dissociation reaction Methods 0.000 description 1
230000005593 dissociations Effects 0.000 description 1
230000037406 food intake Effects 0.000 description 1
238000009472 formulation Methods 0.000 description 1
FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 description 1
239000000174 gluconic acid Substances 0.000 description 1
235000012208 gluconic acid Nutrition 0.000 description 1
229910000040 hydrogen fluoride Inorganic materials 0.000 description 1
230000007062 hydrolysis Effects 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
238000000338 in vitro Methods 0.000 description 1
238000000099 in vitro assay Methods 0.000 description 1
208000015181 infectious disease Diseases 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
229960000367 inositol Drugs 0.000 description 1
239000000543 intermediate Substances 0.000 description 1
238000007918 intramuscular administration Methods 0.000 description 1
238000002955 isolation Methods 0.000 description 1
239000001630 malic acid Substances 0.000 description 1
235000011090 malic acid Nutrition 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
108010010478 neurokinin A(4-10) Proteins 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
229960003104 ornithine Drugs 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
230000001575 pathological effect Effects 0.000 description 1
210000001428 peripheral nervous system Anatomy 0.000 description 1
NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
239000010452 phosphate Substances 0.000 description 1
239000003495 polar organic solvent Substances 0.000 description 1
230000003389 potentiating effect Effects 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 description 1
210000001147 pulmonary artery Anatomy 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
238000010532 solid phase synthesis reaction Methods 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
238000006467 substitution reaction Methods 0.000 description 1
238000001308 synthesis method Methods 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
210000000626 ureter Anatomy 0.000 description 1
239000000052 vinegar Substances 0.000 description 1
JPZXHKDZASGCLU-LBPRGKRZSA-N β-(2-naphthyl)-alanine Chemical compound C1=CC=CC2=CC(C[C@H](N)C(O)=O)=CC=C21 JPZXHKDZASGCLU-LBPRGKRZSA-N 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
- C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
- C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Cardiology (AREA)
Pain & Pain Management (AREA)
Heart & Thoracic Surgery (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Endocrinology (AREA)
Virology (AREA)
Rheumatology (AREA)
Urology & Nephrology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

BG101849A 1995-03-13 1997-08-22 Бициклични тахикининови антагонисти, тяхното приготовляване и използуване в фармацевтични състави BG63208B1 (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IT95FI000044A IT1277835B1 (it)	1995-03-13	1995-03-13	Composti biciclici, loro preparazione ed uso in composizioni farmaceutiche
PCT/EP1996/001028 WO1996028467A1 (en)	1995-03-13	1996-03-11	Bicyclic tachykinins antagonists, preparation thereof and their use in pharmaceutical composition

Publications (2)

Publication Number	Publication Date
BG101849A BG101849A (en)	1998-04-30
BG63208B1 true BG63208B1 (bg)	2001-06-29

Family

ID=11351134

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG101849A BG63208B1 (bg)	1995-03-13	1997-08-22	Бициклични тахикининови антагонисти, тяхното приготовляване и използуване в фармацевтични състави

Country Status (33)

Country	Link
US (1)	US6150325A (de)
EP (1)	EP0815126B1 (de)
JP (1)	JP4618821B2 (de)
KR (1)	KR100405009B1 (de)
CN (1)	CN1189477C (de)
AR (1)	AR004476A1 (de)
AT (1)	ATE198481T1 (de)
AU (1)	AU696528B2 (de)
BG (1)	BG63208B1 (de)
BR (1)	BR9607348A (de)
CZ (1)	CZ287372B6 (de)
DE (1)	DE69611438T2 (de)
DK (1)	DK0815126T3 (de)
EA (1)	EA000697B1 (de)
EE (1)	EE03618B1 (de)
ES (1)	ES2155187T3 (de)
GE (1)	GEP20002271B (de)
GR (1)	GR3035676T3 (de)
HR (1)	HRP960117B1 (de)
HU (1)	HU222051B1 (de)
IL (1)	IL117395A (de)
IT (1)	IT1277835B1 (de)
MX (1)	MX9706927A (de)
NO (1)	NO319290B1 (de)
NZ (1)	NZ303982A (de)
PL (1)	PL184147B1 (de)
PT (1)	PT815126E (de)
RO (1)	RO118297B1 (de)
SK (1)	SK281899B6 (de)
TW (1)	TW565572B (de)
UA (1)	UA48962C2 (de)
WO (1)	WO1996028467A1 (de)
ZA (1)	ZA961983B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6017705A (en) *	1995-03-14	2000-01-25	Ludwig Institute For Cancer Research	Isolated nucleic acid molecules which are members of the MAGE-B family and uses thereof
IT1291776B1 (it) *	1997-02-07	1999-01-21	Menarini Ricerche Spa	Composti monociclici a quattro residui bifunzionali, aventi azione nk-2 antagonista
IT1304888B1 (it) *	1998-08-05	2001-04-05	Menarini Ricerche Spa	Composti monociclici ad azione nk-2 antagonista e formulazioni che licontengono
WO2001095904A1 (en) *	2000-06-12	2001-12-20	University Of Rochester	Method of treating symptoms of hormonal variation, including hot flashes, using tachykinin receptor antagonist
EP1297826A1 (de) *	2001-09-27	2003-04-02	Menarini Ricerche S.p.A.	Pharmazeutische Zusammensetzung zur nasalen Verabreichung enthaltend einen NK-2 Antagonisten
ITFI20020239A1 (it)	2002-12-06	2004-06-07	Menarini Ricerche Spa	Processo per la preparazione di composti peptidici biciclici.
ITFI20040221A1 (it)	2004-10-27	2005-01-27	Guidotti & C Spa	Composizioni farmaceutiche a base di nk2 antagonisti per uso pediatrico
ITRM20120331A1 (it)	2012-07-12	2014-01-13	Guidotti & C Spa Labor	Composizioni pediatriche orali liquide contenenti nepadutant.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1262902B (it) *	1992-04-15	1996-07-22	Menarini Farma Ind	Composti triciclici antagonisti delle tachichinine, loro preparazione e loro uso in composizioni farmaceutiche.

1995
- 1995-03-13 IT IT95FI000044A patent/IT1277835B1/it active IP Right Grant
1996
- 1996-03-01 AR ARP960101616A patent/AR004476A1/es active IP Right Grant
- 1996-03-07 IL IL11739596A patent/IL117395A/xx not_active IP Right Cessation
- 1996-03-11 PL PL96322105A patent/PL184147B1/pl unknown
- 1996-03-11 WO PCT/EP1996/001028 patent/WO1996028467A1/en not_active Ceased
- 1996-03-11 SK SK1212-97A patent/SK281899B6/sk not_active IP Right Cessation
- 1996-03-11 EP EP96907421A patent/EP0815126B1/de not_active Expired - Lifetime
- 1996-03-11 CZ CZ19972862A patent/CZ287372B6/cs not_active IP Right Cessation
- 1996-03-11 ES ES96907421T patent/ES2155187T3/es not_active Expired - Lifetime
- 1996-03-11 BR BR9607348A patent/BR9607348A/pt active IP Right Grant
- 1996-03-11 NZ NZ303982A patent/NZ303982A/en not_active IP Right Cessation
- 1996-03-11 HU HU9801835A patent/HU222051B1/hu active IP Right Grant
- 1996-03-11 KR KR1019970706419A patent/KR100405009B1/ko not_active Expired - Lifetime
- 1996-03-11 RO RO97-01700A patent/RO118297B1/ro unknown
- 1996-03-11 JP JP52726796A patent/JP4618821B2/ja not_active Expired - Lifetime
- 1996-03-11 EE EE9700230A patent/EE03618B1/xx unknown
- 1996-03-11 DK DK96907421T patent/DK0815126T3/da active
- 1996-03-11 MX MX9706927A patent/MX9706927A/es unknown
- 1996-03-11 PT PT96907421T patent/PT815126E/pt unknown
- 1996-03-11 AU AU51059/96A patent/AU696528B2/en not_active Expired
- 1996-03-11 DE DE69611438T patent/DE69611438T2/de not_active Expired - Lifetime
- 1996-03-11 UA UA97104990A patent/UA48962C2/uk unknown
- 1996-03-11 GE GEAP19963873A patent/GEP20002271B/en unknown
- 1996-03-11 EA EA199700223A patent/EA000697B1/ru not_active IP Right Cessation
- 1996-03-11 AT AT96907421T patent/ATE198481T1/de active
- 1996-03-11 CN CNB961937629A patent/CN1189477C/zh not_active Expired - Lifetime
- 1996-03-12 ZA ZA9601983A patent/ZA961983B/xx unknown
- 1996-03-13 TW TW085103008A patent/TW565572B/zh not_active IP Right Cessation
- 1996-03-13 HR HR960117A patent/HRP960117B1/xx not_active IP Right Cessation
1997
- 1997-08-22 BG BG101849A patent/BG63208B1/bg unknown
- 1997-09-03 NO NO19974057A patent/NO319290B1/no not_active IP Right Cessation
- 1997-09-09 US US08/929,215 patent/US6150325A/en not_active Expired - Lifetime
2001
- 2001-03-30 GR GR20010400526T patent/GR3035676T3/el unknown

Also Published As

Publication number	Publication date
NO974057D0 (no)	1997-09-03
UA48962C2 (uk)	2002-09-16
GEP20002271B (en)	2000-10-25
HU222051B1 (hu)	2003-04-28
PL322105A1 (en)	1998-01-05
KR100405009B1 (ko)	2004-05-20
ZA961983B (en)	1997-09-29
AR004476A1 (es)	1998-12-16
RO118297B1 (ro)	2003-04-30
HRP960117A2 (en)	1997-08-31
CZ287372B6 (en)	2000-11-15
CN1189477C (zh)	2005-02-16
DE69611438T2 (de)	2001-06-13
EE9700230A (et)	1998-04-15
NO974057L (no)	1997-11-07
ATE198481T1 (de)	2001-01-15
WO1996028467A1 (en)	1996-09-19
DK0815126T3 (da)	2001-05-07
EP0815126B1 (de)	2001-01-03
CN1183786A (zh)	1998-06-03
ITFI950044A0 (it)	1995-03-13
HUP9801835A3 (en)	2000-05-29
US6150325A (en)	2000-11-21
DE69611438D1 (de)	2001-02-08
HRP960117B1 (en)	2001-06-30
EP0815126A1 (de)	1998-01-07
MX9706927A (es)	1997-11-29
PL184147B1 (pl)	2002-09-30
JP4618821B2 (ja)	2011-01-26
IT1277835B1 (it)	1997-11-12
CZ286297A3 (cs)	1998-02-18
AU696528B2 (en)	1998-09-10
SK121297A3 (en)	1998-02-04
BR9607348A (pt)	1997-12-30
EE03618B1 (et)	2002-02-15
NO319290B1 (no)	2005-07-11
ES2155187T3 (es)	2001-05-01
TW565572B (en)	2003-12-11
AU5105996A (en)	1996-10-02
JPH11501643A (ja)	1999-02-09
ITFI950044A1 (it)	1996-09-13
GR3035676T3 (en)	2001-06-29
EA000697B1 (ru)	2000-02-28
PT815126E (pt)	2001-06-29
IL117395A0 (en)	1996-07-23
NZ303982A (en)	1998-04-27
KR19980703011A (ko)	1998-09-05
EA199700223A1 (ru)	1998-04-30
BG101849A (en)	1998-04-30
HUP9801835A2 (hu)	1999-01-28
IL117395A (en)	1999-12-31
SK281899B6 (sk)	2001-09-11

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