BG64278B1 - 2--ианиминоимидазолови производни, 'ъ''ав, м...'оди за пол"-аван...'о им и 'яхно'о използван... - Google Patents
2--ианиминоимидазолови производни, 'ъ''ав, м...'оди за пол"-аван...'о им и 'яхно'о използван... Download PDFInfo
- Publication number
- BG64278B1 BG64278B1 BG103220A BG10322099A BG64278B1 BG 64278 B1 BG64278 B1 BG 64278B1 BG 103220 A BG103220 A BG 103220A BG 10322099 A BG10322099 A BG 10322099A BG 64278 B1 BG64278 B1 BG 64278B1
- Authority
- BG
- Bulgaria
- Prior art keywords
- alkyl
- substituted
- formula
- hydrogen
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96202749 | 1996-10-02 | ||
| PCT/EP1997/005322 WO1998014432A1 (en) | 1996-10-02 | 1997-09-24 | Pde iv inhibiting 2-cyanoiminoimidazole derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG103220A BG103220A (en) | 1999-11-30 |
| BG64278B1 true BG64278B1 (bg) | 2004-08-31 |
Family
ID=8224456
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG103220A BG64278B1 (bg) | 1996-10-02 | 1999-03-01 | 2--ианиминоимидазолови производни, 'ъ''ав, м...'оди за пол"-аван...'о им и 'яхно'о използван... |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US6051718A (de) |
| EP (1) | EP0934280B1 (de) |
| JP (1) | JP3068208B2 (de) |
| KR (1) | KR100520002B1 (de) |
| CN (1) | CN1106387C (de) |
| AR (1) | AR008875A1 (de) |
| AT (1) | ATE236884T1 (de) |
| AU (1) | AU719561B2 (de) |
| BG (1) | BG64278B1 (de) |
| BR (1) | BR9712256B1 (de) |
| CA (1) | CA2267322C (de) |
| CY (1) | CY2380B1 (de) |
| CZ (1) | CZ297474B6 (de) |
| DE (1) | DE69720757T2 (de) |
| DK (1) | DK0934280T3 (de) |
| EE (1) | EE03825B1 (de) |
| ES (1) | ES2196308T3 (de) |
| HU (1) | HU225158B1 (de) |
| IL (2) | IL129298A0 (de) |
| MY (1) | MY116980A (de) |
| NO (1) | NO312960B1 (de) |
| NZ (1) | NZ334971A (de) |
| PL (1) | PL194673B1 (de) |
| PT (1) | PT934280E (de) |
| RU (1) | RU2180902C2 (de) |
| SI (1) | SI0934280T1 (de) |
| SK (1) | SK285878B6 (de) |
| TR (1) | TR199900732T2 (de) |
| UA (1) | UA62939C2 (de) |
| WO (1) | WO1998014432A1 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU760771B2 (en) * | 1998-04-01 | 2003-05-22 | Janssen Pharmaceutica N.V. | PDE IV inhibiting pyridine derivatives |
| US6953774B2 (en) | 2000-08-11 | 2005-10-11 | Applied Research Systems Ars Holding N.V. | Methods of inducing ovulation |
| EP1394152A4 (de) * | 2001-04-19 | 2005-02-02 | Eisai Co Ltd | 2-iminoimidazolderivate (1) |
| ES2427930T3 (es) | 2001-05-23 | 2013-11-04 | Mitsubishi Tanabe Pharma Corporation | Composición terapéutica para el tratamiento regenerativo de enfermedades de los cartílagos |
| ES2331300T3 (es) * | 2001-07-11 | 2009-12-29 | Nikken Chemicals Company, Limited | Remedios para enfermedades oculares alergicas. |
| TWI221838B (en) | 2001-08-09 | 2004-10-11 | Tanabe Seiyaku Co | Pyrazinoisoquinoline compound or naphthalene compound |
| PT1463493E (pt) | 2001-12-14 | 2008-01-04 | Serono Lab | Método para induzir a ovulação utilizando um modulador de nível camp não polipeptídico |
| CN100439336C (zh) | 2003-02-19 | 2008-12-03 | 卫材R&D管理有限公司 | 制备环状苯甲脒衍生物的方法 |
| EP1928437A2 (de) | 2005-08-26 | 2008-06-11 | Braincells, Inc. | Neurogenese mittels muscarinrezeptormodulation |
| EP2258358A3 (de) | 2005-08-26 | 2011-09-07 | Braincells, Inc. | Neurogenese mit Acetylcholinesterasehemmer |
| EP1940389A2 (de) | 2005-10-21 | 2008-07-09 | Braincells, Inc. | Modulation von neurogenese durch pde-hemmung |
| US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| AU2007249399A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| WO2010099217A1 (en) | 2009-02-25 | 2010-09-02 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
| WO2013106547A1 (en) | 2012-01-10 | 2013-07-18 | President And Fellows Of Harvard College | Beta-cell replication promoting compounds and methods of their use |
| EP3409666A3 (de) * | 2012-06-07 | 2019-01-02 | Georgia State University Research Foundation, Inc. | Seca-hemmer und verfahren zur herstellung und verwendung davon |
| GB2533925A (en) * | 2014-12-31 | 2016-07-13 | Univ Bath | Antimicrobial compounds, compositions and methods |
| CN109438434B (zh) * | 2018-11-19 | 2021-05-04 | 华南农业大学 | 一种含噁唑环的2-氰基亚氨基噻唑烷类化合物及其制备方法和应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0784461B2 (ja) * | 1986-12-19 | 1995-09-13 | 日本バイエルアグロケム株式会社 | 殺虫性ニトロイミノ又はシアノイミノ化合物 |
| JPH05310650A (ja) * | 1991-08-22 | 1993-11-22 | Nippon Soda Co Ltd | 新規なアミン誘導体、その製造方法及び殺虫剤 |
| CZ14795A3 (en) * | 1992-07-28 | 1996-07-17 | Rhone Poulenc Rorer Ltd | Benzene derivative containing phenyl group bound to aryl or heteroaryl fraction through an aliphatic or hetero atom containing group, process of its preparation and pharmaceutical composition containing thereof |
| AU673569B2 (en) * | 1992-12-02 | 1996-11-14 | Pfizer Inc. | Catechol diethers as selective PDE-IV inhibitors |
| GB9304919D0 (en) * | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
| CA2160928C (en) * | 1993-07-28 | 2005-07-05 | Garry Fenton | Compounds as pde iv and tnf inhibitors |
| JPH09502170A (ja) * | 1993-08-19 | 1997-03-04 | スミスクライン・ビーチャム・コーポレイション | フェネチルアミン化合物 |
| GB9401460D0 (en) * | 1994-01-26 | 1994-03-23 | Rhone Poulenc Rorer Ltd | Compositions of matter |
| EP0766676B1 (de) * | 1994-06-24 | 2002-05-22 | Euroceltique S.A. | Verbindungen zur hemmung von phosphodiesrerase iv |
| TW332201B (en) * | 1995-04-06 | 1998-05-21 | Janssen Pharmaceutica Nv | 1,3-Dihydro-1-(phenylalkyl)-2H-imidazol-2-one derivatives |
| TW375612B (en) * | 1995-04-06 | 1999-12-01 | Janssen Pharmaceutica Nv | 1,3-dihydro-2H-imidazol-2-one derivatives for the treatment of disease states related to an abnormal enzymatic or catalytic activity of phosphodiesterase type IV, preparation thereof and pharmaceutical composition containing the same |
| TW424087B (en) * | 1995-04-06 | 2001-03-01 | Janssen Pharmaceutica Nv | 1,3-dihydro-1-(phenylalkenyl)-2H-imidazol-2-one derivatives |
-
1997
- 1997-09-24 US US09/147,925 patent/US6051718A/en not_active Expired - Lifetime
- 1997-09-24 AU AU47792/97A patent/AU719561B2/en not_active Expired
- 1997-09-24 PT PT97910380T patent/PT934280E/pt unknown
- 1997-09-24 KR KR10-1999-7001204A patent/KR100520002B1/ko not_active Expired - Lifetime
- 1997-09-24 BR BRPI9712256-4A patent/BR9712256B1/pt not_active IP Right Cessation
- 1997-09-24 NZ NZ334971A patent/NZ334971A/xx not_active IP Right Cessation
- 1997-09-24 RU RU99109032/04A patent/RU2180902C2/ru active
- 1997-09-24 DK DK97910380T patent/DK0934280T3/da active
- 1997-09-24 JP JP10516215A patent/JP3068208B2/ja not_active Expired - Lifetime
- 1997-09-24 SI SI9730550T patent/SI0934280T1/xx unknown
- 1997-09-24 IL IL12929897A patent/IL129298A0/xx active IP Right Grant
- 1997-09-24 PL PL97332573A patent/PL194673B1/pl unknown
- 1997-09-24 DE DE69720757T patent/DE69720757T2/de not_active Expired - Lifetime
- 1997-09-24 ES ES97910380T patent/ES2196308T3/es not_active Expired - Lifetime
- 1997-09-24 EP EP97910380A patent/EP0934280B1/de not_active Expired - Lifetime
- 1997-09-24 SK SK344-99A patent/SK285878B6/sk not_active IP Right Cessation
- 1997-09-24 CN CN97198460A patent/CN1106387C/zh not_active Expired - Lifetime
- 1997-09-24 WO PCT/EP1997/005322 patent/WO1998014432A1/en not_active Ceased
- 1997-09-24 CZ CZ0102899A patent/CZ297474B6/cs not_active IP Right Cessation
- 1997-09-24 EE EEP199900112A patent/EE03825B1/xx unknown
- 1997-09-24 HU HU9904063A patent/HU225158B1/hu unknown
- 1997-09-24 TR TR1999/00732T patent/TR199900732T2/xx unknown
- 1997-09-24 UA UA99031702A patent/UA62939C2/uk unknown
- 1997-09-24 AT AT97910380T patent/ATE236884T1/de active
- 1997-09-24 CA CA002267322A patent/CA2267322C/en not_active Expired - Lifetime
- 1997-10-01 AR ARP970104528A patent/AR008875A1/es active IP Right Grant
- 1997-10-02 MY MYPI97004600A patent/MY116980A/en unknown
-
1999
- 1999-03-01 BG BG103220A patent/BG64278B1/bg unknown
- 1999-03-30 NO NO19991560A patent/NO312960B1/no not_active IP Right Cessation
- 1999-03-31 IL IL129298A patent/IL129298A/en not_active IP Right Cessation
-
2003
- 2003-11-04 CY CY0300074A patent/CY2380B1/xx unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BG64278B1 (bg) | 2--ианиминоимидазолови производни, 'ъ''ав, м...'оди за пол"-аван...'о им и 'яхно'о използван... | |
| KR19980703450A (ko) | Pde iv 및 사이토킨 억제 활성을 가진 1,3-디하이드로-1-(페닐알케닐)-2h-이미다졸-2-온 유도체 | |
| JP4778612B2 (ja) | Ｐｄｅｉｖ阻害ピリジン誘導体 | |
| KR100400159B1 (ko) | Pdeiv및사이토킨억제활성을가진1,3-디하이드로-2h-이미다졸-2-온유도체 | |
| HK1020344B (en) | Pde iv inhibiting 2-cyanoiminoimidazole derivatives | |
| MXPA00009632A (en) | Pde iv inhibiting pyridine derivatives | |
| HK1033579B (en) | Pde iv inhibiting pyridine derivatives |