BG64288B1 - 'ъ''ави на ов 'ля' про'...ин и м...'оди за 'яхно'о пол"-аван... - Google Patents

'ъ''ави на ов 'ля' про'...ин и м...'оди за 'яхно'о пол"-аван... Download PDF

Info

Publication number: BG64288B1
Authority: BG; Bulgaria
Prior art keywords: pyrrolo; pyrimidin; phenyl; protein; amino
Prior art date: 1996-12-20

Application number

BG103522A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG103522A (en

Inventor

Michael B. Mann

Randy I. Hecht

Original Assignee

Amgen Inc.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-12-20

Filing date

1999-06-23

Publication date

2004-08-31

1999-06-23 Application filed by Amgen Inc. filed Critical Amgen Inc.

2000-03-31 Publication of BG103522A publication Critical patent/BG103522A/xx

2004-08-31 Publication of BG64288B1 publication Critical patent/BG64288B1/bg

Links

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NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
229960000999 sodium citrate dihydrate Drugs 0.000 description 1
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical group [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
239000004296 sodium metabisulphite Substances 0.000 description 1
235000010262 sodium metabisulphite Nutrition 0.000 description 1
239000011684 sodium molybdate Substances 0.000 description 1
235000015393 sodium molybdate Nutrition 0.000 description 1
TVXXNOYZHKPKGW-UHFFFAOYSA-N sodium molybdate (anhydrous) Chemical compound [Na+].[Na+].[O-][Mo]([O-])(=O)=O TVXXNOYZHKPKGW-UHFFFAOYSA-N 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
229940080313 sodium starch Drugs 0.000 description 1
NGDIAZZSCVVCEW-UHFFFAOYSA-M sodium;butyl sulfate Chemical compound [Na+].CCCCOS([O-])(=O)=O NGDIAZZSCVVCEW-UHFFFAOYSA-M 0.000 description 1
239000004071 soot Substances 0.000 description 1
235000019337 sorbitan trioleate Nutrition 0.000 description 1
229960000391 sorbitan trioleate Drugs 0.000 description 1
239000008347 soybean phospholipid Substances 0.000 description 1
241000894007 species Species 0.000 description 1
210000000952 spleen Anatomy 0.000 description 1
239000007921 spray Substances 0.000 description 1
238000010561 standard procedure Methods 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
238000009495 sugar coating Methods 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
238000011477 surgical intervention Methods 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
230000009747 swallowing Effects 0.000 description 1
208000024891 symptom Diseases 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000001839 systemic circulation Effects 0.000 description 1
231100000057 systemic toxicity Toxicity 0.000 description 1
238000009492 tablet coating Methods 0.000 description 1
239000002700 tablet coating Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
239000010409 thin film Substances 0.000 description 1
125000003396 thiol group Chemical group [H]S* 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
229910021654 trace metal Inorganic materials 0.000 description 1
238000012546 transfer Methods 0.000 description 1
230000001052 transient effect Effects 0.000 description 1
CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
229940029284 trichlorofluoromethane Drugs 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
125000005591 trimellitate group Chemical group 0.000 description 1
102000003298 tumor necrosis factor receptor Human genes 0.000 description 1
208000001072 type 2 diabetes mellitus Diseases 0.000 description 1
125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000012178 vegetable wax Substances 0.000 description 1
229940070384 ventolin Drugs 0.000 description 1
235000012773 waffles Nutrition 0.000 description 1
238000005406 washing Methods 0.000 description 1
238000005303 weighing Methods 0.000 description 1
238000004260 weight control Methods 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
239000012138 yeast extract Substances 0.000 description 1
239000011592 zinc chloride Substances 0.000 description 1
235000005074 zinc chloride Nutrition 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/5759—Products of obesity genes, e.g. leptin, obese (OB), tub, fat
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Genetics & Genomics (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Diabetes (AREA)
Molecular Biology (AREA)
Zoology (AREA)
Obesity (AREA)
Biomedical Technology (AREA)
Biochemistry (AREA)
Hematology (AREA)
Wood Science & Technology (AREA)
General Engineering & Computer Science (AREA)
Biotechnology (AREA)
Biophysics (AREA)
Endocrinology (AREA)
Plant Pathology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Microbiology (AREA)
Child & Adolescent Psychology (AREA)
Physics & Mathematics (AREA)
Heart & Thoracic Surgery (AREA)
Toxicology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Gastroenterology & Hepatology (AREA)
Cardiology (AREA)
Vascular Medicine (AREA)

BG103522A 1996-12-20 1999-06-23 'ъ''ави на ов 'ля' про'...ин и м...'оди за 'яхно'о пол"-аван... BG64288B1 (bg)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US77097396A	1996-12-20	1996-12-20
PCT/US1997/023183 WO1998028427A1 (en)	1996-12-20	1997-12-11	Ob fusion protein compositions and methods

Publications (2)

Publication Number	Publication Date
BG103522A BG103522A (en)	2000-03-31
BG64288B1 true BG64288B1 (bg)	2004-08-31

Family

ID=25090296

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG103522A BG64288B1 (bg)	1996-12-20	1999-06-23	'ъ''ави на ов 'ля' про'...ин и м...'оди за 'яхно'о пол"-аван...

Country Status (25)

Country	Link
EP (2)	EP1835030A1 (de)
JP (2)	JP4175668B2 (de)
KR (1)	KR100937550B1 (de)
CN (1)	CN1195858C (de)
AR (2)	AR009436A1 (de)
AT (1)	ATE351910T1 (de)
AU (1)	AU5606098A (de)
BG (1)	BG64288B1 (de)
BR (1)	BR9713755A (de)
CA (1)	CA2275183A1 (de)
CZ (1)	CZ298203B6 (de)
DE (1)	DE69737266T2 (de)
DK (1)	DK0954588T3 (de)
EA (2)	EA004791B1 (de)
ES (1)	ES2280083T3 (de)
HU (1)	HU227088B1 (de)
IL (1)	IL130396A (de)
NO (2)	NO324506B1 (de)
NZ (1)	NZ514145A (de)
PL (1)	PL194159B1 (de)
PT (1)	PT954588E (de)
RS (1)	RS49927B (de)
SK (1)	SK287578B6 (de)
WO (1)	WO1998028427A1 (de)
ZA (1)	ZA9711239B (de)

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RU2178307C2 (ru) *	1995-12-27	2002-01-20	Джинентех Инк.	Производные ов-протеина

1997
- 1997-12-11 CA CA002275183A patent/CA2275183A1/en not_active Abandoned
- 1997-12-11 SK SK774-99A patent/SK287578B6/sk not_active IP Right Cessation
- 1997-12-11 RS YUP-279/99A patent/RS49927B/sr unknown
- 1997-12-11 CZ CZ0203699A patent/CZ298203B6/cs not_active IP Right Cessation
- 1997-12-11 HU HU0000302A patent/HU227088B1/hu not_active IP Right Cessation
- 1997-12-11 ES ES97952464T patent/ES2280083T3/es not_active Expired - Lifetime
- 1997-12-11 BR BR9713755-3A patent/BR9713755A/pt active Search and Examination
- 1997-12-11 CN CNB971818177A patent/CN1195858C/zh not_active Expired - Fee Related
- 1997-12-11 EP EP06024946A patent/EP1835030A1/de not_active Withdrawn
- 1997-12-11 PL PL334242A patent/PL194159B1/pl not_active IP Right Cessation
- 1997-12-11 JP JP52889698A patent/JP4175668B2/ja not_active Expired - Fee Related
- 1997-12-11 DK DK97952464T patent/DK0954588T3/da active
- 1997-12-11 EA EA200100216A patent/EA004791B1/ru not_active IP Right Cessation
- 1997-12-11 EP EP97952464A patent/EP0954588B1/de not_active Expired - Lifetime
- 1997-12-11 DE DE69737266T patent/DE69737266T2/de not_active Expired - Lifetime
- 1997-12-11 IL IL130396A patent/IL130396A/en not_active IP Right Cessation
- 1997-12-11 EA EA199900575A patent/EA004790B1/ru not_active IP Right Cessation
- 1997-12-11 AU AU56060/98A patent/AU5606098A/en not_active Abandoned
- 1997-12-11 PT PT97952464T patent/PT954588E/pt unknown
- 1997-12-11 AT AT97952464T patent/ATE351910T1/de active
- 1997-12-11 WO PCT/US1997/023183 patent/WO1998028427A1/en not_active Ceased
- 1997-12-11 KR KR1019997005618A patent/KR100937550B1/ko not_active Expired - Fee Related
- 1997-12-11 NZ NZ514145A patent/NZ514145A/en not_active IP Right Cessation
- 1997-12-15 ZA ZA9711239A patent/ZA9711239B/xx unknown
- 1997-12-16 AR ARP970105894A patent/AR009436A1/es active IP Right Grant
1999
- 1999-06-08 NO NO19992779A patent/NO324506B1/no not_active IP Right Cessation
- 1999-06-23 BG BG103522A patent/BG64288B1/bg unknown
2007
- 2007-03-16 NO NO20071415A patent/NO325096B1/no not_active IP Right Cessation
- 2007-03-16 AR ARP070101065A patent/AR059907A2/es unknown
2008
- 2008-05-29 JP JP2008140707A patent/JP4659068B2/ja not_active Expired - Fee Related

Also Published As

Publication number	Publication date
ES2280083T3 (es)	2007-09-01
JP4175668B2 (ja)	2008-11-05
HUP0000302A2 (hu)	2000-06-28
PL194159B1 (pl)	2007-05-31
AR009436A1 (es)	2000-04-12
KR100937550B1 (ko)	2010-01-19
RS49927B (sr)	2008-09-29
HK1021388A1 (en)	2000-06-09
EA199900575A1 (ru)	2000-02-28
PT954588E (pt)	2007-03-30
IL130396A0 (en)	2000-06-01
NO992779L (no)	1999-08-19
JP4659068B2 (ja)	2011-03-30
NO20071415L (no)	1999-08-19
EA004791B1 (ru)	2004-08-26
DK0954588T3 (da)	2007-05-14
BR9713755A (pt)	2000-02-01
SK287578B6 (sk)	2011-03-04
JP2008289487A (ja)	2008-12-04
EP0954588B1 (de)	2007-01-17
CZ298203B6 (cs)	2007-07-18
EA004790B1 (ru)	2004-08-26
ATE351910T1 (de)	2007-02-15
AU5606098A (en)	1998-07-17
SK77499A3 (en)	2001-04-09
JP2001512417A (ja)	2001-08-21
NO992779D0 (no)	1999-06-08
WO1998028427A1 (en)	1998-07-02
BG103522A (en)	2000-03-31
YU27999A (sh)	2000-10-30
CZ9902036A3 (cs)	2000-10-11
AR059907A2 (es)	2008-05-07
CA2275183A1 (en)	1998-07-02
CN1195858C (zh)	2005-04-06
EA200100216A1 (ru)	2001-08-27
NZ514145A (en)	2003-08-29
KR20000069617A (ko)	2000-11-25
IL130396A (en)	2011-09-27
NO325096B1 (no)	2008-02-04
HU227088B1 (en)	2010-06-28
DE69737266D1 (de)	2007-03-08
PL334242A1 (en)	2000-02-14
NO324506B1 (no)	2007-11-05
CN1246154A (zh)	2000-03-01
DE69737266T2 (de)	2007-11-08
ZA9711239B (en)	1998-06-23
EP0954588A1 (de)	1999-11-10
HUP0000302A3 (en)	2005-12-28
EP1835030A1 (de)	2007-09-19

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