BG64300B1 - Използване на фанхинон за лечение на болестта на алцхаймер - Google Patents

Използване на фанхинон за лечение на болестта на алцхаймер Download PDF

Info

Publication number: BG64300B1
Authority: BG; Bulgaria
Prior art keywords: pharmaceutical composition; phanquinone; vitamin; clioquinol; disease
Prior art date: 1997-08-21

Application number

BG104179A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG104179A (en

Inventor

Michel Xilinas

Panayotis N. Gerolymatos

Original Assignee

P.N. Gerolymatos S.A.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-21

Filing date

2000-02-22

Publication date

2004-09-30

2000-02-22 Application filed by P.N. Gerolymatos S.A. filed Critical P.N. Gerolymatos S.A.

2000-10-31 Publication of BG104179A publication Critical patent/BG104179A/xx

2004-09-30 Publication of BG64300B1 publication Critical patent/BG64300B1/bg

Links

VLPADTBFADIFKG-UHFFFAOYSA-N phanquone Chemical compound C1=CN=C2C(=O)C(=O)C3=NC=CC=C3C2=C1 VLPADTBFADIFKG-UHFFFAOYSA-N 0.000 title claims abstract description 84
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QCDFBFJGMNKBDO-UHFFFAOYSA-N Clioquinol Chemical compound C1=CN=C2C(O)=C(I)C=C(Cl)C2=C1 QCDFBFJGMNKBDO-UHFFFAOYSA-N 0.000 claims description 61
229960005228 clioquinol Drugs 0.000 claims description 59
239000000203 mixture Substances 0.000 claims description 39
FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical group [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 claims description 33
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ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical group O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims description 10
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

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Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Saccharide Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

BG104179A 1997-08-21 2000-02-22 Използване на фанхинон за лечение на болестта на алцхаймер BG64300B1 (bg)

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GR97100330		1997-08-21
GR97100507		1997-12-31
PCT/IB1998/001095 WO1999009981A1 (en)	1997-08-21	1998-07-17	Use of phanquinone for the treatment of alzheimer's disease

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BG104179A BG104179A (en)	2000-10-31
BG64300B1 true BG64300B1 (bg)	2004-09-30

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US (2)	US6670369B1 (cs)
EP (1)	EP1007040B1 (cs)
JP (1)	JP2001513558A (cs)
CN (1)	CN1145482C (cs)
AT (1)	ATE217191T1 (cs)
AU (1)	AU741782B2 (cs)
BG (1)	BG64300B1 (cs)
BR (1)	BR9814945A (cs)
CA (1)	CA2301706C (cs)
CZ (1)	CZ299739B6 (cs)
DE (1)	DE69805305T2 (cs)
DK (1)	DK1007040T3 (cs)
EA (1)	EA002526B1 (cs)
ES (1)	ES2177024T3 (cs)
HU (1)	HUP0004331A3 (cs)
IL (1)	IL134263A (cs)
IS (1)	IS1910B (cs)
NO (1)	NO317770B1 (cs)
NZ (1)	NZ502565A (cs)
PL (1)	PL191208B1 (cs)
PT (1)	PT1007040E (cs)
SK (1)	SK284708B6 (cs)
TR (1)	TR200000455T2 (cs)
WO (1)	WO1999009981A1 (cs)

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US6638711B1 (en)	1999-04-29	2003-10-28	The General Hospital Corporation	Methods for identifying an agent that inhibits oxygen-dependent hydrogen peroxide formation activity but does not inhibit superoxide-dependent hydrogen peroxide formation
US6323218B1 (en) *	1998-03-11	2001-11-27	The General Hospital Corporation	Agents for use in the treatment of Alzheimer's disease
WO2000040244A1 (en) *	1999-01-07	2000-07-13	P.N. Gerolymatos S.A.	Use of phanquinone for the treatment or prevention of memory impairment
AU2001250573A1 (en) *	2000-04-28	2001-11-12	Michel Xilinas	Treatment of pathological conditions influenced by the action of matrix metalloproteinases (mmps) using phanquinone
WO2001082911A2 (en) *	2000-04-28	2001-11-08	Gerolymatos P N Sa	TREATMENT OF PATHOLOGICAL CONDITIONS INFLUENCED BY THE ACTION OF MATRIX METALLOPROTEINASES (MMPs) USING CLIOQUINOL
AU7602100A (en)	2000-08-18	2002-03-04	Gen Hospital Corp	Method for the identification of agents that inhibit or promote cataracts and uses thereof
FR2818551B1 (fr) *	2000-12-22	2007-06-01	Claude Marc Pierre Hannoun	Utilisation de chelateurs pour le traitement des maladies a prions
AU2002950217A0 (en)	2002-07-16	2002-09-12	Prana Biotechnology Limited	8- Hydroxy Quinoline Derivatives
JP4481928B2 (ja) *	2003-03-11	2010-06-16	株式会社カネカ	コエンザイムｑ▲１０▼を含有した水中油型乳化組成物、及びその製法
WO2006117660A2 (en) *	2005-05-04	2006-11-09	Clio Pharmaceutical Corporation	Method for treating cancer, coronary, inflammatory and macular disease, combining the modulation of zinc- and/or copper dependent proteins
EP3137093B1 (en) *	2014-04-29	2017-09-13	Affiris AG	Treatment and prevention of alzheimer's disease (ad)

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DE1804736A1 (de) *	1967-11-02	1969-06-26	Ciba Geigy	Pharmazeutisches Praeparat
IL40311A (en)	1972-09-06	1973-04-30	Pharmaplantex Ltd	Pharmaceutical preparation for the treatment of gastro-intestinal troubles containing phanquone and furazolidone
GB1472257A (en) *	1973-09-10	1977-05-04	Christiaens Sa A	Derivative of 4-hydroxy-5-azacoumarin
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CA2078019C (en) *	1991-09-13	2002-08-27	Siegbert Heinrich Bissbort	Substance or composition and uses thereof
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US5980914A (en)	1997-08-22	1999-11-09	P.N. Gerolymatos S.A.	Clioquinol for the treatment of Parkinson's disease
US5994323A (en)	1997-12-31	1999-11-30	P.N. Gerolymatos S.A.	Pharmaceutical compositions comprising clioquinol in combination with vitamin B12 and therapeutic and prophylactic uses thereof
WO2000040244A1 (en) *	1999-01-07	2000-07-13	P.N. Gerolymatos S.A.	Use of phanquinone for the treatment or prevention of memory impairment
AU2001250573A1 (en)	2000-04-28	2001-11-12	Michel Xilinas	Treatment of pathological conditions influenced by the action of matrix metalloproteinases (mmps) using phanquinone
WO2001082911A2 (en)	2000-04-28	2001-11-08	Gerolymatos P N Sa	TREATMENT OF PATHOLOGICAL CONDITIONS INFLUENCED BY THE ACTION OF MATRIX METALLOPROTEINASES (MMPs) USING CLIOQUINOL

1998
- 1998-07-17 HU HU0004331A patent/HUP0004331A3/hu unknown
- 1998-07-17 EP EP98930970A patent/EP1007040B1/en not_active Expired - Lifetime
- 1998-07-17 NZ NZ502565A patent/NZ502565A/en unknown
- 1998-07-17 CN CNB988082926A patent/CN1145482C/zh not_active Expired - Fee Related
- 1998-07-17 AU AU81241/98A patent/AU741782B2/en not_active Ceased
- 1998-07-17 BR BR9814945-8A patent/BR9814945A/pt not_active Application Discontinuation
- 1998-07-17 CZ CZ20000611A patent/CZ299739B6/cs not_active IP Right Cessation
- 1998-07-17 DK DK98930970T patent/DK1007040T3/da active
- 1998-07-17 PT PT98930970T patent/PT1007040E/pt unknown
- 1998-07-17 EA EA200000242A patent/EA002526B1/ru not_active IP Right Cessation
- 1998-07-17 TR TR2000/00455T patent/TR200000455T2/xx unknown
- 1998-07-17 SK SK206-2000A patent/SK284708B6/sk not_active IP Right Cessation
- 1998-07-17 DE DE69805305T patent/DE69805305T2/de not_active Expired - Fee Related
- 1998-07-17 WO PCT/IB1998/001095 patent/WO1999009981A1/en not_active Ceased
- 1998-07-17 IL IL134263A patent/IL134263A/en not_active IP Right Cessation
- 1998-07-17 ES ES98930970T patent/ES2177024T3/es not_active Expired - Lifetime
- 1998-07-17 CA CA002301706A patent/CA2301706C/en not_active Expired - Fee Related
- 1998-07-17 JP JP2000507371A patent/JP2001513558A/ja active Pending
- 1998-07-17 AT AT98930970T patent/ATE217191T1/de not_active IP Right Cessation
- 1998-07-17 PL PL338673A patent/PL191208B1/pl not_active IP Right Cessation
- 1998-07-17 US US09/485,909 patent/US6670369B1/en not_active Expired - Fee Related
2000
- 2000-01-28 IS IS5366A patent/IS1910B/is unknown
- 2000-02-16 NO NO20000771A patent/NO317770B1/no not_active IP Right Cessation
- 2000-02-22 BG BG104179A patent/BG64300B1/bg unknown
2003
- 2003-11-18 US US10/717,182 patent/US7629354B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
IL134263A0 (en)	2001-04-30
AU8124198A (en)	1999-03-16
ATE217191T1 (de)	2002-05-15
CZ299739B6 (cs)	2008-11-05
ES2177024T3 (es)	2002-12-01
NZ502565A (en)	2002-03-01
US7629354B2 (en)	2009-12-08
CN1267218A (zh)	2000-09-20
SK284708B6 (sk)	2005-09-08
TR200000455T2 (tr)	2000-09-21
CZ2000611A3 (cs)	2000-08-16
WO1999009981A1 (en)	1999-03-04
CA2301706C (en)	2005-10-04
DE69805305T2 (de)	2002-12-05
EP1007040B1 (en)	2002-05-08
HUP0004331A2 (hu)	2001-05-28
US6670369B1 (en)	2003-12-30
PL338673A1 (en)	2000-11-20
EP1007040A1 (en)	2000-06-14
PT1007040E (pt)	2002-10-31
HUP0004331A3 (en)	2001-09-28
NO20000771D0 (no)	2000-02-16
AU741782B2 (en)	2001-12-06
US20050003018A1 (en)	2005-01-06
EA200000242A1 (ru)	2000-08-28
IS5366A (is)	2000-01-28
SK2062000A3 (en)	2000-08-14
HK1029937A1 (en)	2001-04-20
DE69805305D1 (de)	2002-06-13
CN1145482C (zh)	2004-04-14
CA2301706A1 (en)	1999-03-04
NO317770B1 (no)	2004-12-13
IS1910B (is)	2003-12-31
EA002526B1 (ru)	2002-06-27
PL191208B1 (pl)	2006-03-31
BR9814945A (pt)	2000-09-05
JP2001513558A (ja)	2001-09-04
NO20000771L (no)	2000-04-25
DK1007040T3 (da)	2002-08-26
BG104179A (en)	2000-10-31
IL134263A (en)	2006-04-10

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